| Assay ID | Title | Year | Journal | Article |
|---|
| AID147418 | Binding affinity against rat brain Non N-methyl-D-aspartate glutamate receptor glutamate site expressed in Xenopus oocyte | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID143606 | Displacement of [3H]DCKA at N-methyl-D-aspartate glutamate receptor 1 | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
| AID92343 | Binding affinity in rat brain cortical membranes by the displacement of [3H]AMPA at Ionotropic glutamate receptor AMPA | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
| AID234072 | Selectivity for glycine site | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID144749 | Inhibition of [3H]DCKA binding to NMDA receptor of rat brain membranes. | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors. |
| AID143444 | Compound was tested for inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
| CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor. |
| AID143296 | Binding affinity towards rat brain NMDA receptor glycine site expressed in Xenopus oocyte | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID93561 | Displacement of [3H]kainate from rat brain cortical membrane Ionotropic glutamate receptor kainate | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
| AID144896 | Inhibition of [3H]glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID143164 | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. |
| AID92633 | Inhibition of Ionotropic glutamate receptor AMPA in xenopus oocytes expressing the rat cerebral cortex poly(A+) RNA | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. |
| AID91453 | Apparent dissociation constant of [3H]kainate from Ionotropic glutamate receptor ionotropic kainate was determined in rat cortical slice preparation | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID145182 | Apparent dissociation constant of [3H]glycine from N-methyl-D-aspartate glutamate receptor in rat cortical slice preparation | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID143443 | Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
| CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor. |
| AID163310 | Apparent dissociation constant of [3H]AMPA from quisqualate receptor of rat cortical slice | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID146212 | Functional antagonism of NR1a/2C N-methyl-D-aspartate glutamate receptor of rat membrane expressed in Xenopus oocytes | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID91453 | Apparent dissociation constant of [3H]kainate from Ionotropic glutamate receptor ionotropic kainate was determined in rat cortical slice preparation | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID143616 | Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain cortical membranes. | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor. |
| AID143084 | Affinity for the glycine binding site of NMDA receptor by inhibition of [3H]5,7-dichlorokynurenic acid ([3H]DCKA) binding to rat brain synaptic membrane | 1994 | Journal of medicinal chemistry, Nov-11, Volume: 37, Issue:23
| Tricyclic quinoxalinediones: 5,6-dihydro-1H-pyrrolo[1,2,3-de] quinoxaline-2,3-diones and 6,7-dihydro-1H,5H-pyrido[1,2,3-de] quinoxaline-2,3-diones as potent antagonists for the glycine binding site of the NMDA receptor. |
| AID239197 | Inhibition constant against human liver carboxylesterase 1 (hCE1) using nitrophenyl acetate (o-NPA) as substrate | 2005 | Journal of medicinal chemistry, Apr-21, Volume: 48, Issue:8
| Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. |
| AID239122 | Inhibition constant against human Acetylcholinesterase (hAcChE) using acetylthiocholine (AcTCh) as substrate | 2005 | Journal of medicinal chemistry, Apr-21, Volume: 48, Issue:8
| Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. |
| AID239167 | Inhibition constant against rabbit liver carboxylesterase (rCE) using nitrophenyl acetate (o-NPA) as substrate | 2005 | Journal of medicinal chemistry, Apr-21, Volume: 48, Issue:8
| Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. |
| AID144896 | Inhibition of [3H]glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID143164 | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. |
| AID143303 | Displacement of [3H]glycine from glycine site on the NMDA receptor. | 1992 | Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18
| Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones. |
| AID144455 | Binding affinity at glycine binding site of NMDA receptor in rat cortical membranes by [3H]L-689,560 displacement. | 2001 | Journal of medicinal chemistry, Jun-07, Volume: 44, Issue:12
| Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives. |
| AID163310 | Apparent dissociation constant of [3H]AMPA from quisqualate receptor of rat cortical slice | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID145182 | Apparent dissociation constant of [3H]glycine from N-methyl-D-aspartate glutamate receptor in rat cortical slice preparation | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID143444 | Compound was tested for inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
| CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor. |
| AID92633 | Inhibition of Ionotropic glutamate receptor AMPA in xenopus oocytes expressing the rat cerebral cortex poly(A+) RNA | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. |
| AID239272 | Inhibition constant against human intestinal carboxylesterase 2 (hiCE) using nitrophenyl acetate (o-NPA) as substrate | 2005 | Journal of medicinal chemistry, Apr-21, Volume: 48, Issue:8
| Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. |
| AID143443 | Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
| CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor. |
| AID147418 | Binding affinity against rat brain Non N-methyl-D-aspartate glutamate receptor glutamate site expressed in Xenopus oocyte | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID92652 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA. | 1992 | Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18
| Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones. |
| AID144749 | Inhibition of [3H]DCKA binding to NMDA receptor of rat brain membranes. | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors. |
| AID143250 | In vitro inhibition of cortical slice at NMDA receptor | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential. |
| AID239166 | Inhibition constant against human Butyrylcholinesterase (hBuChE) using butyrylthiocholine (BuTCh) as substrate | 2005 | Journal of medicinal chemistry, Apr-21, Volume: 48, Issue:8
| Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. |
| AID234072 | Selectivity for glycine site | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID145260 | In vitro inhibition of [3H]glycine at NMDA receptor | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID146212 | Functional antagonism of NR1a/2C N-methyl-D-aspartate glutamate receptor of rat membrane expressed in Xenopus oocytes | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. |
| AID143296 | Binding affinity towards rat brain NMDA receptor glycine site expressed in Xenopus oocyte | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1798224 | Enzyme Inhibition Assay from Article 10.1021/jm049011j: \\Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.\\ | 2005 | Journal of medicinal chemistry, Apr-21, Volume: 48, Issue:8
| Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |