| Assay ID | Title | Year | Journal | Article |
|---|
| AID4213 | Binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
| Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. |
| AID258788 | Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID258789 | Displacement of [125I]DOI from cloned human 5HT2A receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID258785 | Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID5472 | In vitro efficacy against rat 5-hydroxytryptamine 2A receptor determined by using PI assay (Emax) | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID258786 | Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID5464 | In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cells | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID126795 | Tested for the ability to lower IOP in conscious cynomolgus monkeys with laser-induced ocular hypertension after 6 hr postdose of the compound | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID5626 | Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligand | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID5487 | In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID258791 | Displacement of [125I]DOI from cloned human 5HT2C receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID126793 | Tested for the ability to lower IOP in conscious cynomolgus monkeys with laser-induced ocular hypertension after 1 hr postdose of the compound | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID126794 | Tested for the ability to lower IOP in conscious cynomolgus monkeys with laser-induced ocular hypertension after 3h postdose of the compound | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID258818 | Head twitch response in SD mice, sc | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID3590 | In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptor | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID5473 | The receptor (5-hydroxytryptamine 2A ) mediated mobilization of intracellular calcium [Ca2+] was studied in rat smooth muscle cells | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID5471 | In vitro efficacy against rat 5-hydroxytryptamine 2A receptor was determined by using CA+ assay (Emax) | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID5157 | Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligand | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID258790 | Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID258787 | Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID3519 | Tested for functional response on CHO cells expressing cloned human 5-hydroxytryptamine 1A receptor | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID5571 | In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| AID5227 | Binding affinity against 5-hydroxytryptamine 2 receptor using [3H]ketanserin as radioligand | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
| Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. |
| AID5770 | Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |