| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347157 | Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347164 | 384 well plate NINDS Rhodamine confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347163 | 384 well plate NINDS AMC confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347156 | DAPI mCherry counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347170 | Vero cells viability counterscreen for qRT-PCR qHTS assay of selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347171 | Orthogonal mCherry assay for qRT-PCR qHTS of selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347158 | ZIKV-mCherry secondary qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347172 | Secondary qRT-PCR qHTS assay for selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID47357 | Transcriptional activation in CV-1 cells expressing RAR alpha at 1E-6M | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID645998 | Induction of apoptosis in human ATRA-resistant HL60R cells at 1 uM after 24 hrs | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1
| Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of |
| AID650085 | Antiproliferative activity against human NCI-H460 cells incubated for 24 hrs drug exposure measured after 48 hrs of recovery by sulforhodamine B assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID1870696 | Inhibition of Mycobacterium tuberculosis PafA expressed in Escherichia coli BL-21(DE3) assessed as inhibition of pup-ylation using Mtb InhA substrate at 20 uM by SDS-PAGE analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID1870695 | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as inhibition of growth measured after 7 days by microplate reader | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID82680 | Induction of apoptosis in HL60R leukemia cells after 24 hr r treatment at 1E-6M | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID646001 | Induction of apoptosis in human MDA-MB-231 cells at 1 uM after 96 hrs | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1
| Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of |
| AID1870699 | Inhibition of Mycobacterium tuberculosis PafA expressed in Escherichia coli BL-21(DE3) assessed as inhibition of pup-ylation using Mtb DHFR substrate at 20 uM by SDS-PAGE analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID47358 | Transcriptional activation in CV-1 cells expressing RAR beta at 1E-6M | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID650087 | Antitumor activity against human NCI-H460 cells xenografted in nude CD1 mouse assessed as tumor volume inhibition at 25 mg/kg, po administered qd 3 times per week for 2 weeks relative to control | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID248756 | Concentration of compound required for inhibition of (IGROV-1/Pt1) human cisplatin resistant ovarian carcinoma cell growth by 50% | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. |
| AID299869 | Activation of p38 kinase in IGROV1/Pt1 cells with p53 mutation assessed as phosphorylation after 18 hrs | 2007 | Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14
| Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. |
| AID240384 | Effective concentration against retinoic acid receptor gamma in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.3) | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. |
| AID93490 | Apoptosis was determined my morphological analysis of propidium-iodide-stained cells following 72 hr exposure to IC80 (0.5 uM), value expressed as percentage of apoptotic cells versus total cell number | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID101801 | Induction of apoptosis in MDA-MB-231 breast cancer cells after 96 hr at 0.5E-6M | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID365035 | Induction of apoptosis in human MDA-MB-231 cells at 1.0 uM after 96 hrs by acridine orange staining | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and |
| AID299860 | Antiproliferative activity against human NB4 cells after 72 hrs | 2007 | Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14
| Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. |
| AID1870697 | Inhibition of Mycobacterium tuberculosis PafA expressed in Escherichia coli BL-21(DE3) assessed as inhibition of pup-ylation using Mtb KasA substrate at 20 uM by SDS-PAGE analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID650090 | Antitumor activity against human A431 cells xenografted in nude CD1 mouse assessed as tumor volume inhibition at 25 mg/kg, po administered qd 3 times per week for 2 weeks relative to control | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID82679 | Induction of apoptosis in HL60R leukemia cells after 24 hr r treatment at 0.1E-6M | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID365036 | Induction of apoptosis in human MDA-MB-231 cells at 2.0 uM after 96 hrs by acridine orange staining | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and |
| AID58230 | Apoptosis was determined my morphological analysis of propidium-iodide-stained cells following 48 hr exposure to IC80 (0.5 uM), value expressed as percentage of apoptotic cells versus total cell number | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID200415 | Antiproliferative effect of compound on SAOS cell line | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID646002 | Induction of apoptosis in human MDA-MB-231 cells at 2 uM after 96 hrs | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1
| Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of |
| AID288576 | Antiproliferative activity against HMVE cells | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and |
| AID78402 | Antiproliferative effect of compound on H460 cell line expressing wild-type p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID650076 | Chemical stability in aqueous buffer containing 5% DMSO and 5% tween 80 at pH 1.2 assessed as compound recovery in anoxic conditions after 12 hrs by UPLC analysis | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID251334 | Percent level of apoptosis induced by 72 hr of exposure with IC80 in (IGROV-1) human ovarian carcinoma cells | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. |
| AID47359 | Transcriptional activation in CV-1 cells expressing RAR gamma at 1E-6M | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID93492 | Antiproliferative effect of compound on IGROV-1 cell line expressing wild-type p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID78410 | Inhibition of H460 cell proliferation after 144 hr treatment at 0.1E-6M; - denotes not determined | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID251335 | Percent level of apoptosis induced by 72 hr of exposure with IC80 in (IGROV-1/Pt1) human cisplatin resistant ovarian carcinoma cells | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. |
| AID101803 | Induction of apoptosis in MDA-MB-231 breast cancer cells after 96 hr at 1E-6M | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID78412 | Inhibition of H460 cell proliferation after 144 hr treatment at 1E-6M; - denotes not determined | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. |
| AID650073 | Chemical stability in aqueous buffer containing 5% DMSO and 5% tween 80 at pH 6.8 assessed as compound recovery in anoxic conditions after 24 hrs by UPLC analysis | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID93488 | Apoptosis was determined my morphological analysis of propidium-iodide-stained cells following 24 hr exposure to IC80 (0.5 uM), value expressed as percentage of apoptotic cells versus total cell number | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID645995 | Growth inhibition of human MDA-MB-231 cells at 1 uM after 96 hrs | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1
| Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of |
| AID645997 | Induction of apoptosis in human ATRA-resistant HL60R cells at 0.1 uM after 24 hrs | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1
| Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of |
| AID288577 | Inhibition of HMVE cell proliferation at 0.5 uM relative to control | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and |
| AID610815 | Transcriptional activation of human RARalpha at 1 uM by (TREpal)2-tk-CAT reporter gene assay | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
| Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. |
| AID81694 | Antiproliferative effect of compound on HCT116 cell line expressing wild-type p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID650244 | Toxicity in iv dosed nude CD1 mouse xenografted with human A431 cells assessed as mortality administered qd 3 times per week for 2 weeks | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID650071 | Chemical stability in aqueous buffer containing 5% DMSO and 5% tween 80 at pH 1.2 assessed as compound recovery in anoxic conditions after 3 hrs by UPLC analysis | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID108454 | Antiproliferative effect of compound on Me665/2/21 cell line expressing mutant p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID650242 | Solubility in water | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID55803 | Antiproliferative effect of compound on DU145 cell line expressing mutant p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID299858 | Antiproliferative activity against human IGROV1 cells after 72 hrs | 2007 | Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14
| Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. |
| AID650075 | Chemical stability in aqueous buffer containing 5% DMSO and 5% tween 80 at pH 7.4 assessed as compound recovery in anoxic conditions after 24 hrs by UPLC analysis | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID1870698 | Inhibition of Mycobacterium tuberculosis PafA expressed in Escherichia coli BL-21(DE3) assessed as inhibition of pup-ylation using Mtb PknB substrate at 20 uM by SDS-PAGE analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID610849 | Transcriptional activation of human RARbeta at 1 uM by (TREpal)2-tk-CAT reporter gene assay | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
| Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. |
| AID365039 | Growth inhibition of HMVE cells after 72 hrs by alamar blue method | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and |
| AID610813 | Transcriptional activation of human RARbeta at 0.1 uM by luciferase reporter gene assay relative to control | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
| Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. |
| AID650088 | Antitumor activity against human NCI-H460 cells xenografted in nude CD1 mouse assessed as tumor volume inhibition at 13 mg/kg, iv administered qd 3 times per week for 2 weeks relative to control | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID299865 | Induction of DNA damage in IGROV1 cells assessed as RPA2 protein phosphorylation after 6 hrs | 2007 | Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14
| Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. |
| AID1870693 | Inhibition of Mycobacterium tuberculosis PafA expressed in Escherichia coli BL-21(DE3) assessed as inhibition of pup-ylation using Mtb PanB substrate by SDS-PAGE analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID248330 | Concentration of compound required for inhibition of (IGROV-1) human ovarian carcinoma cell growth by 50% | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. |
| AID1870694 | Binding affinity to Mycobacterium tuberculosis PafA expressed in Escherichia coli BL-21(DE3) assessed as increase in thermal stability at 40 uM incubated for 15 mins at 25 degC followed by incubated at 52 to 72 degC for 5 mins by CESTA analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID650243 | Toxicity in po dosed nude CD1 mouse xenografted with human A431 cells assessed as mortality administered qd 3 times per week for 2 weeks | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID100550 | Antiproliferative effect of compound on LNcaP cell line expressing wild-type p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID72881 | Antiproliferative effect of compound on GBM cell line expressing mutant p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID1870691 | Inhibition of Mycobacterium tuberculosis PafA expressed in Escherichia coli BL-21(DE3) assessed as inhibition of pup-ylation using Mtb PanB substrate at 20 uM by SDS-PAGE analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID248352 | Concentration of compound required for inhibition of (NB4) human promyelocytic leukemia cell growth by 50% | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. |
| AID214257 | Antiproliferative effect of compound on U2OS cell line expressing wild-type p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID299861 | Induction of apoptosis in IGROV1 cells after 72 hrs by TUNEL assay | 2007 | Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14
| Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. |
| AID93489 | Apoptosis was determined my morphological analysis of propidium-iodide-stained cells following 48 hr exposure to IC80 (0.5 uM), value expressed as percentage of apoptotic cells versus total cell number | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID610850 | Transcriptional activation of human RARgamma at 1 uM by (TREpal)2-tk-CAT reporter gene assay | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
| Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. |
| AID299859 | Antiproliferative activity against human cisplatin-resistant IGROV1/Pt1 cells with p53 mutation after 72 hrs | 2007 | Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14
| Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. |
| AID1870692 | Inhibition of Corynebacterium glutamicum PafA expressed in Escherichia coli BL-21(DE3) assessed as inhibition of pup-ylation using Mtb PanB substrate at 20 uM by SDS-PAGE analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID650099 | Toxicity in nude CD1 mouse xenografted with human NCI-H460 NSCLC cells assessed as body weight loss at 25 mg/kg, po administered qd 3 times per week for 2 weeks | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID365034 | Induction of apoptosis in human HL60R cells at 1.0 uM after 24 hrs by acridine orange staining | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and |
| AID299866 | Induction of DNA damage in IGROV1 cells assessed as p53 protein phosphorylation after 6 hrs | 2007 | Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14
| Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. |
| AID610812 | Transcriptional activation of human RARalpha at 0.1 uM by luciferase reporter gene assay relative to control | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
| Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. |
| AID240375 | Effective concentration against retinoic acid receptor beta in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.3) | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. |
| AID7499 | Antiproliferative effect of compound on A2780/DX cell line | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID650086 | Antiproliferative activity against human A431 cells incubated for 24 hrs drug exposure measured after 48 hrs of recovery by sulforhodamine B assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID365033 | Induction of apoptosis in human HL60R cells at 0.1 uM after 24 hrs by acridine orange staining | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and |
| AID288594 | Inhibition of CD45 PTP at 10 uM relative to control by fluorescence spectrometry | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and |
| AID610855 | Induction of apoptosis in retinoid-resistant p53 null human HL60R cells assessed as DNA fragmentation at 0.1 uM after 24 hrs by acridine orange staining method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
| Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. |
| AID610856 | Induction of apoptosis in retinoid-resistant p53 null human HL60R cells assessed as DNA fragmentation at 1 uM after 24 hrs by acridine orange staining method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
| Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. |
| AID1870700 | Binding affinity to Mycobacterium tuberculosis PafA expressed in Escherichia coli BL-21(DE3) assessed as increase in thermal stability by measuring change in melting temperature in at 50 uM by CESTA analysis | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Discovery and Mechanistic Study of |
| AID58231 | Apoptosis was determined my morphological analysis of propidium-iodide-stained cells following 72 hr exposure to IC80 (0.5 uM), value expressed as percentage of apoptotic cells versus total cell number | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID645996 | Growth inhibition of human MDA-MB-231 cells at 2 uM after 96 hrs | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1
| Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of |
| AID650102 | Toxicity in nude CD1 mouse xenografted with human A431 cells assessed as body weight loss at 25 mg/kg, po administered qd 3 times per week for 2 weeks | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID650100 | Toxicity in nude CD1 mouse xenografted with human NCI-H460 NSCLC cells assessed as body weight loss at 13 mg/kg, iv administered qd 3 times per week for 2 weeks | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| New retinoid derivatives as back-ups of Adarotene. |
| AID58229 | Apoptosis was determined my morphological analysis of propidium-iodide-stained cells following 24 hr exposure to IC80 (0.5 uM), value expressed as percentage of apoptotic cells versus total cell number | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID156647 | Antiproliferative effect of compound on PC3 cell line | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID7886 | Antiproliferative effect of compound on A431 cell line expressing mutant p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID240381 | Effective concentration against retinoic acid receptor alpha in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.1-0.4) | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity. |
| AID610814 | Transcriptional activation of human RARgamma at 0.1 uM by luciferase reporter gene assay relative to control | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11
| Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. |
| AID102035 | Antiproliferative effect of compound on LoVo cell line expressing wild-type p53 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
| A novel atypical retinoid endowed with proapoptotic and antitumor activity. |
| AID365040 | Growth inhibition of HMVE cells at 0.5 uM after 72 hrs by alamar blue method | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |