The compound you described, **1-(benzenesulfonyl)-2-benzimidazolamine**, is also known as **2-amino-1-(phenylsulfonyl)benzimidazole**. It's a synthetic molecule with a complex chemical structure containing a benzimidazole ring, a sulfonyl group, and an amino group.
**Here's why it's important for research:**
* **Pharmaceutical Research:** This compound shows promising potential as a **therapeutic agent**. Studies have shown it exhibits various pharmacological activities, including:
* **Anti-cancer activity:** It has been investigated for its potential to inhibit the growth of various cancer cell lines.
* **Anti-inflammatory activity:** It has shown potential in reducing inflammation in experimental models.
* **Anti-microbial activity:** It has demonstrated activity against certain bacteria and fungi.
* **Other therapeutic effects:** Research is ongoing to explore its potential applications in treating other diseases like diabetes and neurodegenerative disorders.
* **Material Science Research:** This compound can be used as a **building block** for synthesizing new materials. Its unique chemical structure allows it to interact with various molecules and surfaces, leading to potential applications in:
* **Polymer chemistry:** It can be incorporated into polymers to modify their properties.
* **Surface modification:** It can be used to create coatings on surfaces with specific functionalities.
* **Sensors and biosensors:** Its ability to bind to specific molecules could be exploited in developing sensors and biosensors.
**It's important to note:**
* **Research is ongoing:** While this compound shows promise, more research is needed to fully understand its mechanisms of action, optimize its therapeutic potential, and evaluate its safety for human use.
* **Structure-activity relationships:** The chemical structure of 1-(benzenesulfonyl)-2-benzimidazolamine can be modified to create derivatives with potentially improved pharmacological properties.
Overall, 1-(benzenesulfonyl)-2-benzimidazolamine is a fascinating molecule with potential applications in diverse research fields. Continued research will help us further understand its potential and develop its applications for human benefit.
ID Source | ID |
---|---|
PubMed CID | 3025920 |
CHEMBL ID | 1321508 |
CHEBI ID | 93052 |
SCHEMBL ID | 14247143 |
Synonym |
---|
MLS-0425615.0001 , |
1-(phenylsulfonyl)-1h-benzimidazol-2-amine |
smr001548925 |
MLS002639481 |
1-(benzenesulfonyl)benzimidazol-2-amine |
173374-91-9 |
CHEMBL1321508 |
SCHEMBL14247143 |
1-(phenylsulfonyl)benzimidazol-2-amine |
bdbm62171 |
cid_3025920 |
(1-besylbenzimidazol-2-yl)amine |
1-(benzenesulfonyl)-2-benzimidazolamine |
DTXSID60169607 |
CHEBI:93052 |
1-benzenesulfonyl-1h-benzimidazol-2-amine |
Q27164781 |
1-(phenylsulfonyl)benzoimidazol-2-amine |
1-(benzenesulfonyl)benzoimidazol-2-amine |
Class | Description |
---|---|
sulfonamide | An amide of a sulfonic acid RS(=O)2NR'2. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
TDP1 protein | Homo sapiens (human) | Potency | 24.8446 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 14.1254 | 6.3096 | 60.2008 | 112.2020 | AID720709 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
interleukin-8 isoform 1 precursor | Homo sapiens (human) | IC50 (µMol) | 4.1367 | 0.5507 | 4.3977 | 18.7700 | AID2245; AID2250; AID2260 |
tumor necrosis factor | Homo sapiens (human) | IC50 (µMol) | 20.0000 | 0.0793 | 5.8098 | 14.7275 | AID2337 |
nucleotide-binding oligomerization domain-containing protein 1 isoform 1 | Homo sapiens (human) | IC50 (µMol) | 14.3668 | 0.0431 | 3.3619 | 18.4900 | AID2255; AID2261; AID2264; AID2333 |
Nucleotide-binding oligomerization domain-containing protein 2 | Homo sapiens (human) | IC50 (µMol) | 20.0000 | 0.0370 | 4.3307 | 7.9433 | AID655844 |
Nucleotide-binding oligomerization domain-containing protein 1 | Homo sapiens (human) | IC50 (µMol) | 2.2000 | 0.0900 | 0.9691 | 2.7000 | AID655843 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID655843 | Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10 | Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. |
AID655844 | Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10 | Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. |
AID655845 | Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10 | Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. |
AID655846 | Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10 | Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.53) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |