| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1154616 | Displacement of [3H]5-HT from 5-HT2C receptor (unknown origin) expressed in hamster AV12 cells | 2014 | Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13
| Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands. |
| AID1178357 | Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells | 2014 | Journal of medicinal chemistry, Sep-11, Volume: 57, Issue:17
| Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. |
| AID1863242 | Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs by luminescence counter analysis | 2022 | Bioorganic & medicinal chemistry, 09-15, Volume: 70 | Novel difluoromethyl-containing 1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1H-indole scaffold as potent 5-HT |
| AID1729629 | Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membrane measured after 60 mins | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT |
| AID1520010 | Displacement of [3H]-raclopride from human D2R expressed in HEK293 cells after 1 hr by microbeta plate reader analysis | | | |
| AID1729622 | Inhibition of human erythrocyte AChE at 10^-6 M using acetylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based Ellman's method relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT |
| AID1729635 | Antagonist activity at human 5HT6 receptor expressed in COS-7 cells assessed as inhibition of 5HT-induced cAMP accumulation preincubated for 7 mins followed by 5-HT addition and measured after 10 mins by HTRF assay | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT |
| AID1154619 | Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis | 2014 | Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13
| Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands. |
| AID1556435 | Metabolic stability in rat liver microsomes assessed as half life incubated for 20 to 60 mins in presence of metabolic phase 1 cofactors by HPLC-LC/MS analysis | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | 2-Aminoimidazole-based antagonists of the 5-HT |
| AID1351506 | Binding affinity to 5HT6R (unknown origin) | 2018 | European journal of medicinal chemistry, Jan-20, Volume: 144 | Novel non-sulfonamide 5-HT |
| AID1863240 | Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter method | 2022 | Bioorganic & medicinal chemistry, 09-15, Volume: 70 | Novel difluoromethyl-containing 1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1H-indole scaffold as potent 5-HT |
| AID1520013 | Half life in rat liver microsomes up to 60 mins by HPLC-LC/MS analysis | | | |
| AID1520007 | Binding affinity to human 5-HT2AR expressed in HEK293 cells by competitive binding assay | | | |
| AID1626455 | Displacement of [3H]Lu AE60157 from rat brain 5-HT6 receptor | 2016 | ACS medicinal chemistry letters, Jun-09, Volume: 7, Issue:6
| N1-Azinylsulfonyl-1H-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties. |
| AID1916468 | Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constant | 2021 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 49 | Chemical update on the potential for serotonin 5-HT |
| AID1520006 | Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells after 1 hr by microbeta plate reader analysis | | | |
| AID1520012 | Intrinsic clearance in rat liver microsomes up to 60 mins by HPLC-LC/MS analysis relative to control | | | |
| AID1854627 | Displacement of [3H]-LSD from human 5HT6 receptor expressed in CHO cells assessed as inhibition constant incubated for 120 mins by liquid scintillation counting analysis | | | |
| AID1729625 | Inhibition of human BuChE using butyrylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based Ellman's method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT |
| AID1729628 | Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membrane at 10^-5 M measured after 60 mins relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT |
| AID1520008 | Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis | | | |
| AID1556434 | Metabolic stability in rat liver microsomes assessed as intrinsic clearance incubated for 20 to 60 mins in presence of metabolic phase 1 cofactors by HPLC-LC/MS analysis | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | 2-Aminoimidazole-based antagonists of the 5-HT |
| AID1729627 | Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membrane at 10^-6 M measured after 60 mins relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT |
| AID1520009 | Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis | | | |
| AID1729623 | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based Ellman's method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT |
| AID1729636 | Antagonist activity at human 5HT6 receptor expressed in COS-7 cells assessed as inhibition of 5HT-induced cAMP accumulation preincubated for 7 mins followed by 5-HT addition and measured after 10 mins by HTRF assay relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT |
| AID1520032 | Reversal of phencyclidine-induced memory impairment in Sprague-Dawley rat at 1 to 3 mg/kg, po for 2 hrs followed by phencyclidine treatment 45 mins prior to testing by novel object recognition test | | | |
| AID1441516 | Antagonist activity at 5-HT6 receptor (unknown origin) | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT |
| AID1346893 | Human 5-HT2C receptor (5-Hydroxytryptamine receptors) | 2014 | Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13
| Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands. |
| AID1345170 | Human 5-HT6 receptor (5-Hydroxytryptamine receptors) | 2014 | Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13
| Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |