| Assay ID | Title | Year | Journal | Article |
|---|
| AID774921 | Inhibition of TPA-induced EBV early antigen activation infected in human Raji cells assessed as antigen activity at 100 mol ratio/TPA after 48 hrs by immunofluorescence method relative to control | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. |
| AID1736154 | Inhibition of wild type recombinant HIV-1 subtype B BH10 p66/p51 reverse transcriptase heterodimer expressed in Escherichia coli BL21 (DE3) assessed as inhibition of dTTP incorporation on poly(rA)-oligo(dT) template primer duplex at 100 uM preincubated wi | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | Design, synthesis and biological evaluation of quinoxaline compounds as anti-HIV agents targeting reverse transcriptase enzyme. |
| AID774919 | Inhibition of TPA-induced EBV early antigen activation infected in human Raji cells after 48 hrs by immunofluorescence method relative to control | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. |
| AID1588365 | Activation of Trypanosoma cruzi cruzain assessed as increase in enzyme activity using Z-FR-AMC as substrate at 0.1 mM incubated for 15 mins in dark and measured at 5 mins interval for 60 mins by fluorescence based method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Evaluation of quinoxaline compounds as ligands of a site adjacent to S2 (AS2) of cruzain. |
| AID566013 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio by trypan blue staining method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
| Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives. |
| AID91453 | Apparent dissociation constant of [3H]kainate from Ionotropic glutamate receptor ionotropic kainate was determined in rat cortical slice preparation | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID1300691 | Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reader analysis | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor. |
| AID1736153 | Inhibition of wild type recombinant HIV-1 subtype B BH10 p66/p51 reverse transcriptase heterodimer expressed in Escherichia coli BL21 (DE3) assessed as inhibition of dTTP incorporation on poly(rA)-oligo(dT) template primer duplex at 10 uM preincubated wit | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | Design, synthesis and biological evaluation of quinoxaline compounds as anti-HIV agents targeting reverse transcriptase enzyme. |
| AID566011 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 100 molar ratio after 48 hrs relative to positive control | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
| Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives. |
| AID566010 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 500 molar ratio after 48 hrs relative to positive control | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
| Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives. |
| AID92516 | Inhibition [3H]AMPA binding to ionotropic glutamate receptor AMPA in rat whole brain membranes in the presence of 100 uM KSCN | 1996 | Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
| Novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonists: synthesis and structure-activity relationships of 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and related compounds. |
| AID496834 | Displacement of [3H]AMPA from AMPA receptor in rat cortical membrane | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
| alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside. |
| AID566012 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 10 molar ratio after 48 hrs relative to positive control | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
| Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives. |
| AID31588 | Ability to inhibit [3H]AMPA binding to AMPA receptor in rat whole brain at 100 uM concentration | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. |
| AID774923 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 mol ratio/TPA after 48 hrs by trypan blue staining method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. |
| AID774920 | Inhibition of TPA-induced EBV early antigen activation infected in human Raji cells assessed as antigen activity at 10 mol ratio/TPA after 48 hrs by immunofluorescence method relative to control | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. |
| AID163310 | Apparent dissociation constant of [3H]AMPA from quisqualate receptor of rat cortical slice | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID145260 | In vitro inhibition of [3H]glycine at NMDA receptor | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential. |
| AID147418 | Binding affinity against rat brain Non N-methyl-D-aspartate glutamate receptor glutamate site expressed in Xenopus oocyte | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID774922 | Inhibition of TPA-induced EBV early antigen activation infected in human Raji cells assessed as antigen activity at 500 mol ratio/TPA after 48 hrs by immunofluorescence method relative to control | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. |
| AID1593592 | Inhibition of recombinant Cryptosporidium hominis TS-DHFR expressed in Escherichia coli PA414 assessed as reduction in DHFR steady state activity at 500 uM using [3',5',7,9-3H]-H2folate as substrate preincubated for 10 mins before NADPH addition for 5 min | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening. |
| AID144749 | Inhibition of [3H]DCKA binding to NMDA receptor of rat brain membranes. | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors. |
| AID143443 | Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
| CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor. |
| AID1588364 | Inhibition of Trypanosoma cruzi cruzain assessed as reduction in 7-amino-4-methylcoumarin production using Z-FR-AMC as substrate and measured up to 60 mins by fluorescence based method | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Evaluation of quinoxaline compounds as ligands of a site adjacent to S2 (AS2) of cruzain. |
| AID143164 | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. |
| AID234072 | Selectivity for glycine site | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID144896 | Inhibition of [3H]glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID143444 | Compound was tested for inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
| CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor. |
| AID143296 | Binding affinity towards rat brain NMDA receptor glycine site expressed in Xenopus oocyte | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID774918 | Inhibition of TRK in human HepG2 cells after 48 hrs by ELISA | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. |
| AID774917 | Inhibition of TRK in human MCF7 cells after 48 hrs by ELISA | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. |
| AID566009 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 1000 molar ratio after 48 hrs relative to positive control | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
| Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives. |
| AID145182 | Apparent dissociation constant of [3H]glycine from N-methyl-D-aspartate glutamate receptor in rat cortical slice preparation | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID774924 | Inhibition of TPA-induced EBV early antigen activation infected in human Raji cells assessed as antigen activity at 1000 mol ratio/TPA after 48 hrs by immunofluorescence method relative to control | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |