Assay ID | Title | Year | Journal | Article |
AID706388 | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID175310 | Enhancement of coronary flow (A2 response) in isolated rat heart preparation | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
AID30496 | Molar potency ratio (MPR) against adenosine A2 receptor of canine coronary artery | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Dog coronary artery adenosine receptor: structure of the N6-aryl subregion. |
AID30491 | Binding affinity against A2 adenosine receptor | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Dog coronary artery adenosine receptor: structure of the N6-aryl subregion. |
AID30495 | Association constant against A2 adenosine receptor | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Dog coronary artery adenosine receptor: structure of the N6-aryl subregion. |
AID706383 | Selectivity ratio of Ki for rat adenosine A1 receptor to Ki for rat adenosine A3 receptor expressed in CHO cells | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID706382 | Selectivity ratio of Ki for human recombinant adenosine A1 receptor to Ki for human recombinant adenosine A3 receptor expressed in CHO cells | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID175313 | Reduction of heart rate (A1 response) in isolated rat heart preparation | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
AID1694570 | Displacement of [3H]CGS21680 from recombinant human A2AR measured after 60 mins by liquid scintillation counting method | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID239053 | Inhibition of [125I]AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cells | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. |
AID155531 | Inhibition of Trypanosoma brucei phosphoglycerate kinase (PGK); inactive at 4 mM | 2000 | Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
| Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. |
AID1694562 | Antimigratory activity in human MDA-MB-231 cells assessed as wound closure at 2.5 uM after 48 hrs by scratch wound healing assay (Rvb = 93 %) | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID177479 | Effect on Ataxia(ATX) in rat was measured as ED50 by perorally administration of compound. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
AID1694548 | Displacement of FITC-geldanamycin from GRP94 (unknown origin) at 50 uM after 24 hrs by fluorescence polarization assay relative to control | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID25506 | Index of hydrophobicity (k') | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Dog coronary artery adenosine receptor: structure of the N6-aryl subregion. |
AID1694557 | Antimigratory activity in human A549 cells assessed as wound closure at 2.5 uM after 24 hrs by scratch wound healing assay (Rvb = 59 %) | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID1694569 | Displacement of [3H]R-PIA from recombinant human A1AR measured after 60 mins by liquid scintillation counting method | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID232472 | Selectivity ratio for A1 receptor to that of A2 receptor in vitro in rat tissues | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| C2,N6-disubstituted adenosines: synthesis and structure-activity relationships. |
AID1694567 | Antimigratory activity in human MDA-MB-231 cells assessed as rate of wound closure at 20 uM after 24 hrs by scratch wound healing assay | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID1694558 | Antimigratory activity in human A549 cells assessed as wound closure at 2.5 uM after 36 hrs by scratch wound healing assay (Rvb = 88 %) | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID32503 | Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| C2,N6-disubstituted adenosines: synthesis and structure-activity relationships. |
AID32195 | Binding affinity towards adenosine A1 receptor on rat whole brain membrane using [3H]N6-cyclohexyladenosine | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
AID239011 | Inhibition of [3H]R-PIA binding to human Adenosine A1 receptor expressed in CHO cells | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. |
AID1694571 | Displacement of [125I]-AB-MECA from human A3AR expressed in CHO cells measured after 60 mins by liquid scintillation counting method | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID251590 | Relative activation of human Adenosine A3 receptor expressed in CHO cells at 10 uM treatment compared to 10 uM Cl-IB-MECA | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. |
AID706386 | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID1694549 | Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) at 50 uM after 24 hrs by fluorescence polarization assay relative to control | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID706384 | Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID1694561 | Antimigratory activity in human MDA-MB-231 cells assessed as wound closure at 2.5 uM after 24 hrs by scratch wound healing assay (Rvb = 64 %) | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID706387 | Displacement of [3H]CCPA from rat adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID231269 | Ratio of binding affinity against A2 and A1 receptors | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor. |
AID1694568 | Antimigratory activity in human MDA-MB-231 cells assessed as rate of wound closure at 20 uM after 48 hrs by scratch wound healing assay | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID33440 | Binding affinity at adenosine A2 receptor from rat striatal membranes by [3H]NECA displacement. | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor. |
AID706381 | Selectivity ratio of Ki for rat adenosine A2A receptor to Ki for rat adenosine A3 receptor expressed in CHO cells | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID177487 | Effect on Motor activity(MA) in rat was measured as ED50 by perorally administration of compound. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
AID647885 | Binding affinity to A2A adenosine receptor | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1
| Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor. |
AID33567 | Binding affinity to A2 adenosine receptor in rat striatal membranes by [3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide) displacement. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
AID131362 | Effect on Ataxia in mouse following i.p. administration. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
AID229799 | Ratio of Ki at adenosine A2 and A1 receptors | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
AID239092 | Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cells | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. |
AID33588 | Binding affinity towards adenosine A2 receptor on rat striatal membrane using [3H]NECA as radioligand | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
AID706389 | Displacement of [3H]CGS21680 from rat adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID177488 | Effect on Sidman conditioned avoidance in rat. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
AID31866 | Binding affinity at adenosine A1 receptor from rat brain membranes by [3H]N6-cyclohexyladenosine displacement. | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor. |
AID32015 | Binding affinity to adenosine A1 receptor in rat whole brain membranes by [3H]N6-cyclohexyladenosine displacement. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
AID33746 | Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. |
AID706385 | Displacement of [125I]I-AB-MECA from human rat adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID33752 | Ratio of A2 to A1. | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. |
AID706380 | Selectivity ratio of Ki for human recombinant adenosine A2A receptor to Ki for human recombinant adenosine A3 receptor expressed in CHO cells | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID239113 | Inhibition of [3H]-CGS- 21680 binding to human Adenosine A2A receptor expressed in CHO cells | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. |
AID1694572 | Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen c | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
AID251589 | Relative activation of human Adenosine A2B receptor at 10 uM treatment compared to 10 uM Cl-IB-MECA | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. |
AID706377 | Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
AID131363 | Effect on Motor activity in mouse following i.p. administration. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
AID32177 | Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. |
AID33733 | Inhibition of binding of [3H]NECA to adenosine A2 receptor of rat striatal membranes. | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| C2,N6-disubstituted adenosines: synthesis and structure-activity relationships. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |