Page last updated: 2024-11-13

a-1155463

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Description

A-1155463: a Bcl-X(L) inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	59447577
CHEMBL ID	3342332
SCHEMBL ID	2501550
MeSH ID	M000612786

Synonyms (22)

Synonym
bdbm50030754
chembl3342332 ,
S7800
SCHEMBL2501550
3cq ,
2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1h)-yl]-5-(3-{4-[3-(dimethylamino)prop-1-yn-1-yl]-2-fluorophenoxy}propyl)-1,3-thiazole-4-carboxylic acid
a-1155463
1235034-55-5
HY-19725
CS-5398
EX-A1060
AKOS030526342
2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1h)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid
mfcd29924714
2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1h)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-yn-1-yl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid
a1155463
BCP18309
BS-14688
a 1155463
CCG-270355
Q27453707
2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1h-isoquinolin-2-yl]-5-[3-[4-[3-(dimethylamino)prop-1-ynyl]-2-fluorophenoxy]propyl]-1,3-thiazole-4-carboxylic acid

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (11)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Apoptosis regulator Bcl-2	Homo sapiens (human)	IC50 (µMol)	0.3820	0.0010	0.5763	4.3000	AID1791972; AID1914432
Apoptosis regulator Bcl-2	Homo sapiens (human)	Ki	0.0780	0.0000	0.1901	2.9000	AID1168932; AID1293719; AID1914433
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	Ki	0.7940	0.0000	0.2108	5.6234	AID1914437
Translocator protein	Rattus norvegicus (Norway rat)	Ki	0.7941	0.0001	0.6510	8.9300	AID1794444
Delta-type opioid receptor	Homo sapiens (human)	Ki	2.1249	0.0000	0.5978	9.9300	AID1794423; AID1914426
5-hydroxytryptamine receptor 3A	Homo sapiens (human)	Ki	1.1189	0.0000	0.7411	9.9000	AID1794410; AID1914438
Bcl-2-like protein 1	Homo sapiens (human)	IC50 (µMol)	0.0005	0.0003	1.0482	9.5400	AID1791971; AID1913236
Bcl-2-like protein 1	Homo sapiens (human)	Ki	0.0000	0.0000	0.4581	9.0000	AID1168930; AID1168931; AID1293720
Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)	Ki	0.4400	0.0010	1.4653	9.5400	AID1168941
Sigma intracellular receptor 2	Homo sapiens (human)	Ki	0.8084	0.0001	0.8360	4.6005	AID1794446; AID1914439
Bcl-2-like protein 2	Homo sapiens (human)	Ki	0.0190	0.0010	1.2590	8.1900	AID1168940
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	0.1359	0.0000	0.4901	10.0000	AID1794447; AID1914434
Histamine H3 receptor	Homo sapiens (human)	Ki	1.8111	0.0001	0.3399	8.5110	AID1794428; AID1914424
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Bcl-2-like protein 1	Homo sapiens (human)	EC50 (µMol)	0.0650	0.0100	0.0337	0.0650	AID1912781
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (204)

Process	via Protein(s)	Taxonomy
protein polyubiquitination	Apoptosis regulator Bcl-2	Homo sapiens (human)
apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to xenobiotic stimulus	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to toxic substance	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of cell growth	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to cytokine	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of neuron apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of calcium ion transport	Apoptosis regulator Bcl-2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Apoptosis regulator Bcl-2	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Apoptosis regulator Bcl-2	Homo sapiens (human)
ossification	Apoptosis regulator Bcl-2	Homo sapiens (human)
ovarian follicle development	Apoptosis regulator Bcl-2	Homo sapiens (human)
metanephros development	Apoptosis regulator Bcl-2	Homo sapiens (human)
branching involved in ureteric bud morphogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
behavioral fear response	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell homeostasis	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
release of cytochrome c from mitochondria	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of cell-matrix adhesion	Apoptosis regulator Bcl-2	Homo sapiens (human)
lymphoid progenitor cell differentiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell lineage commitment	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of B cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to ischemia	Apoptosis regulator Bcl-2	Homo sapiens (human)
renal system process	Apoptosis regulator Bcl-2	Homo sapiens (human)
melanin metabolic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of nitrogen utilization	Apoptosis regulator Bcl-2	Homo sapiens (human)
autophagy	Apoptosis regulator Bcl-2	Homo sapiens (human)
humoral immune response	Apoptosis regulator Bcl-2	Homo sapiens (human)
DNA damage response	Apoptosis regulator Bcl-2	Homo sapiens (human)
actin filament organization	Apoptosis regulator Bcl-2	Homo sapiens (human)
axonogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
female pregnancy	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of cell population proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
male gonad development	Apoptosis regulator Bcl-2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to oxidative stress	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to radiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to xenobiotic stimulus	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to toxic substance	Apoptosis regulator Bcl-2	Homo sapiens (human)
post-embryonic development	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to iron ion	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to UV-B	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to gamma radiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of gene expression	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of autophagy	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of calcium ion transport into cytosol	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of glycoprotein biosynthetic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
mesenchymal cell development	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of neuron maturation	Apoptosis regulator Bcl-2	Homo sapiens (human)
smooth muscle cell migration	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of smooth muscle cell migration	Apoptosis regulator Bcl-2	Homo sapiens (human)
cochlear nucleus development	Apoptosis regulator Bcl-2	Homo sapiens (human)
gland morphogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of transmembrane transporter activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of ossification	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of cell growth	Apoptosis regulator Bcl-2	Homo sapiens (human)
melanocyte differentiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of cell migration	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of B cell proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
hair follicle morphogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
axon regeneration	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of protein stability	Apoptosis regulator Bcl-2	Homo sapiens (human)
endoplasmic reticulum calcium ion homeostasis	Apoptosis regulator Bcl-2	Homo sapiens (human)
glomerulus development	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of cellular pH reduction	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of protein localization	Apoptosis regulator Bcl-2	Homo sapiens (human)
myeloid cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of myeloid cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
T cell differentiation in thymus	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Apoptosis regulator Bcl-2	Homo sapiens (human)
osteoblast proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of osteoblast proliferation	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to nicotine	Apoptosis regulator Bcl-2	Homo sapiens (human)
organ growth	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of multicellular organism growth	Apoptosis regulator Bcl-2	Homo sapiens (human)
cellular response to glucose starvation	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to hydrogen peroxide	Apoptosis regulator Bcl-2	Homo sapiens (human)
neuron maturation	Apoptosis regulator Bcl-2	Homo sapiens (human)
T cell homeostasis	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
CD8-positive, alpha-beta T cell lineage commitment	Apoptosis regulator Bcl-2	Homo sapiens (human)
ear development	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of viral genome replication	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of melanocyte differentiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
retinal cell programmed cell death	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of retinal cell programmed cell death	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of mitochondrial membrane permeability	Apoptosis regulator Bcl-2	Homo sapiens (human)
focal adhesion assembly	Apoptosis regulator Bcl-2	Homo sapiens (human)
spleen development	Apoptosis regulator Bcl-2	Homo sapiens (human)
thymus development	Apoptosis regulator Bcl-2	Homo sapiens (human)
digestive tract morphogenesis	Apoptosis regulator Bcl-2	Homo sapiens (human)
oocyte development	Apoptosis regulator Bcl-2	Homo sapiens (human)
skeletal muscle fiber development	Apoptosis regulator Bcl-2	Homo sapiens (human)
positive regulation of skeletal muscle fiber development	Apoptosis regulator Bcl-2	Homo sapiens (human)
pigment granule organization	Apoptosis regulator Bcl-2	Homo sapiens (human)
stem cell development	Apoptosis regulator Bcl-2	Homo sapiens (human)
homeostasis of number of cells within a tissue	Apoptosis regulator Bcl-2	Homo sapiens (human)
B cell receptor signaling pathway	Apoptosis regulator Bcl-2	Homo sapiens (human)
response to glucocorticoid	Apoptosis regulator Bcl-2	Homo sapiens (human)
neuron apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
defense response to virus	Apoptosis regulator Bcl-2	Homo sapiens (human)
establishment of localization in cell	Apoptosis regulator Bcl-2	Homo sapiens (human)
regulation of mitochondrial membrane potential	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of mitochondrial depolarization	Apoptosis regulator Bcl-2	Homo sapiens (human)
hematopoietic stem cell differentiation	Apoptosis regulator Bcl-2	Homo sapiens (human)
calcium ion transport into cytosol	Apoptosis regulator Bcl-2	Homo sapiens (human)
T cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of T cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
cellular response to organic substance	Apoptosis regulator Bcl-2	Homo sapiens (human)
cellular response to hypoxia	Apoptosis regulator Bcl-2	Homo sapiens (human)
reactive oxygen species metabolic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
dendritic cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
motor neuron apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
cell-cell adhesion	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Apoptosis regulator Bcl-2	Homo sapiens (human)
epithelial cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of epithelial cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of G1/S transition of mitotic cell cycle	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of dendritic cell apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of motor neuron apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of anoikis	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of apoptotic signaling pathway	Apoptosis regulator Bcl-2	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Apoptosis regulator Bcl-2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Apoptosis regulator Bcl-2	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Apoptosis regulator Bcl-2	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Apoptosis regulator Bcl-2	Homo sapiens (human)
gamma-aminobutyric acid signaling pathway	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
synaptic transmission, GABAergic	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
chloride transmembrane transport	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
inhibitory synapse assembly	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
regulation of postsynaptic membrane potential	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
immune response	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Delta-type opioid receptor	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
adult locomotory behavior	Delta-type opioid receptor	Homo sapiens (human)
negative regulation of gene expression	Delta-type opioid receptor	Homo sapiens (human)
negative regulation of protein-containing complex assembly	Delta-type opioid receptor	Homo sapiens (human)
positive regulation of CREB transcription factor activity	Delta-type opioid receptor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Delta-type opioid receptor	Homo sapiens (human)
response to nicotine	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled opioid receptor signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
eating behavior	Delta-type opioid receptor	Homo sapiens (human)
regulation of mitochondrial membrane potential	Delta-type opioid receptor	Homo sapiens (human)
regulation of calcium ion transport	Delta-type opioid receptor	Homo sapiens (human)
cellular response to growth factor stimulus	Delta-type opioid receptor	Homo sapiens (human)
cellular response to hypoxia	Delta-type opioid receptor	Homo sapiens (human)
cellular response to toxic substance	Delta-type opioid receptor	Homo sapiens (human)
neuropeptide signaling pathway	Delta-type opioid receptor	Homo sapiens (human)
serotonin receptor signaling pathway	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
monoatomic ion transmembrane transport	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
excitatory postsynaptic potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
inorganic cation transmembrane transport	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
regulation of presynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
chemical synaptic transmission	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
regulation of membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
response to cytokine	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Bcl-2-like protein 1	Homo sapiens (human)
ovarian follicle development	Bcl-2-like protein 1	Homo sapiens (human)
in utero embryonic development	Bcl-2-like protein 1	Homo sapiens (human)
release of cytochrome c from mitochondria	Bcl-2-like protein 1	Homo sapiens (human)
endocytosis	Bcl-2-like protein 1	Homo sapiens (human)
germ cell development	Bcl-2-like protein 1	Homo sapiens (human)
spermatogenesis	Bcl-2-like protein 1	Homo sapiens (human)
male gonad development	Bcl-2-like protein 1	Homo sapiens (human)
apoptotic mitochondrial changes	Bcl-2-like protein 1	Homo sapiens (human)
fertilization	Bcl-2-like protein 1	Homo sapiens (human)
regulation of cytokinesis	Bcl-2-like protein 1	Homo sapiens (human)
positive regulation of mononuclear cell proliferation	Bcl-2-like protein 1	Homo sapiens (human)
ectopic germ cell programmed cell death	Bcl-2-like protein 1	Homo sapiens (human)
regulation of growth	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of neuron apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
dendritic cell proliferation	Bcl-2-like protein 1	Homo sapiens (human)
response to cycloheximide	Bcl-2-like protein 1	Homo sapiens (human)
regulation of mitochondrial membrane permeability	Bcl-2-like protein 1	Homo sapiens (human)
epithelial cell proliferation	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of developmental process	Bcl-2-like protein 1	Homo sapiens (human)
neuron apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
defense response to virus	Bcl-2-like protein 1	Homo sapiens (human)
regulation of mitochondrial membrane potential	Bcl-2-like protein 1	Homo sapiens (human)
cellular response to amino acid stimulus	Bcl-2-like protein 1	Homo sapiens (human)
cellular response to alkaloid	Bcl-2-like protein 1	Homo sapiens (human)
cellular response to gamma radiation	Bcl-2-like protein 1	Homo sapiens (human)
apoptotic process in bone marrow cell	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of release of cytochrome c from mitochondria	Bcl-2-like protein 1	Homo sapiens (human)
dendritic cell apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
hepatocyte apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of execution phase of apoptosis	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of protein localization to plasma membrane	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of reproductive process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of dendritic cell apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Bcl-2-like protein 1	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Bcl-2-like protein 1	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Bcl-2-like protein 1	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Bcl-2-like protein 1	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Bcl-2-like protein 1	Homo sapiens (human)
DNA damage response	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
response to cytokine	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
cell fate determination	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
negative regulation of autophagy	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
cellular homeostasis	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
positive regulation of apoptotic process	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
negative regulation of apoptotic process	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
protein transmembrane transport	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
negative regulation of anoikis	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
mitochondrial fusion	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
release of cytochrome c from mitochondria	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
regulation of cell growth	Sigma intracellular receptor 2	Homo sapiens (human)
regulation of intracellular lipid transport	Sigma intracellular receptor 2	Homo sapiens (human)
regulation of intracellular cholesterol transport	Sigma intracellular receptor 2	Homo sapiens (human)
cholesterol homeostasis	Sigma intracellular receptor 2	Homo sapiens (human)
positive regulation of wound healing	Sigma intracellular receptor 2	Homo sapiens (human)
positive regulation of lipoprotein transport	Sigma intracellular receptor 2	Homo sapiens (human)
response to ischemia	Bcl-2-like protein 2	Homo sapiens (human)
spermatogenesis	Bcl-2-like protein 2	Homo sapiens (human)
negative regulation of mitochondrial membrane permeability	Bcl-2-like protein 2	Homo sapiens (human)
regulation of apoptotic process	Bcl-2-like protein 2	Homo sapiens (human)
negative regulation of apoptotic process	Bcl-2-like protein 2	Homo sapiens (human)
Sertoli cell proliferation	Bcl-2-like protein 2	Homo sapiens (human)
cellular response to estradiol stimulus	Bcl-2-like protein 2	Homo sapiens (human)
negative regulation of release of cytochrome c from mitochondria	Bcl-2-like protein 2	Homo sapiens (human)
cellular response to amyloid-beta	Bcl-2-like protein 2	Homo sapiens (human)
cellular response to glycine	Bcl-2-like protein 2	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Bcl-2-like protein 2	Homo sapiens (human)
release of cytochrome c from mitochondria	Bcl-2-like protein 2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Bcl-2-like protein 2	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Bcl-2-like protein 2	Homo sapiens (human)
lipid transport	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
nervous system development	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
G protein-coupled opioid receptor signaling pathway	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
regulation of neuron apoptotic process	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
protein homotrimerization	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
neurotransmitter secretion	Histamine H3 receptor	Homo sapiens (human)
G protein-coupled serotonin receptor signaling pathway	Histamine H3 receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Histamine H3 receptor	Homo sapiens (human)
chemical synaptic transmission	Histamine H3 receptor	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	Histamine H3 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (36)

Process	via Protein(s)	Taxonomy
protease binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
channel activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
channel inhibitor activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
ubiquitin protein ligase binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
identical protein binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
sequence-specific DNA binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein heterodimerization activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
BH3 domain binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein phosphatase 2A binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
molecular adaptor activity	Apoptosis regulator Bcl-2	Homo sapiens (human)
DNA-binding transcription factor binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
BH domain binding	Apoptosis regulator Bcl-2	Homo sapiens (human)
GABA receptor activity	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
GABA-gated chloride ion channel activity	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
GABA-A receptor activity	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
GABA-gated chloride ion channel activity	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
chloride channel activity	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
benzodiazepine receptor activity	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
GABA-A receptor activity	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
G protein-coupled opioid receptor activity	Delta-type opioid receptor	Homo sapiens (human)
protein binding	Delta-type opioid receptor	Homo sapiens (human)
receptor serine/threonine kinase binding	Delta-type opioid receptor	Homo sapiens (human)
G protein-coupled enkephalin receptor activity	Delta-type opioid receptor	Homo sapiens (human)
neuropeptide binding	Delta-type opioid receptor	Homo sapiens (human)
protein binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin-gated monoatomic cation channel activity	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
identical protein binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
excitatory extracellular ligand-gated monoatomic ion channel activity	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
protein binding	Bcl-2-like protein 1	Homo sapiens (human)
protein kinase binding	Bcl-2-like protein 1	Homo sapiens (human)
identical protein binding	Bcl-2-like protein 1	Homo sapiens (human)
BH3 domain binding	Bcl-2-like protein 1	Homo sapiens (human)
BH domain binding	Bcl-2-like protein 1	Homo sapiens (human)
protein binding	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
protein transmembrane transporter activity	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
protein heterodimerization activity	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
BH3 domain binding	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
channel activity	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
BH domain binding	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
protein binding	Sigma intracellular receptor 2	Homo sapiens (human)
oxysterol binding	Sigma intracellular receptor 2	Homo sapiens (human)
cholesterol binding	Sigma intracellular receptor 2	Homo sapiens (human)
protein binding	Bcl-2-like protein 2	Homo sapiens (human)
identical protein binding	Bcl-2-like protein 2	Homo sapiens (human)
protein-containing complex binding	Bcl-2-like protein 2	Homo sapiens (human)
disordered domain specific binding	Bcl-2-like protein 2	Homo sapiens (human)
BH domain binding	Bcl-2-like protein 2	Homo sapiens (human)
G protein-coupled opioid receptor activity	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
protein binding	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
histamine receptor activity	Histamine H3 receptor	Homo sapiens (human)
G protein-coupled acetylcholine receptor activity	Histamine H3 receptor	Homo sapiens (human)
G protein-coupled serotonin receptor activity	Histamine H3 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (52)

Process	via Protein(s)	Taxonomy
mitochondrial outer membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
endoplasmic reticulum membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
nucleus	Apoptosis regulator Bcl-2	Homo sapiens (human)
cytoplasm	Apoptosis regulator Bcl-2	Homo sapiens (human)
mitochondrion	Apoptosis regulator Bcl-2	Homo sapiens (human)
mitochondrial outer membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
endoplasmic reticulum	Apoptosis regulator Bcl-2	Homo sapiens (human)
cytosol	Apoptosis regulator Bcl-2	Homo sapiens (human)
membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
nuclear membrane	Apoptosis regulator Bcl-2	Homo sapiens (human)
myelin sheath	Apoptosis regulator Bcl-2	Homo sapiens (human)
BAD-BCL-2 complex	Apoptosis regulator Bcl-2	Homo sapiens (human)
protein-containing complex	Apoptosis regulator Bcl-2	Homo sapiens (human)
pore complex	Apoptosis regulator Bcl-2	Homo sapiens (human)
plasma membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
cytoplasmic vesicle membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
GABA-ergic synapse	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
postsynaptic specialization membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
GABA-A receptor complex	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
chloride channel complex	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
GABA receptor complex	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
dendrite membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
postsynapse	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
synapse	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
neuron projection	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
plasma membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
transmembrane transporter complex	Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)
plasma membrane	Delta-type opioid receptor	Homo sapiens (human)
synaptic vesicle membrane	Delta-type opioid receptor	Homo sapiens (human)
dendrite membrane	Delta-type opioid receptor	Homo sapiens (human)
presynaptic membrane	Delta-type opioid receptor	Homo sapiens (human)
axon terminus	Delta-type opioid receptor	Homo sapiens (human)
spine apparatus	Delta-type opioid receptor	Homo sapiens (human)
postsynaptic density membrane	Delta-type opioid receptor	Homo sapiens (human)
neuronal dense core vesicle	Delta-type opioid receptor	Homo sapiens (human)
plasma membrane	Delta-type opioid receptor	Homo sapiens (human)
neuron projection	Delta-type opioid receptor	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
cleavage furrow	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
postsynaptic membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin-activated cation-selective channel complex	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
synapse	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
transmembrane transporter complex	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
neuron projection	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
cytoplasm	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrion	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrial outer membrane	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrial inner membrane	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrial matrix	Bcl-2-like protein 1	Homo sapiens (human)
endoplasmic reticulum	Bcl-2-like protein 1	Homo sapiens (human)
centrosome	Bcl-2-like protein 1	Homo sapiens (human)
cytosol	Bcl-2-like protein 1	Homo sapiens (human)
synaptic vesicle membrane	Bcl-2-like protein 1	Homo sapiens (human)
nuclear membrane	Bcl-2-like protein 1	Homo sapiens (human)
Bcl-2 family protein complex	Bcl-2-like protein 1	Homo sapiens (human)
mitochondrial outer membrane	Bcl-2-like protein 1	Homo sapiens (human)
nucleus	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
nucleoplasm	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
cytoplasm	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
mitochondrion	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
mitochondrial outer membrane	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
cytosol	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
membrane	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
Bcl-2 family protein complex	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
mitochondrial outer membrane	Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)
endoplasmic reticulum	Sigma intracellular receptor 2	Homo sapiens (human)
lysosome	Sigma intracellular receptor 2	Homo sapiens (human)
endoplasmic reticulum	Sigma intracellular receptor 2	Homo sapiens (human)
rough endoplasmic reticulum	Sigma intracellular receptor 2	Homo sapiens (human)
plasma membrane	Sigma intracellular receptor 2	Homo sapiens (human)
rough endoplasmic reticulum membrane	Sigma intracellular receptor 2	Homo sapiens (human)
nuclear membrane	Sigma intracellular receptor 2	Homo sapiens (human)
cytosol	Bcl-2-like protein 2	Homo sapiens (human)
Bcl-2 family protein complex	Bcl-2-like protein 2	Homo sapiens (human)
mitochondrial outer membrane	Bcl-2-like protein 2	Homo sapiens (human)
nuclear envelope	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
nuclear inner membrane	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
nuclear outer membrane	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
endoplasmic reticulum	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
endoplasmic reticulum membrane	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
lipid droplet	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
cytosol	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
postsynaptic density	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
membrane	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
growth cone	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
cytoplasmic vesicle	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
anchoring junction	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
postsynaptic density membrane	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
endoplasmic reticulum	Sigma non-opioid intracellular receptor 1	Homo sapiens (human)
plasma membrane	Histamine H3 receptor	Homo sapiens (human)
presynapse	Histamine H3 receptor	Homo sapiens (human)
plasma membrane	Histamine H3 receptor	Homo sapiens (human)
synapse	Histamine H3 receptor	Homo sapiens (human)
dendrite	Histamine H3 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID1168936	Cmax in SCID-Beige mouse at 5 mg/kg, ip	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1853850	Cytotoxicity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs	2022	European journal of medicinal chemistry, Mar-15, Volume: 232	Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment.
AID1168931	Inhibition of BCL-XL (unknown origin) incubated for 1 hr in presence of 1% human serum by TR-FRET assay	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1168932	Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assay	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1168939	Drug concentration in SCID-Beige mouse at 5 mg/kg, ip after 12 hrs	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1853851	Cytotoxicity against human platelets assessed as cell growth inhibition incubated for 24 hrs	2022	European journal of medicinal chemistry, Mar-15, Volume: 232	Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment.
AID1168940	Binding affinity to BCL-W (unknown origin)	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1168938	AUC in SCID-Beige mouse at 5 mg/kg, ip	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1168937	Tmax in SCID-Beige mouse at 5 mg/kg, ip	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1168942	Reduction in platelets count in SCID-Beige mouse at 5 mg/kg, ip after 6 hrs	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1293724	Cytotoxicity against human Bcl-XL dependant MOLT4 cells by cell based assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.
AID1168935	Cytotoxicity against BCL-XL-dependent human NCI-H146 cells in presence of 10% human serum incubated for 48 hrs by Cell titerGlo reagent based assay	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1293725	Cytotoxicity against human Bcl-2 dependant RS4:11 cells by cell based assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.
AID1293720	Binding affinity to Bcl-XL (unknown origin) by FRET assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.
AID1168933	Selectivity index, ratio of Ki for BCL-2 (unknown origin) to Ki for BCL-XL (unknown origin)	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1293719	Binding affinity to Bcl-2 (unknown origin) by FRET assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.
AID1168930	Inhibition of BCL-XL (unknown origin) incubated for 1 hr by TR-FRET assay	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1168941	Binding affinity to MCL1 (unknown origin)	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1168944	Antitumor activity against BCL-XL-dependent human NCI-H146 cells xenografted in SCID-Beige mouse assessed as tumor growth inhibition at 5 mg/kg, ip for 14 days	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
AID1168943	Reduction in platelets count in SCID-Beige mouse at 5 mg/kg, ip after 72 hrs	2014	ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	10 (66.67)	24.3611
2020's	5 (33.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.46 (24.57)
Research Supply Index	2.77 (2.92)
Research Growth Index	4.59 (4.65)
Search Engine Demand Index	23.28 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.46)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (13.33%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (86.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
propofol Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.. propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.	2.13	1	phenols	anticonvulsant; antiemetic; intravenous anaesthetic; radical scavenger; sedative
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.61	2	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
epibatidine epibatidine: a powerful, though toxic, pain killer produced by the poison arrow frog, Epipedobates tricolor; structure given in first source; more potent than morphine but acts at nicotine rather than opiate receptors	2.21	1
docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.	2.11	1	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent
axitinib [no description available]	2.41	1	aryl sulfide; benzamides; indazoles; pyridines	antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist
abt-737 [no description available]	3.66	2	aromatic amine; aryl sulfide; biphenyls; C-nitro compound; monochlorobenzenes; N-arylpiperazine; N-sulfonylcarboxamide; secondary amino compound; tertiary amino compound	anti-allergic agent; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
navitoclax [no description available]	3.92	3	aryl sulfide; monochlorobenzenes; morpholines; N-sulfonylcarboxamide; organofluorine compound; piperazines; secondary amino compound; sulfone; tertiary amino compound	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
bryostatin 1 bryostatin 1: a protein kinase C activator; macrocyclic lactone from marine Bryozoan Bugula neritina; RN given refers to (1S-(1R,3R,5Z,7S,8E,11R,12R(2E,4E),13E,15R,17S(S),21S,23S,25R))-isomer; structure given in first source; activates protein kinase c. bryostatin 1 : A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.	2.31	1
abt-199 venetoclax: A BCL-2 inhibitor with antineoplastic activity that is used in the treatment of CHRONIC LYMPHOCYTIC LEUKEMIA associated with chromosome 17p deletion; structure in first source.. venetoclax : A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.	4.89	5	aromatic ether; C-nitro compound; monochlorobenzenes; N-alkylpiperazine; N-arylpiperazine; N-sulfonylcarboxamide; oxanes; pyrrolopyridine	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
bm-1197 BM-1197: inhibits both Bcl-xL and Bcl-2; has antineoplastic activity	3.51	1
a-1331852 A-1331852: a Bcl-X(L) inhibitor; structure in first source	3.62	2
nitrophenols Nitrophenols: PHENOLS carrying nitro group substituents.	2.21	1
BDA-366 BDA-366: has antineoplastic activity; binds Bcl-2 protein; structure in first source. BDA-366 : A member of the class of anthraquinone that is 1,4-diamino-9,10-anthraquinone in which the two amino groups are carrying 3-(diethylamino)-2-hydroxypropyl and (oxiran-2-yl)methyl substituents. It exhibits anti-cancer properties.	3.51	1	anthraquinone; epoxide; secondary alcohol; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer
nintedanib nintedanib : A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.	2.41	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	3.51	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.51	2
Colorectal Cancer [description not available]	2.59	2
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.59	2
Diffuse Large B-Cell Lymphoma [description not available]	2.25	1
Lymphoma, Large B-Cell, Diffuse Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.	2.25	1
HIV Coinfection [description not available]	2.31	1
HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	2.31	1
Viral Diseases [description not available]	2.15	1
Virus Diseases A general term for diseases caused by viruses.	2.15	1
Benign Neoplasms, Brain [description not available]	2.21	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.21	1
Acute Myelogenous Leukemia [description not available]	2.21	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.21	1
Thrombopenia [description not available]	2.11	1
Neutropenia A decrease in the number of NEUTROPHILS found in the blood.	2.11	1
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	2.11	1

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