Compounds > 1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine
Page last updated: 2024-12-10

1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine

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**1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine** is a chemical compound that serves as a **potent inhibitor of the enzyme carbonic anhydrase (CA)**.

**Carbonic anhydrases** are a family of enzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate and protons. This reaction plays a critical role in various physiological processes, including:

* **Respiratory gas transport:** CA facilitates the conversion of CO2 to bicarbonate in red blood cells, allowing for efficient transport of CO2 from tissues to the lungs.
* **Acid-base balance:** CA helps maintain the pH of blood and other bodily fluids.
* **Bone formation:** CA is involved in the formation of hydroxyapatite, the mineral component of bones.

**Importance for Research:**

* **Drug discovery:** 1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine, along with other CA inhibitors, has potential therapeutic applications in various diseases, including:
* **Glaucoma:** CA inhibitors are used to reduce intraocular pressure by inhibiting CA in the eye.
* **Epilepsy:** Some CA inhibitors have shown anticonvulsant activity.
* **Cancer:** CA inhibitors have been investigated as potential anticancer agents.
* **Obesity:** CA inhibitors may have a role in regulating appetite and body weight.
* **Chemical biology:** 1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine can be used as a tool to study the role of CA in various biological processes.
* **Materials science:** CA inhibitors have been explored for their potential applications in materials science, such as in the development of sensors and catalysts.

**Mechanism of Action:**

1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine inhibits CA by binding to the active site of the enzyme, preventing the hydration of carbon dioxide. The nitro group on the phenyl ring enhances the inhibitory activity of the compound.

**Conclusion:**

1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine is a potent CA inhibitor with significant research interest due to its potential applications in drug discovery, chemical biology, and materials science. Its ability to inhibit CA activity has made it a valuable tool for investigating the role of this enzyme in various physiological and pathological processes.

Cross-References

ID SourceID
PubMed CID3025945
CHEMBL ID1407805
CHEBI ID93634

Synonyms (15)

Synonym
1-((4-nitrophenyl)sulfonyl)-1h-benzimidazol-2-amine
MLS-0425617.0001 ,
MLS002639483
smr001548927
1-(4-nitrophenyl)sulfonylbenzimidazol-2-amine
MLS-0425617.0002
193696-63-8
CHEMBL1407805
bdbm62306
cid_3025945
1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine
(1-nosylbenzimidazol-2-yl)amine
DTXSID40172977
CHEBI:93634
Q27165328
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sulfonamideAn amide of a sulfonic acid RS(=O)2NR'2.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TDP1 proteinHomo sapiens (human)Potency24.84460.000811.382244.6684AID686978; AID686979
Smad3Homo sapiens (human)Potency12.58930.00527.809829.0929AID588855
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency15.84890.058010.694926.6086AID602310
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency5.01196.309660.2008112.2020AID720709
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency89.12513.981146.7448112.2020AID720708
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
interleukin-8 isoform 1 precursorHomo sapiens (human)IC50 (µMol)5.00000.55074.397718.7700AID2245; AID2250; AID2260
tumor necrosis factorHomo sapiens (human)IC50 (µMol)20.00000.07935.809814.7275AID2337
nucleotide-binding oligomerization domain-containing protein 1 isoform 1Homo sapiens (human)IC50 (µMol)22.25000.04313.361918.4900AID2255; AID2261; AID2264; AID2333
nucleotide-binding oligomerization domain-containing protein 2 isoform 1Homo sapiens (human)IC50 (µMol)20.00001.14607.137219.7000AID2334
Nucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)IC50 (µMol)20.00000.03704.33077.9433AID655844
Nucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)IC50 (µMol)14.00000.09000.96912.7000AID655843
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (111)

Processvia Protein(s)Taxonomy
angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 3Homo sapiens (human)
signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 3Homo sapiens (human)
associative learningRap guanine nucleotide exchange factor 3Homo sapiens (human)
Rap protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of actin cytoskeleton organizationRap guanine nucleotide exchange factor 3Homo sapiens (human)
negative regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
intracellular signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of GTPase activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of protein export from nucleusRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of stress fiber assemblyRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
establishment of endothelial barrierRap guanine nucleotide exchange factor 3Homo sapiens (human)
cellular response to cAMPRap guanine nucleotide exchange factor 3Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 3Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 4Homo sapiens (human)
G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
calcium-ion regulated exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
positive regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of synaptic vesicle cycleRap guanine nucleotide exchange factor 4Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
positive regulation of interleukin-10 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
detection of muramyl dipeptideNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of tumor necrosis factor productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of stress-activated MAPK cascadeNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transductionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of JNK cascadeNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activityNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
nucleotide-binding oligomerization domain containing 2 signaling pathwayNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
temperature homeostasisNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
pattern recognition receptor signaling pathwayNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
innate immune response in mucosaNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
adaptive immune responseNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of dendritic cell antigen processing and presentationNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of T cell mediated immunityNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of cytokine production involved in immune responseNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of dendritic cell cytokine productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
biosynthetic process of antibacterial peptides active against Gram-positive bacteriaNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of type 2 immune responseNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of humoral immune response mediated by circulating immunoglobulinNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
phagocytosisNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
defense responseNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteriaNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
JNK cascadeNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
response to nutrientNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
detection of biotic stimulusNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of macrophage cytokine productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
detection of bacteriumNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
maintenance of gastrointestinal epitheliumNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
regulation of appetiteNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
response to muramyl dipeptideNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
detection of muramyl dipeptideNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of type II interferon productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of interleukin-12 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of interleukin-18 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of interleukin-2 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of tumor necrosis factor productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of interleukin-1 beta productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of interleukin-12 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of interleukin-17 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of interleukin-6 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of interleukin-8 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of tumor necrosis factor productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
toll-like receptor 2 signaling pathwayNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of toll-like receptor 2 signaling pathwayNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
response to endoplasmic reticulum stressNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
intracellular signal transductionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
intestinal stem cell homeostasisNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
defense response to bacteriumNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transductionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
response to exogenous dsRNANucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of MAPK cascadeNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
innate immune responseNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of Notch signaling pathwayNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of transcription by RNA polymerase IINucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of gamma-delta T cell activationNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
host-mediated regulation of intestinal microbiota compositionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of epithelial cell proliferationNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
regulation of inflammatory responseNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of phagocytosisNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of B cell activationNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activityNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
stress-activated MAPK cascadeNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
establishment of localization in cellNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic processNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of macrophage cytokine productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
ERK1 and ERK2 cascadeNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
nucleotide-binding oligomerization domain containing 2 signaling pathwayNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
cellular response to lipopolysaccharideNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
cellular response to peptidoglycanNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
cellular response to muramyl dipeptideNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
cellular response to organic cyclic compoundNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of monocyte chemotactic protein-1 productionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
regulation of neutrophil chemotaxisNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
xenophagyNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
antibacterial innate immune responseNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of cytokine production involved in inflammatory responseNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transductionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of mitophagyNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of protein K63-linked ubiquitinationNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
positive regulation of xenophagyNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
negative regulation of macrophage apoptotic processNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transductionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic processNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
pattern recognition receptor signaling pathwayNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of dendritic cell antigen processing and presentationNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
apoptotic processNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
defense responseNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
inflammatory responseNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
signal transductionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
JNK cascadeNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
detection of biotic stimulusNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
detection of bacteriumNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of interleukin-1 beta productionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of interleukin-6 productionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of interleukin-8 productionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of tumor necrosis factor productionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of stress-activated MAPK cascadeNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
response to endoplasmic reticulum stressNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
intracellular signal transductionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
defense response to bacteriumNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of apoptotic processNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transductionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
innate immune responseNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of JNK cascadeNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
defense response to Gram-negative bacteriumNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
defense response to Gram-positive bacteriumNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activityNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
stress-activated MAPK cascadeNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of macrophage cytokine productionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
ERK1 and ERK2 cascadeNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
nucleotide-binding oligomerization domain containing 1 signaling pathwayNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
cellular response to muramyl dipeptideNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
xenophagyNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transductionNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
positive regulation of xenophagyNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (22)

Processvia Protein(s)Taxonomy
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein domain specific bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein-macromolecule adaptor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
small GTPase bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
actin bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
protein bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
ATP bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
enzyme bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
protein kinase bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
Hsp70 protein bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
muramyl dipeptide bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
pattern recognition receptor activityNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
peptidoglycan bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
ubiquitin bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
ADP bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
protein-containing complex bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
CARD domain bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
Hsp90 protein bindingNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
protein bindingNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
ATP bindingNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic processNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
pattern recognition receptor activityNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
identical protein bindingNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
protein homodimerization activityNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
peptidoglycan bindingNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
ubiquitin bindingNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
protein-containing complex bindingNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
CARD domain bindingNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (21)

Processvia Protein(s)Taxonomy
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
cortical actin cytoskeletonRap guanine nucleotide exchange factor 3Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
microvillusRap guanine nucleotide exchange factor 3Homo sapiens (human)
endomembrane systemRap guanine nucleotide exchange factor 3Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
lamellipodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
filopodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
extracellular exosomeRap guanine nucleotide exchange factor 3Homo sapiens (human)
cytosolRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
hippocampal mossy fiber to CA3 synapseRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
cytosolNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
plasma membraneNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
extrinsic component of plasma membraneNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
cytoplasmNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
mitochondrionNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
Golgi apparatusNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
cytosolNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
cytoskeletonNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
plasma membraneNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
cell surfaceNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
basolateral plasma membraneNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
vesicleNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
phagocytic vesicleNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
protein-containing complexNucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)
plasma membraneNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
cytoplasmNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
cytosolNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
plasma membraneNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
basolateral plasma membraneNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
apical plasma membraneNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
phagocytic vesicleNucleotide-binding oligomerization domain-containing protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID655845Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay2011ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
AID655846Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay2011ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
AID655844Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay2011ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
AID655843Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay2011ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-(4-methylphenyl)sulfonyl-2-benzimidazolamine
[no description available]		2.0610sulfonamide
1-(4-chlorophenyl)sulfonyl-2-benzimidazolamine
[no description available]		2.0610sulfonamide
1-(benzenesulfonyl)-2-benzimidazolamine
[no description available]		2.0610sulfonamide
1-(4-methoxyphenyl)sulfonyl-2-benzimidazolamine
[no description available]		2.0610sulfonamide
5,6-dimethyl-1-(4-methylphenyl)sulfonyl-2-benzimidazolamine
[no description available]		2.0610sulfonamide
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510