| Assay ID | Title | Year | Journal | Article |
|---|
| AID145997 | Activation responses to that evoked by Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes at 300 uM | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID236430 | Area under plasma concentration time curve 24 hours after peroral dosing of 10.0 mg/kg (AUC) in rats (N=4) | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
| AID242611 | Inhibition of [3H]-Cytisine binding to nicotinic acetylcholine receptor alpha4-beta2 from rat cerebral cortex | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
| AID418232 | Agonist activity at human recombinant alpha7 nAChR expressed in rat GH3 cells by calcium influx assay | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
| Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists. |
| AID146921 | Potency was determined by measuring current activation in Xenopus oocytes expressing rat alpha-7 nAChRs; ND denotes no data. | 2000 | Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
| (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. |
| AID690417 | Displacement of [3H]-MLA from alpha7 nAChR | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID1338778 | Antagonist activity at 5-HT3A (unknown origin) at 10 uM | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. |
| AID1338774 | Displacement of [125I]alpha-bungarotoxin from rat hippocampal alpha7 nAChR measured after 2 hrs by TopCount scintillation counting method | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. |
| AID236146 | Oral bioavailability of compound after peroral dosing of 10.0 mg/kg in rats (N=4) | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
| AID146957 | Maximum responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-7 expressed in xenopus oocytes | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID146796 | Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-7 expressed in xenopus oocytes | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID690418 | Agonist activity at rat alpha7 nAchR expressed in Xenopus oocyte relative to control | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID146148 | Antagonism of ACh-evoked responses at human Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID690416 | Agonist activity at human recombinant alpha7 nAChR expressed in GH4 cells | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID1338779 | Intrinsic activity at rat alpha7 nAChR expressed in Xenopus oocytes measured after 5 mins relative to acetylcholine | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. |
| AID465084 | Selectivity of beta4 nAChR over beta2 nAChR | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi. |
| AID690279 | Binding affinity to human 5HT3 receptor at 10 uM by radioligand binding assay | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID146645 | Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-3-beta-2-alpha-5 expressed in xenopus oocytes at 100 uM | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID690415 | Agonist activity at human recombinant alpha7 nAChR expressed in GH4 cells relative to control | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID391584 | Agonist activity at human cloned wild-type alpha7 nAChR expressed in Xenopus laevis oocytes assessed as channel opening by voltage clamp electrophysiology | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
| Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding. |
| AID236942 | Half-life of plasma concentration after peroral dosing of 10.0 mg/kg in rats (N=4) | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
| AID690420 | Agonist activity at rat alpha7 nAchR expressed in Xenopus oocyte | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID146303 | Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha4-beta2 | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID237800 | Brain permeability is determined by ratio of concentration of compound in brain to that of in plasma (CB/CP) 1 hr after subcutaneous dosing of 1.0 mg/kg (N=3) | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
| AID146145 | Activation responses to that evoked by ACh at human alpha3-beta4 receptor expressed in xenopus oocytes at 1 mM | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID146304 | Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha4-beta2 expressed in xenopus oocytes at 300 uM | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID145996 | Activation responses to that evoked by Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes at 1 mM | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID391583 | Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
| Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding. |
| AID220455 | binding affinity in rat hippocampi against alpha7 nicotinic receptor | 2000 | Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
| (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. |
| AID146308 | Antagonism of ACh response at Nicotinic acetylcholine receptor alpha4-beta2 expressed in xenopus oocytes | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID690406 | Binding affinity to alpha7 nAChR | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID147081 | Intrinsic activity was determined by measuring current activation in Xenopus oocytes expressing rat alpha-7 nAChRs; ND denotes no data. | 2000 | Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
| (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. |
| AID690419 | Displacement of [125I]alpha-Bungarotoxin from alpha7 nAchR | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID6381 | Ability to block serotonin (30 uM)-evoked responses at rat 5HT3-alpha receptor expressed in xenopus oocytes | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID236625 | Maximum plasma concentration after peroral dosing of 10.0 mg/kg in rats (N=4) | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
| AID6382 | Effect on rat 5-hydroxytryptamine 3a receptor expressed in xenopus oocytes at concentration up to 100 uM | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
| AID391585 | Agonist activity at human cloned alpha7 nAChR Gln117Phe mutant expressed in Xenopus laevis oocytes assessed as channel opening by voltage clamp electrophysiology | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
| Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding. |
| AID242603 | Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1-beta2-delta-gamma from BC3H1 cells | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
| AID220124 | binding affinity in rat forebrain against alpha4-beta2 nicotinic receptor | 2000 | Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
| (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. |
| AID239253 | Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7 | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |