Page last updated: 2024-11-08

1,3(2h,4h)-isoquinolinedione

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,3(2H,4H)-isoquinolinedione: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID349435
CHEMBL ID1210769
SCHEMBL ID422023
MeSH IDM0446928

Synonyms (43)

Synonym
isoquinoline-1,3(2h,4h)-dione
EN300-15352
CHEMBL1210769 ,
1,4h)-isoquinolinedione
mls003373813 ,
homophthalimide
nsc-409146
nsc409146
4456-77-3
1,3,4-tetrahydro-1,3-dioxoisoquinoline
HMS1734A04
AKOS001174017
4h-isoquinoline-1,3-dione
A18787
1,2,3,4-tetrahydroisoquinoline-1,3-dione
bdbm50322995
cid_349435
smr002048609
2,4-dihydroisoquinoline-1,3-dione
STL214583
1,3[2h,4h]-isoquinolinedione
FT-0647852
AM20061083
AB05280
SCHEMBL422023
sr-01000902235
SR-01000902235-2
J-503856
J-650194
1,2,3,4-tetrahydro-1,3-dioxoisoquinoline
1,3(2h,4h)-isoquinolinedione
1,2,3,4-4h-isoquinolin-1,3-dione
DTXSID50325194
CS-W006004
mfcd00234966
Z133528266
AS-18364
BBL100072
Y10382
unii-36c8tut4r4
36c8tut4r4 ,
2h,4h-1,3-isoquinolinedione
SY067196
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (13)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TDP1 proteinHomo sapiens (human)Potency1.30810.000811.382244.6684AID686978; AID686979
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency56.23416.309660.2008112.2020AID720709
TAR DNA-binding protein 43Homo sapiens (human)Potency22.38721.778316.208135.4813AID652104
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency42.28413.981146.7448112.2020AID720708
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
sentrin-specific protease 8Homo sapiens (human)IC50 (µMol)0.37140.040818.929294.8000AID624322; AID651559
Tyrosyl-DNA phosphodiesterase 2Homo sapiens (human)IC50 (µMol)25.00000.97002.21604.1000AID1293599
Mitogen-activated protein kinase kinase kinase 14Homo sapiens (human)IC50 (µMol)51.00000.24401.27202.3000AID493445
putative polyproteinIC50 (µMol)0.47030.25083.82838.4620AID720577; AID720578; AID743296
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Caspase 6, apoptosis-related cysteine peptidaseHomo sapiens (human)AC501.22000.063611.235844.9700AID720632
caspase-3Homo sapiens (human)AC500.74000.740014.357531.7200AID743291
Caspase-7Homo sapiens (human)AC501.32000.371017.049168.4900AID743295
Caspase-9Homo sapiens (human)AC501.34000.21400.62371.3400AID743293
Caspase-8Homo sapiens (human)AC501.09000.310012.451547.9700AID743294
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (115)

Processvia Protein(s)Taxonomy
angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 3Homo sapiens (human)
signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 3Homo sapiens (human)
associative learningRap guanine nucleotide exchange factor 3Homo sapiens (human)
Rap protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of actin cytoskeleton organizationRap guanine nucleotide exchange factor 3Homo sapiens (human)
negative regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
intracellular signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of GTPase activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of protein export from nucleusRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of stress fiber assemblyRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
establishment of endothelial barrierRap guanine nucleotide exchange factor 3Homo sapiens (human)
cellular response to cAMPRap guanine nucleotide exchange factor 3Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 3Homo sapiens (human)
double-strand break repairTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
cell surface receptor signaling pathwayTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
negative regulation of DNA-templated transcriptionTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
neuron developmentTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
proteolysisCaspase-7Homo sapiens (human)
apoptotic processCaspase-7Homo sapiens (human)
heart developmentCaspase-7Homo sapiens (human)
response to UVCaspase-7Homo sapiens (human)
protein processingCaspase-7Homo sapiens (human)
protein catabolic processCaspase-7Homo sapiens (human)
defense response to bacteriumCaspase-7Homo sapiens (human)
fibroblast apoptotic processCaspase-7Homo sapiens (human)
striated muscle cell differentiationCaspase-7Homo sapiens (human)
neuron apoptotic processCaspase-7Homo sapiens (human)
protein maturationCaspase-7Homo sapiens (human)
lymphocyte apoptotic processCaspase-7Homo sapiens (human)
cellular response to lipopolysaccharideCaspase-7Homo sapiens (human)
cellular response to staurosporineCaspase-7Homo sapiens (human)
execution phase of apoptosisCaspase-7Homo sapiens (human)
positive regulation of plasma membrane repairCaspase-7Homo sapiens (human)
positive regulation of neuron apoptotic processCaspase-7Homo sapiens (human)
response to hypoxiaCaspase-9Homo sapiens (human)
kidney developmentCaspase-9Homo sapiens (human)
response to ischemiaCaspase-9Homo sapiens (human)
apoptotic processCaspase-9Homo sapiens (human)
DNA damage responseCaspase-9Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damageCaspase-9Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cCaspase-9Homo sapiens (human)
protein processingCaspase-9Homo sapiens (human)
platelet formationCaspase-9Homo sapiens (human)
response to cobalt ionCaspase-9Homo sapiens (human)
response to estradiolCaspase-9Homo sapiens (human)
response to lipopolysaccharideCaspase-9Homo sapiens (human)
glial cell apoptotic processCaspase-9Homo sapiens (human)
cellular response to UVCaspase-9Homo sapiens (human)
signal transduction in response to DNA damageCaspase-9Homo sapiens (human)
positive regulation of apoptotic processCaspase-9Homo sapiens (human)
fibroblast apoptotic processCaspase-9Homo sapiens (human)
neuron apoptotic processCaspase-9Homo sapiens (human)
protein maturationCaspase-9Homo sapiens (human)
cellular response to dexamethasone stimulusCaspase-9Homo sapiens (human)
leukocyte apoptotic processCaspase-9Homo sapiens (human)
intrinsic apoptotic signaling pathwayCaspase-9Homo sapiens (human)
epithelial cell apoptotic processCaspase-9Homo sapiens (human)
positive regulation of neuron apoptotic processCaspase-9Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processCaspase-9Homo sapiens (human)
negative regulation of protein phosphorylationTAR DNA-binding protein 43Homo sapiens (human)
mRNA processingTAR DNA-binding protein 43Homo sapiens (human)
RNA splicingTAR DNA-binding protein 43Homo sapiens (human)
negative regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
regulation of protein stabilityTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of insulin secretionTAR DNA-binding protein 43Homo sapiens (human)
response to endoplasmic reticulum stressTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of protein import into nucleusTAR DNA-binding protein 43Homo sapiens (human)
regulation of circadian rhythmTAR DNA-binding protein 43Homo sapiens (human)
regulation of apoptotic processTAR DNA-binding protein 43Homo sapiens (human)
negative regulation by host of viral transcriptionTAR DNA-binding protein 43Homo sapiens (human)
rhythmic processTAR DNA-binding protein 43Homo sapiens (human)
regulation of cell cycleTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA destabilizationTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA stabilizationTAR DNA-binding protein 43Homo sapiens (human)
nuclear inner membrane organizationTAR DNA-binding protein 43Homo sapiens (human)
amyloid fibril formationTAR DNA-binding protein 43Homo sapiens (human)
regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
angiogenesisCaspase-8Homo sapiens (human)
regulation of cytokine productionCaspase-8Homo sapiens (human)
proteolysisCaspase-8Homo sapiens (human)
apoptotic processCaspase-8Homo sapiens (human)
heart developmentCaspase-8Homo sapiens (human)
regulation of tumor necrosis factor-mediated signaling pathwayCaspase-8Homo sapiens (human)
natural killer cell activationCaspase-8Homo sapiens (human)
macrophage differentiationCaspase-8Homo sapiens (human)
positive regulation of cell migrationCaspase-8Homo sapiens (human)
response to cobalt ionCaspase-8Homo sapiens (human)
response to estradiolCaspase-8Homo sapiens (human)
response to lipopolysaccharideCaspase-8Homo sapiens (human)
positive regulation of interleukin-1 beta productionCaspase-8Homo sapiens (human)
response to tumor necrosis factorCaspase-8Homo sapiens (human)
TRAIL-activated apoptotic signaling pathwayCaspase-8Homo sapiens (human)
T cell activationCaspase-8Homo sapiens (human)
B cell activationCaspase-8Homo sapiens (human)
positive regulation of apoptotic processCaspase-8Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transductionCaspase-8Homo sapiens (human)
negative regulation of canonical NF-kappaB signal transductionCaspase-8Homo sapiens (human)
regulation of innate immune responseCaspase-8Homo sapiens (human)
response to ethanolCaspase-8Homo sapiens (human)
positive regulation of macrophage differentiationCaspase-8Homo sapiens (human)
positive regulation of proteolysisCaspase-8Homo sapiens (human)
proteolysis involved in protein catabolic processCaspase-8Homo sapiens (human)
protein maturationCaspase-8Homo sapiens (human)
negative regulation of necroptotic processCaspase-8Homo sapiens (human)
syncytiotrophoblast cell differentiation involved in labyrinthine layer developmentCaspase-8Homo sapiens (human)
pyroptosisCaspase-8Homo sapiens (human)
cellular response to mechanical stimulusCaspase-8Homo sapiens (human)
cellular response to organic cyclic compoundCaspase-8Homo sapiens (human)
apoptotic signaling pathwayCaspase-8Homo sapiens (human)
extrinsic apoptotic signaling pathwayCaspase-8Homo sapiens (human)
execution phase of apoptosisCaspase-8Homo sapiens (human)
activation of cysteine-type endopeptidase activityCaspase-8Homo sapiens (human)
self proteolysisCaspase-8Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processCaspase-8Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptorsCaspase-8Homo sapiens (human)
positive regulation of neuron apoptotic processCaspase-8Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 4Homo sapiens (human)
G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
calcium-ion regulated exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
positive regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of synaptic vesicle cycleRap guanine nucleotide exchange factor 4Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
MAPK cascadeMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
immune responseMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
non-canonical NF-kappaB signal transductionMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
defense response to virusMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
cellular response to mechanical stimulusMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
canonical NF-kappaB signal transductionMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (43)

Processvia Protein(s)Taxonomy
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein domain specific bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
magnesium ion bindingTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
single-stranded DNA bindingTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
transcription corepressor activityTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
nuclease activityTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
protein bindingTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
manganese ion bindingTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
tyrosyl-RNA phosphodiesterase activityTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
5'-tyrosyl-DNA phosphodiesterase activityTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
RNA bindingCaspase-7Homo sapiens (human)
aspartic-type endopeptidase activityCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activityCaspase-7Homo sapiens (human)
protein bindingCaspase-7Homo sapiens (human)
peptidase activityCaspase-7Homo sapiens (human)
cysteine-type peptidase activityCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic processCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activity involved in execution phase of apoptosisCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activityCaspase-9Homo sapiens (human)
protein bindingCaspase-9Homo sapiens (human)
enzyme activator activityCaspase-9Homo sapiens (human)
peptidase activityCaspase-9Homo sapiens (human)
SH3 domain bindingCaspase-9Homo sapiens (human)
protein kinase bindingCaspase-9Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic processCaspase-9Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic signaling pathwayCaspase-9Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
double-stranded DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
RNA bindingTAR DNA-binding protein 43Homo sapiens (human)
mRNA 3'-UTR bindingTAR DNA-binding protein 43Homo sapiens (human)
protein bindingTAR DNA-binding protein 43Homo sapiens (human)
lipid bindingTAR DNA-binding protein 43Homo sapiens (human)
identical protein bindingTAR DNA-binding protein 43Homo sapiens (human)
pre-mRNA intronic bindingTAR DNA-binding protein 43Homo sapiens (human)
molecular condensate scaffold activityTAR DNA-binding protein 43Homo sapiens (human)
cysteine-type endopeptidase activityCaspase-8Homo sapiens (human)
death receptor bindingCaspase-8Homo sapiens (human)
tumor necrosis factor receptor bindingCaspase-8Homo sapiens (human)
protein bindingCaspase-8Homo sapiens (human)
peptidase activityCaspase-8Homo sapiens (human)
cysteine-type peptidase activityCaspase-8Homo sapiens (human)
ubiquitin protein ligase bindingCaspase-8Homo sapiens (human)
death effector domain bindingCaspase-8Homo sapiens (human)
identical protein bindingCaspase-8Homo sapiens (human)
protein-containing complex bindingCaspase-8Homo sapiens (human)
scaffold protein bindingCaspase-8Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic processCaspase-8Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic signaling pathwayCaspase-8Homo sapiens (human)
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein-macromolecule adaptor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
small GTPase bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein kinase activityMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
protein serine/threonine kinase activityMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
MAP kinase kinase kinase activityMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
protein bindingMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
ATP bindingMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
protein serine kinase activityMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (36)

Processvia Protein(s)Taxonomy
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
cortical actin cytoskeletonRap guanine nucleotide exchange factor 3Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
microvillusRap guanine nucleotide exchange factor 3Homo sapiens (human)
endomembrane systemRap guanine nucleotide exchange factor 3Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
lamellipodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
filopodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
extracellular exosomeRap guanine nucleotide exchange factor 3Homo sapiens (human)
nucleusTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
nucleoplasmTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
nucleolusTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
cytoplasmTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
aggresomeTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
nuclear bodyTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
PML bodyTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
PML bodyTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
cytoplasmTyrosyl-DNA phosphodiesterase 2Homo sapiens (human)
extracellular spaceCaspase-7Homo sapiens (human)
nucleusCaspase-7Homo sapiens (human)
cytoplasmCaspase-7Homo sapiens (human)
cytosolCaspase-7Homo sapiens (human)
nucleusCaspase-7Homo sapiens (human)
nucleoplasmCaspase-7Homo sapiens (human)
cytosolCaspase-7Homo sapiens (human)
mitochondrionCaspase-9Homo sapiens (human)
nucleusCaspase-9Homo sapiens (human)
cytosolCaspase-9Homo sapiens (human)
caspase complexCaspase-9Homo sapiens (human)
apoptosomeCaspase-9Homo sapiens (human)
protein-containing complexCaspase-9Homo sapiens (human)
cytosolCaspase-9Homo sapiens (human)
cytoplasmCaspase-9Homo sapiens (human)
intracellular non-membrane-bounded organelleTAR DNA-binding protein 43Homo sapiens (human)
nucleusTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
perichromatin fibrilsTAR DNA-binding protein 43Homo sapiens (human)
mitochondrionTAR DNA-binding protein 43Homo sapiens (human)
cytoplasmic stress granuleTAR DNA-binding protein 43Homo sapiens (human)
nuclear speckTAR DNA-binding protein 43Homo sapiens (human)
interchromatin granuleTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
chromatinTAR DNA-binding protein 43Homo sapiens (human)
cytoplasmCaspase-8Homo sapiens (human)
nucleoplasmCaspase-8Homo sapiens (human)
mitochondrionCaspase-8Homo sapiens (human)
mitochondrial outer membraneCaspase-8Homo sapiens (human)
cytosolCaspase-8Homo sapiens (human)
cytoskeletonCaspase-8Homo sapiens (human)
lamellipodiumCaspase-8Homo sapiens (human)
cell bodyCaspase-8Homo sapiens (human)
death-inducing signaling complexCaspase-8Homo sapiens (human)
CD95 death-inducing signaling complexCaspase-8Homo sapiens (human)
protein-containing complexCaspase-8Homo sapiens (human)
ripoptosomeCaspase-8Homo sapiens (human)
cytosolRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
hippocampal mossy fiber to CA3 synapseRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
fibrillar centerMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
nucleoplasmMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
cytosolMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
intracellular membrane-bounded organelleMitogen-activated protein kinase kinase kinase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1293599Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay2016Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).
AID493445Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay2010Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening.
AID1293601Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded oligonucleotide DNA containing 3'-phophotyrosine (N14Y) as substrate at 111 uM incubated for 15 mins by PAGE assay2016Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).
AID493444Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells at 50 uM after 60 mins by radiometric protein kinase assay2010Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's9 (75.00)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.90

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.90 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.90)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]