| Assay ID | Title | Year | Journal | Article |
|---|
| AID191571 | Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 20 mg/kg (n=9) | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID227793 | Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
| AID31709 | Ability to inhibit binding of [3H]CHA to adenosine A1 receptor in rat brain cortical membranes. | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. |
| AID108719 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 0.31 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID33898 | Binding affinity against Adenosine A2 receptor of striatal membrane using [3H]CGS-21680 | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
| AID33174 | Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
| AID170581 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.31 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID30439 | Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]CCPA | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
| AID33594 | Binding affinity against adenosine A2 receptor in rat brain using [3H]- CGS 21680 as radioligand | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. |
| AID239189 | Inhibition of [3H]ZM-241385 binding to adenosine A2a receptor of rat brain tissue | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID108848 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 20 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID33740 | Binding affinity at Adenosine A2 receptor from rat striatal membranes by N-[3H] ethyladenosin-5'- uronamide displacement. | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID229793 | Ratio of Ki for A2 and A1 adenosine receptors | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID250005 | Compound was tested in mouse catalepsy study (po); active at 1 mg/kg | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID239210 | Inhibition of [3H]DPCPX binding to adenosine A1 receptor of rat cerebral cortex | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID170580 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.08 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID108846 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 1.25 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID32508 | Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID239213 | Inhibition of [3H]DPCPX binding to rat cerebral cortex adenosine A1 receptor | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID170591 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 20 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID191565 | Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 1.25 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID21313 | Solubility as determined | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
| AID31886 | Binding affinity for Adenosine A1 receptor using N-[3H] cyclohexyladenosine in rat forebrain membranes | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
| AID25882 | Half life was determined | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
| AID170594 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 5 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID191551 | Retention time in Scopolamine induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID229795 | Ratio of Ki against rat forebrain membrane A1 and rat striatal membrane A2 adenosine receptors | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID237856 | Oral bioavailability in rat | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID35013 | Ability to inhibit binding of [3H]-CGS- 21680 to adenosine A2A receptor in rat brain striatal membranes. | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. |
| AID191560 | Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.31 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID239096 | Inhibition of [3H]ZM-241,385 binding to rat brain adenosine A2a receptor | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID32294 | Binding affinity against Adenosine A1 receptor from guinea pig forebrain membranes by N6-[3H]- cyclohexyladenosine displacement. | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID31867 | Binding affinity against adenosine A1 receptor from rat forebrain membranes using N6-[3H]cyclohexyladenosine | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
| (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. |
| AID34221 | Binding Affinity for adenosine A2A receptor expressed in HEK293 cells compared to [3H]CGS-21680 | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
| AID34081 | Inhibitory activity against cyclic AMP production in rat Adenosine A2A receptor assay | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
| AID191559 | Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.08 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID231678 | Ratio between Ki of adenosine A1 receptor to that of adenosine A2 receptor | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. |
| AID118934 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 20 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID228358 | Ratio against A1 adenosine receptor to the A2 adenosine receptor (guinea pig forebrain membranes, using N6-[3H]cyclohexyladenosine as radioligand. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
| (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. |
| AID118931 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 1.25 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID237084 | Half-life in rats | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID108853 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID233916 | Selectivity ratio as adenosine A1 receptor/adenosine A2A receptor. | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. |
| AID237008 | Volume of distribution in rats | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID246822 | Effective peroral dose in rat catalepsy study | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID231706 | Ratio between binding affinities for adenosine A1 and A2 receptor | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
| AID118938 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID22065 | Concentration in plasma was determined | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
| AID22064 | Concentration in brain was determined | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
| AID30309 | Inhibitory activity against cyclic AMP production in rat Adenosine A1 receptor assay | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
| AID30810 | Binding affinity against adenosine A2 receptor from rat striatal membranes, using N-[3H]-ethyladenosin-5''-uronamide as radioligand (in the presence of 50 nM cyclopentyl adenosine). | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
| (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. |
| AID28858 | Water solubility of the compound | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
| (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. |
| AID118924 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.31 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID34724 | Binding affinity towards adenosine A3 receptor expressed in HEK293 cells versus [125I]AB-MECA | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
| AID32327 | Affinity against Adenosine A1 receptor in rat brain using [3H]- PIA as radioligand | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. |
| AID32162 | Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]cyclohexyladenosine as radioligand. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
| (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. |
| AID244783 | Minimum effective dose (po) for 6-hydroxydopamine rotation in male Sprague-Dawley rats | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
| AID170587 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 1.25 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |