| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
phosphoribosyl-n-formylglycineamide
[no description available] | 1.96 | 1 | 0 | | |
adenine
[no description available] | 3.42 | 7 | 0 | 6-aminopurines;
purine nucleobase | Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
cytosine
[no description available] | 2.05 | 1 | 0 | aminopyrimidine;
pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
5,6-dimethylbenzimidazole
5,6-dimethylbenzimidazole: RN given refers to parent cpd. 5,6-dimethylbenzimidazole : A dimethylbenzimidazole carrying methyl substituents at positions 5 and 6. | 2.03 | 1 | 0 | dimethylbenzimidazole | Escherichia coli metabolite;
human metabolite |
glycine
[no description available] | 1.96 | 1 | 0 | alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid | EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical |
thymine
[no description available] | 2.05 | 1 | 0 | pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder | 2.05 | 1 | 0 | pyrimidine nucleobase;
pyrimidone | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite |
xanthine
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.. 9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated. | 2.03 | 1 | 0 | xanthine | Saccharomyces cerevisiae metabolite |
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. | 2.15 | 1 | 0 | adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate | fundamental metabolite;
human metabolite |
uridine
[no description available] | 2.17 | 1 | 0 | uridines | drug metabolite;
fundamental metabolite;
human metabolite |
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. | 2.15 | 1 | 0 | adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical |
tubercidin
Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus. | 2.05 | 1 | 0 | antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside | antimetabolite;
antineoplastic agent;
bacterial metabolite |
2-aminodiphenyl
aminobiphenyl : Any member of the class of biphenyls in which the biphenyl skeleton is substituted by at least one amino group. | 2.11 | 1 | 0 | | |
2-phenylphenol
2-phenylphenol: RN given refers to parent cpd; structure. biphenyl-2-ol : A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits. | 2.11 | 1 | 0 | hydroxybiphenyls | antifungal agrochemical;
environmental food contaminant |
benzohydrol
diphenylmethanol : A secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1. | 2.11 | 1 | 0 | benzyl alcohols;
secondary alcohol | bacterial xenobiotic metabolite;
human urinary metabolite;
human xenobiotic metabolite;
rat metabolite |
4,4'-dihydroxybiphenyl
biphenyl-4,4'-diol : A member of the class of hydroxybiphenyls that is biphenyl with hydroxy groups at positions 4 and 4'. | 2.11 | 1 | 0 | hydroxybiphenyls | |
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring. | 2.05 | 1 | 0 | mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound | non-polar solvent |
2-chloroadenosine
5-chloroformycin A: structure given in first source | 2.15 | 1 | 0 | purine nucleoside | |
2-fluoroadenosine
[no description available] | 2.15 | 1 | 0 | adenosines;
organofluorine compound | |
pyrimidine
pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions. | 2.13 | 1 | 0 | diazine;
pyrimidines | Daphnia magna metabolite |
methylthioinosine
Methylthioinosine: 6-(Methylthio)-9-beta-D-ribofuranosylpurine. An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. | 2.05 | 1 | 0 | purine ribonucleoside;
thiopurine | |
2-aminopurine
2-Aminopurine: A purine that is an isomer of ADENINE (6-aminopurine).. aminopurine : Any purine having at least one amino substituent.. 2-aminopurine : The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position. | 3.9 | 12 | 0 | 2-aminopurines;
nucleobase analogue | antimetabolite |
2,7-dihydroxynaphthalene
[no description available] | 2.11 | 1 | 0 | | |
5-methylbenzimidazole
5-methylbenzimidazole: structure in first source. 5-methyl-1H-benzimidazole : A member of the class of imidazoles that is 1H-benzimidazole in which the hydrogen at position 5 is substituted by a methyl group. | 2.03 | 1 | 0 | imidazoles | |
2-fluoroadenine
2-fluoroadenine : An organofluorine compound that is adenine in which the hydrogen at position 2 (the carbon between the two nitrogens of the pyrimidine ring) is replaced by a fluorine. | 2.15 | 1 | 0 | organofluorine compound;
purines | antineoplastic agent |
9-benzyladenine
[no description available] | 2.15 | 1 | 0 | | |
isopentenyladenosine
Isopentenyladenosine: N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant growth regulators.. N(6)-(Delta(2)-isopentenyl)adenosine : A nucleoside analogue in which adenosine has been modified by substitution at the 6-amino nitrogen by a Delta(2)-isopentenyl group. | 2.05 | 1 | 0 | N-ribosyl-N(6)-isopentenyladenine;
nucleoside analogue | antineoplastic agent;
plant growth regulator;
plant metabolite |
2,6-diaminopurine
9H-purine-2,6-diamine : A member of the class of 2,6-diaminopurines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by amino groups. | 2.48 | 2 | 0 | 2,6-diaminopurines;
primary amino compound | antineoplastic agent |
desciclovir
[no description available] | 1.97 | 1 | 0 | | |
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | 2.8 | 3 | 0 | adenosines;
purines D-ribonucleoside | analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent |
benzylaminopurine
benzylaminopurine: a plant growth regulator. N-benzyladenine : A member of the class of 6-aminopurines that is adenine in which one of the hydrogens of the amino group is replaced by a benzyl group. | 2.48 | 2 | 0 | 6-aminopurines | cytokinin;
plant metabolite |
xanthosine
[no description available] | 2.05 | 1 | 0 | purines D-ribonucleoside;
xanthosines | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
isoguanosine
[no description available] | 2.05 | 1 | 0 | purine nucleoside | |
o-(6)-methylguanine
O-(6)-methylguanine: structure. 6-O-methylguanine : A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.. methylguanine : A 2-aminopurine that is guanine bearing a single methyl substituent. | 2.03 | 1 | 0 | methylguanine | mutagen |
nebularine
nebularine: structure. nebularine : A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage. | 2.05 | 1 | 0 | purine ribonucleoside;
purines D-ribonucleoside | fungal metabolite |
4,4'-diaminobenzophenone
4,4'-diaminobenzophenone: structure in first source | 2.11 | 1 | 0 | | |
4(5)-phenylimidazole
4(5)-phenylimidazole: tautomeric cpd; cytochrome P450 14alpha-sterol demethylase, CYP51 antagonist | 2.11 | 1 | 0 | | |
9-methyladenine
9-methyladenine : Adenine substituted with a methyl group at position N-9. | 2.15 | 1 | 0 | methyladenine | metabolite |
8-azaadenine
8-azaadenine: xanthine oxidase inhibitor. 8-azaadenine : A triazolopyrimidine that is [1,2,3]triazolo[4,5-d]pyrimidine bearing an amino substituent at position 7. | 2.15 | 1 | 0 | aromatic amine;
nucleobase analogue;
triazolopyrimidines | EC 1.17.3.2 (xanthine oxidase) inhibitor;
Mycoplasma genitalium metabolite |
5-aminoisoquinoline
[no description available] | 2.11 | 1 | 0 | | |
D-alanine
[no description available] | 2.05 | 1 | 0 | alanine zwitterion;
alanine;
D-alpha-amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
Escherichia coli metabolite;
human metabolite |
7-methyladenine
7-methyladenine: potential marker for monitoring exposure to methylatingcarcinogens. 7-methyladenine : Adenine substituted with a methyl group at position N-7. | 2.15 | 1 | 0 | methyladenine | metabolite |
2-aminoadenosine
[no description available] | 2.49 | 2 | 0 | purine nucleoside | |
4-aminopyrazolo(3,4-d)pyrimidine
4-aminopyrazolo(3,4-d)pyrimidine: adenine analog which suppresses growth of E coli & Bacillus cereus; inhibits cell growth & purine biosynthesis in rat hepatoma | 2.03 | 1 | 0 | | |
1-methylxanthine
1-methylxanthine: urinary metabolite of caffeine. 1-methylxanthine : A monomethylxanthine having the methyl group located at the 1-position. It is a metabolite of caffeine in humans.. 1-methyl-7H-xanthine : A 1-methylxanthine tautomer where the imidazole proton is located at the 7-position. | 2.03 | 1 | 0 | 1-methylxanthine | mouse metabolite |
6-chloropurine riboside
[no description available] | 2.05 | 1 | 0 | | |
1-(2-pyridinyl)piperazine
1-(2-pyridinyl)piperazine: metabolite of buspirone & gepirone | 2.11 | 1 | 0 | | |
2-chloroadenine
6-amino-2-chloropurine: RN & structure given in first source | 2.15 | 1 | 0 | | |
6'-o-methylguanosine
[no description available] | 2.05 | 1 | 0 | | |
8-aminoadenosine
[no description available] | 2.05 | 1 | 0 | | |
n(6)-phenyladenosine
[no description available] | 2.15 | 1 | 0 | purine nucleoside | |
n-methyladenosine
N-methyladenosine: is a inhibitor of cell differentiation. N(6)-methyladenosine : A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase. | 2.05 | 1 | 0 | methyladenosine | |
2'-o-methyluridine
[no description available] | 2.17 | 1 | 0 | methyluridine | |
2'-o-methyladenosine
cordysinin B : A member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis. | 2.17 | 1 | 0 | adenosines;
ether | fungal metabolite |
9-(2,3-dihydroxypropyl)adenine
[no description available] | 2.15 | 1 | 0 | | |
n(6),n(6)-dimethyladenosine
N(6),N(6)-dimethyladenosine : A methyladenosine compound with two methyl groups attached to N(6) of the adenine nucleobase. | 2.05 | 1 | 0 | hydrocarbyladenosine | |
mercaptopurine
Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis. | 2.44 | 2 | 0 | aryl thiol;
purines;
thiocarbonyl compound | anticoronaviral agent;
antimetabolite;
antineoplastic agent |
thioinosine
Thioinosine: Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503) | 2.05 | 1 | 0 | | |
2-mercaptobenzimidazole
2-mercaptobenzimidazole: purine synthesis antimetabolite; RN given refers to parent cpd | 2.05 | 1 | 0 | | |
6-thioxanthine
6-thioxanthine: gpt/6-TXenzyme/prodrug pair is a promising alternative to the thymidine kinase gene and ganciclovir combination in the gene therapy of cancer | 2.03 | 1 | 0 | | |
2-thioxanthene
[no description available] | 2.03 | 1 | 0 | | |
thiouracil
Thiouracil: Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.. thiouracil : A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group. | 2.05 | 1 | 0 | nucleobase analogue;
thiocarbonyl compound | antithyroid drug;
metabolite |
pyrimidine-2-thiol
pyrimidine-2-thiol: RN given refers to parent cpd. pyrimidine-2-thiol : Pyrimidine substituted at C-2 by a sulfanyl group. | 2.05 | 1 | 0 | aryl thiol;
pyrimidines | allergen;
corrosion inhibitor |
thioguanine anhydrous
Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia. | 2.98 | 4 | 0 | 2-aminopurines | anticoronaviral agent;
antimetabolite;
antineoplastic agent |
2-thiopyridine
2-thiopyridine: RN given refers to parent cpd. pyridine-2-thiol : Pyridine substituted at C-2 by a sulfanyl group. | 2.05 | 1 | 0 | aryl thiol;
pyridines | allergen;
fluorescence quencher |
4-thiopyridine
4-thiopyridine: RN given refers to 4-thiopyridine cpd | 2.05 | 1 | 0 | | |
6-thioguanosine
6-thioguanosine: RN given refers to cpd without isomeric designation | 2.05 | 1 | 0 | purine nucleoside | |
6-chloropurine
[no description available] | 2.05 | 1 | 0 | purines | |
6-benzylthioinosine
6-benzylthioinosine: a subversive substrate of T gondii adenosine kinase; structure in first source | 2.05 | 1 | 0 | | |
oligonucleotides
[no description available] | 2.25 | 1 | 0 | | |
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections. | 6.97 | 1 | 0 | 2-aminopurines;
oxopurine | antimetabolite;
antiviral drug |
guanine
[no description available] | 8.47 | 7 | 0 | 2-aminopurines;
oxopurine;
purine nucleobase | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
guanosine
ribonucleoside : Any nucleoside where the sugar component is D-ribose. | 2.49 | 2 | 0 | guanosines;
purines D-ribonucleoside | fundamental metabolite |
hypoxanthine
[no description available] | 2.7 | 3 | 0 | nucleobase analogue;
oxopurine;
purine nucleobase | fundamental metabolite |
inosine
[no description available] | 2.49 | 2 | 0 | inosines;
purines D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
ganciclovir
[no description available] | 2.05 | 1 | 0 | 2-aminopurines;
oxopurine | antiinfective agent;
antiviral drug |
8-azaxanthine
methanochondroitin: a heteropolysaccharide from cell wall which resembles the eukaryotic chondroitin | 2.03 | 1 | 0 | triazolopyrimidines | |
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. | 3.12 | 5 | 0 | nucleobase analogue;
organic heterobicyclic compound | antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger |
azaguanine
Azaguanine: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.. 8-azaguanine : A triazolopyrimidine that consists of 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively. | 2.46 | 2 | 0 | nucleobase analogue;
triazolopyrimidines | antimetabolite;
antineoplastic agent;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor |
8-hydroxyguanosine
8-hydroxyguanosine: immunostimulant for B lymphocytes; structure given in first source | 2.05 | 1 | 0 | purine nucleoside | |
7-deazainosine
[no description available] | 2.05 | 1 | 0 | | |
8-azahypoxanthine
8-azahypoxanthine: an antimalarial that inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase; structure. 8-azahypoxanthine : A triazolopyrimidine that consists of 1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing an oxo substituent at position 7. | 2.03 | 1 | 0 | nucleobase analogue;
triazolopyrimidines | antimalarial;
EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitor |
7-methylinosine
7-methylinosine : A positively charged methylinosine in which a single methyl substituent is located at position 7 on the hypoxanthine ring. | 2.05 | 1 | 0 | inosines;
organic cation | metabolite |