Compounds > 2-(oxaloamino)benzoic acid
Page last updated: 2024-12-08

2-(oxaloamino)benzoic acid

Cross-References

ID SourceID
PubMed CID444764
CHEMBL ID139050
CHEBI ID44493
SCHEMBL ID4315667

Synonyms (19)

Synonym
OBA ,
2-(oxalyl-amino)-benzoic acid
CHEBI:44493 ,
2-[(carboxycarbonyl)amino]benzoic acid
2-(oxaloamino)benzoic acid
DB02622
1C85
CHEMBL139050 ,
2-(carboxyformamido)benzoic acid
bdbm50118789
SCHEMBL4315667
benzoic acid,2[(carboxycarbonyl)amino]-
5651-01-4
2-oxaloaminobenzoic acid
Q27093587
PD007813
benzoic acid, 2-[(carboxycarbonyl)amino]-
DTXSID101034398
2-carboxyoxanilic acid

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Although the core structure of these inhibitors is charged, good oral bioavailability has been observed in rat for some compounds."( Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Andersen, HS; Bakir, F; Branner, S; Christensen, MS; Collins, T; Hansen, TK; Iversen, LF; Jeppesen, L; Judge, L; Lau, JF; Moran, EJ; Mortensen, SB; Møller, NP; Newman, MJ; Olsen, OH; Ripka, WC; Shahbaz, M; Su, J; Sørensen, AL; Vo, T, 2002)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
(oxaloamino)benzoic acid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (14)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)Homo sapiens (human)Ki23.000014.000018.500023.0000AID977610
Chain A, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)Homo sapiens (human)Ki23.000014.000018.500023.0000AID977610
Chain A, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)Homo sapiens (human)Ki23.000014.000018.500023.0000AID977610
Chain A, PROTEIN-TYROSINE PHOSPHATASE 1BHomo sapiens (human)Ki23.000014.000018.500023.0000AID977610
Tyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)Ki23.00004.30004.30004.3000AID439576
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)Ki14,483,666,276.63620.19004.83279.6000AID165018; AID257651; AID483153
Type-1 angiotensin II receptorHomo sapiens (human)Ki870.00000.00020.18374.7000AID165337
Type-2 angiotensin II receptorHomo sapiens (human)Ki870.00000.00020.56507.7790AID165337
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (203)

Processvia Protein(s)Taxonomy
MAPK cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
natural killer cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of T cell mediated cytotoxicityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of cytokine-mediated signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
hematopoietic progenitor cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of immunoglobulin productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of humoral immune response mediated by circulating immunoglobulinReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of protein kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein dephosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of cell adhesion involved in substrate-bound cell migrationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
leukocyte cell-cell adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell surface receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
response to gamma radiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of gene expressionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
dephosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of B cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of protein autophosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of interleukin-8 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of interleukin-2 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of interleukin-2 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of tumor necrosis factor productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heterotypic cell-cell adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell activationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
gamma-delta T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of MAPK cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell cycle phase transitionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive thymic T cell selectionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative thymic T cell selectionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of gamma-delta T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of protein kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of receptor signaling pathway via JAK-STATReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
alpha-beta T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of alpha-beta T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of isotype switching to IgG isotypesReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
bone marrow developmentReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
stem cell developmentReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of peptidyl-tyrosine phosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of phagocytosisReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of phagocytosisReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of calcium-mediated signalingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of T cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of antigen receptor-mediated signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
release of sequestered calcium ion into cytosolReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
defense response to virusReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of cell cycleReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of Fc receptor mediated stimulatory signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of protein tyrosine kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
extrinsic apoptotic signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of microglial cell activationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
response to aldosteroneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
DN2 thymocyte differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of hematopoietic stem cell migrationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of stem cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell adhesionReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
cell surface receptor protein tyrosine phosphatase signaling pathwayReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
cell migrationReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
neuron projection regenerationReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
peptidyl-tyrosine dephosphorylationReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
regulation of axon regenerationReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
synaptic membrane adhesionReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
negative regulation of receptor bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
negative regulation of transcription by RNA polymerase IITyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of cell population proliferationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of tumor necrosis factor-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of lipid storageTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
B cell differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
T cell differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
erythrocyte differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of tyrosine phosphorylation of STAT proteinTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
glucose homeostasisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of macrophage differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of gluconeogenesisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of inflammatory responseTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of chemotaxisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
regulation of type II interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of type II interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-6-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-2-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-4-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of macrophage colony-stimulating factor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of positive thymic T cell selectionTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
integrin-mediated signaling pathwayReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
insulin receptor signaling pathwayReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
modulation of chemical synaptic transmissionReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
regulation of focal adhesion assemblyReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
protein dephosphorylationReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
protein dephosphorylationReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
phosphate-containing compound metabolic processReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
glial cell migrationReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
dephosphorylationReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
angiogenesisReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
protein dephosphorylationReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
negative regulation of insulin receptor signaling pathwayReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
MAPK cascadeTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
hematopoietic progenitor cell differentiationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of humoral immune response mediated by circulating immunoglobulinTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
G protein-coupled receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
positive regulation of cell population proliferationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of cell population proliferationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of angiogenesisTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
peptidyl-tyrosine phosphorylationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
cytokine-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
cell differentiationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
platelet formationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
T cell costimulationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of interleukin-6 productionTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of tumor necrosis factor productionTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of mast cell activation involved in immune responseTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
positive regulation of cell adhesion mediated by integrinTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
megakaryocyte developmentTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
T cell proliferationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of T cell proliferationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
natural killer cell mediated cytotoxicityTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
regulation of apoptotic processTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of MAPK cascadeTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
regulation of B cell differentiationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of peptidyl-tyrosine phosphorylationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
T cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
B cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosolTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
platelet aggregationTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
negative regulation of inflammatory response to woundingTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
epididymis developmentTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
regulation of G1/S transition of mitotic cell cycleTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
intracellular signal transductionTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
mitotic cell cycleTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
regulation of cell growthType-1 angiotensin II receptorHomo sapiens (human)
kidney developmentType-1 angiotensin II receptorHomo sapiens (human)
renin-angiotensin regulation of aldosterone productionType-1 angiotensin II receptorHomo sapiens (human)
maintenance of blood vessel diameter homeostasis by renin-angiotensinType-1 angiotensin II receptorHomo sapiens (human)
regulation of systemic arterial blood pressure by renin-angiotensinType-1 angiotensin II receptorHomo sapiens (human)
G protein-coupled receptor signaling pathwayType-1 angiotensin II receptorHomo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwayType-1 angiotensin II receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationType-1 angiotensin II receptorHomo sapiens (human)
Rho protein signal transductionType-1 angiotensin II receptorHomo sapiens (human)
positive regulation of macrophage derived foam cell differentiationType-1 angiotensin II receptorHomo sapiens (human)
regulation of vasoconstrictionType-1 angiotensin II receptorHomo sapiens (human)
calcium-mediated signalingType-1 angiotensin II receptorHomo sapiens (human)
positive regulation of phospholipase A2 activityType-1 angiotensin II receptorHomo sapiens (human)
low-density lipoprotein particle remodelingType-1 angiotensin II receptorHomo sapiens (human)
regulation of renal sodium excretionType-1 angiotensin II receptorHomo sapiens (human)
angiotensin-activated signaling pathwayType-1 angiotensin II receptorHomo sapiens (human)
regulation of cell population proliferationType-1 angiotensin II receptorHomo sapiens (human)
symbiont entry into host cellType-1 angiotensin II receptorHomo sapiens (human)
regulation of inflammatory responseType-1 angiotensin II receptorHomo sapiens (human)
positive regulation of inflammatory responseType-1 angiotensin II receptorHomo sapiens (human)
positive regulation of protein metabolic processType-1 angiotensin II receptorHomo sapiens (human)
cell chemotaxisType-1 angiotensin II receptorHomo sapiens (human)
phospholipase C-activating angiotensin-activated signaling pathwayType-1 angiotensin II receptorHomo sapiens (human)
blood vessel diameter maintenanceType-1 angiotensin II receptorHomo sapiens (human)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisType-1 angiotensin II receptorHomo sapiens (human)
positive regulation of CoA-transferase activityType-1 angiotensin II receptorHomo sapiens (human)
positive regulation of reactive oxygen species metabolic processType-1 angiotensin II receptorHomo sapiens (human)
inflammatory responseType-1 angiotensin II receptorHomo sapiens (human)
blood vessel remodelingType-2 angiotensin II receptorHomo sapiens (human)
regulation of systemic arterial blood pressure by circulatory renin-angiotensinType-2 angiotensin II receptorHomo sapiens (human)
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressureType-2 angiotensin II receptorHomo sapiens (human)
brain renin-angiotensin systemType-2 angiotensin II receptorHomo sapiens (human)
cell surface receptor signaling pathwayType-2 angiotensin II receptorHomo sapiens (human)
G protein-coupled receptor signaling pathwayType-2 angiotensin II receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messengerType-2 angiotensin II receptorHomo sapiens (human)
brain developmentType-2 angiotensin II receptorHomo sapiens (human)
regulation of blood pressureType-2 angiotensin II receptorHomo sapiens (human)
negative regulation of heart rateType-2 angiotensin II receptorHomo sapiens (human)
negative regulation of cell growthType-2 angiotensin II receptorHomo sapiens (human)
positive regulation of phosphoprotein phosphatase activityType-2 angiotensin II receptorHomo sapiens (human)
regulation of metanephros sizeType-2 angiotensin II receptorHomo sapiens (human)
exploration behaviorType-2 angiotensin II receptorHomo sapiens (human)
nitric oxide-cGMP-mediated signalingType-2 angiotensin II receptorHomo sapiens (human)
angiotensin-activated signaling pathwayType-2 angiotensin II receptorHomo sapiens (human)
vasodilationType-2 angiotensin II receptorHomo sapiens (human)
negative regulation of blood vessel endothelial cell migrationType-2 angiotensin II receptorHomo sapiens (human)
positive regulation of DNA-templated transcriptionType-2 angiotensin II receptorHomo sapiens (human)
negative regulation of neurotrophin TRK receptor signaling pathwayType-2 angiotensin II receptorHomo sapiens (human)
neuron apoptotic processType-2 angiotensin II receptorHomo sapiens (human)
positive regulation of metanephric glomerulus developmentType-2 angiotensin II receptorHomo sapiens (human)
positive regulation of branching involved in ureteric bud morphogenesisType-2 angiotensin II receptorHomo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathwayType-2 angiotensin II receptorHomo sapiens (human)
inflammatory responseType-2 angiotensin II receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (33)

Processvia Protein(s)Taxonomy
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
signaling receptor bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heparin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein kinase bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
ankyrin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
spectrin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heparan sulfate proteoglycan bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
heparin bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
chondroitin sulfate proteoglycan bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
protein-containing complex bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
cell adhesion molecule bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
integrin bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
syntaxin bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
STAT family protein bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
protein bindingReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
protein bindingReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
cadherin bindingReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
protein bindingReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
phosphotyrosine residue bindingTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
SH3 domain bindingTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
SH2 domain bindingTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
cell adhesion molecule bindingTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
phosphorylation-dependent protein bindingTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
angiotensin type I receptor activityType-1 angiotensin II receptorHomo sapiens (human)
angiotensin type II receptor activityType-1 angiotensin II receptorHomo sapiens (human)
protein bindingType-1 angiotensin II receptorHomo sapiens (human)
bradykinin receptor bindingType-1 angiotensin II receptorHomo sapiens (human)
protein heterodimerization activityType-1 angiotensin II receptorHomo sapiens (human)
angiotensin type II receptor activityType-2 angiotensin II receptorHomo sapiens (human)
protein bindingType-2 angiotensin II receptorHomo sapiens (human)
receptor antagonist activityType-2 angiotensin II receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (38)

Processvia Protein(s)Taxonomy
plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
focal adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
external side of plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cytoplasmic side of plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell surfaceReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
secretory granule membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
blebReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membrane raftReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
synapseReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
extracellular exosomeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membrane microdomainReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
plasma membraneReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
neuron projectionReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
neuronal cell bodyReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
extracellular exosomeReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
nucleoplasmTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
nucleusTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
plasma membraneReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
focal adhesionReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
membraneReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
extracellular exosomeReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
synaptic membraneReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
Schaffer collateral - CA1 synapseReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
receptor complexReceptor-type tyrosine-protein phosphatase alphaHomo sapiens (human)
plasma membraneReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
specific granule membraneReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
tertiary granule membraneReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
receptor complexReceptor-type tyrosine-protein phosphatase betaHomo sapiens (human)
nucleusReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
cytoplasmReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
plasma membraneReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
extracellular regionTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
nucleusTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
nucleoplasmTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
nucleolusTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
cell-cell junctionTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
membraneTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
specific granule lumenTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
extracellular exosomeTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
tertiary granule lumenTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
alpha-beta T cell receptor complexTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)
plasma membraneType-1 angiotensin II receptorHomo sapiens (human)
membraneType-1 angiotensin II receptorHomo sapiens (human)
plasma membraneType-1 angiotensin II receptorHomo sapiens (human)
plasma membraneType-2 angiotensin II receptorHomo sapiens (human)
plasma membraneType-2 angiotensin II receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID165328Inhibitory effect against protein-tyrosine phosphatase Lar, using p-nitrophenyl phosphate as substrate at pH 5.5.2002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
AID439578Inhibition of PTPRF2009Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
AID165337Inhibitory effect against human protein-tyrosine phosphatase alpha (PTPalpha), using p-nitrophenyl phosphate substrate at pH 5.5.2002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
AID439577Inhibition of PTPRC2009Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
AID483153Binding affinity to human recombinant PTP1B2010Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: Hologram QSAR for OBA and BBB analogues.
AID165018Inhibitory effect against recombinant human protein-tyrosine phosphatase 1B (PTP1B), using p-nitrophenyl phosphate substrate at pH 5.5.2002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
AID439576Inhibition of PTPN22009Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
AID439580Inhibition of PTPRB2009Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
AID439581Inhibition of PTPRE2009Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
AID257651Binding affinity to PTP1B2005Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24
Molecular docking and 3D-QSAR on 2-(oxalylamino) benzoic acid and its analogues as protein tyrosine phosphatase 1B inhibitors.
AID439582Inhibition of PTPRA2009Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
AID439579Inhibition of PTPN62009Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
AID1811Experimentally measured binding affinity data derived from PDB2000The Journal of biological chemistry, Mar-10, Volume: 275, Issue:10
2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2000The Journal of biological chemistry, Mar-10, Volume: 275, Issue:10
2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.03 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5-iodo-2-(oxaloamino)benzoic acid
[no description available]		3.1250organoiodine compound
ConditionIndicatedRelationship StrengthStudiesTrials
Diabetes Mellitus, Adult-Onset
[description not available]		02.0510
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.		02.0510
chemdatabank.com