| Assay ID | Title | Year | Journal | Article |
|---|
| AID1178357 | Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells | 2014 | Journal of medicinal chemistry, Sep-11, Volume: 57, Issue:17
| Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. |
| AID29449 | Bioavailability after oral administration in rat expressed as percentage | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID28668 | Partition coefficient (logD7.4) | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID27452 | Half-life period after oral administration in rat | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID1178358 | Inhibition of human recombinant 5HT6 receptor expressed in CHO cells | 2014 | Journal of medicinal chemistry, Sep-11, Volume: 57, Issue:17
| Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. |
| AID313655 | Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. |
| AID23931 | In vivo plasma clearance after oral administration in rat | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID6529 | Antagonism assessed in a functional cAMP binding assay using 5-CT to stimulate human 5-hydroxytryptamine 6 receptor expressed in HEK 293 cells | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID5661 | Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 2C receptor expressed in 3T3 cells using [3H]5-HT as radioligand | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID6544 | Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]LSD as radioligand | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID28633 | Ratio of brain/plasma concentration after oral administration in rat expressed as percentage | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID5431 | Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 2A receptor expressed in 3T3 cells using [3H]5-HT as radioligand | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID27451 | Half-life period after intravenous administration in rat | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID30157 | Volume of distribution at steady state after oral administration in rat; Not available | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID29162 | Dissociation constant after oral administration was determined in rat | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID23930 | In vivo plasma clearance after intravenous administration in rat | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID4654 | Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 1D receptor expressed in HEK 293 cells using [3H]LSD as radioligand | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID238738 | Binding affinity against 5 Hydroxy tryptamine 6 receptor | 2005 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 15, Issue:6
| 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. |
| AID6618 | Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 7 receptor expressed in CHO cells using [3H]LSD as radioligand | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| AID30156 | Volume of distribution at steady state after intravenous administration in rat | 2003 | Journal of medicinal chemistry, Mar-27, Volume: 46, Issue:7
| Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |