| Assay ID | Title | Year | Journal | Article |
|---|
| AID417508 | Inhibition of apoB secretion in human HepG2 cells after 40 hrs by ELISA | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
| Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors. |
| AID299009 | Decrease in food intake in obese Beagle dog at 0.39 mg/kg, po after 3 months | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298973 | AUC (0 to infinity) in rat at 0.3 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299007 | Bioavailability in Beagle dog at 5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298929 | Clearance in human liver microsomes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298881 | Inhibition of adrenergic a2 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298915 | Inhibition of mu opioid receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298918 | Inhibition of tachykinin receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298991 | Cmax in rat at 30 mg/kg, po after 2.8 hrs | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298896 | Inhibition of NMDA receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298884 | Inhibition of AT1 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298992 | Cmax in rat at 300 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298942 | Ratio of drug level in blood to plasma in rat | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299010 | Decrease in cholesterol level in obese Beagle dog at 0.39 mg/kg, po after 3 months | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688124 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of body weight at 30 mg/kg, po qd for 7 days | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID688266 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of food intake at 10 mg/kg, po administered daily for 3 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298875 | Inhibition of MTP assessed as inhibition of apoB secretion from human HepG2 cells | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298959 | Volume of distribution at steady state in monkey at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298952 | Plasma clearance in portal cannulated Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298953 | Plasma clearance in monkey at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299020 | Inhibition of CYP2D6 | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298928 | Clearance in monkey liver microsomes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299017 | Inhibition of CYP1A2 | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298923 | Intrinsic clearance in dog microsomes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298922 | Intrinsic clearance in rat microsomes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298951 | Plasma clearance in Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688126 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of body weight at 3 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298985 | AUC (0 to infinity) in rat at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298977 | AUC (0 to infinity) in Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298889 | Inhibition of dopamine D1 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299016 | Permeability from basolateral to apical side of the Caco-2 cell membrane at 10 uM in presence of calcium | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298931 | Clearance in human hepatocytes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298887 | Inhibition of bradykinin B1 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688129 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of food intake at 3 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID688128 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of food intake at 10 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298936 | Metabolic stability in human liver microsome at 0.5 uM in presence of 5 uM CYP2D6 inhibitor quinidine | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298924 | Intrinsic clearance in monkey microsomes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298914 | Inhibition of kappa opioid receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298999 | Tmax in portal cannulated Beagle dog at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298970 | AUC (0 to t) in Beagle dog at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688127 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of food intake at 30 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298974 | AUC (0 to infinity) in rat at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298895 | Inhibition of kainate receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298902 | Inhibition of 5HT2C receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688123 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of triglyceride accumulation in liver at 3 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID688265 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction in body weight at 10 mg/kg, po administered daily for 3 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298949 | Plasma clearance in rat at 5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298958 | Volume of distribution at steady state in Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298976 | AUC (0 to infinity) in Beagle dog at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688122 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of triglyceride accumulation in liver at 10 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298933 | Metabolic stability in human liver microsome at 0.5 uM in presence of 1 uM CYP3A4 inhibitor ketoconazole | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298978 | AUC (0 to infinity) in portal cannulated Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298983 | Half life in Beagle dog at 0.5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298946 | Inhibition of hepatic MTP in mouse assessed as reduction of triglyceride | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298903 | Inhibition of 5HT3 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688268 | Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298947 | Plasma clearance in rat at 0.3 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299002 | Bioavailability in rat at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298879 | Inhibition of adenosine A3 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298962 | Half life in rat at 5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299008 | Effect on body weight in obese Beagle dog assessed as weight loss at 0.39 mg/kg, po after 3 months relative to control | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298926 | Clearance in rat liver microsomes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298908 | Inhibition of muscarinic M2 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298961 | Half life in rat at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298917 | Inhibition of glucocorticoid receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299018 | Inhibition of CYP2C9 | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298964 | Half life in Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299012 | Permeability from apical to basolateral side of the Caco-2 cell membrane at 1 uM in presence of calcium | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299015 | Permeability from basolateral to apical side of the Caco-2 cell membrane at 1 uM in presence of calcium | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298906 | Inhibition of melanocortin MC4 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298997 | Tmax in rat at 30 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298930 | Clearance in rat hepatocytes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299014 | Permeability from apical to basolateral side of the Caco-2 cell membrane at 10 uM in presence of calcium | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298913 | Inhibition of delta opioid receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298934 | Metabolic stability in human liver microsome at 0.5 uM in presence of 5 uM CYP2C9 inhibitor sulfaphenazole | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688116 | AUC in high fat diet-induced obese Sprague-Dawley rat at 30 mg/kg, po qd for 7 days | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298904 | Inhibition of 5HT4 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298941 | Percentage unbound ligand in human blood at 0.2 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688269 | Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298920 | Inhibition of N-type calcium channel at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298954 | Volume of distribution at steady state in rat at 0.3 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298898 | Inhibition of histamine H2 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298886 | Inhibition of central benzodiazepine receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298967 | AUC (0 to t) in rat at 0.3 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298897 | Inhibition of histamine H1 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298880 | Inhibition of adrenergic a1 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298996 | Tmax in rat at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298900 | Inhibition of 5HT1A receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688101 | Antiobesity activity in po dosed high fat diet-induced obese Sprague-Dawley rat assessed as reduction of reduction of triglyceride accumulation in liver administered daily for 3 days | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298968 | AUC (0 to t) in rat at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298998 | Tmax in rat at 300 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID417509 | Inhibition of MTP from dog liver microsomes by scintillation counting | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
| Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors. |
| AID298893 | Inhibition of GABA receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298979 | AUC (0 to infinity) in monkey at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298994 | Cmax in Beagle dog at 0.5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298986 | AUC (0 to infinity) in male rat at 30 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298907 | Inhibition of muscarinic M1 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298989 | AUC (0 to infinity) in Beagle dog at 5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688125 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of body weight at 10 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298888 | Inhibition of bradykinin B2 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298921 | Inhibition of IKr potassium channel at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298965 | Half life in portal cannulated Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298956 | Volume of distribution at steady state in rat at 5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298935 | Metabolic stability in human liver microsome at 0.5 uM in presence of 200 uM CYP2C19 inhibitor (S)-mephenytoin | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298944 | Ratio of drug level in blood to plasma in human | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298963 | Half life in Beagle dog at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298972 | AUC (0 to t) in monkey at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298950 | Plasma clearance in Beagle dog at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298919 | Inhibition of L-type calcium channel at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298990 | Cmax in rat at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688264 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of triglyceride accumulation in liver at 10 mg/kg, po administered daily for 3 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID299004 | Bioavailability in rat at 300 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688115 | AUC in high fat diet-induced obese Sprague-Dawley rat at 10 mg/kg, po qd for 7 days | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298901 | Inhibition of 5HT2A receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298938 | Percentage unbound ligand in rat blood at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298955 | Volume of distribution at steady state in rat at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688099 | Antiobesity activity in po dosed high fat diet-induced obese Sprague-Dawley rat assessed as reduction of food intake administered daily for 3 days | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298932 | Metabolic stability in human liver microsome at 0.5 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298975 | AUC (0 to infinity) in rat at 5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298943 | Ratio of drug level in blood to plasma in dog | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298916 | Inhibition of platelet activating factor receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298925 | Intrinsic clearance in human microsomes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688100 | Antiobesity activity in po dosed high fat diet-induced obese Sprague-Dawley rat assessed as reduction of body weight administered daily for 3 days | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID688267 | Fraction unbound in human HepG2 cells by equilibrium dialysis | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID299001 | Tmax in Beagle dog at 5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299019 | Inhibition of CYP2C19 | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID638992 | Activity of recombinant CYP3A4 assessed as metabolite formation | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| Dirlotapide as a model substrate to refine structure-based drug design strategies on CYP3A4-catalyzed metabolism. |
| AID298948 | Plasma clearance in rat at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298980 | Half life in rat at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298878 | Inhibition of adenosine A2a receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298971 | AUC (0 to t) in Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298987 | AUC (0 to infinity) in portal cannulated Beagle dog at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688111 | Toxicity in high fat diet-induced obese Sprague-Dawley rat assessed as change in serum ALT level at 3 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298911 | Inhibition of neuronal nicotinic receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298966 | Half life in monkey at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298984 | Half life in Beagle dog at 5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298939 | Percentage unbound ligand in dog blood at 0.2 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298927 | Clearance in dog liver microsomes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298890 | Inhibition of dopamine D2 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298982 | Half life in portal cannulated Beagle dog at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299013 | Permeability from apical to basolateral side of the Caco-2 cell membrane at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298894 | Inhibition of AMPA receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299005 | Bioavailability in portal cannulated Beagle dog at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298981 | Half life in rat at 30 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298899 | Inhibition of histamine H3 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298957 | Volume of distribution at steady state in Beagle dog at 0.5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299021 | Inhibition of CYP3A4 | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298876 | Inhibition of MTP assessed as inhibition of apoB secretion from canine hepatocytes | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298993 | Cmax in portal cannulated Beagle dog at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688113 | Toxicity in high fat diet-induced obese Sprague-Dawley rat assessed as change in serum ALT level at 30 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298883 | Inhibition of adrenergic b2 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298909 | Inhibition of muscarinic M3 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298945 | Inhibition of intestinal MTP in mouse assessed as inhibition of intestinal fat absorption | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298885 | Inhibition of AT2 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299011 | Increase in fecal fat in obese Beagle dog at 0.39 mg/kg, po after 3 months | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298940 | Percentage unbound ligand in monkey blood at 0.2 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688121 | Antiobesity activity in high fat diet-induced obese Sprague-Dawley rat assessed as reduction of triglyceride accumulation in liver at 30 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID299006 | Bioavailability in Beagle dog at 0.5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID299003 | Bioavailability in rat at 30 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID638991 | Drug metabolism in human liver microsomes at 20 mM | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| Dirlotapide as a model substrate to refine structure-based drug design strategies on CYP3A4-catalyzed metabolism. |
| AID298969 | AUC (0 to t) in rat at 5 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298905 | Inhibition of 5HT7 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298960 | Half life in rat at 0.3 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298892 | Inhibition of dopamine D4 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298912 | Inhibition of muscle nicotinic receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688112 | Toxicity in high fat diet-induced obese Sprague-Dawley rat assessed as change in serum ALT level at 10 mg/kg, po qd for 7 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID299000 | Tmax in Beagle dog at 0.5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298877 | Inhibition of adenosine A1 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID688114 | AUC in high fat diet-induced obese Sprague-Dawley rat at 3 mg/kg, po qd for 7 days | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
| Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. |
| AID298882 | Inhibition of adrenergic b1 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298995 | Cmax in Beagle dog at 5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298910 | Inhibition of muscarinic M4 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298988 | AUC (0 to infinity) in Beagle dog at 0.5 mg/kg, po | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298891 | Inhibition of dopamine D3 receptor at 1 uM | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| AID298937 | Metabolic stability in human liver microsome at 0.5 uM in presence of 5 uM CYP1A2 inhibitor furafylline | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
| In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |