Compounds > 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1h-benzimidazole
Page last updated: 2024-12-10
1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1h-benzimidazole
Description
You're describing a chemical compound, specifically a **benzimidazole derivative**. This compound is likely of interest in research because:
* **Benzimidazoles are a versatile class of heterocyclic compounds with diverse biological activities.** They are known to exhibit antifungal, antibacterial, anti-inflammatory, antiparasitic, and anticancer properties.
* **The specific structure of your compound suggests potential for drug development.** The presence of various functional groups (chlorobenzyl, isobutylphenyl, ethyl) can influence the compound's interactions with biological targets and impact its pharmacological properties.
**To understand the specific importance of this compound in research, more information is needed:**
* **What is the intended biological target?** Understanding the intended target of this compound (e.g., an enzyme, receptor, etc.) can shed light on its potential therapeutic use.
* **What are the desired effects?** Is the compound being investigated for its anti-inflammatory, anticancer, or other therapeutic properties?
* **What are the results of the research?** Has this compound been shown to have any significant biological activity or therapeutic potential?
**Without this additional information, it is difficult to definitively state why this specific compound is important for research.**
It's important to note that many chemical compounds are synthesized and studied in research, and not all of them are ultimately developed into drugs or other therapeutic agents.
**To learn more about this specific compound, you may need to consult scientific publications, databases, or contact researchers working in this field.**
1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzimidazole: targets 5-lipoxygenase-activating protein to inhibit leukotriene biosynthesis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
Synonyms (15)
| Synonym |
|---|
| AKOS001138903 |
| AKOS016257435 |
| STK739435 |
| 1-(2-chlorobenzyl)-2-{1-[4-(2-methylpropyl)phenyl]ethyl}-1h-benzimidazole |
| bdbm50385390 |
| chembl2036163 , |
| AC-31476 |
| 1-[(2-chlorophenyl)methyl]-2-{1-[4-(2-methylpropyl)phenyl]ethyl}-1h-1,3-benzodiazole |
| 612046-20-5 |
| Z57171656 |
| 1-(2-chlorobenzyl)-2-(1-(4-(2-methylpropyl)phenyl)ethyl)-1h-benzimidazole |
| brp-7 |
| SB19087 |
| 1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1h-benzimidazole |
| EN300-26868506 |
Protein Targets (1)
Inhibition Measurements
Biological Processes (7)
Molecular Functions (10)
Ceullar Components (5)
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1395144 | Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187 and arachidonic acid addition and measured after 10 mins by UV based RP-HPLC analysis | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Identification of multi-target inhibitors of leukotriene and prostaglandin E |
| AID665660 | Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins | 2012 | Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
| Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). |
| AID665659 | Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation at 10 uM preincubated for 15 mins measured after 10 mins relative to control | 2012 | Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
| Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). |
| AID1230145 | Inhibition of LTB4 production in human whole blood | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
| Recent advances for FLAP inhibitors. |
| AID665661 | Inhibition of human FLAP in cell-free system assessed as inhibition of 5-LO product formation at 10 uM preincubated for 15 mins measured after 10 mins relative to control | 2012 | Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
| Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.72
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.72 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.51 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |