| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1508627 | Counterscreen qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: GLuc-NoTag assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1508628 | Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508629 | Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID128507 | Analgesic activity was determined by writhing test after subcutaneous administration in mice | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol. |
| AID144597 | Binding affinity against glycine binding site of N-methyl-D-aspartate glutamate receptor from rat synaptic plasma membrane(SPM) using [3H]glycine; NA = No effect | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
| Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. |
| AID150244 | Concentration required to inhibit [3H]naltrexone binding to Opioid receptors | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol. |
| AID113783 | Anticonvulsant activity in mice by intraperitoneal administration measured at 30 mins before maximum electroshock seizure induction | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
| AID144473 | Binding affinity against TCP binding site associated with N-methyl-D-aspartate glutamate receptor from rat synaptic plasma membrane(SPM) determined using [3H]TCP as radioligand. | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
| Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. |
| AID184524 | Effect was expressed as mortality after injection of kainic acid (10 mg/kg) and the drug at the dose of 20 mg/Kg after 48 hr out of 19 animals | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Anticonvulsant effects of new morphinan derivatives. |
| AID122334 | Therapeutic index TI (ED50 rotorod/MES) of the compound; NC- Not calculated | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
| AID196182 | The compound was tested for anticonvulsive activity expressed as seizure score after 4 hr of injection of kainic acid (10 mg/kg) and the drug at the dose of 40 mg/Kg in 15 rats | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Anticonvulsant effects of new morphinan derivatives. |
| AID170083 | The compound was examined for circling behavior (marginal activity) using automated videotracking system 30 min after intraperitoneal injection at the dose of 40 mg/Kg in 12 rats | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Anticonvulsant effects of new morphinan derivatives. |
| AID113784 | Anticonvulsant activity in mice by peroral administration measured at 60 mins before maximum electroshock seizure induction | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
| AID146728 | Binding of [3H]saxitoxin (STX) to rat brain sodium channel | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
| AID178287 | Anticonvulsant activity in rat supramaximal electroshock (MES) test within a dose range of 15-60 mg/kg. | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
| Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. |
| AID212002 | Significant mortality was observed in mice caused by the compound | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
| AID146727 | Binding of [3H]batrachotoxin (BTX) to rat brain sodium channel | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
| AID114226 | Psychomotor side-effect in mice by rotarod test by intraperitoneal administration at 60 mins; NC- Not calculated | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
| AID143909 | Inhibition of [3H]1 binding to dextromethorpin binding site of guinea pig microsomal pellet P3 N-methyl-D-aspartate glutamate receptor | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
| Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. |
| AID188506 | Anticonvulsant activity in rat supramaximal electroshock (MES) test expressed as % rats protected at a dose of 15-60 mg/kg. | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
| Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. |
| AID196181 | The compound was tested for anticonvulsive activity expressed as seizure score after 4 hr of injection of kainic acid (10 mg/kg) and the drug at the dose of 20 mg/Kg in 15 rats | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Anticonvulsant effects of new morphinan derivatives. |
| AID143910 | Binding affinity against dextromethorpin binding site associated with N-methyl-D-aspartate glutamate receptor from guinea pig mitochondrial pellet P2 determined using [3H]1 as radioligand. | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
| Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. |
| AID170082 | The compound was examined for circling behavior (marginal activity) using automated videotracking system 30 min after intraperitoneal injection at the dose of 20 mg/Kg in 12 rats | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Anticonvulsant effects of new morphinan derivatives. |
| AID184525 | Effect was expressed as mortality after injection of kainic acid (10 mg/kg) and the drug at the dose of 40 mg/Kg after 48 hr | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Anticonvulsant effects of new morphinan derivatives. |
| AID144475 | Binding affinity against dextromethorpin binding site of N-methyl-D-aspartate glutamate receptor from rat brain using [3H]1 | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
| Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. |
| AID128505 | Analgesic activity was determined by tail flick assay after subcutaneous administration in mice | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol. |
| AID178286 | Anticonvulsant activity in rat supramaximal electroshock (MES) test within a dose range of 15-60 mg/kg administered subcutaneously | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
| Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |