| Assay ID | Title | Year | Journal | Article |
|---|
| AID132519 | Concentration necessary for 50% inhibition of depolarization induced by 5 uM NMDA in mouse cortical wedge preparation | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. |
| AID132325 | Ability to inhibit depolarizations induced by AMPA in mouse cortical wedge preparations | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| 7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists. |
| AID143635 | Inhibition by displacing [3H]-Glycine of N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
| Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. |
| AID1859130 | Displacement of [3H]kainic acid from AMPA receptor (unknown origin) | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities. |
| AID93119 | Inhibition of specific binding at 100 uM by displacing [3H]KA, from specific binding sites of Ionotropic glutamate receptor ionotropic kainate in rat cortical membranes | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
| Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. |
| AID1859112 | Displacement of [3H]AMPA from AMPA receptor (unknown origin) | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities. |
| AID73797 | Compound was evaluated for inhibition of binding of [3H]glycine to specific binding at glycine receptor in rat cortical membrane | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| 7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists. |
| AID92650 | Compound was evaluated for inhibition of binding of [3H]AMPA to specific binding at Ionotropic glutamate receptor AMPA in rat cortical membrane | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| 7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists. |
| AID132657 | Concentration that inhibits by 50% depolarization induced by 5M NMDA | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
| Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. |
| AID144171 | Antagonism at NMDA receptor in mouse cortical wedge preparation expressed as concentration that inhibits by 50% depolarizations induced by 5 uM AMPA | 2001 | Journal of medicinal chemistry, Sep-13, Volume: 44, Issue:19
| Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173. |
| AID179379 | Concentration giving 50% inhibition of stimulated [3H](+)-MK-801 binding in rat cortical membranes incubated with 10 uM glycine | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. |
| AID132328 | Ability to inhibit depolarizations induced by NMDA in mouse cortical wedge preparations. | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| 7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists. |
| AID132520 | Concentration necessary for 50% inhibition of depolarization induced by 5 uM S-AMPA in mouse cortical wedge preparation | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. |
| AID144899 | Inhibition of [3H]-(+)-MK-801 binding to NMDA receptor ion-channel complex of rat cortical memembranes | 2001 | Journal of medicinal chemistry, Sep-13, Volume: 44, Issue:19
| Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173. |
| AID92778 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA in rat cortical membranes. | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
| Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. |
| AID93718 | Inhibition of [3H]KA binding to kainate receptor of rat brain membranes | 2001 | Journal of medicinal chemistry, Sep-13, Volume: 44, Issue:19
| Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173. |
| AID1859124 | Displacement of [3H]glycine from AMPA receptor (unknown origin) | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities. |
| AID92639 | Binding affinity at ionotropic glutamate receptor AMPA in rat cortical membranes [3H]AMPA displacement. | 2001 | Journal of medicinal chemistry, Sep-13, Volume: 44, Issue:19
| Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173. |
| AID132656 | Concentration that inhibits by 50% depolarization induced by 5M AMPA | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
| Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. |
| AID93571 | Compound was evaluated for inhibition of binding of [3H]KA to specific binding at Ka receptor in rat cortical membrane | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| 7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists. |
| AID1859134 | Antagonist activity at NMDA receptor (unknown origin) assessed as NMDA-induced depolarizations | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities. |
| AID92648 | Binding affinity towards ionotropic glutamate receptor (high-affinity) of rat cortical synaptic membranes by using [3H]AMPA as radioligand | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. |
| AID179408 | Concentration that inhibits 50% S-AMPA stimulated (50 uM) [3H]norepinephrine release from rat hippocampal synaptosomes | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. |
| AID145315 | Ability to displace [3H]glycine from NMDA receptor in rat corticaln membranes | 2001 | Journal of medicinal chemistry, Sep-13, Volume: 44, Issue:19
| Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173. |
| AID143631 | Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]Gly as radioligand | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. |
| AID92047 | Antagonism at ionotropic glutamate receptor AMPA in mouse cortical wedge preparation | 2001 | Journal of medicinal chemistry, Sep-13, Volume: 44, Issue:19
| Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173. |
| AID1859133 | Antagonist activity at AMPA receptor (unknown origin) assessed as AMPA-induced depolarizations | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities. |
| AID93715 | Inhibition concentration towards high-affinity ionotropic glutamate receptor kainate of rat cortical membranes by using [3H]KA as radioligand | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |