Compounds > illudalic acid
Page last updated: 2024-12-10

illudalic acid

Description

illudalic acid: isolated from Clitocybe illudens; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3653077
CHEMBL ID506661
SCHEMBL ID24228643
MeSH IDM0526503

Synonyms (14)

Synonym
bdbm50262987
CHEMBL506661 ,
illudalic acid
3,6-dihydroxy-8,8-dimethyl-1-oxo-3,4,7,9-tetrahydrocyclopenta[h]isochromene-5-carbaldehyde
gtpl8770
18508-77-5
unii-hw3u676a69
3,6-dihydroxy-8,8-dimethyl-1-oxo-1,3,4,7,8,9-hexahydro-cyclopenta(h)isochromene-5-carbaldehyde
cyclopenta(h)-2-benzopyran-5-carboxaldehyde, 1,3,4,7,8,9-hexahydro-3,6-dihydroxy-8,8-dimethyl-1-oxo-
1,3,4,7,8,9-hexahydro-3,6-dihydroxy-8,8-dimethyl-1-oxocyclopenta(h)-2-benzopyran-5-carboxaldehyde
hw3u676a69 ,
illudalate
Q27078041
SCHEMBL24228643
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (9)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Receptor-type tyrosine-protein phosphatase CHomo sapiens (human)IC50 (µMol)10.00000.30002.757110.0000AID1617803
Receptor-type tyrosine-protein phosphatase FHomo sapiens (human)IC50 (µMol)1.70001.30002.66604.2300AID1617804; AID342510
Tyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)IC50 (µMol)100.00000.70004.58049.4500AID1617801
Dual specificity protein phosphatase 3Homo sapiens (human)IC50 (µMol)100.00004.00005.97508.5000AID1617798
Tyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)IC50 (µMol)29.00000.31804.00429.6000AID1617814
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (171)

Processvia Protein(s)Taxonomy
MAPK cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
natural killer cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of T cell mediated cytotoxicityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of cytokine-mediated signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
hematopoietic progenitor cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of immunoglobulin productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of humoral immune response mediated by circulating immunoglobulinReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of protein kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein dephosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of cell adhesion involved in substrate-bound cell migrationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
leukocyte cell-cell adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell surface receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
response to gamma radiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of gene expressionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
dephosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of B cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of protein autophosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of interleukin-8 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of interleukin-2 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of interleukin-2 productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of tumor necrosis factor productionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heterotypic cell-cell adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell activationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
gamma-delta T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of MAPK cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell cycle phase transitionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive thymic T cell selectionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative thymic T cell selectionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of gamma-delta T cell differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of protein kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of receptor signaling pathway via JAK-STATReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
alpha-beta T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of alpha-beta T cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of isotype switching to IgG isotypesReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
bone marrow developmentReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
stem cell developmentReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of peptidyl-tyrosine phosphorylationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of phagocytosisReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of phagocytosisReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of calcium-mediated signalingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
T cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
B cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of T cell receptor signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of antigen receptor-mediated signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
release of sequestered calcium ion into cytosolReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
defense response to virusReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of cell cycleReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of Fc receptor mediated stimulatory signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
regulation of protein tyrosine kinase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
extrinsic apoptotic signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
negative regulation of microglial cell activationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
response to aldosteroneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
DN2 thymocyte differentiationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of hematopoietic stem cell migrationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of stem cell proliferationReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathwayReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell adhesionReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
cell surface receptor protein tyrosine phosphatase signaling pathwayReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
cell migrationReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
neuron projection regenerationReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
peptidyl-tyrosine dephosphorylationReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
regulation of axon regenerationReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
synaptic membrane adhesionReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
negative regulation of receptor bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
negative regulation of transcription by RNA polymerase IITyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of cell population proliferationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of tumor necrosis factor-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of lipid storageTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
B cell differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
T cell differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
erythrocyte differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of tyrosine phosphorylation of STAT proteinTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
glucose homeostasisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of macrophage differentiationTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of gluconeogenesisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of inflammatory responseTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of chemotaxisTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
regulation of type II interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of type II interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-6-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-2-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of interleukin-4-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of macrophage colony-stimulating factor signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of positive thymic T cell selectionTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
positive regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
negative regulation of receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
protein dephosphorylationReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
negative regulation of insulin receptor signaling pathwayReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
negative regulation of endothelial cell proliferationReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
protein dephosphorylationReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
homophilic cell adhesion via plasma membrane adhesion moleculesReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
signal transductionReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
response to xenobiotic stimulusReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
negative regulation of endothelial cell migrationReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
retina layer formationReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
negative regulation of angiogenesisReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
neuron projection developmentReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
retinal ganglion cell axon guidanceReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
MAPK cascadeTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
dephosphorylationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of cell migrationDual specificity protein phosphatase 3Homo sapiens (human)
peptidyl-tyrosine dephosphorylationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathwayDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of MAPK cascadeDual specificity protein phosphatase 3Homo sapiens (human)
positive regulation of mitotic cell cycleDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of JNK cascadeDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of T cell activationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of chemotaxisDual specificity protein phosphatase 3Homo sapiens (human)
regulation of focal adhesion assemblyDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeDual specificity protein phosphatase 3Homo sapiens (human)
cellular response to epidermal growth factor stimulusDual specificity protein phosphatase 3Homo sapiens (human)
positive regulation of focal adhesion disassemblyDual specificity protein phosphatase 3Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityDual specificity protein phosphatase 3Homo sapiens (human)
DNA damage checkpoint signalingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
triglyceride metabolic processTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
epidermal growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
integrin-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
axonogenesisTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
brain developmentTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
heart developmentTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
fibroblast growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
hormone-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
cytokine-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
cerebellar cortex formationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
platelet formationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
T cell costimulationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
negative regulation of chondrocyte differentiationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
negative regulation of type I interferon productionTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
microvillus organizationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of interferon-beta productionTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of interleukin-6 productionTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of tumor necrosis factor productionTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
regulation of cell adhesion mediated by integrinTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
negative regulation of cell adhesion mediated by integrinTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
multicellular organism growthTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
organ growthTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
megakaryocyte developmentTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
atrioventricular canal developmentTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
ERBB signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
hormone metabolic processTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
glucose homeostasisTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
regulation of protein-containing complex assemblyTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of ossificationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of mitotic cell cycleTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of glucose importTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
negative regulation of insulin secretionTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
regulation of protein export from nucleusTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of hormone secretionTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
platelet-derived growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
neurotrophin TRK receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
ephrin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
multicellular organismal reproductive processTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
genitalia developmentTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
inner ear developmentTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
homeostasis of number of cells within a tissueTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
negative regulation of cortisol secretionTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
Bergmann glial cell differentiationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
negative regulation of growth hormone secretionTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
face morphogenesisTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
intestinal epithelial cell migrationTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
cellular response to epidermal growth factor stimulusTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
negative regulation of transcription by RNA polymerase IIDual specificity protein phosphatase 22Homo sapiens (human)
negative regulation of T cell mediated immunityDual specificity protein phosphatase 22Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayDual specificity protein phosphatase 22Homo sapiens (human)
negative regulation of cell migrationDual specificity protein phosphatase 22Homo sapiens (human)
peptidyl-tyrosine dephosphorylationDual specificity protein phosphatase 22Homo sapiens (human)
regulation of cell population proliferationDual specificity protein phosphatase 22Homo sapiens (human)
positive regulation of JNK cascadeDual specificity protein phosphatase 22Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayDual specificity protein phosphatase 22Homo sapiens (human)
negative regulation of T cell activationDual specificity protein phosphatase 22Homo sapiens (human)
negative regulation of focal adhesion assemblyDual specificity protein phosphatase 22Homo sapiens (human)
cellular response to epidermal growth factor stimulusDual specificity protein phosphatase 22Homo sapiens (human)
negative regulation of non-membrane spanning protein tyrosine kinase activityDual specificity protein phosphatase 22Homo sapiens (human)
signal transductionDual specificity protein phosphatase 22Homo sapiens (human)
dephosphorylationDual specificity protein phosphatase 22Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (31)

Processvia Protein(s)Taxonomy
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
signaling receptor bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heparin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein kinase bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
ankyrin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
spectrin bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
heparan sulfate proteoglycan bindingReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
heparin bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
chondroitin sulfate proteoglycan bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
protein-containing complex bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
cell adhesion molecule bindingReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
integrin bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
syntaxin bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
STAT family protein bindingTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
protein bindingReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
transmembrane receptor protein tyrosine phosphatase activityReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
protein bindingReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
phosphatase activityReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
identical protein bindingReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
cadherin bindingReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
protein tyrosine phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein bindingDual specificity protein phosphatase 3Homo sapiens (human)
cytoskeletal protein bindingDual specificity protein phosphatase 3Homo sapiens (human)
protein tyrosine/serine/threonine phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
myosin phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
receptor tyrosine kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
MAP kinase phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein tyrosine kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
phosphotyrosine residue bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
phosphoprotein phosphatase activityTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
signaling receptor complex adaptor activityTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
cell adhesion molecule bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
peptide hormone receptor bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
molecular adaptor activityTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
protein tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
protein tyrosine phosphatase activityDual specificity protein phosphatase 22Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityDual specificity protein phosphatase 22Homo sapiens (human)
protein tyrosine/serine/threonine phosphatase activityDual specificity protein phosphatase 22Homo sapiens (human)
myosin phosphatase activityDual specificity protein phosphatase 22Homo sapiens (human)
protein tyrosine kinase bindingDual specificity protein phosphatase 22Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (31)

Processvia Protein(s)Taxonomy
plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
focal adhesionReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
external side of plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cytoplasmic side of plasma membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
cell surfaceReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
secretory granule membraneReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
blebReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membrane raftReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
synapseReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
extracellular exosomeReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
membrane microdomainReceptor-type tyrosine-protein phosphatase CHomo sapiens (human)
plasma membraneReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
neuron projectionReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
neuronal cell bodyReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
extracellular exosomeReceptor-type tyrosine-protein phosphatase FHomo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
nucleoplasmTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
nucleusTyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)
nucleusReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
cytoplasmReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
plasma membraneReceptor-type tyrosine-protein phosphatase epsilonHomo sapiens (human)
cell-cell junctionReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
cytoplasmReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
plasma membraneReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
cell-cell junctionReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
adherens junctionReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
lamellipodiumReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
perinuclear region of cytoplasmReceptor-type tyrosine-protein phosphatase muHomo sapiens (human)
nucleoplasmTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
cytoplasmic side of plasma membraneTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
microtubule cytoskeletonTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
mitotic spindleTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
immunological synapseDual specificity protein phosphatase 3Homo sapiens (human)
nucleusDual specificity protein phosphatase 3Homo sapiens (human)
nucleoplasmDual specificity protein phosphatase 3Homo sapiens (human)
cytosolDual specificity protein phosphatase 3Homo sapiens (human)
cytosolDual specificity protein phosphatase 3Homo sapiens (human)
cytoplasmDual specificity protein phosphatase 3Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
nucleusTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
nucleoplasmTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)
cytoplasmDual specificity protein phosphatase 22Homo sapiens (human)
plasma membraneDual specificity protein phosphatase 22Homo sapiens (human)
leading edge of lamellipodiumDual specificity protein phosphatase 22Homo sapiens (human)
filamentous actinDual specificity protein phosphatase 22Homo sapiens (human)
plasma membraneDual specificity protein phosphatase 22Homo sapiens (human)
cytosolDual specificity protein phosphatase 22Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID1617801Inhibition of TCPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID342510Inhibition of human recombinant LAR2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.
AID1617806Inhibition of PTPep (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617796Covalent inhibition of LAR (unknown origin) using DiFMUP as substrate assessed as fast inactivation constant incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617794Inhibition of LAR (unknown origin) assessed as time required for half of the protein to be covalently modified using DiFMUP as substrate incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence
AID1617808Inhibition of HePTP (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617809Inhibition of TCPTP (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617811Inhibition of SHP2 (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617810Inhibition of PTPmu (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617814Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617795Non-covalent inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617815Time-dependent inhibition of LAR (unknown origin) using DiFMUP as substrate at 1 uM incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617804Inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617813Inhibition of LAR (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617798Inhibition of VHR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617803Inhibition of CD45 (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617812Inhibition of CD45 (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617800Inhibition of PTPep (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617819Ratio of Kinact to Ki for LAR (unknown origin) using DiFMUP as substrate incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617807Inhibition of VHR (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617818Time-dependent inhibition of PTPmu (unknown origin) using DiFMUP as substrate at 10 uM incubated for 5 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617802Inhibition of PTPmu (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617799Inhibition of HePTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617805Inhibition of LMWPTP (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617817Time dependent inhibition of CD45 (unknown origin) using DiFMUP as substrate at 10 uM incubated for 5 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1617797Inhibition of LMWPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
AID1345593Human RTP Type F (Receptor tyrosine phosphatase (RTP) family)2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's3 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		7.610amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.610cysteiniumfundamental metabolite
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		3.0340benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
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