illudalic acid: isolated from Clitocybe illudens; structure in first source [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 3653077 |
| CHEMBL ID | 506661 |
| SCHEMBL ID | 24228643 |
| MeSH ID | M0526503 |
| Synonym |
|---|
| bdbm50262987 |
| CHEMBL506661 , |
| illudalic acid |
| 3,6-dihydroxy-8,8-dimethyl-1-oxo-3,4,7,9-tetrahydrocyclopenta[h]isochromene-5-carbaldehyde |
| gtpl8770 |
| 18508-77-5 |
| unii-hw3u676a69 |
| 3,6-dihydroxy-8,8-dimethyl-1-oxo-1,3,4,7,8,9-hexahydro-cyclopenta(h)isochromene-5-carbaldehyde |
| cyclopenta(h)-2-benzopyran-5-carboxaldehyde, 1,3,4,7,8,9-hexahydro-3,6-dihydroxy-8,8-dimethyl-1-oxo- |
| 1,3,4,7,8,9-hexahydro-3,6-dihydroxy-8,8-dimethyl-1-oxocyclopenta(h)-2-benzopyran-5-carboxaldehyde |
| hw3u676a69 , |
| illudalate |
| Q27078041 |
| SCHEMBL24228643 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Receptor-type tyrosine-protein phosphatase C | Homo sapiens (human) | IC50 | 10.0000 | AID1617803 |
| Receptor-type tyrosine-protein phosphatase F | Homo sapiens (human) | IC50 | 1.7000 | AID1617804; AID342510 |
| Receptor-type tyrosine-protein phosphatase F | Homo sapiens (human) | Ki | 130.0000 | AID1617795 |
| Tyrosine-protein phosphatase non-receptor type 2 | Homo sapiens (human) | IC50 | 100.0000 | AID1617801 |
| Receptor-type tyrosine-protein phosphatase epsilon | Homo sapiens (human) | IC50 | 100.0000 | AID1617800 |
| Receptor-type tyrosine-protein phosphatase mu | Homo sapiens (human) | IC50 | 16.0000 | AID1617802 |
| Tyrosine-protein phosphatase non-receptor type 7 | Homo sapiens (human) | IC50 | 100.0000 | AID1617799 |
| Dual specificity protein phosphatase 3 | Homo sapiens (human) | IC50 | 100.0000 | AID1617798 |
| Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens (human) | IC50 | 29.0000 | AID1617814 |
| Dual specificity protein phosphatase 22 | Homo sapiens (human) | IC50 | 100.0000 | AID1617797 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1617801 | Inhibition of TCPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID342510 | Inhibition of human recombinant LAR | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 ISSN: 1464-3391 | Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. |
| AID1617806 | Inhibition of PTPep (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617796 | Covalent inhibition of LAR (unknown origin) using DiFMUP as substrate assessed as fast inactivation constant incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617794 | Inhibition of LAR (unknown origin) assessed as time required for half of the protein to be covalently modified using DiFMUP as substrate incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617808 | Inhibition of HePTP (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617809 | Inhibition of TCPTP (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617811 | Inhibition of SHP2 (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617810 | Inhibition of PTPmu (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617814 | Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617795 | Non-covalent inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617815 | Time-dependent inhibition of LAR (unknown origin) using DiFMUP as substrate at 1 uM incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617804 | Inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617813 | Inhibition of LAR (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617798 | Inhibition of VHR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617803 | Inhibition of CD45 (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617812 | Inhibition of CD45 (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617800 | Inhibition of PTPep (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617819 | Ratio of Kinact to Ki for LAR (unknown origin) using DiFMUP as substrate incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617807 | Inhibition of VHR (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617818 | Time-dependent inhibition of PTPmu (unknown origin) using DiFMUP as substrate at 10 uM incubated for 5 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617802 | Inhibition of PTPmu (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617799 | Inhibition of HePTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617805 | Inhibition of LMWPTP (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617817 | Time dependent inhibition of CD45 (unknown origin) using DiFMUP as substrate at 10 uM incubated for 5 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1617797 | Inhibition of LMWPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 ISSN: 1520-6025 | |
| AID1345593 | Human RTP Type F (Receptor tyrosine phosphatase (RTP) family) | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15 ISSN: 1464-3391 | Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| histidine | amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid | algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite | 2023 | 2023 | 1.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| cysteine | cysteinium | fundamental metabolite | 2023 | 2023 | 1.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| warfarin | benzenes; hydroxycoumarin; methyl ketone | 2008 | 2022 | 8.8 | high | 0 | 0 | 0 | 2 | 0 | 2 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| Article | Year |
|---|---|
| Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development. Biochemical pharmacology, , Volume: 195 | 2022 |