a-582941 profile

A-582941: nicotinic acetylcholine receptor (alpha7 nAChR) agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	44190553
CHEMBL ID	526281
SCHEMBL ID	14479461
MeSH ID	M0515249

Synonym
CHEMBL526281 ,
a-582941
cis-2-(6-phenyl-pyridazin-3-yl)-5-methyloctahydro-pyrrolo[3,4-c]-pyrrole
bdbm50278956
(3ar,6as)-2-methyl-5-(6-phenylpyridazin-3-yl)octahydropyrrolo[3,4-c]pyrrole
a-582941 free base
pyrrolo(3,4-c)pyrrole, octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-, (3ar,6as)-rel-
unii-2muw0l49bn
pyrrolo(3,4-c)pyrrole, octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-
848591-90-2
2muw0l49bn ,
a 582941
1173179-34-4
GTMRUYCIJSNXGB-GASCZTMLSA-N
cis-2-methyl-5-(6-phenylpyridazin-3-yl)perhydropyrrolo[3,4-c]pyrrole
SCHEMBL14479461
octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole
AKOS024458103
NCGC00370937-01
a-582491
Q27254996
YIB59190
3-[(3ar,6as)-5-methyl-octahydropyrrolo[3,4-c]pyrrol-2-yl]-6-phenylpyridazine
(3as,6ar)-2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole
Z1900765470

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Protein Targets (11)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	37.9083	0.0123	7.9835	43.2770	AID1645841
G	Vesicular stomatitis virus	Potency	30.1116	0.0123	8.9648	39.8107	AID1645842
Interferon beta	Homo sapiens (human)	Potency	30.1116	0.0033	9.1582	39.8107	AID1645842
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	30.1116	0.0123	8.9648	39.8107	AID1645842
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	30.1116	0.0123	8.9648	39.8107	AID1645842
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	30.1116	0.0123	8.9648	39.8107	AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	Ki	100.0000	0.0000	0.1117	3.5400	AID452525
Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)	Ki	4.7000	0.0001	0.6294	5.4000	AID452526
Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)	Ki	4.7000	0.0000	0.6522	5.4000	AID452526
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	Ki	100.0000	0.0000	0.1157	3.5400	AID452525
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	EC50 (µMol)	100.0000	0.0000	1.5172	9.4000	AID397992
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	EC50 (µMol)	4.2600	0.1280	2.8018	8.9000	AID397994; AID452529
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	EC50 (µMol)	100.0000	0.0000	1.6186	9.4000	AID397992
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (123)

Process	via Protein(s)	Taxonomy
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell activation involved in immune response	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to virus	Interferon beta	Homo sapiens (human)
positive regulation of autophagy	Interferon beta	Homo sapiens (human)
cytokine-mediated signaling pathway	Interferon beta	Homo sapiens (human)
natural killer cell activation	Interferon beta	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT protein	Interferon beta	Homo sapiens (human)
cellular response to interferon-beta	Interferon beta	Homo sapiens (human)
B cell proliferation	Interferon beta	Homo sapiens (human)
negative regulation of viral genome replication	Interferon beta	Homo sapiens (human)
innate immune response	Interferon beta	Homo sapiens (human)
positive regulation of innate immune response	Interferon beta	Homo sapiens (human)
regulation of MHC class I biosynthetic process	Interferon beta	Homo sapiens (human)
negative regulation of T cell differentiation	Interferon beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Interferon beta	Homo sapiens (human)
defense response to virus	Interferon beta	Homo sapiens (human)
type I interferon-mediated signaling pathway	Interferon beta	Homo sapiens (human)
neuron cellular homeostasis	Interferon beta	Homo sapiens (human)
cellular response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
cellular response to virus	Interferon beta	Homo sapiens (human)
negative regulation of Lewy body formation	Interferon beta	Homo sapiens (human)
negative regulation of T-helper 2 cell cytokine production	Interferon beta	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell differentiation	Interferon beta	Homo sapiens (human)
natural killer cell activation involved in immune response	Interferon beta	Homo sapiens (human)
adaptive immune response	Interferon beta	Homo sapiens (human)
T cell activation involved in immune response	Interferon beta	Homo sapiens (human)
humoral immune response	Interferon beta	Homo sapiens (human)
positive regulation of T cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
adaptive immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of T cell anergy	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
defense response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
detection of bacterium	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-12 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-6 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protection from natural killer cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
innate immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of dendritic cell differentiation	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
response to hypoxia	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
monoatomic ion transport	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
calcium ion transport	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
smooth muscle contraction	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
signal transduction	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
synaptic transmission, cholinergic	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
visual perception	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
sensory perception of sound	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
learning	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
memory	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
locomotory behavior	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
associative learning	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
visual learning	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of dopamine secretion	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
sensory perception of pain	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
vestibulocochlear nerve development	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
optic nerve morphogenesis	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
lateral geniculate nucleus development	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
central nervous system projection neuron axonogenesis	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
positive regulation of B cell proliferation	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of synaptic transmission, dopaminergic	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
positive regulation of dopamine secretion	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
monoatomic ion transmembrane transport	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
response to nicotine	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
behavioral response to nicotine	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
social behavior	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of dopamine metabolic process	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
B cell activation	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
response to cocaine	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of circadian sleep/wake cycle, REM sleep	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
response to ethanol	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
negative regulation of action potential	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of dendrite morphogenesis	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
nervous system process	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
cognition	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
membrane depolarization	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of synapse assembly	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
synaptic transmission involved in micturition	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine receptor signaling pathway	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
response to acetylcholine	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
chemical synaptic transmission	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
monoatomic ion transport	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
smooth muscle contraction	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
regulation of smooth muscle contraction	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
signal transduction	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
synaptic transmission, cholinergic	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
locomotory behavior	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
neuronal action potential	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
monoatomic ion transmembrane transport	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
behavioral response to nicotine	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
regulation of neurotransmitter secretion	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
positive regulation of transmission of nerve impulse	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
synaptic transmission involved in micturition	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
chemical synaptic transmission	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
acetylcholine receptor signaling pathway	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
membrane depolarization	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
monoatomic ion transport	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
regulation of smooth muscle contraction	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
signal transduction	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
activation of transmembrane receptor protein tyrosine kinase activity	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
synaptic transmission, cholinergic	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
nervous system development	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
locomotory behavior	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
regulation of acetylcholine secretion, neurotransmission	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
monoatomic ion transmembrane transport	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
behavioral response to nicotine	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
regulation of membrane potential	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
regulation of dendrite morphogenesis	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
synaptic transmission involved in micturition	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
acetylcholine receptor signaling pathway	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
response to acetylcholine	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
response to nicotine	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
membrane depolarization	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
negative regulation of tumor necrosis factor production	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
response to hypoxia	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of protein phosphorylation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
monoatomic ion transport	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
calcium ion transport	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
intracellular calcium ion homeostasis	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
signal transduction	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
synaptic transmission, cholinergic	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
learning or memory	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
memory	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
short-term memory	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of cell population proliferation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
negative regulation of tumor necrosis factor production	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
monoatomic ion transmembrane transport	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
response to nicotine	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of MAPK cascade	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of angiogenesis	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
synapse organization	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
cognition	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
sensory processing	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of protein metabolic process	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
calcium ion transmembrane transport	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine receptor signaling pathway	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
dendritic spine organization	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
modulation of excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
dendrite arborization	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of long-term synaptic potentiation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of amyloid-beta formation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
negative regulation of amyloid-beta formation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
regulation of amyloid precursor protein catabolic process	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
response to amyloid-beta	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
response to acetylcholine	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
regulation of amyloid fibril formation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of CoA-transferase activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
regulation of membrane potential	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
chemical synaptic transmission	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
action potential	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
response to hypoxia	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
DNA repair	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
monoatomic ion transport	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
calcium ion transport	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
response to oxidative stress	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
signal transduction	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
chemical synaptic transmission	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
synaptic transmission, cholinergic	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
regulation of dopamine secretion	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
sensory perception of pain	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
monoatomic ion transmembrane transport	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
response to nicotine	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
behavioral response to nicotine	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
B cell activation	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
regulation of membrane potential	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
nervous system process	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
cognition	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
membrane depolarization	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
inhibitory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine receptor signaling pathway	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
inositol phosphate metabolic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (31)

Process	via Protein(s)	Taxonomy
cytokine activity	Interferon beta	Homo sapiens (human)
cytokine receptor binding	Interferon beta	Homo sapiens (human)
type I interferon receptor binding	Interferon beta	Homo sapiens (human)
protein binding	Interferon beta	Homo sapiens (human)
chloramphenicol O-acetyltransferase activity	Interferon beta	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
signaling receptor binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
peptide antigen binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein-folding chaperone binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
ligand-gated monoatomic ion channel activity	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine receptor activity	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activity	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
protein-containing complex binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
quaternary ammonium group binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
heterocyclic compound binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
protein binding	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
ligand-gated monoatomic ion channel activity	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
acetylcholine receptor activity	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activity	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
protein binding	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
ligand-gated monoatomic ion channel activity	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
acetylcholine receptor activity	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activity	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
acetylcholine binding	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
amyloid-beta binding	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
monoatomic ion channel activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
calcium channel activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
protein binding	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine receptor activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
toxic substance binding	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
chloride channel regulator activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine binding	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
protein homodimerization activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
protein binding	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
ligand-gated monoatomic ion channel activity	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine receptor activity	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activity	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine binding	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol heptakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
protein binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
ATP binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 1-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 3-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (37)

Process	via Protein(s)	Taxonomy
extracellular space	Interferon beta	Homo sapiens (human)
extracellular region	Interferon beta	Homo sapiens (human)
Golgi membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
endoplasmic reticulum	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
Golgi apparatus	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
cell surface	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
ER to Golgi transport vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
secretory granule membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
phagocytic vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
early endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
recycling endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular exosome	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
lumenal side of endoplasmic reticulum membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
MHC class I protein complex	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular space	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
external side of plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
external side of plasma membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
presynaptic membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
plasma membrane raft	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
cholinergic synapse	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
postsynaptic specialization membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine-gated channel complex	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
neuron projection	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
synapse	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
membrane	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
specific granule membrane	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
postsynaptic membrane	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
tertiary granule membrane	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
cholinergic synapse	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
acetylcholine-gated channel complex	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
neuron projection	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
synapse	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)
endoplasmic reticulum	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
Golgi apparatus	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
postsynaptic density	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
membrane	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
nuclear speck	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
dendrite	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
neuronal cell body	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
plasma membrane raft	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
postsynaptic membrane	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
acetylcholine-gated channel complex	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
neuron projection	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
synapse	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
membrane	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
plasma membrane raft	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
postsynaptic membrane	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
postsynapse	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine-gated channel complex	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
neuron projection	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
synapse	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
external side of plasma membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
dendrite	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
neuronal cell body	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
postsynaptic membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine-gated channel complex	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
synapse	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
neuron projection	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
fibrillar center	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytosol	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleus	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (17)

Assay ID	Title	Year	Journal	Article
AID452529	Agonist activity at human recombinant alpha7 nAChR expressed in xenopus oocytes assessed as induction of Ca2+ current	2010	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1	Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.
AID452525	Inhibition of alpha4beta2 nAChR	2010	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1	Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.
AID452530	Agonist activity at human recombinant alpha7 nAChR expressed in xenopus oocytes assessed as induction of Ca2+ current relative to acetylcholine	2010	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1	Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.
AID452526	Inhibition of alpha3beta4 nAChR	2010	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1	Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.
AID397990	Displacement of [3H]A585539 from alpha7 nicotinic acetylcholine receptor in rat brain minus cerebellum membrane	2009	Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14	Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
AID397995	Agonist activity at human recombinant alpha7 nicotinic acetylcholine receptor expressed in xenopus laevis oocytes at 100 uM by parallel oocyte electrophysiological assay relative to acetylcholine	2009	Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14	Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
AID397994	Agonist activity at human recombinant alpha7 nicotinic acetylcholine receptor expressed in xenopus laevis oocytes by parallel oocyte electrophysiological assay	2009	Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14	Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
AID397993	Agonist activity at human recombinant alpha4beta2 nicotinic acetylcholine receptor expressed in HEK293 cells assessed as changes in intracellular calcium level at 100 uM by FLIPR relative to nicotine	2009	Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14	Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
AID397991	Selectivity ratio of Ki for alpha7 nicotinic acetylcholine receptor to Ki for alpha4beta2 nicotinic acetylcholine receptor in rat brain minus cerebellum membrane	2009	Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14	Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
AID397992	Agonist activity at human recombinant alpha4beta2 nicotinic acetylcholine receptor expressed in HEK293 cells assessed as changes in intracellular calcium level by FLIPR	2009	Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14	Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
AID452524	Displacement of [3H]585539 from alpha7 nAChR in rat brain	2010	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1	Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.
AID397989	Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain minus cerebellum membrane	2009	Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14	Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (38.89)	29.6817
2010's	7 (38.89)	24.3611
2020's	4 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.56%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (94.44%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
epibatidine [no description available]	2.46	2	alkaloid
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	5.11	13	pyrrole; secondary amine
isoxazoles Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.	2.85	3	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
aminoacetonitrile Aminoacetonitrile: Cyanomethylamine.	2.03	1
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.05	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
pnu 120596 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea: an alpha7nAChR agonist; structure in first source	2.85	3	ureas
3-(2,4-dimethoxybenzylidene)anabaseine 3-(2,4-dimethoxybenzylidene)anabaseine: an alpha7nAChR nicotinic receptor agonist	2.11	1	dimethoxybenzene
dizocilpine maleate Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.. dizocilpine maleate : A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.	2.69	2	maleate salt; tetracyclic antidepressant	anaesthetic; anticonvulsant; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist
sl 327 SL 327: a MEK inhibitor. SL-327 : A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4-aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.	2.03	1
piperacillin 5-(2-azetidinylmethoxy)-2-chloropyridine: affects neuronal nicotinic acetylcholine receptors; structure in first source	2.03	1
oxadiazoles Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.	2.05	1
scopolamine hydrobromide [no description available]	2.11	1
clozapine Clozapine: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.. clozapine : A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.	2.25	1	benzodiazepine; N-arylpiperazine; N-methylpiperazine; organochlorine compound	adrenergic antagonist; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; GABA antagonist; histamine antagonist; muscarinic antagonist; second generation antipsychotic; serotonergic antagonist; xenobiotic

Condition	Relationship Strength	Studies
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.08	4
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1
Dementia Praecox [description not available]	2.69	2
Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.	2.69	2
Cognitive Decline [description not available]	2.31	1
Cognitive Dysfunction Diminished or impaired mental and/or intellectual function.	2.31	1
Amyloid Deposits [description not available]	2.1	1
Acute Confusional Senile Dementia [description not available]	2.47	2
Innate Inflammatory Response [description not available]	2.1	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2.47	2
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.47	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.1	1
Cognition Disorders Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.	2.05	1

a-582941

Description

Cross-References

Synonyms (25)

Research Excerpts

Bioavailability

Protein Targets (11)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (123)

Molecular Functions (31)

Ceullar Components (37)

Bioassays (17)

Research

Studies (18)

Study Types

a-582941

Description

Cross-References

Synonyms (25)

Research Excerpts

Bioavailability

Protein Targets (11)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (123)

Molecular Functions (31)

Ceullar Components (37)

Bioassays (17)

Research

Studies (18)

Study Types

Related Drugs (13)

Related Conditions (14)