barettin: isolated as a Z/E mixture from sponge Geodia barretti; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 11177588 |
| CHEMBL ID | 255898 |
| CHEBI ID | 194574 |
| SCHEMBL ID | 16158381 |
| MeSH ID | M0465269 |
| Synonym |
|---|
| CHEMBL255898 , |
| cyclo[(6-bromo-8-entryptophan)arginine] |
| (cyclo[(6-bromo-8-entryptophan)arginine]) |
| bdbm50234920 |
| 2-[3-[(2s,5z)-5-[(6-bromo-1h-indol-3-yl)methylidene]-3,6-dioxopiperazin-2-yl]propyl]guanidine |
| CHEBI:194574 |
| barettin |
| lam9w2p97t , |
| gbb 1-z |
| 104311-70-8 |
| (-)-barettine |
| SCHEMBL16158381 |
| Q808098 |
| (s,z)-1-(3-(5-((6-bromo-1h-indol-3-yl)methylene)-3,6-dioxopiperazin-2-yl)propyl)guanidine |
| DTXSID101317811 |
| (-)-barettin |
| STARBLD0009037 |
| guanidine, [3-[(2s,5z)-5-[(6-bromo-1h-indol-3-yl)methylene]-3,6-dioxo-2-piperazinyl]propyl]- |
| guanidine, n-[3-[(2s)-5-[(5z)-(6-bromo-1h-indol-3-yl)methylene]-3,6-dioxo-2-piperazinyl]propyl]- |
Barettin is a marine natural compound with reported anti-inflammatory and antioxidant properties.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Barettin is a marine natural compound with reported anti-inflammatory and antioxidant properties. " | ( The immunomodulatory effects of barettin and involvement of the kinases CAMK1α and RIPK2. Andersen, JH; Hansen, E; Jørgensen, TØ; Lind, KF; Østerud, B, 2015) | 2.14 |
| Class | Description |
|---|---|
| organic molecular entity | Any molecular entity that contains carbon. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Ki | 10.0000 | 0.0016 | 2.1212 | 9.0000 | AID378829 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 10.0000 | 0.0001 | 0.5326 | 10.0000 | AID378825 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 10.0000 | 0.0001 | 0.8087 | 10.0000 | AID378826 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 1.9300 | 0.0000 | 0.3855 | 10.0000 | AID378827 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.3400 | 0.0001 | 0.9549 | 10.0000 | AID378828 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 10.0000 | 0.0003 | 0.3806 | 10.0000 | AID378833 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.7411 | 9.9000 | AID378829 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 10.0000 | 0.0008 | 0.9433 | 5.1600 | AID378831 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 10.0000 | 0.0002 | 0.5229 | 10.0000 | AID378832 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 1.9100 | 0.0000 | 0.4439 | 10.0000 | AID378830 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID378832 | Displacement of [N-methyl-3H]LSD from human 5HT6 receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378826 | Displacement of [1,2-3H]5-carboxamidotryptamine from human 5HT1D receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378833 | Displacement of [1,2-3H]5-carboxamidotryptamine from human 5HT7A receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378820 | Inhibition of settlement of barnacle larvae of Balanus improvisus | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378821 | Selectivity for human 5HT2C receptor over human 5HT2A receptor | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378825 | Displacement of [1,2-3H]5-carboxamidotryptamine from human 5HT1A receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378831 | Displacement of [1,2-3H]5-carboxamidotryptamine from human 5HT5A receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378827 | Displacement of [N-methyl-3H]LSD from human 5HT2A receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378828 | Displacement of [N-methyl-3H]LSD from human 5HT2C receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378829 | Displacement of [9-methyl-3H]BRL-43694 from human 5HT3A receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID378830 | Displacement of [N-methyl-3H]GR-113808 from human 5HT4 receptor expressed in HEK293 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
| AID329587 | Antifouling activity in Balanus improvisus assessed as inhibition of cyprid larvae settlement | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3 | Antifouling activity of a dibrominated cyclopeptide from the marine sponge Geodia barretti. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (61.45) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 15 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||