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desnitroimidacloprid

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Description

desnitroimidacloprid: a nicotinic receptor agonist; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10130527
CHEMBL ID309804
SCHEMBL ID6829628
MeSH IDM0522305

Synonyms (29)

Synonym
1-(6-chloro-pyridin-3-ylmethyl)-imidazolidin-(2z)-ylideneamine
1-(6-chloro-pyridin-3-ylmethyl)-imidazolidin-2-ylideneamine
bdbm50078048
1-(6-chloro-pyridin-3-ylmethyl)-imidazolidin-2-ylidene-ammonium
1-[(6-chloropyridin-3-yl)methyl]-4,5-dihydroimidazol-2-amine
desnitroimidacloprid
CHEMBL309804 ,
desnitro-imidacloprid
115970-17-7
SCHEMBL6829628
(2z)-1-[(6-chloropyridin-3-yl)methyl]imidazolidin-2-imine
UEQZFAGVRGWPDK-UHFFFAOYSA-N
1-(6-chloro-3-pyridyl)methyl-2-iminoimidazolidine
DTXSID90436011
1h-imidazol-2-amine, 1-((6-chloro-3-pyridinyl)methyl)-4,5-dihydro-
1-[(6-chloro-3-pyridinyl)methyl]-4,5-dihydro-1h-imidazol-2-amine
imidacloprid-guanidine
imidacloprid-desnitro
ntn33893-desnitro
FT-0714011
Q27463661
1-[(6-chloropyridin-3-yl)methyl]-4,5-dihydro-1h-imidazol-2-amine
EN300-7432244
1h-imidazol-2-amine, 1-[(6-chloro-3-pyridinyl)methyl]-4,5-dihydro-
1-((6-chloropyridin-3-yl)methyl)-4,5-dihydro-1h-imidazol-2-amine
1-[(6-chloro-3-pyridinyl)methyl]-2-imidazolidinimine
1-((6-chloro-3-pyridinyl)methyl)-4,5-dihydro-1h-imidazol-2-amine
unii-wt3f2k5pf2
wt3f2k5pf2 ,
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (13)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuronal acetylcholine receptor subunit alpha-4Mus musculus (house mouse)IC50 (µMol)0.00820.00000.57992.6000AID1101291
Acetylcholine receptor subunit alphaHomo sapiens (human)IC50 (µMol)11.00000.00794.71367.9000AID1101295
Neuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)Ki0.00220.00000.31570.9700AID1092036
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)IC50 (µMol)0.00600.00030.30952.3000AID220121
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)IC50 (µMol)0.00600.00030.32092.3000AID220121
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)Ki0.00220.00000.11173.5400AID146171
Acetylcholine receptor subunit beta-like 2Drosophila melanogaster (fruit fly)IC50 (µMol)1.53000.00230.85314.0000AID1101298
Acetylcholine receptor subunit beta-like 2Drosophila melanogaster (fruit fly)Ki1.00000.00120.57192.7000AID1092037
Neuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)IC50 (µMol)0.01400.00181.31326.5000AID1101292
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)IC50 (µMol)9.90000.00204.15279.9000AID1101293
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)Ki0.00220.00000.11573.5400AID146171
Acetylcholine-binding proteinLymnaea stagnalis (great pond snail)Ki0.01800.00011.881128.0000AID1092034
Liver carboxylesterase B-1Rattus norvegicus (Norway rat)IC50 (µMol)0.01400.01400.02950.0450AID1101292
Soluble acetylcholine receptorAplysia californica (California sea hare)Ki0.01500.00101.22766.3096AID1092035
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (86)

Processvia Protein(s)Taxonomy
neuromuscular synaptic transmissionAcetylcholine receptor subunit alphaHomo sapiens (human)
neuromuscular junction developmentAcetylcholine receptor subunit alphaHomo sapiens (human)
regulation of membrane potentialAcetylcholine receptor subunit alphaHomo sapiens (human)
skeletal muscle contractionAcetylcholine receptor subunit alphaHomo sapiens (human)
monoatomic cation transportAcetylcholine receptor subunit alphaHomo sapiens (human)
neuronal action potentialAcetylcholine receptor subunit alphaHomo sapiens (human)
monoatomic ion transmembrane transportAcetylcholine receptor subunit alphaHomo sapiens (human)
regulation of membrane potentialAcetylcholine receptor subunit alphaHomo sapiens (human)
muscle cell cellular homeostasisAcetylcholine receptor subunit alphaHomo sapiens (human)
skeletal muscle tissue growthAcetylcholine receptor subunit alphaHomo sapiens (human)
musculoskeletal movementAcetylcholine receptor subunit alphaHomo sapiens (human)
neuromuscular processAcetylcholine receptor subunit alphaHomo sapiens (human)
excitatory postsynaptic potentialAcetylcholine receptor subunit alphaHomo sapiens (human)
neuron cellular homeostasisAcetylcholine receptor subunit alphaHomo sapiens (human)
membrane depolarizationAcetylcholine receptor subunit alphaHomo sapiens (human)
acetylcholine receptor signaling pathwayAcetylcholine receptor subunit alphaHomo sapiens (human)
response to nicotineAcetylcholine receptor subunit alphaHomo sapiens (human)
synaptic transmission, cholinergicAcetylcholine receptor subunit alphaHomo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
response to nicotineNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
membrane depolarizationNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
response to hypoxiaNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
calcium ion transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
smooth muscle contractionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
visual perceptionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
sensory perception of soundNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
memoryNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
locomotory behaviorNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
associative learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
visual learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dopamine secretionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
sensory perception of painNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
vestibulocochlear nerve developmentNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
optic nerve morphogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
lateral geniculate nucleus developmentNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
central nervous system projection neuron axonogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
positive regulation of B cell proliferationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of synaptic transmission, dopaminergicNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
positive regulation of dopamine secretionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
behavioral response to nicotineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
social behaviorNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dopamine metabolic processNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
B cell activationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to cocaineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of circadian sleep/wake cycle, REM sleepNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to ethanolNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
negative regulation of action potentialNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dendrite morphogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
nervous system processNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
cognitionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
membrane depolarizationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of synapse assemblyNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synaptic transmission involved in micturitionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to acetylcholineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
chemical synaptic transmissionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
regulation of smooth muscle contractionNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
activation of transmembrane receptor protein tyrosine kinase activityNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
nervous system developmentNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
locomotory behaviorNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
regulation of acetylcholine secretion, neurotransmissionNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
behavioral response to nicotineNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
regulation of membrane potentialNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
regulation of dendrite morphogenesisNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
synaptic transmission involved in micturitionNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
response to acetylcholineNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
membrane depolarizationNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
negative regulation of tumor necrosis factor productionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
response to hypoxiaNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of protein phosphorylationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
calcium ion transportNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
intracellular calcium ion homeostasisNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
learning or memoryNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
memoryNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
short-term memoryNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of cell population proliferationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
negative regulation of tumor necrosis factor productionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of MAPK cascadeNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of angiogenesisNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
synapse organizationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
cognitionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
sensory processingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of protein metabolic processNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
calcium ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
dendritic spine organizationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
modulation of excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
dendrite arborizationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of long-term synaptic potentiationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of amyloid-beta formationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
negative regulation of amyloid-beta formationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
regulation of amyloid precursor protein catabolic processNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
response to amyloid-betaNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
response to acetylcholineNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
regulation of amyloid fibril formationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of CoA-transferase activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
regulation of membrane potentialNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
chemical synaptic transmissionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
action potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to hypoxiaNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
DNA repairNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
calcium ion transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to oxidative stressNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
chemical synaptic transmissionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
regulation of dopamine secretionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
sensory perception of painNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
behavioral response to nicotineNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
B cell activationNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
regulation of membrane potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
nervous system processNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
cognitionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
membrane depolarizationNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
inhibitory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
lipid catabolic processLiver carboxylesterase B-1Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (16)

Processvia Protein(s)Taxonomy
acetylcholine receptor activityAcetylcholine receptor subunit alphaHomo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityAcetylcholine receptor subunit alphaHomo sapiens (human)
acetylcholine bindingAcetylcholine receptor subunit alphaHomo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityAcetylcholine receptor subunit alphaHomo sapiens (human)
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialAcetylcholine receptor subunit alphaHomo sapiens (human)
protein bindingNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
protein bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
ligand-gated monoatomic ion channel activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
protein-containing complex bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
quaternary ammonium group bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
heterocyclic compound bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
protein bindingNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
ligand-gated monoatomic ion channel activityNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
amyloid-beta bindingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
monoatomic ion channel activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
calcium channel activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
protein bindingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
toxic substance bindingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
chloride channel regulator activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
protein homodimerization activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
protein bindingNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
ligand-gated monoatomic ion channel activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
carboxylic ester hydrolase activityLiver carboxylesterase B-1Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (21)

Processvia Protein(s)Taxonomy
neuromuscular junctionAcetylcholine receptor subunit alphaHomo sapiens (human)
plasma membraneAcetylcholine receptor subunit alphaHomo sapiens (human)
cell surfaceAcetylcholine receptor subunit alphaHomo sapiens (human)
neuromuscular junctionAcetylcholine receptor subunit alphaHomo sapiens (human)
postsynaptic membraneAcetylcholine receptor subunit alphaHomo sapiens (human)
postsynaptic specialization membraneAcetylcholine receptor subunit alphaHomo sapiens (human)
acetylcholine-gated channel complexAcetylcholine receptor subunit alphaHomo sapiens (human)
synapseAcetylcholine receptor subunit alphaHomo sapiens (human)
plasma membraneAcetylcholine receptor subunit alphaHomo sapiens (human)
neuron projectionAcetylcholine receptor subunit alphaHomo sapiens (human)
postsynaptic membraneNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
neuron projectionNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
synapseNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
plasma membraneNeuronal acetylcholine receptor subunit alpha-4Gallus gallus (chicken)
plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
external side of plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
presynaptic membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
plasma membrane raftNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
cholinergic synapseNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
postsynaptic specialization membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
endoplasmic reticulumNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
Golgi apparatusNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
postsynaptic densityNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
nuclear speckNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
dendriteNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
neuronal cell bodyNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
plasma membrane raftNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
postsynaptic membraneNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
plasma membrane raftNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
postsynaptic membraneNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
postsynapseNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
external side of plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
dendriteNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
neuronal cell bodyNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
postsynaptic membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
endoplasmic reticulumLiver carboxylesterase B-1Rattus norvegicus (Norway rat)
lipid dropletLiver carboxylesterase B-1Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID1092037Binding affinity to Drosophila brain nicotinic acetylcholine receptor assessed as [3H]IMI binding by radioligand binding assay2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Unique neonicotinoid binding conformations conferring selective receptor interactions.
AID318725Displacement of [3H]ACE from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay2007Proceedings of the National Academy of Sciences of the United States of America, May-22, Volume: 104, Issue:21
Mapping the elusive neonicotinoid binding site.
AID1092035Binding affinity to salt water mollusc Aplysia californica AChBP Y55W mutant assessed as [3H]acetamiprid binding by radioligand binding assay2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Unique neonicotinoid binding conformations conferring selective receptor interactions.
AID145345Potency to displace [3H]IMI binding to Nicotinic acetylcholine receptor from Drosophila head membranes2002Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13
Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.
AID146171Potency to displace [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 immuno-isolated from M10 cells2002Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13
Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.
AID1101289Retention time under acidic conditions using H20/MeOH mobile phase containing 0.1% TFA (1:1) by HPLC method2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID1101293Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID1101290Retention time under neutral conditions using H20/MeOH (1:1) mobile phase by HPLC method2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID1092036Binding affinity to recombinant Gallus gallus (chicken) alpha4beta2 nicotinic acetylcholine receptor assessed as [3H]NIC binding by radioligand binding assay2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Unique neonicotinoid binding conformations conferring selective receptor interactions.
AID220121Inhibition of [3H](-)-nicotine binding to recombinant rat alpha4-beta2 nAChR.1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Novel and potent 6-chloro-3-pyridinyl ligands for the alpha4beta2 neuronal nicotinic acetylcholine receptor.
AID1101288Retention time under basic conditions using 20 mM Na2HPO4 (pH9.9)/MeOH (1:1) mobile phase by HPLC method2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID318726Displacement of [3H]EPI from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay2007Proceedings of the National Academy of Sciences of the United States of America, May-22, Volume: 104, Issue:21
Mapping the elusive neonicotinoid binding site.
AID1101291Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylcholine receptor subunits2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID1101292Inhibition of [3H]nicotine binding to alpha3 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells co-expressing beta2beta4alpha5 Nicotinic acetylcholine receptor subunits2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID145850Selectivity ratio of Ki of Nicotinic acetylcholine receptor of Drosophila to Nicotinic acetylcholine receptor alpha4-beta22002Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13
Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.
AID1101298Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptor2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID1092034Binding affinity to freshwater snail Lymnaea stagnalis AChBP assessed as [3H]EPI binding by radioligand binding assay2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Unique neonicotinoid binding conformations conferring selective receptor interactions.
AID1101296Toxicity against Musca domestica (house fly) dosed with compound through intra-thoracic injection pre-treated with 100 ug/g metabolic detoxification inhibitor O-propyl O-(2-propynyl)phenylphosphonate2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID1101295Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta1 nicotinic acetylcholine receptor subunits2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
AID1091945Insecticidal activity against Nephotettix cincticeps (green rice leafhopper) assessed as mortality measured after 4 days2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Discovery of imidacloprid and further developments from strategic molecular designs.
AID1101297Toxicity in ip dosed Mus musculus (mouse)2000Journal of agricultural and food chemistry, Dec, Volume: 48, Issue:12
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]