trimethoprim--sulfamethoxazole-drug-combination and Rocky-Mountain-Spotted-Fever

Sulfonamide antibiotics are not effective for the treatment of Rocky Mountain spotted fever (RMSF). Patients suspected of having RMSF based on history and physical exam should be treated with doxycycline and not a sulfonamide to avoid increased morbidity and mortality.

Topics: Anti-Bacterial Agents; Contraindications; Dihydropteroate Synthase; Drug Resistance, Bacterial; Humans; Rickettsia rickettsii; Rocky Mountain Spotted Fever; Sulfonamides; Tetrahydrofolate Dehydrogenase; Trimethoprim, Sulfamethoxazole Drug Combination