rifampin and Rocky-Mountain-Spotted-Fever

rifampin has been researched along with Rocky-Mountain-Spotted-Fever* in 1 studies

Other Studies

1 other study(ies) available for rifampin and Rocky-Mountain-Spotted-Fever

Article	Year
Characterization of mutations in the rpoB gene in naturally rifampin-resistant Rickettsia species. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:10 Rickettsiae are gram-negative, obligately intracellular bacteria responsible for arthropod-borne spotted fevers and typhus. Experimental studies have delineated a cluster of naturally rifampin-resistant spotted fever group species. We sequenced the 4, 122- to 4,125-bp RNA polymerase beta-subunit-encoding gene (rpoB) from typhus and spotted fever group representatives and obtained partial sequences for all naturally rifampin-resistant species. A single point mutation resulting in a phenylalanine-to-leucine change at position 973 of the Rickettsia conorii rpoB sequence and present in all the rifampin-resistant species was absent in all the rifampin-susceptible species. rpoB-based phylogenetic relationships among these rickettsial species yielded topologies which were in accordance with previously published phylogenies. Topics: Antibiotics, Antitubercular; DNA-Directed RNA Polymerases; Drug Resistance, Microbial; Humans; Molecular Sequence Data; Mutation; Phylogeny; Rickettsia; Rifampin; Rocky Mountain Spotted Fever	1999

Article

Year

Characterization of mutations in the rpoB gene in naturally rifampin-resistant Rickettsia species.

Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:10

Rickettsiae are gram-negative, obligately intracellular bacteria responsible for arthropod-borne spotted fevers and typhus. Experimental studies have delineated a cluster of naturally rifampin-resistant spotted fever group species. We sequenced the 4, 122- to 4,125-bp RNA polymerase beta-subunit-encoding gene (rpoB) from typhus and spotted fever group representatives and obtained partial sequences for all naturally rifampin-resistant species. A single point mutation resulting in a phenylalanine-to-leucine change at position 973 of the Rickettsia conorii rpoB sequence and present in all the rifampin-resistant species was absent in all the rifampin-susceptible species. rpoB-based phylogenetic relationships among these rickettsial species yielded topologies which were in accordance with previously published phylogenies.

Topics: Antibiotics, Antitubercular; DNA-Directed RNA Polymerases; Drug Resistance, Microbial; Humans; Molecular Sequence Data; Mutation; Phylogeny; Rickettsia; Rifampin; Rocky Mountain Spotted Fever

1999