Page last updated: 2024-11-13

chaetoviridin E

Description

chaetoviridin E : An azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a methyl group at position 6a, a 2-methylbut-2-enoyl group at position 9 and a 3-methylpent-1-en-1-yl group at position 3. It has been isolated from Chaetomium globosum. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID25108108
CHEMBL ID1802154
CHEBI ID67614

Synonyms (7)

Synonym
chaetoviridin e
chebi:67614 ,
CHEMBL1802154
chaetoviridine e
(6as)-5-chloro-6a-methyl-9-[(2e)-2-methylbut-2-enoyl]-3-[(1e,3s)-3-methylpent-1-en-1-yl]-6h-furo[2,3-h]isochromene-6,8(6ah)-dione
Q27136081
(6as)-5-chloro-6a-methyl-9-[(e)-2-methylbut-2-enoyl]-3-[(e,3s)-3-methylpent-1-enyl]furo[2,3-h]isochromene-6,8-dione

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" These compounds may act as safe anticancer drug leads according to this result."( Azaphilones from the Endophyte Diaporthe sp. and Their Toxicity.
Huang, F; Lin, X; Lu, Q, 2022
)
0.72
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
Chaetomium metaboliteAny fungal metabolite produced during a metabolic reaction in the mould, Chaetomium.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
azaphiloneAny member of a family of natural products which contains a 6H-isochromene-6,8(7H)-dione or an isoquinoline-6,8(2H,7H)-dione skeleton and its substituted derivatives thereof.
enoneAn alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
organic heterotricyclic compoundAn organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.
gamma-lactoneA lactone having a five-membered lactone ring.
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID606811Antibiotic activity against cytolysin-positive Enterococcus faecalis MMH594 infected in intestine of Caenorhabditis elegans glp-4(bn2ts);sek-1(km4) mutant infection model assessed as nematode survival at 50 to 100 ug/mL after 168 hrs by liquid infection a2011Journal of natural products, May-27, Volume: 74, Issue:5
Azaphilones from the endophyte Chaetomium globosum.
AID746548Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay2013Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10
Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1.
AID1651829Cytotoxicity against human AGS cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2020Journal of natural products, 04-24, Volume: 83, Issue:4
Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus
AID713894Antimycobacterial activity against Mycobacterium tuberculosis H37Ra2012European journal of medicinal chemistry, Mar, Volume: 49Recent advances in antitubercular natural products.
AID1651828Cytotoxicity against human MGC803 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2020Journal of natural products, 04-24, Volume: 83, Issue:4
Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.80 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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