corylifol a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

corylifol A: isolated from Psoralea corylifolia; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Psoralea	genus	A plant genus of the family FABACEAE that is a source of psoralen (FICUSIN).[MeSH]	Fabaceae	The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID Source	ID
PubMed CID	25056407
CHEMBL ID	4207318
SCHEMBL ID	23028385
MeSH ID	M0547021

Synonyms (15)

Synonym
CS-3753
AC-34049
HY-N0897
corylifol a
775351-88-7
SCHEMBL23028385
3-[3-[(2e)-3,7-dimethylocta-2,6-dienyl]-4-hydroxyphenyl]-7-hydroxychromen-4-one
AKOS032948982
BCP18858
3'-geranyl-4',7-dihydroxyisoflavone
corylinin
MS-26509
CHEMBL4207318
7,4'-dihydroxy-3'-[(e)-3,7-dimethyl2,6-octadienyl] isoflavone
DTXSID401345950

Research Excerpts

Overview

Corylifol A (CA) is a flavonoid extracted from the Psoralea fruit.

Excerpt	Reference	Relevance
"Corylifol A (CA) is a flavonoid extracted from the Psoralea fruit."	( Corylifol A protects against ovariectomized-induced bone loss and attenuates RANKL-induced osteoclastogenesis via ROS reduction, ERK inhibition, and NFATc1 activation. Hai, N; Liang, J; Lin, X; Liu, Q; Peng, H; Song, D; Su, Y; Xu, Y; Zhao, J, 2023)	3.07

Pharmacokinetics

Excerpt	Reference	Relevance
" The developed method was applied to evaluating the pharmacokinetic study of 13 bioactive compounds after oral administration of Psoraleae Fructus in rat of different genders."	( Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics. Cheng, LY; Song, L; Wu, YL; Yang, L; Yu, YL; Zhang, Y; Zhou, K; Zhou, ZX, 2020)	0.56

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1410200	Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-stimulated IL-6 production by measuring IL-6 level in serum at 10 uM preincubated for 2 hrs followed by LPS addition measured after 22 hrs by flow cytometry (Rvb = 6100 +/- 200 pg	2018	Journal of natural products, 04-27, Volume: 81, Issue:4	Imidazole Alkaloids and Their Zinc Complexes from the Calcareous Marine Sponge Leucetta chagosensis.
AID1387685	Immunosuppressive activity in PMA-differentiated human THP1 cells assessed as inhibition of LPS-stimulated IL-6 production by flow cytometry	2018	Journal of natural products, 10-26, Volume: 81, Issue:10	Preussins with Inhibition of IL-6 Expression from Aspergillus flocculosus 16D-1, a Fungus Isolated from the Marine Sponge Phakellia fusca.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (63.64)	24.3611
2020's	4 (36.36)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.71 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	5.56 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.71)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2.07	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
ficusin Ficusin: A naturally occurring furocoumarin, found in PSORALEA. After photoactivation with UV radiation, it binds DNA via single and double-stranded cross-linking.. psoralen : The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.	2.52	2	psoralens	plant metabolite
angelicin angelicin: used as tranquillizer; sedative; or anticonvulsant; structure	2.52	2	furanocoumarin
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.17	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.15	1	D-glucopyranose	epitope; mouse metabolite
pomalidomide 3-aminophthalimidoglutarimide: structure in first source	2.17	1	aromatic amine; dicarboximide; isoindoles; piperidones	angiogenesis inhibitor; antineoplastic agent; immunomodulator
isobavachin isobavachin: RN given for (S)-isomer; structure in first source	2.25	1	flavanones
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.25	1
bilirubin [no description available]	2.11	1	biladienes; dicarboxylic acid	antioxidant; human metabolite; mouse metabolite
isobavachalcone isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.	2.83	3	chalcones; polyphenol	antibacterial agent; metabolite; platelet aggregation inhibitor
psoralidin psoralidin : A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively.	2.25	1	coumestans; delta-lactone; polyphenol	estrogen receptor agonist; plant metabolite
corylin corylin: from Psoralea corylifolia (Leguminosae), has osteoblastic proliferation stimulating activity; structure in first source	2.53	2
neobavaisoflavone neobavaisoflavone: isolated from Psoralea corylifolia; structure in first source. neobavaisoflavone : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with an additonal hydroxy group at position 4' and a prenyl group at position 3'. Isolated from seeds of Psoralea corylifolia, it exhibits inhibitory activity against DNA polymerase and platelet aggregation.	3	4	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; plant metabolite; platelet aggregation inhibitor
bakuchiol bakuchiol: chief component of Psoralea corylifolia Linn; structure	2.81	3
4-hydroxylonchocarpin 4-hydroxylonchocarpin: structure in first source	7.6	1
bavachalcone bavachalcone: structure in first source	2.25	1	chalcones
bavachinin bavachinin: do not confuse with bavachin	3.03	4	flavanones
bavachin bavachin: from Psoralea corylifolia (Leguminosae), has osteoblastic proliferation stimulating activity; do not confuse with bavachinin	2.81	3
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.25	1	benzenes; hydroxycoumarin; methyl ketone
phytoestrogens Phytoestrogens: Compounds derived from plants, primarily ISOFLAVONES that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.	2.05	1

Condition	Relationship Strength	Studies
Bone Loss, Osteoclastic [description not available]	2.6	1
Age-Related Osteoporosis [description not available]	2.6	1
Osteoporosis Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.	2.6	1
Acute Liver Injury, Drug-Induced [description not available]	2.61	2
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.61	2
Atrophy, Muscle [description not available]	2.25	1
Muscular Atrophy Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.	2.25	1
Breast Cancer [description not available]	2.05	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.05	1

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