Any fungal metabolite produced during a metabolic reaction in the mould, Chaetomium.
ChEBI ID: 76960
| Member | Definition | Class |
|---|---|---|
| (E)-5-hydroxy-6-(3-methylbut-2-enyl)-2-(pent-1-enyl)benzofuran-4-carbaldehyde | A member of the class of 1-benzofurans that is 1-benzofuran substituted by a hydroxy group at position 5, a prenyl group at position 6 and a pent-1-en-1-yl group at position 2. Isolated from Chaetomium globosum, it exhibits radical scavenging activity. | (E)-5-hydroxy-6-(3-methylbut-2-enyl)-2-(pent-1-enyl)benzofuran-4-carbaldehyde |
| 4'-epichaetoviridin A | An azaphilone that is the 4'-epimer of chaetoviridin A. It has been isolated from Chaetomium globosum. | 4'-epichaetoviridin A |
| chaetoglobosin A | A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii. | chaetoglobosin A |
| chaetoviridin a | An azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a 3-hydroxy-2-methylbutanoyl group at position 9, a methyl group at position 6a and a 3-methylpent-1-en-1yl group at position 3. Isolated from Chaetomium globosum, it exhibits natifungal activity against plant pathogenic fungi. | chaetoviridin A |
| chaetoviridin E | An azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a methyl group at position 6a, a 2-methylbut-2-enoyl group at position 9 and a 3-methylpent-1-en-1-yl group at position 3. It has been isolated from Chaetomium globosum. | chaetoviridin E |
| chetomin | An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity. | chetomin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (6.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (20.97) | 29.6817 |
| 2010's | 35 (56.45) | 24.3611 |
| 2020's | 10 (16.13) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (1.41%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 70 (98.59%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 14.9922 | 2 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 23.0999 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 16.8158 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 63.5144 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 9.2727 | 2 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 100.6636 | 1 | 2 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 8.1995 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 8.4218 | 2 | 2 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 12.5893 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 6.6918 | 1 | 2 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 11.2202 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 69.6219 | 1 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 33.9508 | 1 | 2 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 16.3262 | 1 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 7.0193 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 100.6636 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 11.9352 | 2 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 37.6188 | 1 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 6.6918 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 6.6918 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 19.9526 | 1 | 2 |
| Vpr | Human immunodeficiency virus 1 | Potency | 35.4813 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| large T antigen | Betapolyomavirus macacae | IC50 | 43.9600 | 1 | 1 |
| neuropeptide Y receptor type 1 | Homo sapiens (human) | IC50 | 10.5900 | 1 | 1 |
| neuropeptide Y receptor type 2 | Homo sapiens (human) | IC50 | 4.7600 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| bcl-2-like protein 11 isoform 1 | Homo sapiens (human) | EC50 | 216.4000 | 1 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | EC50 | 216.4000 | 1 | 1 |
| E3 ubiquitin-protein ligase Mdm2 isoform a | Homo sapiens (human) | EC50 | 12.0200 | 1 | 1 |
| Hsf1 protein | Mus musculus (house mouse) | EC50 | 6.2430 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | EC50 | 50.0000 | 1 | 1 |
| neuropeptide Y receptor type 1 | Homo sapiens (human) | EC50 | 35.4300 | 1 | 1 |
| neuropeptide Y receptor type 2 | Homo sapiens (human) | EC50 | 35.4300 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bcl-2-like protein 11 | Homo sapiens (human) | AC50 | 9.8410 | 1 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | AC50 | 133.3303 | 3 | 3 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 15.1890 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 7.4120 | 1 | 1 |
| POsterior Segregation | Caenorhabditis elegans | AC50 | 14.5540 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | AC50 | 42.9970 | 1 | 1 |