Compounds > 4-hydroxycordoin
Page last updated: 2024-11-11

4-hydroxycordoin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-hydroxycordoin: antibacterial and anti-inflammatory from Lonchocarpus neuroscapha Benth. (Fabaceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

4-hydroxycordoin : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at position 4 and 2' and a (3-methylbut-2-en-1-yl)oxy group at position 4'. It has been isolated from Lonchocarpus neuroscapha. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Lonchocarpusgenus[no description available]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]
Neuroscaphagenus[no description available]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]
Lonchocarpus neuroscaphaspecies[no description available]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID SourceID
PubMed CID5879763
CHEMBL ID460400
CHEBI ID70080
SCHEMBL ID7570307
MeSH IDM0557501

Synonyms (14)

Synonym
nsc270893
55524-25-9
nsc-270893
4-hydroxycordoin
LMPK12120044
chebi:70080 ,
CHEMBL460400
p-hydroxy-cordoin
(e)-1-[2-hydroxy-4-(3-methylbut-2-enoxy)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
(2e)-1-{2-hydroxy-4-[(3-methylbut-2-enyl)oxy]phenyl}-3-(4-hydroxyphenyl)prop-2-en-1-one)
nsc 270893
(2e)-1-{2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-(4-hydroxyphenyl)prop-2-en-1-one
SCHEMBL7570307
Q27138419
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
anti-inflammatory agentAny compound that has anti-inflammatory effects.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
chalconesA ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (51)

Assay IDTitleYearJournalArticle
AID568604Antibacterial activity against Fusobacterium nucleatum ATCC 25586 after 24 hrs2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID607593Cytotoxicity against human U373 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID568627Cytotoxicity against human GMSM-K cells assessed as reduction of cell viability at up to 50 ug/ml after 2 hrs by MTT assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568605Antibacterial activity against Prevotella intermedia ATCC 25611 after 24 hrs2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID388004Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microdilution broth method2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
Structure-activity relationship of antibacterial chalcones.
AID659716Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 100 uM after 24 hrs by dual-luciferase assay relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID568618Antiinflammatory activity in human U937 cells assessed as inhibition of IL-8 production at 5 ug/ml after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID607600Induction of human U373 cell death assessed as morphological changes at MTT assay-related IC50 after 72 hrs by quantitative video microscopy2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID449575Anticonvulsant activity in mouse at 300 mg/kg, ip after 60 mins by MES test2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID388001Antibacterial activity against Bacillus cereus ATCC 11778 after 24 hrs by microdilution broth method2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
Structure-activity relationship of antibacterial chalcones.
AID568611Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced IL1-beta production at 5 ug/ml treated 2 hrs before LPS challenge measured after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID449573Anticonvulsant activity in mouse at 300 mg/kg, ip after 15 mins by MES test2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID568607Antibacterial activity against 14C-labeled Porphyromonas gingivalis ATCC 33277 assessed as inhibition of adhesion to human GMSM-K cells after 30 mins by scintillation counting2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID607598Cytotoxicity against human LoVo cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID568603Antibacterial activity against Porphyromonas gingivalis ATCC 33277 after 24 hrs2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID659712Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 5 uM after 24 hrs by dual-luciferase assay relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID388003Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microdilution broth method2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
Structure-activity relationship of antibacterial chalcones.
AID659713Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 10 uM after 24 hrs by dual-luciferase assay relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID568623Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced MMP9 production at 1 ug/ml treated 2 hrs before LPS challenge measured after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568625Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced NF-kappaB p65 activation at 5 ug/ml treated 1 hrs before LPS challenge measured after 1 hr2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568610Antibacterial activity against 14C-labeled Porphyromonas gingivalis ATCC 33277 assessed as inhibition of adhesion to human GMSM-K cells at 5 ug/ml after 30 mins by scintillation counting relative to control2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID388002Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution broth method2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
Structure-activity relationship of antibacterial chalcones.
AID659711Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 1 uM after 24 hrs by dual-luciferase assay relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID659710Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 0.1 uM after 24 hrs by dual-luciferase assay relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID568608Antibacterial activity against 14C-labeled Porphyromonas gingivalis ATCC 33277 assessed as inhibition of adhesion to human GMSM-K cells at 0.2 ug/ml after 30 mins by scintillation counting2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568619Antiinflammatory activity in human U937 cells assessed as inhibition of TNFalpha production at 5 ug/ml after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID659714Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 25 uM after 24 hrs by dual-luciferase assay relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID568626Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced AP-1 activation at 5 ug/ml treated 1 hrs before LPS challenge measured after 1 hr2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID449574Anticonvulsant activity in mouse at 300 mg/kg, ip after 30 mins by MES test2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID449572Anticonvulsant activity in mouse at 300 mg/kg, ip after 5 mins by MES test2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID568621Antiinflammatory activity in human U937 cells assessed as inhibition of CCL5 production at 5 ug/ml after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568612Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced IL-8 production at 5 ug/ml treated 2 hrs before LPS challenge measured after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568620Antiinflammatory activity in human U937 cells assessed as inhibition of IL-6 production at 5 ug/ml after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568628Cytotoxicity against human U937 cells assessed as reduction of cell viability at up to 50 ug/ml after 2 hrs by MTT assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568616Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced PGE2 production at 5 ug/ml treated 2 hrs before LPS challenge measured after 24 hrs2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568617Antiinflammatory activity in human U937 cells assessed as inhibition of IL1-beta production at 5 ug/ml after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID607595Cytotoxicity against human A549 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID607596Cytotoxicity against human PC3 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID607594Cytotoxicity against human OE21 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID568609Antibacterial activity against 14C-labeled Porphyromonas gingivalis ATCC 33277 assessed as inhibition of adhesion to human GMSM-K cells at 1 ug/ml after 30 mins by scintillation counting relative to control2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568615Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 production at 5 ug/ml treated 2 hrs before LPS challenge measured after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568613Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced TNFalpha production at 5 ug/ml treated 2 hrs before LPS challenge measured after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID568614Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced IL-6 production at 5 ug/ml treated 2 hrs before LPS challenge measured after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID607597Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID568624Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced MMP9 production at 5 ug/ml treated 2 hrs before LPS challenge measured after 24 hrs by ELISA2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID659715Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 50 uM after 24 hrs by dual-luciferase assay relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID449576Anticonvulsant activity in mouse at 300 mg/kg, ip after 120 mins by MES test2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID568622Antiinflammatory activity in human U937 cells assessed as inhibition of PGE2 production at 5 ug/ml after 24 hrs2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
AID659717Agonist activity at human farnesoid X receptor expressed in human HepG2 cells after 24 hrs by dual-luciferase assay relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID607601Cytotoxicity against human U373 cells assessed as growth inhibition at MTT assay-related IC50 by quantitative video microscopy relative to control2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID568606Antibacterial activity against Prevotella intermedia ATCC 25611 assessed as reduction of bacterial growth at 1.25 ug/ml after 24 hrs2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.79 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzoic acid
4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.		2.0610monohydroxybenzoic acidalgal metabolite;
plant metabolite
emodin
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.		2.0610trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
phloretin
[no description available]		2.0410dihydrochalconesantineoplastic agent;
plant metabolite
resacetophenone
resacetophenone: structure in first source. 2',4'-dihydroxyacetophenone : A dihydroxyacetophenone that is acetophenone carrying hydroxy substituents at positions 2' and 4'.		2.0610dihydroxyacetophenone;
resorcinols		plant metabolite
vanillic acid
Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).. vanillic acid : A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.		2.0610methoxybenzoic acid;
monohydroxybenzoic acid		plant metabolite
chenodeoxycholic acid
Chenodeoxycholic Acid: A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.. chenodeoxycholic acid : A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.. chenodeoxycholate : Conjugate base of chenodeoxycholic acid; major species at pH 7.3.		2.0710bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid		human metabolite;
mouse metabolite
2,4,6-trihydroxyacetophenone
monoacetylphloroglucinol: structure in first source. 2',4',6'-trihydroxyacetophenone : A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acidic glycans and glycopeptides.		2.0610aromatic ketone;
benzenetriol;
methyl ketone		MALDI matrix material;
plant metabolite
a-130a
[no description available]		2.7530
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		2.0610ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
trans-4-coumaric acid
hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents.. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid.. 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring.		2.06104-coumaric acidfood component;
mouse metabolite;
plant metabolite
isoliquiritigenin
[no description available]		2.4620chalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist
coniferyl alcohol
coniferyl alcohol: structure. coniferol : A phenylpropanoid that is one of the main monolignols, produced by the reduction of the carboxy functional group in cinnamic acid and the addition of a hydroxy and a methoxy substituent to the aromatic ring.		2.0610guaiacols;
phenylpropanoid		animal metabolite;
monolignol;
mouse metabolite;
pheromone;
plant metabolite;
volatile oil component
aurapten
aurapten: RN refers to (E)-isomer; structure given in first source. auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.		2.7530coumarins;
monoterpenoid		antihypertensive agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
dopaminergic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
gamma-secretase modulator;
gastrointestinal drug;
hepatoprotective agent;
matrix metalloproteinase inhibitor;
neuroprotective agent;
plant metabolite;
PPARalpha agonist;
vulnerary
umbelliprenin
umbelliprenin: RN given refers to cpd with unspecified isomeric designation		2.0610terpene lactone
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0610prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
sinapyl alcohol
sinapyl alcohol: has anti-inflammatory and antinociceptive properties; structure in first source. trans-sinapyl alcohol : Sinapyl alcohol in which the configuration of the propenyl double bond is E. It is one of the main monolignols.. sinapyl alcohol : A primary alcohol, being cinnamyl alcohol hydroxylated at C-4 and methoxylated at C-3 and -5.		2.0610sinapyl alcoholmonolignol
coniferaldehyde
coniferaldehyde: from aqueous extract of Senra incana. coniferyl aldehyde : A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3.		2.0610cinnamaldehydes;
guaiacols;
phenylpropanoid		antifungal agent;
plant metabolite
sinapaldehyde
sinapyl aldehyde: structure in first source. (E)-sinapaldehyde : A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and methoxy groups at positions 3 and 5.		2.0610cinnamaldehydes;
dimethoxybenzene;
phenols		antifungal agent;
plant metabolite
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		2.0410chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
7-hydroxycoumarin
7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.		2.0610hydroxycoumarinfluorescent probe;
food component;
plant metabolite
collinin
collinin: the active principle of Zanthoxylum spp.; structure in first source		2.4620
lacinartin
lacinartin: from Zanthoxylum schinifolium; structure in first source		2.7530
2',4'-dihydroxychalcone
2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source		2.0610
4-hydroxylonchocarpin
4-hydroxylonchocarpin: structure in first source		2.0410
derricidin
derricidin: from Lonchocarpus sericeus; structure in first source		2.7430chalcones
isocordoin
isocordoin: a metabolite biotransformed from Morus nigra; structure in first source		2.0410chalcones
Lonchocarpin
lonchocarpine: has anti-bacterial, anti-inflammatory, antiproliferative, antioxidant, and antiepileptic activities; isolated from Abrus precatorius; structure in first source		2.0410chalcones
4-hydroxyderricin
4-hydroxyderricin: from Angelica keiskei; RN given refers to (E)-isomer; structure in first source		2.0410chalcones
o-geranylsinapyl alcohol
O-geranylsinapyl alcohol: structure given in first source; isolated from the bark of Fagara rhetza, an Indonesian medicinal plant		2.4720
nelumal a
nelumal A: aromatase inhibitor from Ligularia nelumbifolia; structure in first source		2.4720
4'-geranyloxyferulic acid
4'-geranyloxyferulic acid: a colon cancer chemopreventive agent isolated from grapefruit skin; structure in first source		2.7530
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		2.0410
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure
[description not available]		02.0510
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.0510
Parodontosis
[description not available]		02.0610
Periodontal Diseases
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.		02.0610