Page last updated: 2024-11-09

6,7-dehydroroyleanone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

6,7-dehydroroyleanone: diterpene abietane quinone isolated from Salvia moorcraftiana or Lepechinia bullata (both Lamiaceae); Rn given from CA Index Guide; RN not in Chemline 12/84; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Lepechiniagenus[no description available]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]
SalviagenusA genus in the mint family (LAMIACEAE).[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]
Lepechinia bullataspecies[no description available]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID2751794
CHEMBL ID242491
CHEBI ID149879
SCHEMBL ID22861893
MeSH IDM0128093

Synonyms (13)

Synonym
12-hydroxy-abieta-6,8,12-trien-11,14-dione
6855-99-8
1,4-phenanthrenedione, 4b,5,6,7,8,8a-hexahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bs-trans)-
6,7-dehydroroyleanone
6,7-dhra
CHEMBL242491
CHEBI:149879
(4bs,8as)-1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,4-dione
AKOS004901855
(4bs)-3-hydroxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a-hexahydrophenanthrene-1,4-dione
DTXSID70988225
14-hydroxyabieta-6,8,13-triene-11,12-dione
SCHEMBL22861893
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID355591Cytotoxicity against mouse P388 cells
AID355590Cytotoxicity against human KB cells
AID297145Inhibition of SARS coronavirus-induced cytopathogenicity in Vero E6 cells at 20 uM2007Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
AID1058388Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID297151Selectivity index, Ratio of CC50 for Vero E6 cells to EC50 for SARS coronavirus2007Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
AID713897Antimycobacterial activity against Mycobacterium tuberculosis H37Rv2012European journal of medicinal chemistry, Mar, Volume: 49Recent advances in antitubercular natural products.
AID1058384Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID297147Inhibition of SARS virus-induced cytopathogenicity in Vero E6 cells at 3.3 uM2007Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
AID1520329Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2019European journal of medicinal chemistry, Mar-15, Volume: 166All that glitters is not gold: Panning cytotoxic natural products and derivatives with a fused tricyclic backbone by the estimation of their leadlikeness for cancer treatment.
AID297148Inhibition of SARS virus-induced cytopathogenicity in Vero E6 cells at 1 uM2007Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
AID1058385Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1058386Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID297150Cytotoxicity against Vero E6 cells by MTT assay2007Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
AID297146Inhibition of SARS coronavirus-induced cytopathogenicity in Vero E6 cells at 10 uM2007Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
AID713898Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis2012European journal of medicinal chemistry, Mar, Volume: 49Recent advances in antitubercular natural products.
AID1058387Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID297149Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA2007Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
AID1058382Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's7 (63.64)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.54 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]