Compounds > 6-prenylapigenin
Page last updated: 2024-11-12

6-prenylapigenin

Description

6-prenylapigenin: from Dorstenia; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10382485
CHEMBL ID4643387
SCHEMBL ID4834777
MeSH IDM0572613

Synonyms (16)

Synonym
4',5,7-trihydroxy-6-prenylflavone
68097-13-2
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)chromen-4-one
5,7,4'-trihydroxy-6-prenylflavone
LMPK12110412
6-c-prenylapigenin
6-prenylapigenin
AKOS022184682
SCHEMBL4834777
FS-8954
6-c-prenylapigenin; 6-prenyl-4',5,7-trihydroxyflavone
CHEMBL4643387
E80686
HY-N2732
CS-0023230
B0005-148007
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID1732447Induction of apoptotis in human HeLa cells assessed as early apoptotic cells at 20 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 5.46 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732462Activation of AKT signaling pathway in human HeLa cells assessed as reduction in phosphorylated AKT expression measured after 24 hrs by Western blot analysis2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732455Induction of apoptotis in human HeLa cells assessed as early apoptotic cells at 40 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 5.46 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732444Induction of apoptotis in human HeLa cells assessed as late apoptotic cells at 10 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 2.74 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732443Induction of apoptotis in human HeLa cells assessed as early apoptotic cells at 10 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 5.46 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732456Induction of apoptotis in human HeLa cells assessed as late apoptotic cells at 40 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 2.74 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1651637Antiinflammatory activity in LPS-induced human PBMC cells assessed as GM-CSF release at 100 uM after 24 hrs by luminex based bead assay relative to control2020Journal of natural products, 04-24, Volume: 83, Issue:4
Anti-inflammatory Flavanones and Flavones from
AID1732452Induction of apoptotis in human HeLa cells assessed as late apoptotic cells at 30 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 2.74 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732461Activation of MAPK signaling pathway in human HeLa cells assessed as reduction in phosphorylated ERK expression measured after 24 hrs by Western blot analysis2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732446Induction of apoptotis in human HeLa cells assessed as live cells at 20 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 89.2 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732441Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation by MTT assay2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732439Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation by MTT assay2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732449Induction of apoptotis in human HeLa cells assessed as necrotic cells at 20 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 2.59 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1651636Antiinflammatory activity in LPS-induced human PBMC cells assessed as IL-6 release at 100 uM after 24 hrs by luminex based bead assay relative to control2020Journal of natural products, 04-24, Volume: 83, Issue:4
Anti-inflammatory Flavanones and Flavones from
AID1732457Induction of apoptotis in human HeLa cells assessed as necrotic cells at 40 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 2.59 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732450Induction of apoptotis in human HeLa cells assessed as live cells at 30 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 89.2 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732451Induction of apoptotis in human HeLa cells assessed as early apoptotic cells at 30 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 5.46 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732445Induction of apoptotis in human HeLa cells assessed as necrotic cells at 10 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 2.59 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732448Induction of apoptotis in human HeLa cells assessed as late apoptotic cells at 20 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 2.74 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732459Activation of MAPK signaling pathway in human HeLa cells assessed as increase in phosphorylated JNK protein level at 30 uM measured after 24 hrs by Western blot analysis2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732438Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation by MTT assay2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1651638Antiinflammatory activity in LPS-induced human PBMC cells assessed as TNFalpha release at 100 uM after 24 hrs by luminex based bead assay relative to control2020Journal of natural products, 04-24, Volume: 83, Issue:4
Anti-inflammatory Flavanones and Flavones from
AID1651634Antiinflammatory activity in LPS-induced human PBMC cells assessed as IL-1beta release at 100 uM after 24 hrs by luminex based bead assay relative to control2020Journal of natural products, 04-24, Volume: 83, Issue:4
Anti-inflammatory Flavanones and Flavones from
AID1732454Induction of apoptotis in human HeLa cells assessed as live cells at 40 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 89.2 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732460Activation of MAPK signaling pathway in human HeLa cells assessed as increase in phosphorylated p38 protein level at 30 uM measured after 24 hrs by Western blot analysis2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732442Induction of apoptotis in human HeLa cells assessed as live cells at 10 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 89.2 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1651635Antiinflammatory activity in LPS-induced human PBMC cells assessed as IL-2 release at 100 uM after 24 hrs by luminex based bead assay relative to control2020Journal of natural products, 04-24, Volume: 83, Issue:4
Anti-inflammatory Flavanones and Flavones from
AID1732453Induction of apoptotis in human HeLa cells assessed as necrotic cells at 30 uM measured after 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 2.59 %)2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732440Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation by MTT assay2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
AID1732458Induction of apoptosis in human HeLa cells assessed as increase in PARP cleavage measured after 24 hrs by Western blot analysis2021Bioorganic & medicinal chemistry letters, 04-15, Volume: 38Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.80 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ibuprofen
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine		2.2510monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
xanthone
xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.		2.0710xanthonesinsecticide
xanthenes
Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.		2.0610xanthene
resazurin
resazurin: used as indicator in detection of hyposulfite (sulfoxylate); in food research (reductase test); structure		2.0610phenoxazine
aromadedrin
aromadedrin: inhibits protein kinase C; the dihydro makes it a flavone rather than a flavonol. (+)-dihydrokaempferol : A tetrahydroxyflavanone having hydroxy groupa at the 3-, 4'-, 5- and 7-positions.		2.07104'-hydroxyflavanones;
dihydroflavonols;
secondary alpha-hydroxy ketone;
tetrahydroxyflavanone		metabolite
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		2.2510trihydroxyflavoneantineoplastic agent;
metabolite
luteolin
[no description available]		2.25103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
genistein
[no description available]		2.07107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		2.0810chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
scutellarein
scutellarein: aglycone of scutellarin from Scutellaria baicalensis; carthamidin is 2S isomer of scutellarein; do not confuse with isoscutellarein and/or isocarthamidin which are respective regioisomers, or with the scutelarin protein. scutellarein : Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.		2.0710tetrahydroxyflavonemetabolite
5,4'-dihydroxy-7,3'-dimethoxyflavone
5,4'-dihydroxy-7,3'-dimethoxyflavone: has anti-inflammatory activity; isolated from acai, Euterpe oleracea; structure in first source. velutin : A dimethoxyflavone that is luteolin in which the hydroxy groups at positions 7 and 3' are replaced by methoxy groups.		2.2510dihydroxyflavone;
dimethoxyflavone		anti-allergic agent;
anti-inflammatory agent;
antibacterial agent;
antioxidant;
melanin synthesis inhibitor;
plant metabolite
4-hydroxylonchocarpin
4-hydroxylonchocarpin: structure in first source		7.4820
licoflavone c
licoflavone C: Antimutagenic Agent; a naturally occurring prenyl-flavone extracted from Genista ephedroides; structure in first source		2.5420
derrone
derrone: from Retama raetam flowers; structure in first source		2.0710isoflavonoid
ConditionIndicatedRelationship StrengthStudiesTrials
Angiogenesis, Pathologic
[description not available]		02.0610
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