Page last updated: 2024-12-11

2',6'-dihydroxy-4'-methoxychalcone

Description

2',6'-dihydroxy-4'-methoxychalcone: isolated from Piper aduncum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PipergenusA plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.[MeSH]PiperaceaeA family of flowering plants in the order Piperales best known for the black pepper widely used in SPICES, and for KAVA and Betel used for neuroactive properties.[MeSH]

Cross-References

ID SourceID
PubMed CID5316793
CHEMBL ID317221
CHEBI ID174555
SCHEMBL ID3483741
MeSH IDM0304713

Synonyms (27)

Synonym
(e)-1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one
77129-49-8
CHEBI:174555
pinostrobin chalcone
NCGC00090582-01
LMPK12120244
2',6'-dihydroxy-4'-methoxychalcone
CHEMBL317221
einecs 278-629-7
AKOS016009445
18956-15-5
SCHEMBL3483741
1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one
CUGDOWNTXKLQMD-BQYQJAHWSA-N
2-propen-1-one, 1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenyl-
(2e)-1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenyl-2-propen-1-one #
2-propen-1-one, 1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenyl-, (e)-
chalcone, 2',6'-dihydroxy-4'-methoxy-
ncgc00090582-03!(e)-1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one
(2s)-3,3-dimethyl-1,2-pyrrolidinedicarboxylicacid1-(1,1-dimethylethyl)ester
2-propen-1-one, 1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenyl-, (e)-; chalcone, 2',6'-dihydroxy-4'-methoxy- ; 2',6'-dihydroxy-4'-methoxychalcone
MS-23821
E88646
A880446
CS-0023108
HY-N3057
2-propen-1-one, 1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenyl-, (2e)-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
chalconesA ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency7.94330.003245.467312,589.2998AID2517
cytochrome P450 2C19 precursorHomo sapiens (human)Potency1.58490.00255.840031.6228AID899
cytochrome P450 2C9 precursorHomo sapiens (human)Potency1.99530.00636.904339.8107AID883
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency1.99530.00638.235039.8107AID883
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID310870Antileishmanial activity against Leishmania amazonensis intracellular amastigotes2007European journal of medicinal chemistry, Feb, Volume: 42, Issue:2
A review of anti-infective and anti-inflammatory chalcones.
AID1395332Antileishmanial activity against Leishmania amazonensis LV/79 (MPRO/BR/72/M 1841) amastigotes infected in Balb/c mouse macrophages after 48 hrs by Giemsa staining based light microscopic method2018European journal of medicinal chemistry, Apr-25, Volume: 150A comprehensive review of chalcone derivatives as antileishmanial agents.
AID102612The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells2001Bioorganic & medicinal chemistry letters, Dec-17, Volume: 11, Issue:24
Flavonoids: structural requirements for antiproliferative activity on breast cancer cells.
AID1244008Anti-leishmanial activity against Leishmania amazonensis intracellular amastigotes2015European journal of medicinal chemistry, Aug-28, Volume: 101Chalcone scaffolds as anti-infective agents: structural and molecular target perspectives.
AID310828Antileishmanial activity against Leishmania amazonensis promastigotes2007European journal of medicinal chemistry, Feb, Volume: 42, Issue:2
A review of anti-infective and anti-inflammatory chalcones.
AID1244007Anti-leishmanial activity against Leishmania amazonensis promastigotes2015European journal of medicinal chemistry, Aug-28, Volume: 101Chalcone scaffolds as anti-infective agents: structural and molecular target perspectives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's3 (42.86)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (42.86%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (57.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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