Compounds > altholactone
Page last updated: 2024-12-08

altholactone

Description

altholactone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID442513
CHEMBL ID512401
CHEBI ID5522
MeSH IDM0430373

Synonyms (13)

Synonym
65408-91-5
altholactone
C09930 ,
chebi:5522 ,
CHEMBL512401 ,
AC1L9CZK ,
(2r,3r,3as,7as)-3-hydroxy-2-phenyl-2,3,3a,7a-tetrahydrofuro[3,2-b]pyran-5-one
zinc04098425
DTXSID90331855
altholactone, >=95% (lc/ms-elsd)
AKOS032948434
FS-9444
Q27106790

Research Excerpts

Treatment

Treatment with altholactone resulted in a significant reduction in cell viability, induction of apoptosis and generation of reactive oxygen species (ROS) in T24 cells. Althlactone treatment was also found to result in a loss of mitochondrial membrane potential, Bcl-2 downregulation and caspase-3 activation.

ExcerptReferenceRelevance
"Altholactone treatment was also found to result in a significant loss of mitochondrial membrane potential, Bcl-2 downregulation and caspase-3 activation."( Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression.
Li, X; Zhao, B, 2014)		2.57
"Treatment with altholactone resulted in a significant reduction in cell viability, induction of apoptosis and generation of reactive oxygen species (ROS) in T24 cells."( Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression.
Li, X; Zhao, B, 2014)		2.18
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
furopyranAny organic heterobicyclic compound containing ortho-fused furan and pyran rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (28)

Assay IDTitleYearJournalArticle
AID460116Cytotoxicity against human MCF12A cells after 48 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL.
AID756422Cytotoxicity against human MCF10A cells up to 100 uM after 20 hrs by MTT assay2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756427Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-1beta mRNA expression by quantitative real-time PCR analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756421Cytotoxicity against human MDA-MB-231 cells up to 100 uM after 20 hrs by MTT assay2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756424Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-6 mRNA expression by quantitative real-time PCR analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756435Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756425Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced G-CSF mRNA expression by quantitative real-time PCR analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756418Cytotoxicity against human PC3 cells up to 100 uM after 20 hrs by MTT assay2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID460117Antiproliferative activity against human CEM cells after 48 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL.
AID460123Cytotoxicity against human CEM cells assessed as viable cells at 120 uM after 24 hrs by Annexin-V-FITC and porpidium iodide staining based flow cytometry2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL.
AID713894Antimycobacterial activity against Mycobacterium tuberculosis H37Ra2012European journal of medicinal chemistry, Mar, Volume: 49Recent advances in antitubercular natural products.
AID756432Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced iNOS expression at 5 uM after 4 hrs by Western blot analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID380842Cell cycle arrest in mouse L1210 cells by accumulation at G2M phase after 21 hrs relative to control1999Journal of natural products, Aug, Volume: 62, Issue:8
Semisynthesis and cytotoxicity of styryl-lactone derivatives.
AID756431Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced COX2 expression at 5 uM after 4 hrs by Western blot analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID460121Cytotoxicity against human CEM cells assessed as late apoptotic/necrotic cells at 120 uM after 24 hrs by Annexin-V-FITC and porpidium iodide staining based flow cytometry2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL.
AID756430Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced iNOS mRNA expression by quantitative real-time PCR analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756420Cytotoxicity against human MCF7 cells up to 100 uM after 20 hrs by MTT assay2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID460115Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL.
AID756419Cytotoxicity against human LNCAP cells up to 100 uM after 20 hrs by MTT assay2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756423Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IFN-beta mRNA expression by quantitative real-time PCR analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756433Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells assessed as reduction of IkappaBalpha phosphorylation at 1.5 to 12 uM after 4 hrs by Western blot analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756434Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756429Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced COX2 mRNA expression by quantitative real-time PCR analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756428Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IP-10 mRNA expression by quantitative real-time PCR analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID380841Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay1999Journal of natural products, Aug, Volume: 62, Issue:8
Semisynthesis and cytotoxicity of styryl-lactone derivatives.
AID460122Cytotoxicity against human CEM cells assessed as early apoptotic cells at 120 uM after 24 hrs by Annexin-V-FITC and porpidium iodide staining based flow cytometry2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL.
AID756436Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
AID756426Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced MCP1 mRNA expression by quantitative real-time PCR analysis2013Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (5.00)18.2507
2000's5 (25.00)29.6817
2010's13 (65.00)24.3611
2020's1 (5.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.41 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index5.27 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (95.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyrazinamide
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.		3.1710monocarboxylic acid amide;
N-acylammonia;
pyrazines		antitubercular agent;
prodrug
4-aminopyridine
[no description available]		2.1310aminopyridine;
aromatic amine		avicide;
orphan drug;
potassium channel blocker
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		2.0110
ethaverine
ethaverine: tetraethyl homolog of papaverine; smooth muscle relaxant; RN given refers to parent cpd; structure		2.0410isoquinolines
ofloxacin
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.		3.17103-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
papaverine
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.		2.0410benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
propidium
Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.		2.0710phenanthridines;
quaternary ammonium ion		fluorochrome;
intercalator
ethylene
Plastipore: high density polyethylene sponge biocompatible material; used as posts in dental bridges		7.0310alkene;
gas molecular entity		plant hormone;
refrigerant
3-hydroxybutanal
[no description available]		2.1110
thiazoles
[no description available]		2.07101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
liriodenine
liriodenine: structure given in first source. liriodenine : An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities.		3.1710alkaloid antibiotic;
cyclic ketone;
organic heteropentacyclic compound;
oxacycle;
oxoaporphine alkaloid		antifungal agent;
antimicrobial agent;
antineoplastic agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
dicyclohexylcarbodiimide
1,3-dicyclohexylcarbodiimide : A carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms.		2.1310carbodiimideATP synthase inhibitor;
cross-linking reagent;
peptide coupling reagent
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.7430acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
ethambutol
Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.		3.1710ethanolamines;
ethylenediamine derivative		antitubercular agent;
environmental contaminant;
xenobiotic
4-dimethylaminopyridine
4-dimethylaminopyridine: catalyst for acetylation of hydroxy cpds; structure		2.1310dialkylarylamine;
tertiary amino compound
carbonates
Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed). carbonates : Organooxygen compounds that are salts or esters of carbonic acid, H2CO3.		2.0310carbon oxoanion
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.0310metal allergen;
nickel group element atom;
platinum group metal atom
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		2.0610copper group element atom;
elemental gold
7-methyljuglone
7-methyljuglone: antineoplastic from roots of Euclea natalensis and Drosera aliciae; structure in first source		3.1710hydroxy-1,4-naphthoquinone
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.1110benzenes;
phenyl acetates
thiazolyl blue
thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.		2.0710organic bromide saltcolorimetric reagent;
dye
betulinic acid
[no description available]		3.1710hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
pinocembrin
pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.		3.1710(2S)-flavan-4-one;
dihydroxyflavanone		antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent
inermin
inermin: phytoalexin produced in plants after injection with fungi; RN given refers to (cis-(+-))-isomer; RN for cpd without isomeric designation; structure. (-)-maackiain : The (-)-enantiomer of maackiain.		3.1710maackiain
diffractaic acid
difractaic acid: from Lichen, Usnea steineri; active against Gram-positive, multidrug-resistant bacteria; structure in first source		3.1710carbonyl compound
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		7.0810cobalt group element atom;
metal allergen		micronutrient
diacetyldichlorofluorescein
diacetyldichlorofluorescein: stable storage form of dichlorofluorescein		2.0110
7-goniofufurone
7-goniofufurone: from Goniothalamus giganteus; structure given in first source		2.0410
proximadiol
proximadiol: dicyclic sesquiterpenediol from Cymbopogon proximus with antispasmodic activity		2.0710eudesmane sesquiterpenoidmetabolite
goniodiol
goniodiol: from Malaysian medicinal plant; structure in first source		2.0310
ascididemin
ascididemin: can be viewed as a fused phenanthroline with quinoline; from the Mediterranean ascidian Cystodytes dellechiajei; structure in first source		3.1710
pimaric acid
pimaric acid: RN given refers to (D)-isomer; structure		3.1710diterpenoid
Harringtonine
harringtonin: alkaloid C from Caphalotaxus fortunei		2.0310alkaloid
malabaricone a
malabaricone A: from Myristica malabarica (rampatri), has antipromastigote activity; structure in first source		3.1710
australine
australine: RN & structure given in first source; inhibits amyloglucosidase & glycoprotein processing		7.0310
squalene
Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate		3.1710triterpenehuman metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
3,7-dimethoxyflavone
3,7-dimethoxyflavone: structure given in first source		3.1710ether;
flavonoids
methyl caffeate
methyl caffeate: from plant Gaillardia pulchella. methyl caffeate : An alkyl caffeate ester formed by the formal condensation of caffeic acid with methyl alcohol.		3.1710alkyl caffeate ester;
methyl ester
tocopherylquinone
tocopherylquinone: RN refers to (3R-(3R*,7R*,11R*))-isomer; structure		3.1710
6,7-dehydroroyleanone
6,7-dehydroroyleanone: diterpene abietane quinone isolated from Salvia moorcraftiana or Lepechinia bullata (both Lamiaceae); Rn given from CA Index Guide; RN not in Chemline 12/84; structure given in first source		3.1710
horminone
horminone: RN refers to (4bS-(4balpha,8abeta,10beta))-isomer; from root of Salvia officinalis; structure given in second source. horminone : An abietane diterpenoid that is abieta-8,12-diene substituted by hydroxy groups at positions 7 and 12 and oxo groups at positions 11 and 14 (the 7alpha stereoisomer) .		3.1710
ethionamide
Ethionamide: A second-line antitubercular agent that inhibits mycolic acid synthesis.. ethionamide : A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.		3.1710pyridines;
thiocarboxamide		antilipemic drug;
antitubercular agent;
fatty acid synthesis inhibitor;
leprostatic drug;
prodrug
trans-phytol
trans-phytol: structure in first source		3.1710diterpenoid;
long-chain primary fatty alcohol		algal metabolite;
plant metabolite;
schistosomicide drug
scopoletin
[no description available]		3.1710hydroxycoumarinplant growth regulator;
plant metabolite
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		3.1710chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
mangostin
mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.		3.1710aromatic ether;
phenols;
xanthones		antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite
ethyl 4-methoxycinnamate
ethyl 4-methoxycinnamate: an antifungal agent isolated from Curcumba zedoaria		3.1710
pellitorine
pellitorine: consists of piper sylvaticum Roxb.; structure		3.1710fatty amidemetabolite
ergosterol-5,8-peroxide
ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source. ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.		3.17103beta-sterol;
ergostanoid;
organic peroxide;
phytosterols		antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug
furanoheliangolide
furanoheliangolide: structure in first source		3.1710
3,7,11,15-tetramethyl-2-hexadecen-1-ol
3,7,11,15-tetramethyl-2-hexadecen-1-ol: a fragrance ingredient; structure in first source		3.1710
goniothalamin
goniothalamin: has antineoplastic activity; structure given in first source		2.4820
beta-sitosterone
beta-sitosterone: from Torreya jackii		3.1710
2-methoxyjuglone
2-methoxyjuglone: from Juglan; structure in first source		3.1710
azadiradione
azadiradione: structure in first source. azadiradione : A tetracyclic triterpenoid that is 4,4,8-trimethylandrosta-1,14-diene substituted by oxo groups at positions 3 and 16, an acetoxy group at position 7 and a furan-3-yl group at position 17. Isolated from Azadirachta indica, it exhibits antimycobacterial and anti-inflammatory activities.		3.1710acetate ester;
cyclic terpene ketone;
furans;
limonoid;
tetracyclic triterpenoid		anti-inflammatory agent;
antimycobacterial drug;
plant metabolite
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.0810
thuggacin a
thuggacin A: structure in first source		3.1710
(1S,3aR,4S,6S,6aS,9aS,9bS)-9a-isocyano-6-(2-isocyano-2-methylpropyl)-1,4-dimethyl-7-methylidene-2,3,3a,4,5,6,6a,8,9,9b-decahydro-1H-phenalene
[no description available]		3.1710diterpenoidmetabolite
chaetoviridin E
chaetoviridin E : An azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a methyl group at position 6a, a 2-methylbut-2-enoyl group at position 9 and a 3-methylpent-1-en-1-yl group at position 3. It has been isolated from Chaetomium globosum.		3.1710azaphilone;
enone;
gamma-lactone;
organic heterotricyclic compound;
organochlorine compound		Chaetomium metabolite
centratherin
centratherin: from Eremanthus eriopus (Asteraceae); structure in first source		3.1710
epoxyazadiradione
epoxyazadiradione: limonoid from neem tree Azadirachta indica; RN given for (5alpha,7alpha,13alpha,14beta,15beta,17alpha)-isomer; structure in first source. epoxyazadiradione : A limonoid that is azadiradione with an epoxy group across positions 14 and 15. Isolated from Azadirachta indica it exhibits insecticidal activitry against mosquitoes.		3.1710acetate ester;
cyclic terpene ketone;
epoxide;
furans;
limonoid;
pentacyclic triterpenoid		anti-inflammatory agent;
insecticide;
plant metabolite
sch 419560
Sch 419560: isolated from Pseudomonas fluorescens; structure in first source		3.1710
sansanmycin
sansanmycin: isolated from Streptomyces; structure in first source		3.1710
myxopyronin a
myxopyronin A: from Myxococcus fulvus; structure given in first source		3.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		0210
Koch's Disease
[description not available]		02.9910
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.9910
Innate Inflammatory Response
[description not available]		02.0810
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0810
Cholangiocellular Carcinoma
[description not available]		02.2510
Bile Duct Cancer
[description not available]		02.2510
Bile Duct Neoplasms
Tumors or cancer of the BILE DUCTS.		02.2510
Cholangiocarcinoma
A malignant tumor arising from the epithelium of the BILE DUCTS.		07.2510
Cancer of Cervix
[description not available]		02.0810
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.0810
Bladder Cancer
[description not available]		07.110
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		02.110
Cancer of Prostate
[description not available]		02.1510
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.1510
Colorectal Cancer
[description not available]		07.0710
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.0710
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