derricidin profile

derricidin: from Lonchocarpus sericeus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Lonchocarpus	genus	[no description available]	Fabaceae	The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

ID Source	ID
PubMed CID	5961410
CHEMBL ID	450771
CHEBI ID	196253
SCHEMBL ID	18265486
MeSH ID	M000606782

Synonym
51619-65-9
nsc-270894
nsc270894
derricidin
trans-1-(2-hydroxy-4-((3-methyl-2-butenyl)oxy)phenyl)-3-phenyl-2-propen-1-one
2-propen-1-one, 1-(2-hydroxy-4-((3-methyl-2-butenyl)oxy)phenyl)-3-phenyl-, (e)-
cordoin
LMPK12120040
bdbm29137
substituted chalcone, 5a
CHEMBL450771
(e)-1-[2-hydroxy-4-(3-methylbut-2-enoxy)phenyl]-3-phenylprop-2-en-1-one
CHEBI:196253
38965-74-1
SCHEMBL18265486
DTXSID301318508

Class	Description
chalcones	A ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50 (µMol)	18.7600	0.0000	2.3789	9.7700	AID1798967
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50 (µMol)	4,669.2603	0.0000	1.8914	9.5700	AID1057563; AID1798967; AID349912
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
biogenic amine metabolic process	Amine oxidase [flavin-containing] A	Homo sapiens (human)
positive regulation of signal transduction	Amine oxidase [flavin-containing] A	Homo sapiens (human)
dopamine catabolic process	Amine oxidase [flavin-containing] A	Homo sapiens (human)
response to xenobiotic stimulus	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to toxic substance	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to aluminum ion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to selenium ion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
negative regulation of serotonin secretion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
phenylethylamine catabolic process	Amine oxidase [flavin-containing] B	Homo sapiens (human)
substantia nigra development	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to lipopolysaccharide	Amine oxidase [flavin-containing] B	Homo sapiens (human)
dopamine catabolic process	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to ethanol	Amine oxidase [flavin-containing] B	Homo sapiens (human)
positive regulation of dopamine metabolic process	Amine oxidase [flavin-containing] B	Homo sapiens (human)
hydrogen peroxide biosynthetic process	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to corticosterone	Amine oxidase [flavin-containing] B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
protein binding	Amine oxidase [flavin-containing] A	Homo sapiens (human)
primary amine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
aliphatic amine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
monoamine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
flavin adenine dinucleotide binding	Amine oxidase [flavin-containing] A	Homo sapiens (human)
protein binding	Amine oxidase [flavin-containing] B	Homo sapiens (human)
primary amine oxidase activity	Amine oxidase [flavin-containing] B	Homo sapiens (human)
electron transfer activity	Amine oxidase [flavin-containing] B	Homo sapiens (human)
identical protein binding	Amine oxidase [flavin-containing] B	Homo sapiens (human)
aliphatic amine oxidase activity	Amine oxidase [flavin-containing] B	Homo sapiens (human)
monoamine oxidase activity	Amine oxidase [flavin-containing] B	Homo sapiens (human)
flavin adenine dinucleotide binding	Amine oxidase [flavin-containing] B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
mitochondrion	Amine oxidase [flavin-containing] A	Homo sapiens (human)
mitochondrial outer membrane	Amine oxidase [flavin-containing] A	Homo sapiens (human)
cytosol	Amine oxidase [flavin-containing] A	Homo sapiens (human)
mitochondrion	Amine oxidase [flavin-containing] A	Homo sapiens (human)
mitochondrion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
mitochondrial envelope	Amine oxidase [flavin-containing] B	Homo sapiens (human)
mitochondrial outer membrane	Amine oxidase [flavin-containing] B	Homo sapiens (human)
dendrite	Amine oxidase [flavin-containing] B	Homo sapiens (human)
neuronal cell body	Amine oxidase [flavin-containing] B	Homo sapiens (human)
mitochondrion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (32)

Assay ID	Title	Year	Journal	Article
AID349918	Inhibition of human MAO-B at 20 uM before washing	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Chalcones: a valid scaffold for monoamine oxidases inhibitors.
AID388004	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microdilution broth method	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	Structure-activity relationship of antibacterial chalcones.
AID388001	Antibacterial activity against Bacillus cereus ATCC 11778 after 24 hrs by microdilution broth method	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	Structure-activity relationship of antibacterial chalcones.
AID607593	Cytotoxicity against human U373 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID449576	Anticonvulsant activity in mouse at 300 mg/kg, ip after 120 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID1359727	Cytotoxicity against human THP1 cells after 72 hrs by Alamar blue assay	2018	European journal of medicinal chemistry, May-25, Volume: 152	Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.
AID1359724	Cytotoxicity against African green monkey Vero cells after 72 hrs by Alamar blue assay	2018	European journal of medicinal chemistry, May-25, Volume: 152	Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.
AID349910	Inhibition of human recombinant MAO-A assessed as hydrogen peroxide production at 20 uM	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Chalcones: a valid scaffold for monoamine oxidases inhibitors.
AID1359728	Selectivity index, ratio of CC50 for human THP1 cells to IC50 for Leishmania donovani MHOM/NP/02/BPK282/0c14	2018	European journal of medicinal chemistry, May-25, Volume: 152	Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.
AID449574	Anticonvulsant activity in mouse at 300 mg/kg, ip after 30 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID388003	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microdilution broth method	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	Structure-activity relationship of antibacterial chalcones.
AID349916	Selectivity index, ratio of inhibition of human recombinant MAO-A at 20 uM or 50 uM to IC50 for human recombinant MAO-B	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Chalcones: a valid scaffold for monoamine oxidases inhibitors.
AID449575	Anticonvulsant activity in mouse at 300 mg/kg, ip after 60 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID1057563	Inhibition of MAO-B (unknown origin)	2013	Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24	Chromenylchalcones with inhibitory effects on monoamine oxidase B.
AID635592	Antiplatelet activity against New Zealand white rabbit platelets assessed as inhibition of ADP-induced platelet aggregation at 50 ug/mL treated 2 mins before ADP challenge measured after 4 mins by turbidimetric analysis	2011	Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24	Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation.
AID607594	Cytotoxicity against human OE21 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID449572	Anticonvulsant activity in mouse at 300 mg/kg, ip after 5 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID607598	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID635593	Antiplatelet activity against New Zealand white rabbit platelets assessed as inhibition of collagen-induced platelet aggregation at 50 ug/mL treated 2 mins before collagen challenge measured after 4 mins by turbidimetric analysis	2011	Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24	Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation.
AID607597	Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID349912	Inhibition of human recombinant MAO-B assessed as hydrogen peroxide production	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Chalcones: a valid scaffold for monoamine oxidases inhibitors.
AID607601	Cytotoxicity against human U373 cells assessed as growth inhibition at MTT assay-related IC50 by quantitative video microscopy relative to control	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID1359726	Antileishmanial activity against promastigote stage of Leishmania donovani MHOM/NP/02/BPK282/0c14 assessed as parasite growth inhibition up to 40 uM after 72 hrs by Alamar blue assay	2018	European journal of medicinal chemistry, May-25, Volume: 152	Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.
AID607600	Induction of human U373 cell death assessed as morphological changes at MTT assay-related IC50 after 72 hrs by quantitative video microscopy	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID607596	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID388002	Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution broth method	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	Structure-activity relationship of antibacterial chalcones.
AID607595	Cytotoxicity against human A549 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.
AID349919	Inhibition of human MAO-B at 20 uM after repeated washing	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Chalcones: a valid scaffold for monoamine oxidases inhibitors.
AID1057564	Inhibition of MAO-B (unknown origin) assessed as residual activity	2013	Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24	Chromenylchalcones with inhibitory effects on monoamine oxidase B.
AID449573	Anticonvulsant activity in mouse at 300 mg/kg, ip after 15 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID1359725	Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for Leishmania donovani MHOM/NP/02/BPK282/0c14	2018	European journal of medicinal chemistry, May-25, Volume: 152	Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.
AID1798967	MAO Enzyme Inhibition Assay from Article 10.1021/jm801590u: \\Chalcones: a valid scaffold for monoamine oxidases inhibitors.\\	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Chalcones: a valid scaffold for monoamine oxidases inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	6 (66.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	2.06	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	2.06	1	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
iproniazid [no description available]	2.05	1	carbohydrazide; pyridines
moclobemide Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.. moclobemide : A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.	2.05	1	benzamides; monochlorobenzenes; morpholines	antidepressant; environmental contaminant; xenobiotic
clorgyline Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.. clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.	2.05	1	aromatic ether; dichlorobenzene; terminal acetylenic compound; tertiary amino compound	antidepressant; EC 1.4.3.4 (monoamine oxidase) inhibitor
phloretin [no description available]	2.04	1	dihydrochalcones	antineoplastic agent; plant metabolite
resacetophenone resacetophenone: structure in first source. 2',4'-dihydroxyacetophenone : A dihydroxyacetophenone that is acetophenone carrying hydroxy substituents at positions 2' and 4'.	2.06	1	dihydroxyacetophenone; resorcinols	plant metabolite
vanillic acid Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).. vanillic acid : A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.	2.06	1	methoxybenzoic acid; monohydroxybenzoic acid	plant metabolite
selegiline Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl.	2.47	2	selegiline; terminal acetylenic compound	geroprotector
clopidogrel Clopidogrel: A ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION.. clopidogrel : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.	2.06	1	methyl ester; monochlorobenzenes; thienopyridine	anticoagulant; P2Y12 receptor antagonist; platelet aggregation inhibitor
2,4,6-trihydroxyacetophenone monoacetylphloroglucinol: structure in first source. 2',4',6'-trihydroxyacetophenone : A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acidic glycans and glycopeptides.	2.06	1	aromatic ketone; benzenetriol; methyl ketone	MALDI matrix material; plant metabolite
a-130a [no description available]	2.46	2
ferulic acid ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.	2.06	1	ferulic acids	anti-inflammatory agent; antioxidant; apoptosis inhibitor; cardioprotective agent; MALDI matrix material; plant metabolite
trans-4-coumaric acid hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents.. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid.. 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring.	2.06	1	4-coumaric acid	food component; mouse metabolite; plant metabolite
chalcone trans-chalcone : The trans-isomer of chalcone.	2.47	2	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
isoliquiritigenin [no description available]	2.46	2	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist
coniferyl alcohol coniferyl alcohol: structure. coniferol : A phenylpropanoid that is one of the main monolignols, produced by the reduction of the carboxy functional group in cinnamic acid and the addition of a hydroxy and a methoxy substituent to the aromatic ring.	2.06	1	guaiacols; phenylpropanoid	animal metabolite; monolignol; mouse metabolite; pheromone; plant metabolite; volatile oil component
aurapten aurapten: RN refers to (E)-isomer; structure given in first source. auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.	2.46	2	coumarins; monoterpenoid	antihypertensive agent; antineoplastic agent; antioxidant; apoptosis inducer; dopaminergic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; gamma-secretase modulator; gastrointestinal drug; hepatoprotective agent; matrix metalloproteinase inhibitor; neuroprotective agent; plant metabolite; PPARalpha agonist; vulnerary
umbelliprenin umbelliprenin: RN given refers to cpd with unspecified isomeric designation	2.06	1	terpene lactone
sinapyl alcohol sinapyl alcohol: has anti-inflammatory and antinociceptive properties; structure in first source. trans-sinapyl alcohol : Sinapyl alcohol in which the configuration of the propenyl double bond is E. It is one of the main monolignols.. sinapyl alcohol : A primary alcohol, being cinnamyl alcohol hydroxylated at C-4 and methoxylated at C-3 and -5.	2.06	1	sinapyl alcohol	monolignol
coniferaldehyde coniferaldehyde: from aqueous extract of Senra incana. coniferyl aldehyde : A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3.	2.06	1	cinnamaldehydes; guaiacols; phenylpropanoid	antifungal agent; plant metabolite
sinapaldehyde sinapyl aldehyde: structure in first source. (E)-sinapaldehyde : A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and methoxy groups at positions 3 and 5.	2.06	1	cinnamaldehydes; dimethoxybenzene; phenols	antifungal agent; plant metabolite
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.17	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
isobavachalcone isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.	2.04	1	chalcones; polyphenol	antibacterial agent; metabolite; platelet aggregation inhibitor
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.06	1	hydroxycoumarin	fluorescent probe; food component; plant metabolite
collinin collinin: the active principle of Zanthoxylum spp.; structure in first source	2.05	1
lacinartin lacinartin: from Zanthoxylum schinifolium; structure in first source	2.46	2
2',4'-dihydroxychalcone 2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source	2.06	1
4-hydroxycordoin 4-hydroxycordoin: antibacterial and anti-inflammatory from Lonchocarpus neuroscapha Benth. (Fabaceae); structure in first source. 4-hydroxycordoin : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at position 4 and 2' and a (3-methylbut-2-en-1-yl)oxy group at position 4'. It has been isolated from Lonchocarpus neuroscapha.	2.74	3	aromatic ether; chalcones; polyphenol	anti-inflammatory agent; antibacterial agent; plant metabolite
4-hydroxylonchocarpin 4-hydroxylonchocarpin: structure in first source	2.04	1
isocordoin isocordoin: a metabolite biotransformed from Morus nigra; structure in first source	2.04	1	chalcones
Lonchocarpin lonchocarpine: has anti-bacterial, anti-inflammatory, antiproliferative, antioxidant, and antiepileptic activities; isolated from Abrus precatorius; structure in first source	2.04	1	chalcones
4-hydroxyderricin 4-hydroxyderricin: from Angelica keiskei; RN given refers to (E)-isomer; structure in first source	2.04	1	chalcones
o-geranylsinapyl alcohol O-geranylsinapyl alcohol: structure given in first source; isolated from the bark of Fagara rhetza, an Indonesian medicinal plant	2.06	1
nelumal a nelumal A: aromatase inhibitor from Ligularia nelumbifolia; structure in first source	2.06	1
4'-geranyloxyferulic acid 4'-geranyloxyferulic acid: a colon cancer chemopreventive agent isolated from grapefruit skin; structure in first source	2.46	2
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	2.04	1

Condition	Relationship Strength	Studies
Absence Seizure [description not available]	2.05	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	2.05	1
Cancer of Colon [description not available]	2.11	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.11	1

derricidin

Description

Cross-References

Synonyms (16)

Drug Classes (1)

Protein Targets (2)

Inhibition Measurements

Biological Processes (15)

Molecular Functions (7)

Ceullar Components (6)

Bioassays (32)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.43

Study Types

derricidin

Description

Related Flora

Cross-References

Synonyms (16)

Drug Classes (1)

Protein Targets (2)

Inhibition Measurements

Biological Processes (15)

Molecular Functions (7)

Ceullar Components (6)

Bioassays (32)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.43

Study Types

Related Drugs (37)

Related Conditions (4)