Acropachy, Hereditary

A condition chiefly characterized by thickening of the skin of the head and distal extremities, deep folds and furrows of the skin of the forehead, cheeks, and scalp, SEBORRHEA; HYPERHIDROSIS; periostosis of the long bones, digital clubbing, and spadelike enlargement of the hands and feet. It is more prevalent in the male, and is usually first evident during adolescence. Inheritance is primarily autosomal recessive, but an autosomal dominant form exists.

Synonym
Primary Hypertrophic Osteoarthropathy, Autosomal Dominant
Cranioosteoarthropathy
Touraine-Solente-Gole Syndrome
Osteoarthropathy, Primary Hypertrophic
Idiopathic Hypertrophic Osteoarthropathy
Pachydermoperiostosis, Autosomal Recessive
Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant
Digital Clubbing, Isolated Congenital
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive
Pachydermoperiostosis, Autosomal Dominant
Clubbing of Digits
Acropachy, Hereditary
Pachydermoperiostosis
Familial Idiopathic Osteoarthropathy Of Childhood
Currarino Idiopathic Osteoarthropathy

Excerpt	Reference
"Pachydermoperiostosis is a rare osteo-cutaneous disease characterized by hypertrophy of bones and surrounding soft tissues."	( Bianchi, L; Carrozzo, AM; Iraci, S; Lubrano, C; Nini, G; Spera, G; Tomassoli, M, 1995)
"Pachydermoperiostosis is manifested by finger clubbing, hypertrophic skin changes, and periosteal bone formation."	( Chastanet, P; Cortet, B; Cotten, A; Delcambre, B; Deprez, X; Flipo, RM; Guyot-Drouot, MH; Solau-Gervais, E, 2000)
"Idiopathic hypertrophic osteoarthropathy is a rare syndrome, characterized by clubbing, progressive enlargement of the joints, coarse facial features suggesting acromegaly, palmoplantar hyperhidrosis, fibrous covering at the ends of long bones (periostosis), and acro-osteolysis."	( Kalyoncu, M; Mungan, I; Okten, A; Orbak, Z, 2007)
"Three variants of primary hypertrophic osteoarthropathy are distinguished: pachydermoperiostosis, which shows as additional symptom pachydermia; cranio-osteoarthropathy, which has a decreased neurocranium ossification as additional feature; and a secondary form."	( Bennett, C; Dabir, T; Hall, CM; Hennekam, RCM; Sills, AM; Wilson, LC, 2007)
"Pachydermoperiostosis is a rare clinical entity characterized by skin thickening of the forehead, eyelids, and hands, digital clubbing, and periostosis."	( Costa, MM; Fonseca, JE; Gaião, L; Janeiro, A; Madruga Dias, JA; Miltenberger-Miltenyi, G; Pereira da Silva, JA; Perpétuo, I; Rodrigues, AM; Rosa, RS, 2014)
"Pachydermoperiostosis is a rare genetic disease known as primary or idiopathic hypertrophic osteoarthropathy (HOA)/Touraine-Solente-Gole syndrome."	( Field, AY; Fleming, JC; Hlaing, SS; Mattis, AC; Mowatt, LL; Nelson, CC; Noguera, CM; Palmer, GL; Yee, HL, 2023)

Excerpt	Reference
"We report a case of pachydermoperiostosis with arthralgia, acroosteolysis, and recurrent staphylococcal folliculitis of the face, treated with colchicine (0."	( Fattorini, L; Gerini, G; Lombardi, A; Lotti, T; Matucci-Cerinic, M; Petrini, N; Pignone, A, 1988)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	47 (31.97)	23.3326
1990's	24 (16.33)	12.5806
2000's	22 (14.97)	18.1394
2010's	41 (27.89)	28.8240
2020's	13 (8.84)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
salicylic acid	low	8	0
uric acid	low	2	0
urea	low	1	0
aspirin	low	2	0
azathioprine	low	2	0
celecoxib	low	1	0
etidronate	low	2	0
etodolac	low	1	0
hydroxychloroquine	low	1	0
hydroxyurea	low	1	0
ibuprofen	low	1	0
indomethacin	low	1	0
pamidronate	low	3	0
propranolol	low	1	0
sodium fluoride	low	1	0
risedronic acid	low	1	0
sulfasalazine	low	2	0
tazarotene	low	1	0
krypton	low	1	0
prednisolone	low	6	0
estriol	low	1	0
aldosterone	low	1	0
prednisone	low	4	0
estrone	low	1	0
colchicine	low	3	0
technetium	low	5	0
fluorine	low	2	0
trolamine salicylate	medium	17	1
fluorodeoxyglucose f18	low	2	0
zoledronic acid	low	1	0
voriconazole	low	1	0
mk 0663	medium	6	1
methotrexate	low	2	0
7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid	low	2	0
organophosphonates	low	1	0
bortezomib	low	1	0
bradykinin	low	2	0
retinol	low	2	0
glycosides	low	1	0
pyrophosphate	low	2	0
tamoxifen	low	2	0
17-ketosteroids	low	2	0
dinoprostone	medium	21	1
isotretinoin	medium	2	1
phenylephrine hydrochloride	low	2	0
morphine	low	1	0
gallium	low	1	0
technetium tc 99m pyrophosphate	low	2	0
beta-escin	low	1	0
pituitrin	low	1	0
acid phosphatase	low	1	0
gastrins	low	1	0
endothelin-1	low	1	0
sodium pertechnetate tc 99m	low	1	0
cardiovascular agents	low	1	0
chondroitin	low	1	0
epidermal growth factor	low	2	0
transforming growth factor beta	low	3	0
cyclin d1	low	1	0
technetium tc 99m sulfur colloid	low	1	0
cyclosporine	low	1	0
technetium tc 99m medronate	low	2	0
eye	low	1	0

Protein Targets (837)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
AR protein	24	0	0	24
glucocorticoid receptor [Homo sapiens]	20	0	0	20
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
geminin	19	0	0	19
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	4	0	4
Mineralocorticoid receptor	0	3	3	6
Androgen receptor	0	11	0	11
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	3	0	4
Guanine nucleotide-binding protein G	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
interleukin 8	5	0	0	5
thioredoxin reductase	11	0	0	11
GLS protein	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
thyroid stimulating hormone receptor	8	0	0	8
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
EWS/FLI fusion protein	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
estrogen-related nuclear receptor alpha	23	0	0	23
estrogen nuclear receptor alpha	27	0	0	27
cytochrome P450 2D6	4	0	0	4
glucocerebrosidase	5	0	0	5
peroxisome proliferator-activated receptor delta	12	0	0	12
Rac1 protein	0	0	2	2
IDH1	10	0	0	10
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
Bloom syndrome protein isoform 1	8	0	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	9	0	0	9
DNA polymerase kappa isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Prostaglandin-H2 D-isomerase	0	2	0	2
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	21
Solute carrier family 22 member 6	0	5	0	5
Prostaglandin G/H synthase 1	0	4	0	5
Prostaglandin G/H synthase 2	0	4	0	5
Bile salt export pump	0	27	0	27
Epidermal growth factor receptor	0	4	0	4
Carbonic anhydrase 1	0	13	0	13
Carbonic anhydrase 2	0	14	1	16
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	2	1	0	3
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	8
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	2	1	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	9	0	10
Adenosine receptor A1	0	4	0	4
Adenosine receptor A2a	0	3	0	3
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	12	2	15
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	7	0	0	7
Ras-related protein Rab-2A	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	8	3	1	12
Prostaglandin G/H synthase 2	0	8	0	8
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Canalicular multispecific organic anion transporter 1	0	18	0	18
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Ferritin light chain	5	0	0	5
acetylcholinesterase	9	0	0	9
phosphopantetheinyl transferase	4	0	0	4
RAR-related orphan receptor gamma	16	0	0	16
SMAD family member 2	8	0	0	8
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	6	0	0	6
SMAD family member 3	8	0	0	8
TDP1 protein	19	0	0	19
GLI family zinc finger 3	15	0	0	15
Microtubule-associated protein tau	7	0	0	7
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
retinoid X nuclear receptor alpha	18	0	0	18
farnesoid X nuclear receptor	12	0	0	12
pregnane X nuclear receptor	15	0	0	15
G	8	0	0	8
polyprotein	6	0	0	6
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	14	0	0	14
arylsulfatase A	5	0	0	5
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
thyroid stimulating hormone receptor	9	0	0	9
activating transcription factor 6	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	10	0	0	10
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	14	0	0	14
heat shock protein beta-1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	6	0	0	6
lamin isoform A-delta10	18	0	0	18
Gamma-aminobutyric acid receptor subunit pi	8	1	1	10
Bile salt export pump	0	6	0	6
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Interferon beta	12	0	0	12
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Cellular tumor antigen p53	16	0	0	16
Gamma-aminobutyric acid receptor subunit beta-1	8	1	1	10
Gamma-aminobutyric acid receptor subunit delta	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	1	10
Glutamate receptor 2	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	1	10
Gamma-aminobutyric acid receptor subunit beta-3	8	1	1	10
Gamma-aminobutyric acid receptor subunit beta-2	8	1	1	10
GABA theta subunit	8	1	1	10
Inositol hexakisphosphate kinase 1	8	0	0	8
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit epsilon	8	1	1	10
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	8	0	0	8
Dihydroorotate dehydrogenase	0	1	0	1
Protease	0	1	0	1
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
PPM1D protein	5	0	0	5
caspase 7, apoptosis-related cysteine protease	4	0	0	4
estrogen receptor 2 (ER beta)	12	0	0	12
progesterone receptor	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
caspase-3	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Caspase-7	4	0	0	4
caspase-3	4	0	0	4
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	2	0	2
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	4	0	4
Prothrombin	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Carbonic anhydrase 3	0	3	0	3
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Carbonic anhydrase 4	0	5	0	5
Carbonic anhydrase 6	0	3	0	3
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	3
Carbonic anhydrase 5A, mitochondrial	0	4	0	4
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Carbonic anhydrase 7	0	3	0	3
26S proteasome regulatory subunit 6B	0	1	0	1
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	2	0	2
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	6	0	7
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	2	0	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	2	0	2
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	4	0	4
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Carbonic anhydrase 14	0	4	0	4
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	4	1	7
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	1	3	4
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Cruzipain	5	0	0	5
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
glp-1 receptor, partial	2	0	0	2
pregnane X receptor	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
USP1 protein, partial	9	0	0	9
Smad3	2	0	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
67.9K protein	7	0	0	7
Carbonic anhydrase	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
interferon gamma precursor	0	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
Prostaglandin E synthase	0	2	0	2
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	2	0	2
Procathepsin L	0	2	2	4
Aldo-keto reductase family 1 member B1	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	7	1	8
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	7	0	7
Neuronal acetylcholine receptor subunit beta-2	1	2	0	3
Beta-3 adrenergic receptor	0	6	1	7
Alpha-1B adrenergic receptor	0	7	1	8
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	7	1	9
5-hydroxytryptamine receptor 1A	0	5	1	7
D(1A) dopamine receptor	0	5	1	6
Prostaglandin G/H synthase 1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	4	0	4
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	10	0	10
Sodium-dependent serotonin transporter	0	1	1	2
Delta-type opioid receptor	0	2	0	3
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	5	2	10
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	4
Carbonic anhydrase	0	4	0	4
Alpha-1A adrenergic receptor	0	7	1	8
Carbonic anhydrase	0	1	0	1
Histone deacetylase 4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	5	1	6
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Mitogen-activated protein kinase 14	0	3	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	4
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Carbonic anhydrase 4	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Beta-lactamase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Efflux transporter	0	1	0	1
Beta-lactamase	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Chain A, Beta-lactamase	2	0	0	2
Luciferase	6	0	0	6
endonuclease IV	2	0	0	2
PAX8	0	0	0	1
Thrombopoietin	1	0	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	3	0	0	3
chromobox protein homolog 1	8	0	0	8
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	7	2	10
Cytochrome P450 3A4	0	5	2	7
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Histamine H2 receptor	4	0	0	4
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
ATP-dependent phosphofructokinase	4	0	0	4
regulator of G-protein signaling 4	3	0	0	3
vitamin D3 receptor isoform VDRA	9	0	0	9
mitogen-activated protein kinase 1	4	0	0	4
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	4	0	7
Solute carrier family 22 member 7	0	0	0	3
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	4	0	6
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Endothelin-1 receptor	0	2	1	3
Estrogen receptor	0	8	2	12
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	2
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Alpha-synuclein	1	3	0	4
Lanosterol 14-alpha demethylase	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
NFKB1 protein, partial	4	0	0	4
GALC protein	2	0	0	2
nonstructural protein 1	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
glucokinase regulatory protein	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Steryl-sulfatase	0	1	0	1
Aromatase	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
5-hydroxytryptamine receptor 2B	0	8	1	9
Inositol monophosphatase 1	2	0	0	2
TAR DNA-binding protein 43	4	0	0	4
Cytochrome P450 1B1	0	1	0	1
Estrogen receptor beta	0	5	2	8
Ghrelin O-acyltransferase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
acid sphingomyelinase	2	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
15-lipoxygenase, partial	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Dihydrofolate reductase	0	4	0	5
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	3	3
Transmembrane protease serine 2	0	0	2	2
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	4	3	8
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Muscarinic acetylcholine receptor M1	0	4	1	5
Alpha-2C adrenergic receptor	0	2	2	5
Muscarinic acetylcholine receptor M3	0	4	1	5
Alpha-1D adrenergic receptor	0	4	1	6
Spike glycoprotein	4	0	2	6
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Albumin	0	3	3	6
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
Acetylcholinesterase	0	2	0	2
Caspase-1	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	2
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Cytochrome P450 2J2	0	4	0	4
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	4	0	0	4
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	3	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	4	0	4
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Lanosterol 14-alpha demethylase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	5	2	8
Delta-type opioid receptor	0	5	2	8
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	5	2	8
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	4
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	5	0	6
Farnesyl pyrophosphate synthase	0	6	0	6
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	5	0	5
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	3
D(1A) dopamine receptor	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Cytochrome P450 1A2	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
D(2) dopamine receptor	0	3	1	4
Beta-1 adrenergic receptor	0	2	1	4
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	1	5
5-hydroxytryptamine receptor 1B	0	4	0	4
Adenosine receptor A2a	0	3	1	4
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	4	1	5
Beta-2 adrenergic receptor	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Butyrophilin subfamily 3 member A1	0	0	2	3
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
H	0	2	0	2
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Flavin reductase (NADPH)	0	0	1	1
Cystine/glutamate transporter	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Substance-K receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Retinoic acid receptor alpha	0	0	1	1
Retinoic acid receptor beta	0	0	1	1
Retinoic acid receptor gamma	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(15)

Research Excerpts

Overview

Treatment

Research

Studies (147)

Protein Targets (837)

Acropachy, Hereditary

Synonyms(15)

Research Excerpts

Overview

Treatment

Research

Studies (147)

Drugs Studied (82)

Protein Targets (837)