Hemangioblastoma

A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)

Synonym
Hemangioblastoma

Excerpt	Reference
"Hemangioblastomas are highly vascular tumors of the central nervous system that overexpress the hypoxia-inducible gene, vascular endothelial growth factor (VEGF), as a consequence of mutational inactivation of the von Hippel-Lindau tumor suppressor gene (VHL)."	( Krieg, M; Marti, HH; Plate, KH, 1998)
"Hemangioblastomas are intracranial and intraspinal tumors arising sporadically or in patients with von Hippel-Lindau disease."	( Boyd, AS; Zhang, J, 2001)
"Retinal capillary hemangioblastoma is one of the earliest manifestations of VHL disease."	( Agostini, HT; Junker, B; Schmidt, D, 2007)
"Filum terminale hemangioblastoma is an extremely rare tumour with only a few case reports in the literature."	( Biggs, M; Sergides, IG; Wainwright, KL, 2009)
"Complications from hemangioblastoma are among the principal causes of death from this syndrome."	( Aricò, M; Buccoliero, AM; Genitori, L; Giordano, F; Mussa, F; Sanzo, M; Sardi, I, 2009)
"Hemangioblastoma is a benign tumor that can occur sporadically, or in association with von Hippel-Lindau disease in approximately one-quarter of the cases."	( Chan, JK; Cheung, H; Ip, YT; Yuan, JQ, 2010)
"Hemangioblastoma is a highly vascular benign tumor that typically arises in the cerebellum or spine."	( Hara, T; Hasuo, K; Ito, K; Kubota, K; Morooka, M; Okamoto, K, 2011)
"Intracranial hemangioblastomas are benign but hypervascular tumors, most commonly located in the cerebellum, which are difficult to resect without significant operative blood loss."	( Ding, D; Evans, AJ; Liu, KC; Starke, RM, 2014)
"Retinal hemangioblastoma is one of the most common tumors in von Hippel-Lindau disease."	( Chan, CC; Chen, S; Chew, EY, 2015)
"Hemangioblastoma is a rare benign neoplasm, accounting for less than 2% of all primitive brain tumors."	( Dietrich, PY; Haller, S; Koka, A; Leemann, B; Merkler, D; Migliorini, D; Pugliesi-Rinaldi, A; Schaller, K, 2015)
"Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome."	( Bagci, U; Jassel, IS; Karantanas, AH; Millo, C; Papadakis, GZ; Patronas, NJ; Sadowski, SM, 2017)
"Retinal hemangioblastoma is the ocular hallmark lesion of von Hippel-Lindau disease."	( Caporossi, A; Federici, M; Gambini, G; Maceroni, M; Minnella, AM; Pagliei, V, 2018)
"Hemangioblastoma is a rare tumor of the central nervous system (CNS)."	( Al-Rahawan, MM; Belirgen, M; Brewer, D; Nguyen, TH; Pham, T; Strickland, T, 2018)
"Retinal hemangioblastomas are the hallmark ophthalmic finding."	( Kumar, KC; Saluja, K; Tyagi, S, 2023)

Excerpt	Reference
"To date, hemangioblastomas have not been described in the skin."	( Boyd, AS; Zhang, J, 2001)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (1.53)	23.3326
1990's	22 (16.79)	12.5806
2000's	37 (28.24)	18.1394
2010's	59 (45.04)	28.8240
2020's	11 (8.40)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	2	0
choline	low	2	0
dimethyl sulfoxide	low	3	0
inositol	low	1	0
urea	low	1	0
vanilmandelic acid	low	1	0
alendronate	low	1	0
aspirin	low	1	0
carbamazepine	low	1	0
pentetic acid	low	4	0
2-propanol	low	1	0
midodrine	low	1	0
propranolol	low	4	0
rofecoxib	low	1	0
vorinostat	low	1	0
thalidomide	low	4	0
lysine	low	1	0
leucine	low	1	0
methionine	low	2	0
asparagine	low	1	0
tryptophan	low	1	0
arginine	low	1	0
perflutren	low	1	0
pyrroles	medium	6	2
quinazolines	low	1	0
indazoles	low	3	0
thiazoles	low	1	0
fluorescein	low	1	0
sulfur hexafluoride	medium	1	1
enbucrilate	low	3	0
ruthenium	low	1	0
tantalum	low	1	0
gadolinium	medium	10	1
iodine	low	1	0
transferrin	low	1	0
diltiazem	low	1	0
propiconazole	low	2	0
fomesafen	low	1	0
3-iodobenzylguanidine	low	1	0
fluorodeoxyglucose f18	low	4	0
anecortave acetate	low	1	0
landiolol	low	1	0
proline	low	2	0
erlotinib hydrochloride	low	1	0
bromochloroacetic acid	low	6	0
iodopyracet	low	1	0
deamino arginine vasopressin	low	1	0
semaxinib	medium	4	1
su 11248	medium	3	1
ici 118551	low	2	0
everolimus	low	1	0
gadolinium dtpa	low	5	0
pazopanib	low	3	0
losartan potassium	low	10	0
indocyanine green	low	12	0
hes1 protein, human	low	1	0
neuropeptide y	low	1	0
oligonucleotides	low	1	0
chiniofon	low	1	0
tetracycline	low	1	0
roquinimex	low	1	0
cyclin d1	low	1	0
lewis x antigen	low	2	0
epoetin alfa	low	1	0
transforming growth factor alpha	low	1	0
gallium ga 68 dotatate	low	3	0
technetium tc-99m tetrofosmin	low	1	0
68ga-dotanoc	low	1	0
dacarbazine	low	1	0
eye	low	3	0

Protein Targets (1,187)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
RAR-related orphan receptor gamma	13	0	0	13
GLI family zinc finger 3	10	0	0	10
AR protein	16	0	0	16
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	8	0	0	8
estrogen nuclear receptor alpha	16	0	0	16
peroxisome proliferator-activated receptor delta	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	4	0	0	4
thyroid hormone receptor beta isoform a	5	0	0	5
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
lamin isoform A-delta10	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Glutamate receptor 2	5	0	0	5
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	8	0	0	8
GLS protein	8	0	0	8
Thrombopoietin	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
ras-related protein Rab-9A	1	0	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
lethal factor (plasmid)	6	0	0	6
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	6	0	0	6
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	4	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Chain A, Beta-lactamase	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
geminin	11	0	0	11
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
glucocorticoid receptor [Homo sapiens]	13	0	0	13
thyroid hormone receptor beta isoform 2	9	0	0	9
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	4	0	0	4
NFKB1 protein, partial	3	0	0	3
thyroid stimulating hormone receptor	8	0	0	8
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
chromobox protein homolog 1	7	0	0	7
flap endonuclease 1	5	0	0	5
DNA polymerase iota isoform a (long)	9	0	0	9
muscarinic acetylcholine receptor M1	3	0	0	3
Cytochrome P450 3A4	0	6	0	9
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Carbonic anhydrase 1	0	3	0	5
Carbonic anhydrase 2	0	3	0	5
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
EWS/FLI fusion protein	6	0	0	6
estrogen-related nuclear receptor alpha	14	0	0	14
cytochrome P450 2D6	6	0	0	6
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	2	0	0	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase kappa isoform 1	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	12
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Bile salt export pump	0	14	0	14
Epidermal growth factor receptor	0	6	3	9
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	4	2	6
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	3	1	6
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	11	0	11
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
thyroid stimulating hormone receptor	3	0	0	3
Cellular tumor antigen p53	11	0	0	11
acetylcholinesterase	4	0	0	4
USP1 protein, partial	6	0	0	6
TDP1 protein	12	0	0	12
pregnane X nuclear receptor	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
mitogen-activated protein kinase 1	3	0	0	3
Vpr	1	0	0	1
Bile salt export pump	0	2	0	2
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	4	0	4
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Cytochrome P450 2J2	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	3	0	4
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
peroxisome proliferator activated receptor gamma	9	0	0	9
survival motor neuron protein isoform d	1	0	0	1
Matrix metalloproteinase-9	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Isocitrate lyase	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
estrogen receptor 2 (ER beta)	7	0	0	7
regulator of G-protein signaling 4	3	0	0	3
D(1A) dopamine receptor	3	0	0	3
huntingtin isoform 2	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	1	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit delta	2	1	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	2	1	1	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	2	1	1	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	1	1	4
Gamma-aminobutyric acid receptor subunit gamma-3	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-6	2	1	1	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Histamine H2 receptor	5	1	0	6
5-hydroxytryptamine receptor 7	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-2	2	1	1	4
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	4	0	4
GABA theta subunit	2	1	1	4
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	1	1	4
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Cereblon isoform 4	0	4	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
Insulin-like growth factor-binding protein 5	0	0	1	1
Protein cereblon	0	4	1	6
Receptor tyrosine-protein kinase erbB-2	0	2	2	4
Serine/threonine-protein kinase B-raf	0	1	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
nuclear receptor ROR-gamma isoform 1	4	0	0	4
peripheral myelin protein 22	5	0	0	5
Bone morphogenetic protein receptor type-1B	0	0	3	3
Cell division cycle 7-related protein kinase	0	0	2	2
Serine/threonine-protein kinase PLK4	0	1	3	4
ATP-dependent RNA helicase DDX3X	0	0	3	3
Pyridoxal kinase	0	0	3	3
Citron Rho-interacting kinase	0	0	3	3
Serine/threonine-protein kinase Chk1	0	1	3	4
Aurora kinase A	0	1	3	4
Cyclin-G-associated kinase	0	0	3	3
Ephrin type-B receptor 6	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 3	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 2	0	0	3	3
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	3	3
Dynamin-like 120 kDa protein, mitochondrial	0	0	3	3
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	0	3	3
Serine/threonine-protein kinase ULK1	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	3	3
Ribosomal protein S6 kinase alpha-5	0	0	3	3
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	3	3
Ribosomal protein S6 kinase alpha-4	0	0	3	3
Serine/threonine-protein kinase 16	0	0	3	3
Serine/threonine-protein kinase 10	0	0	3	3
Serine/threonine-protein kinase D3	0	0	3	3
Structural maintenance of chromosomes protein 2	0	0	3	3
Mitogen-activated protein kinase kinase kinase 6	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	3	3
Serine/threonine-protein kinase LATS1	0	0	3	3
Serine/threonine-protein kinase PAK 4	0	2	3	5
Tyrosine-protein kinase ABL1	0	4	4	8
High affinity nerve growth factor receptor	0	0	3	3
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	3	3
ADP/ATP translocase 2	0	0	3	3
Protein kinase C beta type	0	0	3	3
Insulin receptor	0	1	3	4
Tyrosine-protein kinase Lck	0	1	3	4
Tyrosine-protein kinase Fyn	0	0	3	3
Cyclin-dependent kinase 1	0	2	3	5
Glycogen phosphorylase, liver form	0	0	3	3
Tyrosine-protein kinase Fes/Fps	0	0	3	3
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	0	3	3
Tyrosine-protein kinase Lyn	0	0	3	3
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	3	5
Insulin-like growth factor 1 receptor	0	1	3	4
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	3	3
Hepatocyte growth factor receptor	0	1	3	4
Tyrosine-protein kinase HCK	0	1	3	4
Platelet-derived growth factor receptor beta	0	5	3	8
Tyrosine-protein kinase Fgr	0	0	3	3
Serine/threonine-protein kinase A-Raf	0	0	3	3
Glycogen phosphorylase, brain form	0	0	3	3
Breakpoint cluster region protein	0	0	4	4
Serine/threonine-protein kinase pim-1	0	0	3	3
Fibroblast growth factor receptor 1	0	3	3	6
DNA topoisomerase 2-alpha	0	0	3	3
Cyclin-dependent kinase 4	0	0	3	3
ADP/ATP translocase 3	0	0	3	3
Inosine-5'-monophosphate dehydrogenase 2	0	0	3	3
Proto-oncogene tyrosine-protein kinase Src	0	2	3	5
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	3	3
Serine/threonine-protein kinase B-raf	0	0	3	3
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	3	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	3	3
Tyrosine-protein kinase Fer	0	0	3	3
Protein kinase C alpha type	0	0	3	3
cAMP-dependent protein kinase catalytic subunit alpha	0	0	3	3
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	3	3
Casein kinase II subunit alpha'	0	0	3	3
Ras-related protein Rab-6A	0	0	2	2
Ephrin type-A receptor 1	0	0	3	3
Multifunctional protein ADE2	0	0	3	3
cAMP-dependent protein kinase catalytic subunit gamma	0	0	3	3
cAMP-dependent protein kinase catalytic subunit beta	0	0	3	3
Ferrochelatase, mitochondrial	0	0	3	3
Ribosomal protein S6 kinase beta-1	0	0	3	3
Tyrosine-protein kinase JAK1	0	0	3	3
Cyclin-dependent kinase 2	0	2	3	5
Beta-adrenergic receptor kinase 1	0	0	3	3
Probable ATP-dependent RNA helicase DDX6	0	0	3	3
Mitogen-activated protein kinase 3	0	0	3	3
MAP/microtubule affinity-regulating kinase 3	0	0	3	3
Deoxycytidine kinase	0	0	3	3
Mitogen-activated protein kinase 1	0	0	3	3
Ephrin type-A receptor 2	0	0	3	3
Ephrin type-B receptor 2	0	0	3	3
Non-receptor tyrosine-protein kinase TYK2	0	0	3	3
UMP-CMP kinase	0	0	2	2
Phosphatidylethanolamine-binding protein 1	0	0	3	3
Wee1-like protein kinase	0	0	3	3
Heme oxygenase 2	0	0	3	3
S-adenosylmethionine synthase isoform type-2	0	0	3	3
DnaJ homolog subfamily A member 1	0	0	3	3
RAC-alpha serine/threonine-protein kinase	0	2	3	5
RAC-beta serine/threonine-protein kinase	0	0	3	3
Dual specificity protein kinase TTK	0	0	3	3
DNA replication licensing factor MCM4	0	0	3	3
Myosin-10	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 2	0	0	3	3
Receptor-type tyrosine-protein kinase FLT3	0	3	3	7
Bone morphogenetic protein receptor type-1A	0	0	3	3
Activin receptor type-1B	0	0	3	3
TGF-beta receptor type-1	0	0	3	3
TGF-beta receptor type-2	0	0	3	3
Electron transfer flavoprotein subunit beta	0	0	2	2
Tyrosine-protein kinase CSK	0	0	3	3
Glycine--tRNA ligase	0	0	3	3
Protein kinase C iota type	0	0	3	3
Exosome RNA helicase MTR4	0	0	3	3
Serine/threonine-protein kinase mTOR	0	2	3	5
Tyrosine-protein kinase Tec	0	0	3	3
Tyrosine-protein kinase ABL2	0	0	3	3
Tyrosine-protein kinase FRK	0	0	3	3
G protein-coupled receptor kinase 6	0	0	3	3
Tyrosine-protein kinase SYK	0	0	3	3
26S proteasome regulatory subunit 6B	0	0	3	3
Mitogen-activated protein kinase 8	0	0	3	3
Mitogen-activated protein kinase 9	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 3	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	3	3
Casein kinase I isoform alpha	0	1	3	4
Casein kinase I isoform delta	0	0	3	3
MAP kinase-activated protein kinase 2	0	0	3	3
Elongation factor Tu, mitochondrial	0	0	3	3
Choline-phosphate cytidylyltransferase A	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	3	3
Casein kinase I isoform epsilon	0	0	3	3
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	3	3
Dual specificity protein kinase CLK1	0	0	3	3
Dual specificity protein kinase CLK2	0	0	3	3
Dual specificity protein kinase CLK3	0	0	3	3
Glycogen synthase kinase-3 alpha	0	0	3	3
Glycogen synthase kinase-3 beta	0	0	3	3
Cyclin-dependent kinase 7	0	0	3	3
Cyclin-dependent kinase 9	0	0	3	3
Ras-related protein Rab-27A	0	0	3	3
Interleukin-1 receptor-associated kinase 1	0	0	3	3
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Ribosomal protein S6 kinase alpha-3	0	1	3	4
Serine/threonine-protein kinase Nek2	0	1	3	4
Serine/threonine-protein kinase Nek3	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 6	0	0	3	3
Serine/threonine-protein kinase PLK1	0	2	3	5
LIM domain kinase 1	0	0	3	3
LIM domain kinase 2	0	0	3	3
Mitogen-activated protein kinase 10	0	0	3	3
Tyrosine--tRNA ligase, cytoplasmic	0	0	3	3
5'-AMP-activated protein kinase subunit gamma-1	0	0	3	3
Ephrin type-B receptor 3	0	0	3	3
Ephrin type-A receptor 5	0	0	3	3
Ephrin type-B receptor 4	0	1	3	4
Ephrin type-A receptor 4	0	0	3	3
Adenylate kinase 2, mitochondrial	0	0	3	3
Adenosine kinase	0	0	3	3
Ras-related protein Rab-10	0	0	3	3
Actin-related protein 3	0	0	3	3
Actin-related protein 2	0	0	3	3
GTP-binding nuclear protein Ran	0	0	3	3
Casein kinase I isoform gamma-2	0	0	3	3
Cyclin-dependent kinase 3	0	0	3	3
Cyclin-dependent kinase 6	0	0	3	3
Cyclin-dependent-like kinase 5	0	0	3	3
Cyclin-dependent kinase 16	0	0	3	3
Cyclin-dependent kinase 17	0	0	3	3
ATP-dependent 6-phosphofructokinase, platelet type	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 1	0	0	3	3
DNA topoisomerase 2-beta	0	0	3	3
Protein kinase C theta type	0	0	3	3
Activin receptor type-1	0	0	3	3
Macrophage-stimulating protein receptor	0	1	3	4
Focal adhesion kinase 1	0	1	3	4
Protein kinase C delta type	0	0	3	3
Tyrosine-protein kinase BTK	0	0	3	3
Activated CDC42 kinase 1	0	0	3	3
Epithelial discoidin domain-containing receptor 1	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	3	3
Serine/threonine-protein kinase 4	0	0	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	3	4
Dual specificity mitogen-activated protein kinase kinase 5	0	0	3	3
Mitogen-activated protein kinase 7	0	0	3	3
Serine/threonine-protein kinase PAK 2	0	0	3	3
Serine/threonine-protein kinase 3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 1	0	0	3	3
Integrin-linked protein kinase	0	0	3	3
Rho-associated protein kinase 1	0	0	3	3
Non-receptor tyrosine-protein kinase TNK1	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	3	3
Activin receptor type-2B	0	0	3	3
Bone morphogenetic protein receptor type-2	0	0	3	3
Protein-tyrosine kinase 6	0	0	3	3
cGMP-dependent protein kinase 1	0	0	3	3
Cyclin-dependent kinase 13	0	0	3	3
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	3	3
Protein-tyrosine kinase 2-beta	0	0	3	3
Maternal embryonic leucine zipper kinase	0	0	3	3
Structural maintenance of chromosomes protein 1A	0	0	3	3
Chromodomain-helicase-DNA-binding protein 4	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 1	0	0	3	3
Ephrin type-A receptor 7	0	0	3	3
Delta(24)-sterol reductase	0	0	3	3
Ribosomal protein S6 kinase alpha-1	0	1	3	4
Dual specificity testis-specific protein kinase 1	0	0	3	3
Myosin light chain kinase, smooth muscle	0	0	3	3
Mitogen-activated protein kinase 11	0	0	3	3
Serine/threonine-protein kinase STK11	0	0	3	3
Serine/threonine-protein kinase N1	0	0	3	3
Serine/threonine-protein kinase N2	0	0	3	3
Mitogen-activated protein kinase 14	0	0	3	3
Calcium/calmodulin-dependent protein kinase type IV	0	0	3	3
Mitogen-activated protein kinase kinase kinase 11	0	0	3	3
Discoidin domain-containing receptor 2	0	1	3	4
AP2-associated protein kinase 1	0	1	3	4
Myosin light chain kinase 3	0	0	3	3
Putative heat shock protein HSP 90-beta 2	0	0	3	3
Serine/threonine-protein kinase MRCK alpha	0	0	3	3
Serine/threonine-protein kinase MRCK gamma	0	0	3	3
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase N3	0	0	3	3
Serine/threonine-protein kinase ULK3	0	0	3	3
Uncharacterized protein FLJ45252	0	0	3	3
Acyl-CoA dehydrogenase family member 11	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	3	3
Serine/threonine-protein kinase MARK2	0	0	3	3
ATP-dependent RNA helicase DHX30	0	0	3	3
Serine/threonine-protein kinase TAO1	0	0	3	3
STE20-related kinase adapter protein alpha	0	0	3	3
Myosin-14	0	0	3	3
AarF domain-containing protein kinase 1	0	0	3	3
ATP-dependent RNA helicase DDX42	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	3	3
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Atypical kinase COQ8A, mitochondrial	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	3	3
Mitogen-activated protein kinase 15	0	0	3	3
Serine/threonine-protein kinase Nek9	0	0	3	3
Serine/threonine-protein kinase Nek7	0	0	3	3
ATP-dependent RNA helicase DDX1	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	3	3
Aurora kinase B	0	1	3	4
MAP/microtubule affinity-regulating kinase 4	0	0	3	3
Serine/threonine-protein kinase Nek1	0	0	3	3
ATPase family AAA domain-containing protein 5	5	0	0	5
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	3	3
EKC/KEOPS complex subunit TP53RK	0	0	3	3
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	3	3
Mitogen-activated protein kinase kinase kinase 5	0	0	3	3
Ataxin-2	6	0	0	6
Mitogen-activated protein kinase kinase kinase 3	0	0	3	3
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	3	3
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	3	3
Serine/threonine-protein kinase D2	0	0	3	3
NUAK family SNF1-like kinase 2	0	0	3	3
RNA cytidine acetyltransferase	0	0	3	3
Serine/threonine-protein kinase SIK2	0	0	3	3
STE20-like serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase TAO3	0	0	3	3
dCTP pyrophosphatase 1	0	0	3	3
Dual specificity protein kinase CLK4	0	0	3	3
Casein kinase I isoform gamma-1	0	0	3	3
Phenylalanine--tRNA ligase beta subunit	0	0	3	3
BMP-2-inducible protein kinase	0	0	3	3
Obg-like ATPase 1	0	0	3	3
Midasin	0	0	3	3
Interleukin-1 receptor-associated kinase 4	0	0	3	3
Mitogen-activated protein kinase kinase kinase 20	0	0	3	3
Cyclin-dependent kinase 12	0	0	3	3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	3	3
Serine/threonine-protein kinase 26	0	0	3	3
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	3	3
Serine/threonine-protein kinase NLK	0	0	3	3
5'-AMP-activated protein kinase subunit gamma-2	0	0	3	3
Serine/threonine-protein kinase TBK1	0	1	3	4
Septin-9	0	0	3	3
Potassium voltage-gated channel subfamily D member 3	0	2	0	2
Ribosomal protein S6 kinase alpha-6	0	0	3	3
TRAF2 and NCK-interacting protein kinase	0	0	3	3
Serine/threonine-protein kinase TAO2	0	0	3	3
Long-chain-fatty-acid--CoA ligase 5	0	0	3	3
RAC-gamma serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase SIK3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 2	0	0	3	3
Thyroid hormone receptor-associated protein 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 3	0	0	3	3
Serine/threonine-protein kinase MRCK beta	0	0	3	3
Interleukin-1 receptor-associated kinase 3	0	0	3	3
Casein kinase I isoform gamma-3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 4	0	0	3	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	3	0	0	3
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
Microtubule-associated protein tau	4	0	0	4
progesterone receptor	6	0	0	6
farnesoid X nuclear receptor	6	0	0	6
aryl hydrocarbon receptor	6	0	0	6
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
Luciferase	4	0	0	4
cellular tumor antigen p53 isoform a	1	0	0	1
Beta-2 adrenergic receptor	0	4	2	6
Beta-1 adrenergic receptor	0	2	2	4
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Heat shock protein HSP 90-alpha	0	1	1	2
G2/mitotic-specific cyclin-B1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	1	3
Cyclin-A2	0	1	0	1
Cyclin-A1	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Amyloid-beta precursor protein	0	2	0	2
TAR DNA-binding protein 43	3	0	0	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 15	0	1	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	3	0	3
Proton-coupled amino acid transporter 1	0	2	0	3
Phospholipase A-2-activating protein	0	2	0	2
Smad3	4	0	0	4
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Glutathione reductase, mitochondrial	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Leukotriene C4 synthase	0	0	2	2
Fumarate hydratase	1	0	0	1
PPM1D protein	3	0	0	3
G	2	0	0	2
polyprotein	1	0	0	1
tyrosine-protein kinase Yes	3	0	0	3
Membrane-associated progesterone receptor component 1	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	2	3
Serine/threonine-protein kinase 25	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	2	2
Serine/threonine-protein kinase RIO3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 7	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	2	2
Peripheral plasma membrane protein CASK	0	0	2	2
Serine/threonine-protein kinase DCLK1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	2	2
Muscle, skeletal receptor tyrosine-protein kinase	0	0	2	2
Mitogen-activated protein kinase 13	0	0	2	2
3-phosphoinositide-dependent protein kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 13	0	0	2	2
Death-associated protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
NUAK family SNF1-like kinase 1	0	1	2	3
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	2	2
Tyrosine-protein kinase JAK2	0	1	2	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	2	2
Serine/threonine-protein kinase PAK 3	0	0	2	2
Cyclin-dependent kinase-like 5	0	0	2	2
Serine/threonine-protein kinase 17B	0	0	2	2
Cyclin-dependent kinase 14	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	2	2
Serine/threonine-protein kinase Chk2	0	1	2	3
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
RAF proto-oncogene serine/threonine-protein kinase	0	1	2	3
Macrophage colony-stimulating factor 1 receptor	0	3	2	5
Proto-oncogene tyrosine-protein kinase ROS	0	0	2	2
Wee1-like protein kinase 2	0	0	2	2
Uncharacterized serine/threonine-protein kinase SBK3	0	0	2	2
Cytochrome P450 2D6	0	3	0	3
Mast/stem cell growth factor receptor Kit	0	5	2	7
Myosin light chain kinase, smooth muscle	0	0	2	2
Insulin receptor-related protein	0	0	2	2
Platelet-derived growth factor receptor alpha	0	4	2	6
Vascular endothelial growth factor receptor 1	0	4	2	6
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	2	2
Cyclin-dependent kinase 11B	0	0	2	2
Fibroblast growth factor receptor 2	0	2	2	4
Receptor tyrosine-protein kinase erbB-3	0	0	2	2
Fibroblast growth factor receptor 4	0	1	2	3
Fibroblast growth factor receptor 3	0	1	2	3
Protein kinase C eta type	0	0	2	2
Activin receptor type-2A	0	0	2	2
Ephrin type-A receptor 3	0	0	2	2
Ephrin type-A receptor 8	0	0	2	2
Leukocyte tyrosine kinase receptor	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	1	2	3
Mitogen-activated protein kinase 4	0	0	2	2
G protein-coupled receptor kinase 4	0	0	2	2
Tyrosine-protein kinase receptor Tie-1	0	0	2	2
Vascular endothelial growth factor receptor 3	0	4	2	6
Vascular endothelial growth factor receptor 2	0	6	2	9
Serine/threonine-protein kinase receptor R3	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	2	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	2	3
Megakaryocyte-associated tyrosine-protein kinase	0	0	2	2
Tyrosine-protein kinase TXK	0	0	2	2
Tyrosine-protein kinase ZAP-70	0	1	2	3
Dual specificity mitogen-activated protein kinase kinase 4	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	2	3
Cyclin-dependent kinase 8	0	0	2	2
Tyrosine-protein kinase Blk	0	0	2	2
Cytoplasmic tyrosine-protein kinase BMX	0	0	2	2
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	2	2
Tyrosine-protein kinase JAK3	0	0	2	2
Death-associated protein kinase 1	0	0	2	2
Mitogen-activated protein kinase 12	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	2	3
Ephrin type-B receptor 1	0	0	2	2
Hormonally up-regulated neu tumor-associated kinase	0	0	2	2
Serine/threonine-protein kinase SIK1	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 4	0	0	2	2
Cell division control protein 2 homolog	0	0	2	2
Calcium-dependent protein kinase 1	0	0	2	2
Tubulin alpha-1A chain	0	0	2	2
Casein kinase II subunit alpha	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	2	2
SRSF protein kinase 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 9	0	0	2	2
Serine/threonine-protein kinase PknB	0	0	2	2
Cyclin-dependent kinase-like 1	0	0	2	2
Protein kinase C epsilon type	0	0	2	2
Angiopoietin-1 receptor	0	2	2	4
Mitogen-activated protein kinase kinase kinase 10	0	0	2	2
Tyrosine-protein kinase receptor TYRO3	0	0	2	2
Cyclin-dependent kinase 18	0	0	2	2
Tyrosine-protein kinase ITK/TSK	0	0	2	2
Myotonin-protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	2	2
Tyrosine-protein kinase Mer	0	0	2	2
Serine/threonine-protein kinase PAK 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	2	2
Serine/threonine-protein kinase PRP4 homolog	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 1	0	1	2	3
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1	0	0	2	2
Serine/threonine-protein kinase D1	0	0	2	2
Serine/threonine-protein kinase 38	0	0	2	2
Receptor tyrosine-protein kinase erbB-4	0	0	2	2
Ribosomal protein S6 kinase alpha-2	0	0	2	2
Rhodopsin kinase GRK1	0	0	2	2
NT-3 growth factor receptor	0	0	2	2
BDNF/NT-3 growth factors receptor	0	0	2	2
Mitogen-activated protein kinase 6	0	0	2	2
Carbonic anhydrase 9	0	1	0	2
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	2	2
Receptor protein-tyrosine kinase	0	1	0	1
Serine/threonine-protein kinase SBK1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 19	0	0	2	2
Serine/threonine-protein kinase TNNI3K	0	0	2	2
Rab-like protein 3	0	0	2	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	1	2	3
Serine/threonine-protein kinase Nek5	0	0	2	2
Dual serine/threonine and tyrosine protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 15	0	0	2	2
Serine/threonine-protein kinase tousled-like 2	0	0	2	2
Serine/threonine-protein kinase 32C	0	0	2	2
Serine/threonine-protein kinase pim-3	0	0	2	2
Serine/threonine-protein kinase VRK2	0	0	2	2
Myosin light chain kinase family member 4	0	0	2	2
Homeodomain-interacting protein kinase 1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1D	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	2	2
MAP kinase-activated protein kinase 5	0	0	2	2
Serine/threonine-protein kinase BRSK2	0	0	2	2
Serine/threonine-protein kinase NIM1	0	0	2	2
Serine/threonine-protein kinase ULK2	0	0	2	2
Misshapen-like kinase 1	0	0	2	2
Serine/threonine-protein kinase DCLK2	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	2	2
Casein kinase I isoform alpha-like	0	0	2	2
Homeodomain-interacting protein kinase 4	0	0	2	2
Myosin-IIIa	0	0	2	2
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	2	2
Serine/threonine-protein kinase Nek11	0	0	2	2
Serine/threonine-protein kinase BRSK1	0	0	2	2
Serine/threonine-protein kinase 35	0	0	2	2
Rhodopsin kinase GRK7	0	0	2	2
Serine/threonine-protein kinase 32A	0	0	2	2
Myosin-IIIb	0	0	2	2
Inositol hexakisphosphate kinase 1	2	0	0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	2	2
Cyclin-dependent kinase-like 2	0	0	2	2
Serine/threonine-protein kinase Sgk3	0	0	2	2
Atypical kinase COQ8B, mitochondrial	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Cyclin-dependent kinase 15	0	0	2	2
SRSF protein kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO2	0	0	2	2
Cyclin-dependent kinase 19	0	0	2	2
Transient receptor potential cation channel subfamily M member 6	0	0	2	2
Testis-specific serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase 33	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	2	2
Homeodomain-interacting protein kinase 2	0	0	2	2
Tyrosine-protein kinase Srms	0	0	2	2
Homeodomain-interacting protein kinase 3	0	0	2	2
Serine/threonine-protein kinase PLK3	0	1	2	3
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	2	2
Serine/threonine-protein kinase Nek6	0	0	2	2
Serine/threonine-protein kinase PAK 6	0	1	2	3
SNF-related serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase LATS2	0	0	2	2
Serine/threonine-protein kinase 36	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	2	2
Serine/threonine-protein kinase 32B	0	0	2	2
Serine/threonine-protein kinase PLK2	0	1	2	3
Serine/threonine-protein kinase MARK1	0	0	2	2
Serine/threonine-protein kinase pim-2	0	0	2	2
Serine/threonine-protein kinase PAK 5	0	1	2	3
eIF-2-alpha kinase GCN2	0	0	2	2
Phosphatidylinositol 4-kinase beta	0	0	2	2
Serine/threonine-protein kinase 17A	0	0	2	2
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	2	2
Ephrin type-A receptor 6	0	0	2	2
Death-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase tousled-like 1	0	0	2	2
ALK tyrosine kinase receptor	0	2	2	4
SRSF protein kinase 3	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	2	2
Cyclin-dependent kinase 11A	0	0	2	2
Aurora kinase C	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	2	2
Microtubule-associated serine/threonine-protein kinase 1	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	2	2
Serine/threonine-protein kinase 24	0	0	2	2
cytochrome P450 2C9, partial	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
endonuclease IV	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
GALC protein	1	0	0	1
nonstructural protein 1	3	0	0	3
arylsulfatase A	5	0	0	5
peripheral myelin protein 22 isoform 1	3	0	0	3
M-phase phosphoprotein 8	4	0	0	4
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
glp-1 receptor, partial	2	0	0	2
pregnane X receptor	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
5-hydroxytryptamine receptor 4	0	2	0	2
Albumin	0	1	1	2
Cytochrome P450 1A2	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	1	2	4
Adenosine receptor A3	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	1	2
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	3	1	4
Alpha-2B adrenergic receptor	0	0	1	2
Beta-1 adrenergic receptor	0	2	1	4
Alpha-2C adrenergic receptor	0	1	2	4
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	1	5
Alpha-2B adrenergic receptor	0	0	1	1
Muscarinic acetylcholine receptor M3	0	1	1	2
D(1A) dopamine receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	3	1	4
Alpha-1D adrenergic receptor	0	0	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Mu-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
Alpha-1A adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 6	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
Chain A, Cruzipain	4	0	0	4
SUMO-1	0	1	0	1
WRN	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
pyruvate kinase	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
DNA polymerase beta	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
tumor susceptibility gene 101 protein	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
POsterior Segregation	0	0	2	2
chaperonin GroEL	1	0	0	1
neuropeptide S receptor isoform A	3	0	0	3
60 kDa chaperonin	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Sodium-dependent noradrenaline transporter	0	0	2	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Exoribonuclease H	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Coproheme decarboxylase	0	0	1	1
60 kDa chaperonin	0	1	0	1
Protease	0	1	0	1
10 kDa chaperonin	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Zinc finger protein mex-5	0	0	2	2
phosphoglycerate kinase	1	0	0	1
inositol monophosphatase 1	1	0	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Calpain-2 catalytic subunit	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Transporter	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	0	1	0	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	0	1	0	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
vasopressin V1a receptor	0	0	1	1
oxytocin receptor	0	0	1	1
transcriptional regulator ERG isoform 3	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
transient receptor potential cation channel subfamily V member 1	1	0	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Tubulin alpha-1A chain	0	2	0	2
Tubulin beta chain	0	2	0	2
Platelet-derived growth factor receptor beta	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Platelet-derived growth factor receptor alpha	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
1,25-dihydroxyvitamin D-3 receptor	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	1	0	1
Aromatase	0	1	0	1
Translocator protein	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Protein delta homolog 1	0	1	1	2
Protein kinase C zeta type	0	0	1	1
Serine/threonine-protein kinase ATR	0	0	1	1
Cyclin-dependent kinase 10	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	0	1	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	2	0	2
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-synuclein	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
thioredoxin glutathione reductase	2	0	0	2
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Histone deacetylase 8	0	1	0	1
Nrf2	1	0	0	1
PAX8	0	0	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
Gli1	0	1	0	1
Caspase-7	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
caspase-3	1	0	0	1
steroidogenic factor 1	0	1	0	1
protein Wnt-3a precursor	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 3	0	2	1	6
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Bromodomain-containing protein 4	0	1	0	1
Nuclear receptor corepressor 1	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Protein Tat	0	0	1	1
Leukotriene A-4 hydrolase	0	1	0	1
Aminopeptidase N	0	1	0	1
Androgen receptor	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Histone deacetylase 4	0	2	1	6
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Apoptosis regulator BAX	0	0	1	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Histone deacetylase 1	0	2	2	7
Histone deacetylase 1	0	1	0	1
Histone deacetylase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	1	3
Histone deacetylase	0	1	0	1
Histone deacetylase 7	0	2	2	7
Histone deacetylase 2	0	2	2	7
HD2 type histone deacetylase HDA106	0	2	0	2
Polyamine deacetylase HDAC10	0	2	1	6
Histone deacetylase 11	0	2	1	6
Carboxypeptidase B2	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 8	0	2	2	7
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
REST corepressor 3	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Histone deacetylase 6	0	2	2	7
Histone deacetylase 9	0	2	1	6
Histone deacetylase 5	0	2	1	6
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (131)

Protein Targets (1,187)

Hemangioblastoma

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (131)

Drugs Studied (82)

Protein Targets (1,187)