technetium-tc-99m-medronate and Osteoradionecrosis

Seven patients with mandibular osteonecrosis (three osteoradionecrosis, three medication-related osteonecrosis of the jaw (MRONJ), and one rheumatoid arthritis) underwent SPECT/CT at 4 hours after injection of technetium 99m hydroxymethylene diphosphonate. The SPECT/CT parameters SUV

Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Bisphosphonate-Associated Osteonecrosis of the Jaw; Female; Humans; Male; Mandibular Diseases; Middle Aged; Osteoradionecrosis; Radiopharmaceuticals; Single Photon Emission Computed Tomography Computed Tomography; Technetium Tc 99m Medronate; Whole Body Imaging

Four years after radiation therapy to the lower extremity for a bone metastasis, persistent F-18 FDG and Tc99m MDP uptake were noted in the radiation port. Presumably ongoing inflammatory cellular processes accounts for this finding.

Topics: Adult; Female; Fluorodeoxyglucose F18; Humans; Lower Extremity; Osteoradionecrosis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Three-phase bone scintigraphy was undertaken to check the anastomotic patency and monitor the viability of vascularized bone grafts. Ten consecutive patients who underwent vascularized bone grafting of the mandible were reviewed. A successful clinical outcome was achieved in 8 patients. The graft failed in 2 patients. In this series, 3-phase bone scintigraphy of radiolabeled (99m)Tc-methylene-diphosphonate was performed at 7 days, and at 1, 3, 6, and 12 months after reconstruction. Assessments made using 3-phase bone images were compared with the clinical findings. The clinical outcome of the cases presented in our series correlated extremely well with 3-phase bone images. Three-phase bone scintigraphy is a useful method for the assessment of patency and viability of vascularized bone grafts. The use of this method can be very helpful in assessing the anastomotic patency and viability of a graft which for clinical reasons is suspected of being non-viable.

Topics: Aged; Anastomosis, Surgical; Bone Transplantation; Carcinoma, Squamous Cell; Female; Graft Survival; Humans; Male; Mandible; Mandibular Diseases; Middle Aged; Mouth Neoplasms; Osteoradionecrosis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Vascular Patency

A prospective study of 85 patients with oral cancer, treated with high-dose radiation therapy, was performed to assess the value of magnetic resonance imaging (MRI) and scintigraphy for diagnosis of pathologic changes in the mandible. During postradiotherapeutic monitoring, radiation osteomyelitis occurred in 12 cases, tumor recurrences infiltrating the mandible in five cases, and progressive periodontal disease in nine cases. MRI permitted early diagnosis of radiation osteomyelitis in 11 out of 12 cases; only two cases were false positive. In scintigraphy with 99mTc-HDP, all alterations of the mandible, such as osteoradionecrosis, tumor infiltration, and periodontitis, showed a high uptake, resulting in a sensitivity of up to 100%, but a low specificity of 57%. Scintigraphy permitted assessment of the extension and location of the lesions. Both methods were superior to conventional radiography and clinical examination and should be integrated into a comprehensive follow-up program after radiation therapy.

Topics: Adult; Aged; False Positive Reactions; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Mandible; Mandibular Diseases; Mandibular Neoplasms; Middle Aged; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Osteomyelitis; Osteoradionecrosis; Periodontitis; Prospective Studies; Radiation Injuries; Radiation Monitoring; Radiopharmaceuticals; Radiotherapy; Radiotherapy Dosage; Sensitivity and Specificity; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Biopsy; Breast Neoplasms; Clavicle; Cobalt Radioisotopes; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Osteoradionecrosis; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

The need for a reliable non-invasive investigation in osteoradionecrosis (ORN) of the mandible is discussed. The results of 99mTc-methylene diphosphonate bone scans using single photon emission tomography, and measuring dynamic uptake in 13 patients are presented. These suggest that sites of osteoradionecrosis may be defined by a paradoxically increased uptake of 99mTc-methylene diphosphonate.

Topics: Gamma Cameras; Humans; Mandible; Mandibular Diseases; Osteoradionecrosis; Technetium Tc 99m Medronate; Time Factors; Tomography, Emission-Computed, Single-Photon

Controlled studying findings from 62 radionuclide scintigraphic and X-ray photographic examinations of the same stage in the experimental animals indicated. The diagnosis of ORN could hardly be established while bone scintigraphic examination is negative, but it is recommended that ORN mostly exists if scintigraphic result is positive. The grading of bone scanning based on the difference of radionuclide concentration in diseased area offered a reference for treatment. Measuring and calculating both examination pictures, we put forward a method to quantitatively determine the limits of lesions. The facts showed by bone scanning that blood supply was rich and metabolism was vigorous in diseased area of ORN presented a new object for research on fundamental theory.

Topics: Animals; Dogs; Gamma Cameras; Mandible; Mandibular Diseases; Osteoradionecrosis; Radiation Injuries; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Animals; Disease Models, Animal; Dogs; Jaw; Jaw Diseases; Lasers; Osteoradionecrosis; Radiation Injuries; Radiation Injuries, Experimental; Radionuclide Imaging; Technetium Tc 99m Medronate; Time Factors; Ultrasonography