pentoxifylline has been researched along with Osteoradionecrosis in 49 studies
Osteoradionecrosis: Necrosis of bone following radiation injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osteoradionecrosis of the jaws (ORNJ) is a severe and challenging complication of head and neck radiation therapy." | 9.41 | Pentoxifylline and tocopherol for the treatment of osteoradionecrosis of the jaws. A systematic review. ( Arqueros-Lemus, M; Mariño-Recabarren, D; Martínez-Flores, R; Moraga, V; Niklander, S, 2023) |
| "This systematic review aimed to determine whether the pentoxifylline and tocopherol (PENTO) protocol effectively reduce the risk of osteoradionecrosis (ORN) in patients undergoing tooth extraction after head and neck radiotherapy." | 9.41 | Can the prophylactic use of pentoxifylline and tocopherol before dental extractions prevent osteoradionecrosis? A systematic review. ( de Campos, WG; Dos Santos Silva, AR; Júnior, CAL; Migliorati, CA; Paiva, GLA; Rocha, AC, 2023) |
| "The effect of combined application of pentoxifylline and vitamin E for the treatment of osteoradionecrosis of the jaws: A meta-analysis Chin J Stomatol Res (Electronic Edition)." | 9.05 | RETRACTED: The effect of combined application of pentoxifylline and vitamin E for the treatment of osteoradionecrosis of the jaws: a meta-analysis. ( Chen, Y; Jia, J; Tian, L; Xiao, W; Zhang, Z; Zhao, L; Zong, C, 2020) |
| "The purpose of this study was to evaluate the healing benefit provided by the antioxidant and antifibrotic properties of pentoxifylline-tocopherol or pentoxifylline-tocopherol-clodronate in combination therapy for osteoradionecrosis." | 8.98 | Pentoxifylline, tocopherol, and clodronate for the treatment of mandibular osteoradionecrosis: a systematic review. ( Balibrea-Del-Castillo, JM; Bescós-Atín, C; Estrugo-Devesa, A; López-López, J; Martos-Fernández, M; Saez-Barba, M, 2018) |
| "The aim of the present study was to evaluate the efficacy of pentoxifylline and tocopherol for the management of osteoradionecrosis of the jaws." | 8.02 | Pentoxifylline, tocopherol, and sequestrectomy are effective for the management of advanced osteoradionecrosis of the jaws-a case series. ( Carvalho, AAT; de Hollanda Valente, RO; de Pádua Walfrido, GN; Dos Anjos, RS; Gueiros, LA; Leão, JC; Patel, P; Porter, S; Silva, IHM, 2021) |
| "Medical management of osteoradionecrosis (ORN) via pentoxifylline, tocopherol (PENTO) and clodronate (PENTOCLO) has shown both promise and early positive outcomes." | 8.02 | The use of pentoxifylline, tocopherol and clodronate in the management of osteoradionecrosis of the jaws. ( Patel, N; Patel, S; Patel, V; Sassoon, I, 2021) |
| "In cases of advanced ORN with pathological fractures, many centres still advocate surgical resection and reconstruction." | 6.61 | Is there a role for pentoxifylline and tocopherol in the management of advanced osteoradionecrosis of the jaws with pathological fractures? Case reports and review of the literature. ( Breik, O; Briggs, K; Richardson, S; Tasfia Saief, S; Tocaciu, S, 2019) |
| "Pentoxifylline has been used to treat complications related to fibrosis for over 20 years." | 6.55 | Pentoxifylline - a review of its use in osteoradionecrosis. ( Brennan, PA; Lyons, AJ, 2017) |
| "Osteoradionecrosis is a complication of head and neck radiotherapy, with a difficult resolution and no well-established treatment." | 5.43 | Tissue repair in osteoradionecrosis using pentoxifylline and tocopherol--report of three cases. ( Bohn, JC; Sassi, LM; Schussel, JL; Stramandinoli-Zanicotti, RT, 2016) |
| "Osteoradionecrosis of the jaws (ORNJ) is a severe and challenging complication of head and neck radiation therapy." | 5.41 | Pentoxifylline and tocopherol for the treatment of osteoradionecrosis of the jaws. A systematic review. ( Arqueros-Lemus, M; Mariño-Recabarren, D; Martínez-Flores, R; Moraga, V; Niklander, S, 2023) |
| "This systematic review aimed to determine whether the pentoxifylline and tocopherol (PENTO) protocol effectively reduce the risk of osteoradionecrosis (ORN) in patients undergoing tooth extraction after head and neck radiotherapy." | 5.41 | Can the prophylactic use of pentoxifylline and tocopherol before dental extractions prevent osteoradionecrosis? A systematic review. ( de Campos, WG; Dos Santos Silva, AR; Júnior, CAL; Migliorati, CA; Paiva, GLA; Rocha, AC, 2023) |
| "The effect of combined application of pentoxifylline and vitamin E for the treatment of osteoradionecrosis of the jaws: A meta-analysis Chin J Stomatol Res (Electronic Edition)." | 5.05 | RETRACTED: The effect of combined application of pentoxifylline and vitamin E for the treatment of osteoradionecrosis of the jaws: a meta-analysis. ( Chen, Y; Jia, J; Tian, L; Xiao, W; Zhang, Z; Zhao, L; Zong, C, 2020) |
| " Interest in pentoxifylline and tocopherol is growing because these agents have been shown to be effective in treating osteoradionecrosis of the jaw." | 5.01 | Systematic review of the use of pentoxifylline and tocopherol for the treatment of medication-related osteonecrosis of the jaw. ( Abdelsamie, S; Campbell, CB; Fielding, AF; Heifetz-Li, JJ; Mulligan, JP; Roth, S, 2019) |
| "The purpose of this study was to evaluate the healing benefit provided by the antioxidant and antifibrotic properties of pentoxifylline-tocopherol or pentoxifylline-tocopherol-clodronate in combination therapy for osteoradionecrosis." | 4.98 | Pentoxifylline, tocopherol, and clodronate for the treatment of mandibular osteoradionecrosis: a systematic review. ( Balibrea-Del-Castillo, JM; Bescós-Atín, C; Estrugo-Devesa, A; López-López, J; Martos-Fernández, M; Saez-Barba, M, 2018) |
| "To review the conservative and surgical management options of osteoradionecrosis, in particular, highlighting the recent the use of anti-radiation fibrosis drugs (pentoxifylline, tocopherol and clodronate)." | 4.91 | The management of osteoradionecrosis of the jaws--a review. ( Ekanayake, K; Omer, O; Polyzois, I; Rice, N; Stassen, LF, 2015) |
| "The main components of the medical management of osteoradionecrosis (ORN) are combinations of clodronate, pentoxifylline, tocopherol, sometimes with antibiotics or chlorhexidine rinses." | 4.12 | Patients' experience and perceived concerns regarding obtaining and taking prescriptions for head and neck osteoradionecrosis. ( Lim, YBY; Rogers, SN; Willcocks, EJ, 2022) |
| "The aim of the present study was to evaluate the efficacy of pentoxifylline and tocopherol for the management of osteoradionecrosis of the jaws." | 4.02 | Pentoxifylline, tocopherol, and sequestrectomy are effective for the management of advanced osteoradionecrosis of the jaws-a case series. ( Carvalho, AAT; de Hollanda Valente, RO; de Pádua Walfrido, GN; Dos Anjos, RS; Gueiros, LA; Leão, JC; Patel, P; Porter, S; Silva, IHM, 2021) |
| "Medical management of osteoradionecrosis (ORN) via pentoxifylline, tocopherol (PENTO) and clodronate (PENTOCLO) has shown both promise and early positive outcomes." | 4.02 | The use of pentoxifylline, tocopherol and clodronate in the management of osteoradionecrosis of the jaws. ( Patel, N; Patel, S; Patel, V; Sassoon, I, 2021) |
| "A combination of pentoxifylline (PTX) and tocopherol (TP) is believed to reduce chronic fibrosis and induce bone healing in osteoradionecrosis (ORN) of the mandible, but evidence of its therapeutic effectiveness for cortical bone is lacking." | 3.91 | Effects of pentoxifylline and tocopherol on a rat-irradiated jaw model using micro-CT cortical bone analysis. ( Eo, MY; Kim, SM; Lee, JH; Myoung, H; Nguyen, TTH; Seo, MH, 2019) |
| "Osteoradionecrosis (ORN) is a complication seen intermittently in patients who have had radiotherapy to the head and neck, and results of treatment with pentoxifylline and tocopherol (PVe) have been encouraging." | 3.83 | Prophylactic use of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy for cancer of the head and neck. ( Gadiwalla, Y; Kwok, J; McGurk, M; Patel, V; Sassoon, I; Sproat, C, 2016) |
| "This study is a retrospective review of treatment outcomes of osteoradionecrosis (ORN) of the mandible with specific reference to the evolving role of medical management with pentoxifylline, tocopherol, and doxycycline." | 3.80 | Changing trends and the role of medical management on the outcome of patients treated for osteoradionecrosis of the mandible: experience from a regional head and neck unit. ( D'Souza, J; Lowe, D; Rogers, SN, 2014) |
| "In cases of advanced ORN with pathological fractures, many centres still advocate surgical resection and reconstruction." | 2.61 | Is there a role for pentoxifylline and tocopherol in the management of advanced osteoradionecrosis of the jaws with pathological fractures? Case reports and review of the literature. ( Breik, O; Briggs, K; Richardson, S; Tasfia Saief, S; Tocaciu, S, 2019) |
| "Pentoxifylline has been used to treat complications related to fibrosis for over 20 years." | 2.55 | Pentoxifylline - a review of its use in osteoradionecrosis. ( Brennan, PA; Lyons, AJ, 2017) |
| "Osteoradionecrosis is a complication of head and neck radiotherapy, with a difficult resolution and no well-established treatment." | 1.43 | Tissue repair in osteoradionecrosis using pentoxifylline and tocopherol--report of three cases. ( Bohn, JC; Sassi, LM; Schussel, JL; Stramandinoli-Zanicotti, RT, 2016) |
| "Pentoxifylline is a methylxanthine derivative that produces dose-related hemorrheologic effects, lower blood viscosity, improved erythrocyte flexibility, and increased tissue oxygen levels." | 1.30 | Pentoxifylline in the treatment of radiation-related soft tissue injury: preliminary observations. ( Futran, ND; Gwede, C; Trotti, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.04) | 18.2507 |
| 2000's | 3 (6.12) | 29.6817 |
| 2010's | 26 (53.06) | 24.3611 |
| 2020's | 19 (38.78) | 2.80 |
| Authors | Studies |
|---|---|
| Marjanowski, SD | 1 |
| Maldonado, A | 1 |
| Schaller, B | 1 |
| Burkhard, JM | 1 |
| Banjar, A | 1 |
| Patel, V | 6 |
| Abed, H | 1 |
| Samani, M | 1 |
| Beheshti, S | 1 |
| Cheng, H | 1 |
| Sproat, C | 4 |
| Kwok, J | 4 |
| Willcocks, EJ | 1 |
| Lim, YBY | 1 |
| Rogers, SN | 2 |
| Lombardi, N | 1 |
| Varoni, E | 1 |
| Villa, G | 1 |
| Salis, A | 1 |
| Lodi, G | 1 |
| Arqueros-Lemus, M | 1 |
| Mariño-Recabarren, D | 1 |
| Niklander, S | 1 |
| Martínez-Flores, R | 1 |
| Moraga, V | 1 |
| Paiva, GLA | 1 |
| de Campos, WG | 1 |
| Rocha, AC | 1 |
| Júnior, CAL | 1 |
| Migliorati, CA | 1 |
| Dos Santos Silva, AR | 1 |
| Young, H | 1 |
| Mellor, A | 1 |
| Cape, A | 1 |
| Mahendran, K | 1 |
| Nguyen, TTH | 1 |
| Eo, MY | 1 |
| Seo, MH | 2 |
| Myoung, H | 2 |
| Kim, SM | 2 |
| Lee, JH | 2 |
| Heifetz-Li, JJ | 1 |
| Abdelsamie, S | 1 |
| Campbell, CB | 1 |
| Roth, S | 1 |
| Fielding, AF | 1 |
| Mulligan, JP | 1 |
| Bettoni, J | 1 |
| Tocaciu, S | 2 |
| Breik, O | 2 |
| Dissard, A | 1 |
| P Dang, N | 1 |
| Barthelemy, I | 1 |
| Delbet, C | 1 |
| Puechmaille, M | 1 |
| Depeyre, A | 1 |
| Pereira, B | 1 |
| Martin, F | 1 |
| Guillemin, F | 2 |
| Biau, J | 2 |
| Mirafzal, S | 1 |
| Mom, T | 1 |
| Gilain, L | 1 |
| Saroul, N | 2 |
| Li, J | 1 |
| Wang, W | 1 |
| Zhang, Z | 1 |
| Xiao, W | 1 |
| Jia, J | 1 |
| Chen, Y | 1 |
| Zong, C | 1 |
| Zhao, L | 1 |
| Tian, L | 1 |
| Yang, HC | 1 |
| Woo, KM | 1 |
| Lee, SK | 1 |
| Lovin, BD | 1 |
| Choi, JS | 1 |
| Lindquist, NR | 1 |
| Phan, J | 1 |
| Gidley, PW | 1 |
| Nader, ME | 1 |
| Dos Anjos, RS | 1 |
| de Pádua Walfrido, GN | 1 |
| de Hollanda Valente, RO | 1 |
| Gueiros, LA | 1 |
| Carvalho, AAT | 1 |
| Patel, P | 1 |
| Porter, S | 1 |
| Leão, JC | 1 |
| Silva, IHM | 1 |
| Patel, S | 1 |
| Patel, N | 1 |
| Sassoon, I | 3 |
| Dutheil, F | 1 |
| Pham-Dang, N | 1 |
| Clavère, P | 1 |
| Lapeyre, M | 1 |
| Rivero, JA | 1 |
| Shamji, O | 1 |
| Kolokythas, A | 2 |
| Martin, K | 1 |
| Nathwani, S | 1 |
| Bunyan, R | 1 |
| Martos-Fernández, M | 1 |
| Saez-Barba, M | 1 |
| López-López, J | 1 |
| Estrugo-Devesa, A | 1 |
| Balibrea-Del-Castillo, JM | 1 |
| Bescós-Atín, C | 1 |
| Dhanda, J | 1 |
| Rennie, L | 1 |
| Shaw, R | 1 |
| Magremanne, M | 1 |
| Rasmussen, JT | 1 |
| Reardon, J | 1 |
| Feng, C | 1 |
| Bulsara, VM | 1 |
| Bulsara, MK | 1 |
| Lewis, E | 1 |
| Briggs, K | 1 |
| Tasfia Saief, S | 1 |
| Richardson, S | 1 |
| Dinnoo, A | 1 |
| Bidault, F | 1 |
| Lassau, N | 1 |
| Elmaalouf, M | 1 |
| Moya-Plana, A | 1 |
| Ruffier, A | 1 |
| Janot, F | 1 |
| Benmoussa, N | 1 |
| D'Souza, J | 1 |
| Lowe, D | 1 |
| Lyons, A | 2 |
| Osher, J | 1 |
| Warner, E | 1 |
| Kumar, R | 1 |
| Brennan, PA | 3 |
| McCaul, JA | 1 |
| Robard, L | 1 |
| Louis, MY | 1 |
| Blanchard, D | 1 |
| Babin, E | 1 |
| Delanian, S | 4 |
| Rice, N | 1 |
| Polyzois, I | 1 |
| Ekanayake, K | 1 |
| Omer, O | 1 |
| Stassen, LF | 1 |
| Glicksman, JT | 1 |
| Khalili, S | 1 |
| Fung, K | 1 |
| Parnes, LS | 1 |
| Agrawal, SK | 1 |
| Bohn, JC | 1 |
| Schussel, JL | 1 |
| Stramandinoli-Zanicotti, RT | 1 |
| Sassi, LM | 1 |
| Gadiwalla, Y | 2 |
| McGurk, M | 2 |
| Costa, DA | 1 |
| Costa, TP | 1 |
| Netto, EC | 1 |
| Joaquim, N | 1 |
| Ventura, I | 1 |
| Pratas, AC | 1 |
| Winckler, P | 1 |
| Silva, IP | 1 |
| Pinho, AC | 1 |
| Sargento, IG | 1 |
| Guerreiro, FG | 1 |
| Moreira, AR | 1 |
| Lyons, AJ | 1 |
| Ghazali, N | 1 |
| Thariat, J | 1 |
| de Mones, E | 1 |
| Darcourt, V | 1 |
| Poissonnet, G | 1 |
| Marcy, PY | 1 |
| Guevara, N | 1 |
| Bozec, A | 1 |
| Ortholan, C | 1 |
| Santini, J | 1 |
| Bensadoun, RJ | 1 |
| Dassonville, O | 1 |
| Chatel, C | 1 |
| Porcher, R | 1 |
| Depondt, J | 2 |
| Lefaix, JL | 3 |
| McLeod, NM | 1 |
| Pratt, CA | 1 |
| Mellor, TK | 1 |
| Kahenasa, N | 1 |
| Sung, EC | 1 |
| Nabili, V | 1 |
| Kelly, J | 1 |
| Garrett, N | 1 |
| Nishimura, I | 1 |
| Nabil, S | 1 |
| Futran, ND | 1 |
| Trotti, A | 1 |
| Gwede, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Advances in the Management of Mandibular Osteoradionecrosis: Pentoxifylline and Tocopherol as Medical Treatment[NCT02368457] | Phase 4 | 24 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment[NCT03040778] | Phase 3 | 100 participants (Anticipated) | Interventional | 2018-04-01 | Enrolling by invitation | ||
| Normal Tissue Oxygenation Following Radiotherapy[NCT00677040] | 20 participants (Actual) | Observational | 2008-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Clinical healing assessment as measured with the classification of ORN stages, area of bone exposed (mm2) and radiological findings (OPG).~Intraoral bone exposure is measured in mm2." (NCT02368457)
Timeframe: From baseline to 1, 3, 6, and 9 months of starting treatment
| Intervention | mm2 (Mean) | |||
|---|---|---|---|---|
| 1 month of starting treatment | 3 month of starting treatment | 6 month of starting treatment | 9 month of starting treatment | |
| Control Group | 15 | 15 | 15 | 15 |
| Pentoxifylline and Tocopherol | 14 | 13 | 11.5 | 10 |
"Evaluation of symptoms improvement using the LENT-SOMA scale (Late Effect Normal Tissue Task Force / Subjective, Objective, Management, Analytic scale).~To examine the LENT/SOMA scale prospectively using interviews and questionnaires~Assessments were made from baseline to 1, 3, 6 and 9 months of starting treatments. The acceptability and feasibility of using the scales was examined using compliance in completion of the questionnaires.~Maximum score: 36 Minimum score: 0~Questionnaires have been completed for 24 patients after treatment. Higher values represents worse outcome.~Scale categories:~Subjective: pain, nutritional problems, difficulty in mouth openning. Objective: bone exposure, trismus, Management: analgesic treatment, oral treatment, nutrition. Analytic: radiological findings." (NCT02368457)
Timeframe: From baseline to 1,3, 6, 9 months of starting treatment
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| 1 month of starting treatment | 3 month of starting treatment | 6 month of starting treatment | 9 month of starting treatment | |
| CONTROL | 15.5 | 15.5 | 15.5 | 15.5 |
| Pentoxifylline and Tocopherol | 14.5 | 14 | 14 | 13.3 |
Transcutaneous oxygen detector is used to measure the partial pressure of oxygen. The unit detects electrolytes ionized by oxygen. The measuring electrode also heats the skin being measured to facilitate maximal bloodflow to the area. (NCT00677040)
Timeframe: One visit for 20 minutes
| Intervention | mmHg (Mean) |
|---|---|
| Subjects | 62.5 |
(NCT00677040)
Timeframe: One visit
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| late subcutaneous toxicitiy score 1 | late subcutaneous toxcity score 2 | late skin toxicity score 1 | late skin toxicity score 2 | |
| Subjects | 19 | 1 | 19 | 1 |
16 reviews available for pentoxifylline and Osteoradionecrosis
| Article | Year |
|---|---|
[Pentoxifylline and tocopherol - The importance in the treatment of osteoradionecrosis - Literature review and case report].
Topics: Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylline; Tocopherols | 2021 |
Pentoxifylline and tocopherol (vitamin E) with/without clodronate for the management of osteoradionecrosis: A scoping review.
Topics: Clodronic Acid; Drug Therapy, Combination; Humans; Observational Studies as Topic; Osteoradionecrosi | 2023 |
Pentoxifylline and tocopherol for the treatment of osteoradionecrosis of the jaws. A systematic review.
Topics: Head and Neck Neoplasms; Humans; Jaw; Osteoradionecrosis; Pentoxifylline; Tocopherols | 2023 |
Can the prophylactic use of pentoxifylline and tocopherol before dental extractions prevent osteoradionecrosis? A systematic review.
Topics: Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylline; Retrospective Studies; Tocopher | 2023 |
Systematic review of the use of pentoxifylline and tocopherol for the treatment of medication-related osteonecrosis of the jaw.
Topics: Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Humans; Osteor | 2019 |
RETRACTED: The effect of combined application of pentoxifylline and vitamin E for the treatment of osteoradionecrosis of the jaws: a meta-analysis.
Topics: Humans; Hyperbaric Oxygenation; Jaw; Osteoradionecrosis; Pentoxifylline; Vitamin E | 2020 |
[Predictive factors for mandibular osteoradionecrosis after irradiation of head and neck cancers].
Topics: Bone Density Conservation Agents; Clodronic Acid; Drug Therapy, Combination; Head and Neck Neoplasms | 2021 |
Osteoradionecrosis: a review of pathophysiology, prevention and pharmacologic management using pentoxifylline, α-tocopherol, and clodronate.
Topics: Clodronic Acid; Drug Combinations; Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylli | 2017 |
Pentoxifylline, tocopherol, and clodronate for the treatment of mandibular osteoradionecrosis: a systematic review.
Topics: Clodronic Acid; Drug Combinations; Head and Neck Neoplasms; Humans; Mandibular Diseases; Osteoradion | 2018 |
Management of osteoradionecrosis of the jaws with pentoxifylline-tocopherol: a systematic review of the literature and meta-analysis.
Topics: Antioxidants; Drug Combinations; Head and Neck Neoplasms; Humans; Jaw Diseases; Osteoradionecrosis; | 2019 |
Is there a role for pentoxifylline and tocopherol in the management of advanced osteoradionecrosis of the jaws with pathological fractures? Case reports and review of the literature.
Topics: Fractures, Spontaneous; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Mandibular Diseases | 2019 |
Pharmacologic modalities in the treatment of osteoradionecrosis of the jaw.
Topics: Anti-Bacterial Agents; Antioxidants; Bone Density Conservation Agents; Chemoradiotherapy; Clodronic | 2014 |
The management of osteoradionecrosis of the jaws--a review.
Topics: Algorithms; Anti-Inflammatory Agents; Clodronic Acid; Fibrosis; Head and Neck Neoplasms; Humans; Hyp | 2015 |
New perspectives on the conservative management of osteoradionecrosis of the mandible: A literature review.
Topics: Antioxidants; Bone Density Conservation Agents; Clodronic Acid; Conservative Treatment; Drug Therapy | 2016 |
Pentoxifylline - a review of its use in osteoradionecrosis.
Topics: Humans; Jaw Diseases; Osteoradionecrosis; Pentoxifylline | 2017 |
[Teeth and irradiation: dental care and treatment of osteoradionecrosis after irradiation in head and neck cancer].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Dental Care; Fluorides; Head and Nec | 2010 |
3 trials available for pentoxifylline and Osteoradionecrosis
| Article | Year |
|---|---|
Protocol for prospective randomised assessor-blinded pilot study comparing hyperbaric oxygen therapy with PENtoxifylline+TOcopherol± CLOdronate for the management of early osteoradionecrosis of the mandible.
Topics: Adult; Bone Density Conservation Agents; Clinical Protocols; Clodronic Acid; Drug Combinations; Fema | 2019 |
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru | 2011 |
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru | 2011 |
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru | 2011 |
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru | 2011 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.
Topics: Adult; Aged; Antimetabolites; Antioxidants; Clodronic Acid; Drug Therapy, Combination; Female; Head | 2005 |
30 other studies available for pentoxifylline and Osteoradionecrosis
| Article | Year |
|---|---|
Prophylactic pentoxifylline and vitamin E use for dental extractions in irradiated patients with head and neck cancer.
Topics: Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylline; Retrospective Studies; Tooth Ex | 2022 |
Patients' experience and perceived concerns regarding obtaining and taking prescriptions for head and neck osteoradionecrosis.
Topics: Chlorhexidine; Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylline; Prescriptions; T | 2022 |
Pentoxifylline and tocopherol for prevention of osteoradionecrosis in patients who underwent oral surgery: A clinical audit.
Topics: Head and Neck Neoplasms; Humans; Oral Surgical Procedures; Osteoradionecrosis; Pentoxifylline; Tocop | 2023 |
The use of liquid formulation pentoxifylline and vitamin E in both established and as a prophylaxis for dental extractions "at risk" of osteoradionecrosis.
Topics: Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylline; Retrospective Studies; Tooth Ex | 2023 |
Effects of pentoxifylline and tocopherol on a rat-irradiated jaw model using micro-CT cortical bone analysis.
Topics: Animals; Antioxidants; Bone Diseases, Metabolic; Cortical Bone; Fibrosis; Male; Mandible; Osteoradio | 2019 |
Re: Breik O, Tocaciu K, Tasfia Saief S, Richardson S. Is there a role for pentoxifylline and tocopherol in the management of advanced osteoradionecrosis of the jaws with pathological fractures? Case reports and review of the literature.
Topics: Fractures, Spontaneous; Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylline; Tocophe | 2020 |
The need for more robust research on the role of pentoxifylline and tocopherol in the management of osteoradionecrosis of the jaws.
Topics: Fractures, Spontaneous; Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylline; Tocophe | 2020 |
Efficacy of pentoxifylline-tocopherol-clodronate in mandibular osteoradionecrosis.
Topics: Aged; Aged, 80 and over; Bone Density Conservation Agents; Clodronic Acid; Drug Combinations; Female | 2020 |
Positive effect of pentoxifylline on medication-related osteonecrosis of the jaw.
Topics: Humans; Microcirculation; Osteonecrosis; Osteoradionecrosis; Pentoxifylline | 2020 |
Effects of pentoxifylline and tocopherol on an osteoradionecrosis animal model.
Topics: Animals; Disease Models, Animal; Osteoradionecrosis; Pentoxifylline; Rats; Rats, Sprague-Dawley; Toc | 2020 |
Pentoxifylline and Tocopherol in the Management of Temporal Bone Osteoradionecrosis: A Case Series.
Topics: Aged; Female; Humans; Middle Aged; Osteoradionecrosis; Pentoxifylline; Retrospective Studies; Tempor | 2020 |
Pentoxifylline, tocopherol, and sequestrectomy are effective for the management of advanced osteoradionecrosis of the jaws-a case series.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Female; Humans; Jaw; Male; Middle Aged; Osteoradionecr | 2021 |
The use of pentoxifylline, tocopherol and clodronate in the management of osteoradionecrosis of the jaws.
Topics: Clodronic Acid; Head and Neck Neoplasms; Humans; Jaw; Osteoradionecrosis; Pentoxifylline; Retrospect | 2021 |
Re: Pentoxifylline: a review of its use in osteoradionecrosis.
Topics: Head and Neck Neoplasms; Humans; Osteoradionecrosis; Pentoxifylline; Tocopherols | 2018 |
Current trends in the medical management of osteoradionecrosis using triple therapy.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bone Density Conservat | 2018 |
Successful treatment of grade III osteoradionecrosis with mandibular fracture with pentoxifylline, tocopherol and clodronate.
Topics: Clodronic Acid; Female; Head and Neck Neoplasms; Humans; Mandibular Fractures; Middle Aged; Osteorad | 2018 |
Long-term recurrences of jaw osteoradionecrosis after apparent healing with the PENTOCLO protocol.
Topics: Clodronic Acid; Drug Combinations; Head and Neck Neoplasms; Humans; Neoplasm Recurrence, Local; Oste | 2020 |
Changing trends and the role of medical management on the outcome of patients treated for osteoradionecrosis of the mandible: experience from a regional head and neck unit.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antioxidants; Carcinoma, Squamous Cell; Debridement; | 2014 |
Osteoradionecrosis--a review of current concepts in defining the extent of the disease and a new classification proposal.
Topics: Antioxidants; Free Radical Scavengers; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Oste | 2014 |
Medical treatment of osteoradionecrosis of the mandible by PENTOCLO: preliminary results.
Topics: Aged; Aged, 80 and over; Bone Density Conservation Agents; Clodronic Acid; Drug Combinations; Female | 2014 |
Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone.
Topics: Bone Density Conservation Agents; Clodronic Acid; Drug Combinations; Female; Humans; Middle Aged; Os | 2015 |
Tissue repair in osteoradionecrosis using pentoxifylline and tocopherol--report of three cases.
Topics: Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Thera | 2016 |
Use of pentoxifylline and tocopherol in the management of osteoradionecrosis.
Topics: Anti-Bacterial Agents; Humans; Hyperbaric Oxygenation; Mandibular Diseases; Osteoradionecrosis; Pent | 2016 |
Prophylactic use of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy for cancer of the head and neck.
Topics: Head and Neck Neoplasms; Humans; Neck; Osteoradionecrosis; Pentoxifylline; Platelet Aggregation Inhi | 2016 |
Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment.
Topics: Animals; Antioxidants; Cranial Irradiation; Cytokines; Drug Combinations; Drug Synergism; Fibrosis; | 2008 |
Pentoxifylline and tocopherol in the management of patients with osteoradionecrosis, the Portsmouth experience.
Topics: Aged; Antioxidants; Female; Follow-Up Studies; Humans; Jaw Diseases; Male; Middle Aged; Mouth Neopla | 2012 |
Resolution of pain and complete healing of mandibular osteoradionecrosis using pentoxifylline and tocopherol: a case report.
Topics: Aged; alpha-Tocopherol; Antioxidants; Cranial Irradiation; Drug Combinations; Humans; Male; Mandibul | 2012 |
Redefining osteoradionecrosis.
Topics: alpha-Tocopherol; Antioxidants; Humans; Male; Mandibular Diseases; Osteoradionecrosis; Pentoxifyllin | 2012 |
Pentoxifylline in the treatment of radiation-related soft tissue injury: preliminary observations.
Topics: Administration, Oral; Aged; Analgesics; Anti-Bacterial Agents; Atrophy; Debridement; Dose-Response R | 1997 |
Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate.
Topics: Aged; Antimetabolites; Antioxidants; Breast Neoplasms; Clodronic Acid; Drug Therapy, Combination; Fe | 2002 |