Encephalitis, Limbic

A paraneoplastic syndrome marked by degeneration of neurons in the LIMBIC SYSTEM. Clinical features include HALLUCINATIONS, loss of EPISODIC MEMORY; ANOSMIA; AGEUSIA; TEMPORAL LOBE EPILEPSY; DEMENTIA; and affective disturbance (depression). Circulating anti-neuronal antibodies (e.g., anti-Hu; anti-Yo; anti-Ri; and anti-Ma2) and small cell lung carcinomas or testicular carcinoma are frequently associated with this syndrome.

Synonym
Encephalitis, Limbic
Limbic Encephalitis
Paraneoplastic Limbic Encephalitis

Excerpt	Reference
"Limbic encephalitis is a novel form of VZV infection."	( Dautheville, S; de Broucker, T; Schortgen, F; Tattevin, P; Wolff, M, 2001)
"Limbic encephalitis is typically a paraneoplastic syndrome with a poor prognosis; thus, identifying those patients with potentially reversible symptoms is important."	( Baker, I; Bien, CG; Buckley, C; Clover, L; Detert, N; Dewar, BK; Lang, B; Omer, S; Palace, J; Parkinson, A; Rossor, MN; Schott, JM; Vincent, A, 2004)
"Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed."	( Clover, L; Grubneac, A; Irani, SR; Jacob, S; Rajabally, YA; Vincent, A; Walters, RJ; Yazaki, M, 2008)
"Limbic encephalitis is a multifocal inflammatory disorder characterized by personality changes, irritability, memory loss, seizures, and, in some cases, dementia."	( Davis, M; Ravenel, JG, 2008)
"Limbic encephalitis is a rare central nervous system (CNS) manifestation of relapsing polychondritis (RP)."	( Kashihara, K; Kawada, S; Takahashi, Y, 2009)
"Paraneoplastic limbic encephalitis is a rare disorder characterized by personality changes, seizures, memory loss, and psychiatric symptoms often associated with antineuronal antibodies."	( Fountain, NB; Goodkin, HP; Langer, JE; Lopes, MB; Pranzatelli, MR; Rust, RS; Thiele, EA, 2012)
"Autoimmune limbic encephalitis is a rare disorder, characterised by the subacute onset of seizures, short-term memory loss, and psychiatric and behavioural symptoms."	( Hartong, EG; Meulstee, J; Mulleners, WM; van Vliet, J, 2012)
"Limbic encephalitis is characterized by subacute onset of short-term memory loss, seizures, sleep disturbances, as well as psychiatric and behavioral symptoms."	( Meulstee, J; Mulleners, W; van Vliet, J, 2012)
"Limbic encephalitis is a subacute syndrome characterized by memory impairment, confusion, seizures, hypothalamic dysfunction and psychiatric symptoms."	( Cartier, LR; Grandjean, MB; Guerrero, RT; Martínez, DB, 2012)
"Limbic encephalitis is one of the most common paraneoplastic neurological syndromes, which is mostly associated with small cell lung cancer, testicular tumors, and breast cancer."	( Al-Nahhas, A; Chondrogiannis, S; Ferretti, A; Maffione, AM; Rubello, D, 2013)
"Limbic encephalitis is a subacute onset syndrome characterized by short-term memory impairment, confusion, temporal lobe epilepsy, hypothalamic dysfunction, and psychiatric symptoms."	( Aguilar Barrios, JE; Cózar Santiago, Mdel P; Ferrer Rebolleda, J; Sanchez Jurado, R; Sanz Llorens, R, 2016)
"Limbic encephalitis is characterized by rapid onset of working memory deficit, mood changes, and often seizures."	( Chan, KH; Cheung, SSL; Lai, JSM; Lau, GKK; Shih, KC; Tang, WK; Wong, IYH, 2018)
"Limbic encephalitis is an inflammatory process of the limbic structures, with polymorphic clinical features, caused by paraneoplastic and nonparaneoplastic conditions and infections."	( Baratto, A; Ferri, G; Follador, H; Martino, N; Miola, A; Perini, GI; Scupola, N; Toffanin, T, 2019)
"Limbic encephalitis is one of the most common paraneoplastic neurological disorders (PND)."	( Capoccetti, F; Castagnoli, H; Fattori, S; Manni, C; Marchesani, F; Rossi, G, 2019)
"Limbic encephalitis is an inflammatory process involving the limbic structures of the brain, manifested with short-term memory deficits, confusion, depression and seizures."	( Alexiou, G; Asimakopoulos, A; Fotopoulos, A; Jabbour, P; Kyritsis, AP; Markoula, S; Sioka, C, 2020)
"Limbic encephalitis is often reported to present as seizures and impaired cognition with little focus on psychiatric presentations."	( Garrels, E; Huq, F; McKay, G, 2020)
"Autoimmune limbic encephalitis is a rare autoimmune disease characterised by inflammation of the limbic system of the brain."	( Alam, M; Ali, S; Ayaz-Ul-Haq, M; Iqbal, A; Ismail, S; Nabi, D, 2021)
"Limbic encephalitis is an inflammatory encephalopathy caused by viruses, immune responses, or other factors involving the limbic system."	( Li, R; Li, X; Wang, J; Wang, Y; Wei, W; Wu, X, 2022)

Excerpt	Reference
"Limbic encephalitis has been rarely associated with SLE."	( Castro, A; Geraldes, R; Pereira da Silva, JA; Romeu, JC, 2017)

Excerpt	Reference
"A case of limbic encephalitis in a patient who had undergone prolonged immunosuppressive treatment with i."	( Dautheville, S; de Broucker, T; Schortgen, F; Tattevin, P; Wolff, M, 2001)
"To describe a case of acute nonherpetic limbic encephalitis (LE) with negative testing for antibodies directed against onconeuronal and cell membrane antigens, including voltage-gated potassium channels and N-methyl-D-aspartate receptor, that showed a dramatic response to immune therapy."	( Andreetta, F; Marra, C; Masciullo, M; Modoni, A; Silvestri, G; Spinelli, P; Tartaglione, T; Tonali, P, 2009)
"Autoimmune limbic encephalitis (ALE) is a severe, but treatable, neuropsychiatric disorder that is difficult to diagnose clinically."	( Fisher, RE; Lai, EC; Patel, NR; Schulz, PE, 2012)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	53 (25.00)	18.1394
2010's	96 (45.28)	28.8240
2020's	63 (29.72)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	9	0
choline	low	1	0
creatine	low	1	0
lactic acid	low	2	0
dalteparin	low	2	0
pyruvic acid	low	1	0
thiamine	low	1	0
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	low	9	0
4-aminopyridine	low	1	0
homovanillic acid	low	1	0
phenytoin	low	2	0
hydroxyindoleacetic acid	low	1	0
acetazolamide	low	1	0
azathioprine	low	2	0
baclofen	low	1	0
carbamazepine	low	1	0
clonazepam	low	1	0
diazepam	low	2	0
valproic acid	low	1	0
foscarnet	low	3	0
isoniazid	low	1	0
lamotrigine	low	1	0
mechlorethamine	low	1	0
phenobarbital	low	1	0
piracetam	low	3	0
procarbazine	low	1	0
prednisolone	medium	18	1
estriol	low	1	0
thyroxine	low	2	0
prednisone	low	8	0
penicillin g	low	2	0
aspartic acid	low	1	0
leucine	low	27	0
methylprednisolone	medium	42	1
thiophenes	low	1	0
estriol succinate	low	1	0
lithium carbonate	low	1	0
ethambutol	low	1	0
vancomycin	low	1	0
n-methylaspartate	low	4	0
gadolinium	low	1	0
glutamic acid	low	4	0
etoposide	low	2	0
n 0437, (-)-isomer	low	1	0
emtricitabine	low	1	0
efavirenz	low	1	0
n-acetylaspartic acid	low	1	0
fluorodeoxyglucose f18	low	49	0
tandospirone	low	1	0
cortisone	low	1	0
tacrolimus	low	1	0
mycophenolic acid	medium	2	1
tenofovir	low	1	0
humulene	low	1	0
levetiracetam	low	3	0
cysteine	low	1	0
cgp 56999a	low	1	0
technetium tc 99m exametazime	low	1	0
mefloquine	low	1	0
peptide 31d	low	2	0
glycolipids	low	1	0
cyclosporine	low	2	0
acyclovir	low	6	0
rifampin	low	1	0
ganciclovir	low	5	0
olanzapine	low	1	0
technetium tc 99m bicisate	low	1	0
leptin	low	1	0

Protein Targets (879)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Cruzipain	2	0	0	2
thioredoxin reductase	16	0	0	16
RAR-related orphan receptor gamma	13	0	0	13
USP1 protein, partial	8	0	0	8
Microtubule-associated protein tau	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
thyroid stimulating hormone receptor	11	0	0	11
estrogen receptor 2 (ER beta)	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
glucocorticoid receptor [Homo sapiens]	20	0	0	20
cytochrome P450 2D6	8	0	0	8
glucocerebrosidase	2	0	0	2
IDH1	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	27	0	0	27
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
cytochrome P450 2D6 isoform 1	4	0	0	4
chromobox protein homolog 1	8	0	0	8
transcriptional regulator ERG isoform 3	4	0	0	4
thyroid hormone receptor beta isoform 2	17	0	0	17
mitogen-activated protein kinase 1	5	0	0	5
geminin	22	0	0	22
peripheral myelin protein 22	8	0	0	8
survival motor neuron protein isoform d	6	0	0	6
lethal factor (plasmid)	4	0	0	4
lamin isoform A-delta10	16	0	0	16
Potassium channel subfamily K member 2	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	18	0	0	18
Potassium voltage-gated channel subfamily A member 3	0	0	1	1
Acetylcholinesterase	0	1	0	2
Pteridine reductase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
GALC protein	2	0	0	2
GLI family zinc finger 3	18	0	0	18
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	19	0	0	19
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	12	0	0	12
Carbonic anhydrase	0	1	0	1
Bloom syndrome protein isoform 1	11	0	0	11
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	8	8	2	18
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	19
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	3
Carbonic anhydrase 12	0	2	1	5
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	25	0	25
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	4	1	12
Carbonic anhydrase 2	0	5	1	11
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Carbonic anhydrase 3	0	2	1	5
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	8	0	9
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	5	0	5
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2A6	0	3	0	3
Cytochrome P450 2C9	0	7	0	7
5-hydroxytryptamine receptor 2A	0	6	0	6
Androgen receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	8	8	2	18
Translocator protein	0	2	1	4
Gamma-aminobutyric acid receptor subunit delta	8	8	2	18
Gamma-aminobutyric acid receptor subunit gamma-2	8	8	4	20
Gamma-aminobutyric acid receptor subunit alpha-5	8	8	2	18
Gamma-aminobutyric acid receptor subunit alpha-3	8	8	2	18
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	2	4
Carbonic anhydrase 4	0	3	1	5
Carbonic anhydrase 6	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	8	8	2	18
Gamma-aminobutyric acid receptor subunit alpha-2	8	8	2	18
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	0	3
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	8	8	2	18
Gamma-aminobutyric acid receptor subunit gamma-3	8	8	2	18
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	8	8	2	18
Adenosine receptor A2a	0	1	0	1
5-hydroxytryptamine receptor 2B	0	5	0	5
Sodium-dependent serotonin transporter	0	4	0	4
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	3	0	4
Carbonic anhydrase 7	0	2	1	4
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	2	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	8	8	4	20
Gamma-aminobutyric acid receptor subunit beta-3	8	8	2	18
Gamma-aminobutyric acid receptor subunit beta-2	8	8	4	20
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	9	2	13
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Carbonic anhydrase 9	0	3	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	8	8	2	18
Canalicular multispecific organic anion transporter 1	0	19	0	20
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 15	0	1	0	2
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	8	8	2	18
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	1	5
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	7	0	0	7
Thymidine kinase	0	2	0	2
phosphopantetheinyl transferase	7	0	0	7
GLS protein	13	0	0	13
TDP1 protein	24	0	0	24
Smad3	2	0	0	2
EWS/FLI fusion protein	12	0	0	12
activating transcription factor 6	6	0	0	6
Histone H2A.x	5	0	0	5
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Solute carrier family 22 member 1	0	2	0	6
Bile salt export pump	0	7	0	7
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2J2	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	2	1	0	3
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	0	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Thymidine kinase	0	1	0	1
flap endonuclease 1	4	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Integrin beta-3	1	1	1	3
Integrin alpha-IIb	1	1	1	3
Glutamate receptor 1	0	6	2	8
Glutamate receptor 2	9	6	2	17
Glutamate receptor 3	0	6	2	8
Glutamate receptor 4	0	6	2	8
Glutamate receptor ionotropic, kainate 1	0	5	1	6
Glutamate receptor 1	0	1	1	2
Glutamate receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	8	2	12
Glutamate receptor ionotropic, kainate 1	0	3	1	4
Glutamate receptor ionotropic, kainate 2	0	5	1	6
Glutamate receptor 1	0	4	2	6
Glutamate receptor 2	0	4	2	6
Glutamate receptor 3	0	3	1	4
Glutamate receptor ionotropic, kainate 3	0	4	0	4
Excitatory amino acid transporter 1	0	4	0	5
Excitatory amino acid transporter 2	0	4	0	5
Excitatory amino acid transporter 3	0	4	0	5
Glutamate receptor 4	0	4	1	5
Glutamate receptor ionotropic, NMDA 2A	0	8	2	12
Glutamate receptor ionotropic, NMDA 2C	0	8	2	12
Glutamate receptor ionotropic, kainate 4	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, kainate 2	0	3	1	4
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	8	2	12
Glutamate receptor ionotropic, kainate 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	8	2	12
Glutamate receptor ionotropic, NMDA 3A	0	8	2	12
Glutamate receptor 4	0	1	0	1
Glutamate receptor 3	0	1	0	1
cytochrome P450 2C19 precursor	3	0	0	3
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	2
interleukin 8	2	0	0	2
acetylcholinesterase	9	0	0	9
SMAD family member 2	4	0	0	4
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	6	0	0	6
SMAD family member 3	4	0	0	4
AR protein	24	0	0	24
thioredoxin glutathione reductase	3	0	0	3
farnesoid X nuclear receptor	8	0	0	8
pregnane X nuclear receptor	16	0	0	16
estrogen nuclear receptor alpha	26	0	0	26
G	9	0	0	9
polyprotein	6	0	0	6
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	11	0	0	11
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
thyroid stimulating hormone receptor	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
peripheral myelin protein 22 isoform 1	6	0	0	6
cellular tumor antigen p53 isoform a	2	0	0	2
heat shock protein beta-1	6	0	0	6
DNA polymerase iota isoform a (long)	5	0	0	5
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	5	0	0	5
muscarinic acetylcholine receptor M1	9	0	0	9
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Nuclear receptor ROR-gamma	3	0	0	3
Inositol hexakisphosphate kinase 1	9	0	0	9
ATPase family AAA domain-containing protein 5	11	0	0	11
Ataxin-2	11	0	0	11
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	9	0	0	9
NFKB1 protein, partial	5	0	0	5
regulator of G-protein signaling 4	8	0	0	8
67.9K protein	5	0	0	5
D(1A) dopamine receptor	5	0	0	5
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
Vpr	1	0	0	1
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	7
Sodium channel protein type 4 subunit alpha	0	4	0	7
Sodium channel protein type 9 subunit alpha	0	5	0	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	3	0	3
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Gamma-aminobutyric acid receptor subunit pi	0	6	0	6
Gamma-aminobutyric acid receptor subunit delta	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	7	4	11
Gamma-aminobutyric acid receptor subunit beta-1	0	6	2	8
Gamma-aminobutyric acid receptor subunit gamma-2	0	7	3	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	7	3	10
Translocator protein	0	2	0	2
Translocator protein	0	3	0	3
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	6	4	10
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit beta-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	2	8
Gamma-aminobutyric acid receptor subunit epsilon	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	6	2	8
Gamma-aminobutyric acid receptor subunit gamma-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit theta	0	6	0	6
endonuclease IV	4	0	0	4
dopamine D1 receptor	1	0	0	1
pregnane X receptor	3	0	0	3
progesterone receptor	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
Glucocorticoid receptor	0	10	2	17
Sex hormone-binding globulin	0	0	2	2
Glycine receptor subunit alpha-1	0	10	0	10
Corticosteroid-binding globulin	0	3	0	3
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
TAR DNA-binding protein 43	4	0	0	4
Multidrug and toxin extrusion protein 1	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	4
Gamma-aminobutyric acid	0	2	1	3
glp-1 receptor, partial	5	0	0	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Fatty acid-binding protein, liver	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	4	5
ATP-dependent translocase ABCB1	0	4	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
5-hydroxytryptamine receptor 1A	0	6	1	8
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
PPM1D protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	4	0	0	4
caspase-3	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
nuclear receptor ROR-gamma isoform 1	8	0	0	8
neuropeptide S receptor isoform A	3	0	0	3
Prothrombin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Microsomal triglyceride transfer protein large subunit	0	1	0	1
Spike glycoprotein	6	0	0	6
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Reverse transcriptase/RNaseH	0	4	3	14
Protease	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Reverse transcriptase	0	1	1	2
Cholesterol 24-hydroxylase	0	0	1	1
Estrogen receptor	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Sodium-dependent serotonin transporter	0	7	0	7
Alpha-synuclein	1	2	0	3
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	4
Pantothenate synthetase	0	2	0	2
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	3
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	3
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Histone deacetylase 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ClpP	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
Transitional endoplasmic reticulum ATPase	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Metabotropic glutamate receptor 5	0	1	1	3
Metabotropic glutamate receptor 8	0	0	1	1
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate carboxypeptidase 2	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
15-lipoxygenase, partial	3	0	0	3
Thrombopoietin	1	0	0	1
nonstructural protein 1	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	5
5-hydroxytryptamine receptor 4	0	6	0	6
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	5	0	5
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	5	1	6
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	5	0	5
Alpha-2A adrenergic receptor	0	6	0	6
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	4	1	5
Angiotensin-converting enzyme	0	2	0	2
Integrin alpha-4	0	1	0	1
D(2) dopamine receptor	0	8	2	13
Alpha-1B adrenergic receptor	0	5	0	5
Carbonyl reductase [NADPH] 1	0	0	0	1
Alpha-2B adrenergic receptor	0	5	0	5
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	5	0	5
D	0	4	0	4
D(3) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	4	0	4
D(2) dopamine receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	4	0	4
D(1A) dopamine receptor	0	5	1	7
D(4) dopamine receptor	0	7	1	10
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	4	0	4
UDP-glucuronosyltransferase 1A4	0	0	0	3
Alpha-2A adrenergic receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	5	0	5
Sodium-dependent noradrenaline transporter	0	5	0	5
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	6	0	6
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	6	0	7
5-hydroxytryptamine receptor 2C	0	7	0	7
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1F	0	1	0	1
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	5	1	7
Alpha-1B adrenergic receptor	0	4	0	4
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	6	1	9
Sodium channel protein type 1 subunit alpha	0	3	0	3
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	7	0	7
Alpha-1A adrenergic receptor	0	5	0	5
Histamine H2 receptor	4	0	0	5
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 6	0	4	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	3	0	3
Cholecystokinin receptor type A	0	1	0	1
Adenylyl cyclase 7	0	1	0	1
D	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	2	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Solute carrier family 22 member 8	0	1	0	3
hypothetical protein, conserved	1	0	0	1
alpha-galactosidase	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
vitamin D3 receptor isoform VDRA	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Luciferase	2	0	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	1	0	1
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
DNA polymerase kappa isoform 1	3	0	0	3
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
5-hydroxytryptamine receptor 3E	0	2	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Histamine H1 receptor	0	1	1	2
5-hydroxytryptamine receptor 3A	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
Nuclear receptor subfamily 3 group C member 3	0	1	0	1
5-hydroxytryptamine receptor 3D	0	2	0	2
5-hydroxytryptamine receptor 3C	0	2	0	2
Transporter	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	3	0	5
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Adenylate kinase isoenzyme 1	0	0	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Capsid protein	0	0	1	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (212)

Protein Targets (879)

Encephalitis, Limbic

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (212)

Drugs Studied (82)

Protein Targets (879)