hydroxylysine and Vitamin-D-Deficiency

In chick bone collagen the degree of lysine hydroxylation and the magnitude of the crosslink ratio dihydroxylysinonorleucine/hydroxylysinonorleucine were both found to be inversely related to the concentration of plasma calcium. Lysine hydroxylation was also affected by a second factor related to vitamin D status.

Topics: Animals; Bone and Bones; Calcium; Chickens; Cholecalciferol; Collagen; Hydroxylysine; Male; Vitamin D Deficiency

Topics: 2-Aminoadipic Acid; Animals; Aorta; Bone and Bones; Calcium; Chemical Phenomena; Chemistry; Chickens; Collagen; Histidine; Humans; Hydroxylysine; Lysine; Macromolecular Substances; Osteogenesis Imperfecta; Phosphates; Protein-Lysine 6-Oxidase; Rickets; Vitamin D Deficiency

Topics: Animals; Bone Development; Bone Matrix; Chickens; Collagen; Hydroxylysine; Norleucine; Vitamin D Deficiency

Radioisotope studies have shown that collagen synthesized in the shafts of bones from rachitic rats and chicks is similar in chain composition to that normally synthesized. However, the extent of lysine hydroxylation in both alpha1- and alpha2-chains is increased, by approx. 15-30% in the rat and by 50% in the chick.

Topics: Animals; Bone and Bones; Chickens; Cholecalciferol; Chromatography, Ion Exchange; Collagen; Hydroxylation; Hydroxylysine; Lysine; Peptides; Rats; Time Factors; Tritium; Vitamin D Deficiency

Topics: Aldehydes; Amino Alcohols; Aminocaproates; Animals; Body Weight; Bone and Bones; Bone Development; Borohydrides; Chickens; Chromatography; Collagen; Dipeptides; Hydroxylysine; Male; Oxidation-Reduction; Protein Conformation; Tibia; Tritium; Vitamin D Deficiency