Compounds > 1,4-diaminobutanone
Page last updated: 2024-12-08

1,4-diaminobutanone

Description

It seems you might be referring to **1,4-diaminobutane** (also known as putrescine), not 1,4-diaminobutanone.

1,4-diaminobutane (putrescine) is a diamine with the formula H₂N(CH₂)₄NH₂. It is a colorless, hygroscopic solid with a characteristic odor. It is a naturally occurring compound found in living organisms.

Here's why it's important for research:

* **Biological Roles:**
* **Polyamine Precursor:** Putrescine is a precursor to other polyamines, like spermidine and spermine, which are essential for cell growth, proliferation, and differentiation.
* **Cellular Function:** It plays a role in a wide range of biological processes, including signal transduction, gene expression, and apoptosis.
* **Metabolic Pathway:** Putrescine is involved in the decarboxylation of ornithine, an important step in the urea cycle.

* **Research Applications:**
* **Cancer Research:** Putrescine levels are often elevated in cancer cells, and it's being investigated as a potential biomarker for cancer diagnosis and as a target for cancer therapy.
* **Neuroscience:** Putrescine is involved in neurotransmission and has been linked to neurodegenerative diseases like Alzheimer's.
* **Plant Science:** Putrescine is vital for plant growth and stress response. It's being studied for its potential in enhancing plant tolerance to environmental stresses.
* **Microbiology:** Putrescine is a crucial molecule in the metabolism of various microorganisms.

* **Other Applications:**
* **Agriculture:** Putrescine is being explored as a potential biofertilizer for crops.
* **Food Industry:** It's used as a flavoring agent in food products.

However, there is no known compound called **1,4-diaminobutanone**. This is likely a typo. If you meant to ask about another compound, please clarify.

1,4-diaminobutanone: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID151733
CHEMBL ID4160234
SCHEMBL ID2179702
MeSH IDM0062980

Synonyms (11)

Synonym
einecs 222-914-0
nsc 60541
1,4-diaminobutan-2-one
2-butanone, 1,4-diamino-
1,4-diaminobutanone
1,4-diamino-2-butanone
13123-70-1
AKOS006220478
SCHEMBL2179702
DTXSID30927135
CHEMBL4160234

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Electron microscopic examination of control versus DAB-treated trichomonads did not reveal any adverse effects on the number and integrity of hydrogenosomes."( Trichomonas vaginalis polyamine metabolism is linked to host cell adherence and cytotoxicity.
Alderete, JF; Benchimol, M; Garcia, AF, 2005)		0.33
" Pre-addition of either catalase (5 μM) or aminoguanidine (20 mM) was observed to partially inhibit the toxic effects of DAB to the cells, while N-acetyl-L-cysteine (NAC, 5 mM) or reduced glutathione (GSH, 5 mM) provided almost complete protection against DAB."( Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imbalance.
Bechara, EJ; Boiani, M; Marnett, LJ; Soares, CO, 2013)		0.39
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1353319Antiparasitic activity against Leishmania amazonensis MHOM/Br/75/Josefa promastigotes by light microscopic method2018European journal of medicinal chemistry, Mar-10, Volume: 147Targeting polyamine transport in Trypanosoma cruzi.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (31)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (12.90)18.7374
1990's10 (32.26)18.2507
2000's9 (29.03)29.6817
2010's8 (25.81)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.24 (24.57)
Research Supply Index3.50 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.13%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other31 (96.88%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cadaverine
[no description available]		2.1310alkane-alpha,omega-diamineDaphnia magna metabolite;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite
putrescine
[no description available]		5.84300alkane-alpha,omega-diamineantioxidant;
fundamental metabolite
spermidine
[no description available]		2.6730polyazaalkane;
triamine		autophagy inducer;
fundamental metabolite;
geroprotector
spermine
[no description available]		2.6930polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.		2.4220acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
eflornithine
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.. eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.		1.9810alpha-amino acid;
fluoroamino acid		trypanocidal drug
hydroxyurea
[no description available]		1.9710one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		1.9510antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
thiazoles
[no description available]		2.04101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
azacitidine
Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.		2.3820N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
1,6-diaminohexane
1,6-diaminohexane: Russian drug; RN given refers to parent cpd; structure. hexane-1,6-diamine : A C6 alkane-alpha,omega-diamine.		2.1310alkane-alpha,omega-diaminehuman xenobiotic metabolite
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		2.1310chromium group element atommicronutrient
chromium
Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.		2.1310chromium group element atom;
metal allergen		micronutrient
ozone
Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).. ozone : An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.		2.0110elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen		antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer
transferrin
Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.		2.0610
thiazolyl blue
thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.		2.0410organic bromide saltcolorimetric reagent;
dye
bisucaberin
bisucaberin: structure given in first source; isolated from broth of Alteromonas haloplanktis SB-1123		2.1310azamacrocycle;
keratan 6'-sulfate
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.		2.0610oxygen hydride;
oxygen radical;
reactive oxygen species
hydroxylysine
Hydroxylysine: A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.. hydroxylysine : A hydroxy-amino acid in which the amino acid specified is lysine. A "closed" class.. erythro-5-hydroxy-L-lysine : A 5-hydroxylysine consisting of L-lysine having an (R)-hydroxy group at the 5-position.. 5-hydroxylysine : A hydroxylysine that is lysine substituted by a hydroxy group at position 5.		1.98105-hydroxylysine;
hydroxy-L-lysine		human metabolite
alpha-chymotrypsin
Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.		1.9510
sterigmatocystin
[no description available]		1.9910sterigmatocystinsmetabolite
alcaligin
alcaligin: a siderophore produced by Bordetella & Alcaligenes sp.; structure given in first source		1.9910cyclic hydroxamic acid
putrebactin
putrebactin: an iron-chelating agent isolated from Shewanella putrefaciens; structure in first source		2.520cyclic hydroxamic acid
avaroferrin
avaroferrin: a siderophore isolated from Shewanella algae; structure in first source		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Fungal Diseases
[description not available]		01.9910
Mycoses
Diseases caused by FUNGI.		01.9910
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