1,4-diaminobutanone profile

It seems you might be referring to **1,4-diaminobutane** (also known as putrescine), not 1,4-diaminobutanone.

1,4-diaminobutane (putrescine) is a diamine with the formula H₂N(CH₂)₄NH₂. It is a colorless, hygroscopic solid with a characteristic odor. It is a naturally occurring compound found in living organisms.

Here's why it's important for research:

* **Biological Roles:**
* **Polyamine Precursor:** Putrescine is a precursor to other polyamines, like spermidine and spermine, which are essential for cell growth, proliferation, and differentiation.
* **Cellular Function:** It plays a role in a wide range of biological processes, including signal transduction, gene expression, and apoptosis.
* **Metabolic Pathway:** Putrescine is involved in the decarboxylation of ornithine, an important step in the urea cycle.

* **Research Applications:**
* **Cancer Research:** Putrescine levels are often elevated in cancer cells, and it's being investigated as a potential biomarker for cancer diagnosis and as a target for cancer therapy.
* **Neuroscience:** Putrescine is involved in neurotransmission and has been linked to neurodegenerative diseases like Alzheimer's.
* **Plant Science:** Putrescine is vital for plant growth and stress response. It's being studied for its potential in enhancing plant tolerance to environmental stresses.
* **Microbiology:** Putrescine is a crucial molecule in the metabolism of various microorganisms.

* **Other Applications:**
* **Agriculture:** Putrescine is being explored as a potential biofertilizer for crops.
* **Food Industry:** It's used as a flavoring agent in food products.

However, there is no known compound called **1,4-diaminobutanone**. This is likely a typo. If you meant to ask about another compound, please clarify.

1,4-diaminobutanone: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	151733
CHEMBL ID	4160234
SCHEMBL ID	2179702
MeSH ID	M0062980

Synonym
einecs 222-914-0
nsc 60541
1,4-diaminobutan-2-one
2-butanone, 1,4-diamino-
1,4-diaminobutanone
1,4-diamino-2-butanone
13123-70-1
AKOS006220478
SCHEMBL2179702
DTXSID30927135
CHEMBL4160234

Excerpt	Reference	Relevance
" Electron microscopic examination of control versus DAB-treated trichomonads did not reveal any adverse effects on the number and integrity of hydrogenosomes."	( Trichomonas vaginalis polyamine metabolism is linked to host cell adherence and cytotoxicity. Alderete, JF; Benchimol, M; Garcia, AF, 2005)	0.33
" Pre-addition of either catalase (5 μM) or aminoguanidine (20 mM) was observed to partially inhibit the toxic effects of DAB to the cells, while N-acetyl-L-cysteine (NAC, 5 mM) or reduced glutathione (GSH, 5 mM) provided almost complete protection against DAB."	( Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imbalance. Bechara, EJ; Boiani, M; Marnett, LJ; Soares, CO, 2013)	0.39

Assay ID	Title	Year	Journal	Article
AID1353319	Antiparasitic activity against Leishmania amazonensis MHOM/Br/75/Josefa promastigotes by light microscopic method	2018	European journal of medicinal chemistry, Mar-10, Volume: 147	Targeting polyamine transport in Trypanosoma cruzi.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (12.90)	18.7374
1990's	10 (32.26)	18.2507
2000's	9 (29.03)	29.6817
2010's	8 (25.81)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.13%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	31 (96.88%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cadaverine [no description available]	2.13	1	alkane-alpha,omega-diamine	Daphnia magna metabolite; Escherichia coli metabolite; mouse metabolite; plant metabolite
putrescine [no description available]	5.84	30	alkane-alpha,omega-diamine	antioxidant; fundamental metabolite
spermidine [no description available]	2.67	3	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector
spermine [no description available]	2.69	3	polyazaalkane; tetramine	antioxidant; fundamental metabolite; immunosuppressive agent
deferoxamine Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.	2.42	2	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore
eflornithine Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.. eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.	1.98	1	alpha-amino acid; fluoroamino acid	trypanocidal drug
hydroxyurea [no description available]	1.97	1	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	1.95	1	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
thiazoles [no description available]	2.04	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
azacitidine Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.	2.38	2	N-glycosyl-1,3,5-triazine; nucleoside analogue	antineoplastic agent
1,6-diaminohexane 1,6-diaminohexane: Russian drug; RN given refers to parent cpd; structure. hexane-1,6-diamine : A C6 alkane-alpha,omega-diamine.	2.13	1	alkane-alpha,omega-diamine	human xenobiotic metabolite
molybdenum Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.	2.13	1	chromium group element atom	micronutrient
chromium Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.	2.13	1	chromium group element atom; metal allergen	micronutrient
ozone Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).. ozone : An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.	2.01	1	elemental molecule; gas molecular entity; reactive oxygen species; triatomic oxygen	antiseptic drug; disinfectant; electrophilic reagent; greenhouse gas; mutagen; oxidising agent; tracer
transferrin Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.	2.06	1
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2.04	1	organic bromide salt	colorimetric reagent; dye
bisucaberin bisucaberin: structure given in first source; isolated from broth of Alteromonas haloplanktis SB-1123	2.13	1	azamacrocycle; keratan 6'-sulfate
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	2.06	1	oxygen hydride; oxygen radical; reactive oxygen species
hydroxylysine Hydroxylysine: A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.. hydroxylysine : A hydroxy-amino acid in which the amino acid specified is lysine. A "closed" class.. erythro-5-hydroxy-L-lysine : A 5-hydroxylysine consisting of L-lysine having an (R)-hydroxy group at the 5-position.. 5-hydroxylysine : A hydroxylysine that is lysine substituted by a hydroxy group at position 5.	1.98	1	5-hydroxylysine; hydroxy-L-lysine	human metabolite
alpha-chymotrypsin Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.	1.95	1
sterigmatocystin [no description available]	1.99	1	sterigmatocystins	metabolite
alcaligin alcaligin: a siderophore produced by Bordetella & Alcaligenes sp.; structure given in first source	1.99	1	cyclic hydroxamic acid
putrebactin putrebactin: an iron-chelating agent isolated from Shewanella putrefaciens; structure in first source	2.5	2	cyclic hydroxamic acid
avaroferrin avaroferrin: a siderophore isolated from Shewanella algae; structure in first source	2.13	1

1,4-diaminobutanone

Description

Cross-References

Synonyms (11)

Research Excerpts

Toxicity

Bioassays (1)

Research

Studies (31)

Market Indicators

Research Demand Index: 11.24

Study Types

Condition	Indicated	Relationship Strength	Studies	Trials
Fungal Diseases [description not available]	0	1.99	1	0
Mycoses Diseases caused by FUNGI.	0	1.99	1	0