Page last updated: 2024-09-28

Fong Disease

A syndrome of multiple abnormalities characterized by the absence or hypoplasia of the PATELLA and congenital nail dystrophy. It is a genetically determined autosomal dominant trait.

Synonyms(9)

Synonym
Onychoosteodysplasia
Hereditary Osteo-Onychodysplasias
Osterreicher Syndrome
Nail-Patella Syndrome
Fong Disease
Osteo-Onychodysplasia, Hereditary
Turner-Kieser Syndrome
Pelvic Horn Syndrome
Hereditary Onycho-Osteodysplasia

Research

Studies (44)

TimeframeStudies, This Condition (%)All Conditions %
pre-199020 (45.45)23.3326
1990's6 (13.64)12.5806
2000's10 (22.73)18.1394
2010's8 (18.18)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aspirin0low10
furosemide0low10
2-propanol0low70
losartan0low10
metoprolol0low10
prednisolone0low20
hydroxyproline0low20
aldosterone0low10
adenosine monophosphate0low10
durapatite0low10
calcium pyrophosphate0low10
trolamine salicylate0low30
fomesafen0low10
lovastatin0low10
pyridinoline0low10
proline0low20
atropine0low10
glycosides0low10
hydroxylysine0low10
enalapril0low10
cysteine0low10
glycolipids0low10
globotriaosylceramide0medium11
nephrin0low10
technetium tc 99m medronate0low20
eye0low20

Protein Targets (337)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma6006
GLI family zinc finger 35005
AR protein9009
aldehyde dehydrogenase 1 family, member A13003
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha4004
estrogen nuclear receptor alpha7007
peroxisome proliferator-activated receptor delta3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x2002
thyroid hormone receptor beta isoform a2002
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 14004
lamin isoform A-delta104004
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 23003
Chain A, Glycogen Phosphorylase B0011
Chain B, Glycogen Phosphorylase B0011
Chain A, ADP-dependent glucokinase0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, phosphodiesterase-nucleotide pyrophosphatase0101
Chain A, GLYCOGEN PHOSPHORYLASE B0011
Chain B, GLYCOGEN PHOSPHORYLASE B0011
Chain A, GLYCOGEN PHOSPHORYLASE B0011
regulator of G-protein signaling 41001
glucocorticoid receptor [Homo sapiens]8008
estrogen-related nuclear receptor alpha6006
euchromatic histone-lysine N-methyltransferase 23003
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
Mitogen-activated protein kinase kinase kinase 70011
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
5'-AMP-activated protein kinase subunit beta-20011
Transient receptor potential cation channel subfamily M member 20101
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
L-lactate dehydrogenase A chain0112
Adenylate kinase isoenzyme 10001
Fructose-1,6-bisphosphatase 10101
Alkaline phosphatase, tissue-nonspecific isozyme0001
Fructose-1,6-bisphosphatase 10101
2-dehydropantoate 2-reductase0112
Inosine-5'-monophosphate dehydrogenase0101
Cytochrome P450 2C9 0505
Proto-oncogene tyrosine-protein kinase Src0101
Amine oxidase [flavin-containing] B0101
5'-nucleotidase0001
Choline O-acetyltransferase0101
Adenylate kinase 2, mitochondrial0102
GTP:AMP phosphotransferase AK3, mitochondrial0001
Adenosine receptor A10213
Adenylate kinase isoenzyme 1 0102
P2Y purinoceptor 20011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
5'-AMP-activated protein kinase subunit gamma-10022
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Adenylate kinase 2, mitochondrial0001
Glycine--tRNA ligase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Adenosine deaminase-like protein0001
Protease 0112
P2Y purinoceptor 110011
Histamine H3 receptor0101
5'-AMP-activated protein kinase subunit gamma-30011
5'-AMP-activated protein kinase subunit gamma-20011
5'-AMP-activated protein kinase subunit beta-10022
ATP-dependent phosphofructokinase1001
nuclear factor erythroid 2-related factor 2 isoform 23003
geminin3003
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0336
Androgen receptor0404
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10002
Guanine nucleotide-binding protein G1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
thioredoxin reductase1001
GLS protein1001
thyroid stimulating hormone receptor2002
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 45005
EWS/FLI fusion protein3003
cytochrome P450 2D62002
glucocerebrosidase1001
Rac1 protein0011
IDH12002
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0707
Epidermal growth factor receptor0101
Carbonic anhydrase 10304
Carbonic anhydrase 20304
Fatty acid-binding protein, liver0202
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0202
Substance-P receptor0101
Prostaglandin G/H synthase 20404
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma2002
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-12114
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10606
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
nuclear receptor subfamily 1, group I, member 33003
pregnane X nuclear receptor4004
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0101
5-hydroxytryptamine receptor 40202
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30215
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M10216
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30215
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor0001
5-hydroxytryptamine receptor 70101
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
endonuclease IV1001
USP1 protein, partial2002
farnesoid X nuclear receptor3003
peripheral myelin protein 221001
histone acetyltransferase KAT2A isoform 12002
Angiotensin-converting enzyme 0303
Angiotensin-converting enzyme0101
Type-2 angiotensin II receptor0303
Succinyl-diaminopimelate desuccinylase0101
Solute carrier family 15 member 10101
Angiotensin-converting enzyme0101
Solute carrier family 15 member 10101
Multidrug and toxin extrusion protein 10303
Angiotensin-converting enzyme 2 0101
Luciferase1001
progesterone receptor3003
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
estrogen receptor 2 (ER beta)3003
aryl hydrocarbon receptor2002
thyrotropin-releasing hormone receptor2002
thyroid hormone receptor beta isoform 22002
Carbonic anhydrase 120102
Bile salt export pump0101
Albumin0101
Carbonic anhydrase 30101
Glucose-6-phosphate 1-dehydrogenase0101
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20303
6-phosphogluconate dehydrogenase, decarboxylating0101
Spike glycoprotein3003
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90102
Carbonic anhydrase 130102
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140102
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Carbonic anhydrase 5B, mitochondrial0102
Glutamine synthetase0101
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Proton-coupled amino acid transporter 10202
Amino acid transporter0202
Chain A, Cruzipain2002
TDP1 protein3003
G1001
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2013
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
ATP-dependent translocase ABCB10306
Neprilysin0101
Gamma-aminobutyric acid receptor subunit beta-12013
Atrial natriuretic peptide receptor 30101
Gamma-aminobutyric acid receptor subunit delta2013
Gamma-aminobutyric acid receptor subunit gamma-22013
5-hydroxytryptamine receptor 1A0213
Gamma-aminobutyric acid receptor subunit alpha-52013
Gamma-aminobutyric acid receptor subunit alpha-32013
Thromboxane A2 receptor 0102
Gamma-aminobutyric acid receptor subunit gamma-12013
Gamma-aminobutyric acid receptor subunit alpha-22013
Type-1A angiotensin II receptor 0213
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit alpha-42013
Gamma-aminobutyric acid receptor subunit gamma-32013
Type-1B angiotensin II receptor0202
Gamma-aminobutyric acid receptor subunit alpha-62013
Type-1 angiotensin II receptor0215
Type-1 angiotensin II receptor0112
Type-2 angiotensin II receptor0101
Gamma-aminobutyric acid receptor subunit beta-32013
Gamma-aminobutyric acid receptor subunit beta-22013
Squalene synthase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
GABA theta subunit2013
Inositol hexakisphosphate kinase 11001
Gamma-aminobutyric acid receptor subunit epsilon2013
Platelet glycoprotein VI0113
Solute carrier organic anion transporter family member 1B30202
Type-1 angiotensin II receptor0112
Solute carrier organic anion transporter family member 1B10303
cytochrome P450 2C9, partial1001
Chain A, Antigen Cd11a (p180)0101
Chain A, Beta-lactamase1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, Ferritin light chain1001
15-lipoxygenase, partial1001
pregnane X receptor1001
phosphopantetheinyl transferase1001
SMAD family member 21001
SMAD family member 31001
Microtubule-associated protein tau1001
thioredoxin glutathione reductase1001
Smad31001
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
PINK11001
isocitrate dehydrogenase 1, partial1001
Parkin1001
caspase-31001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
nuclear receptor subfamily 1, group I, member 22002
vitamin D3 receptor isoform VDRA1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 11001
survival motor neuron protein isoform d1001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Cellular tumor antigen p532002
Integrin beta-20101
Intercellular adhesion molecule 10101
Aldo-keto reductase family 1 member B10202
Neutrophil elastase0101
Insulin receptor 0101
Integrin alpha-L0112
Substance-K receptor0202
Sodium-dependent noradrenaline transporter 0202
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Sodium-dependent dopamine transporter 0202
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0101
Rap guanine nucleotide exchange factor 41001
Histone deacetylase 20101
Acyl-CoA:cholesterol acyltransferase 0101
Histone deacetylase 60101
Beta-1 adrenergic receptor 0011
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0213
Cytochrome P450 2D60101
Beta-3 adrenergic receptor0011
Beta-1 adrenergic receptor0112
Beta-1 adrenergic receptor0101
Beta-2 adrenergic receptor0011
luciferase0001
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glutamine synthetase0011
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Glutamate 5-kinase0001
Glutamate receptor ionotropic, NMDA 1 0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]