hydroxylysine has been researched along with delta-1-pyrroline-5-carboxylate* in 1 studies
1 other study(ies) available for hydroxylysine and delta-1-pyrroline-5-carboxylate
Article | Year |
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Periodate oxidation products of hydroxylysine in the synthesis of 5-substituted prolines.
The amino acid hydroxylysine was subjected to oxidation by sodium metaperiodate under various conditions. It was found that in acid and high temperature, the initial oxidation product alpha-aminoglutaric gamma-semialdehyde was converted to glutamic acid with a yield of 60%. The use of alkaline conditions of oxidation favored the cyclization of alpha-aminoglutaric gamma-semialdehyde to form delta 1-pyrroline 5-carboxylic acid. Addition of NaCN to this intermediate generated new proline analogs, likely a mixture of cis- and trans-5-cyanoprolines, with a yield of 30%. Upon hydrolysis, the 5-cyanoprolines were converted to a probable mixture of cis- and trans-5-carboxyprolines. Infrared and high-resolution mass spectral data of the analogs and visual absorption spectra of the ninhydrin products were obtained to confirm the structures. Topics: Hydrogen-Ion Concentration; Hydroxylysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Periodic Acid; Proline; Pyrroles; Spectrophotometry, Infrared; Temperature | 1985 |