Compounds > isosungucine
Page last updated: 2024-12-11

isosungucine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

isosungucine: isolated from Strychnos icaja; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
StrychnosgenusA plant genus of the family LOGANIACEAE (classified by some botanists as Strychnaceae).[MeSH]LoganiaceaeA plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida. They have leaflike appendages at the base of the leafstalks, have terminal flower clusters. Petals have four or five overlapping lobes and the fruit is a capsule containing winged or wingless seeds.[MeSH]

Cross-References

ID SourceID
PubMed CID5471853
CHEMBL ID524656
MeSH IDM0438250

Synonyms (5)

Synonym
nsc-715083
nsc715083
isosungucine
CHEMBL524656
(1r,12s,13r,14e,19s,21s)-14-ethylidene-10-[(1r,13s,14e,17r,19s,21s)-14-ethylidene-9-oxo-8,16-diazahexacyclo[11.5.2.11,8.02,7.016,19.012,21]henicosa-2,4,6,11-tetraen-17-yl]-8,16-diazahexacyclo[11.5.2.11,8.02,7.016,19.012,21]henicosa-2,4,6,10-tetraen-9-one

Research Excerpts

Overview

Isosungucine is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja.

ExcerptReferenceRelevance
"Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. "( In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja.
Angenot, L; De Mol, P; Frédérich, M; Philippe, G; Tits, M, 2007)		2.06
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID361155Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
Antiplasmodial activity of alkaloids from various strychnos species.
AID358504Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana by [3H]hypoxanthine uptake2001Journal of natural products, Jan, Volume: 64, Issue:1
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358510Selectivity index, ratio of IC50 for human KB cells to IC50 for chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana2001Journal of natural products, Jan, Volume: 64, Issue:1
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358509Cytotoxicity against human WI38 cells by WST1 assay2001Journal of natural products, Jan, Volume: 64, Issue:1
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358512Selectivity index, ratio of IC50 for human WI38 cells to IC50 for chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana2001Journal of natural products, Jan, Volume: 64, Issue:1
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358511Selectivity index, ratio of IC50 for human KB cells to IC50 for chloroquine-resistant Plasmodium falciparum W2 Indochina2001Journal of natural products, Jan, Volume: 64, Issue:1
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358508Cytotoxicity against human KB cells by WST1 assay2001Journal of natural products, Jan, Volume: 64, Issue:1
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358513Selectivity index, ratio of IC50 for human WI38 cells to IC50 for chloroquine-resistant Plasmodium falciparum W2 Indochina2001Journal of natural products, Jan, Volume: 64, Issue:1
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID361157Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
Antiplasmodial activity of alkaloids from various strychnos species.
AID358505Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake2001Journal of natural products, Jan, Volume: 64, Issue:1
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID361154Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
Antiplasmodial activity of alkaloids from various strychnos species.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indole
[no description available]		2.1310indole;
polycyclic heteroarene		Escherichia coli metabolite
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.4120aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
mefloquine hydrochloride
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.		210organofluorine compound;
piperidines;
quinolines;
secondary alcohol
ethane
Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.		2.0110alkane;
gas molecular entity		plant metabolite;
refrigerant
emetine
Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.. emetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.		210isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor
strychnine n-oxide
strychnine N-oxide: structure in first source. strychnine N-oxide : A tertiary amine oxide resulting from the oxidation of the non-acylated nitrogen of strychnine. It is a metabolite of strychnine.		2.1310monoterpenoid indole alkaloid;
organic heteroheptacyclic compound;
tertiary amine oxide		plant metabolite
strychnine
Strychnine: An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.. strychnine : A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.		7.4520monoterpenoid indole alkaloid;
organic heteroheptacyclic compound		avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide
quinine
[no description available]		2.4120cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic
usambarensine
usambarensine: structure given in first source		2.4120harmala alkaloid
ConditionIndicatedRelationship StrengthStudiesTrials
Leucocythaemia
[description not available]		02.0110
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		07.0110