Compounds > isosungucine
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isosungucine

Description

isosungucine: isolated from Strychnos icaja; structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID5471853
CHEMBL ID524656
MeSH IDM0438250

Synonyms (5)

Synonym
nsc-715083
nsc715083
isosungucine
CHEMBL524656
(1r,12s,13r,14e,19s,21s)-14-ethylidene-10-[(1r,13s,14e,17r,19s,21s)-14-ethylidene-9-oxo-8,16-diazahexacyclo[11.5.2.11,8.02,7.016,19.012,21]henicosa-2,4,6,11-tetraen-17-yl]-8,16-diazahexacyclo[11.5.2.11,8.02,7.016,19.012,21]henicosa-2,4,6,10-tetraen-9-one

Bioassays (11)

Assay IDTitleYearJournalArticle
AID361155Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
ISSN: 0163-3864		Antiplasmodial activity of alkaloids from various strychnos species.
AID358504Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana by [3H]hypoxanthine uptake2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358510Selectivity index, ratio of IC50 for human KB cells to IC50 for chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358509Cytotoxicity against human WI38 cells by WST1 assay2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358512Selectivity index, ratio of IC50 for human WI38 cells to IC50 for chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358511Selectivity index, ratio of IC50 for human KB cells to IC50 for chloroquine-resistant Plasmodium falciparum W2 Indochina2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358508Cytotoxicity against human KB cells by WST1 assay2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID358513Selectivity index, ratio of IC50 for human WI38 cells to IC50 for chloroquine-resistant Plasmodium falciparum W2 Indochina2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID361157Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
ISSN: 0163-3864		Antiplasmodial activity of alkaloids from various strychnos species.
AID358505Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake2001Journal of natural products, Jan, Volume: 64, Issue:1
ISSN: 0163-3864		Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
AID361154Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake2002Journal of natural products, Oct, Volume: 65, Issue:10
ISSN: 0163-3864		Antiplasmodial activity of alkaloids from various strychnos species.

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
chloroquine
2
aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug		2001200222.5medium000200
mefloquine hydrochloride
1
organofluorine compound;
piperidines;
quinolines;
secondary alcohol		2001200123.0low000100
ethane
1
alkane;
gas molecular entity		plant metabolite;
refrigerant		2002200222.0low000100
emetine
1
isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor		2001200123.0low000100
quinine
2
cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic		2001200222.5medium000200
usambarensine
2
harmala alkaloid2001200222.5high000200
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
indole
1
indole;
polycyclic heteroarene		Escherichia coli metabolite201620168.0low000010
strychnine n-oxide
1
monoterpenoid indole alkaloid;
organic heteroheptacyclic compound;
tertiary amine oxide		plant metabolite201620168.0medium000010
strychnine
2
monoterpenoid indole alkaloid;
organic heteroheptacyclic compound		avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide		2002201615.0medium000110
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Leucocythaemia0
1
2002200222.0high000100
Leukemia0
1
2002200222.0high000100