Page last updated: 2024-09-28

Depth Intoxication

Progressive mental disturbances and unconsciousness due to breathing mixtures of oxygen and inert gases (argon, helium, xenon, krypton, and atmospheric nitrogen) at high pressure.

Synonyms(3)

Synonym
Inert Gas Narcosis
Nitrogen Narcosis
Depth Intoxication

Research Excerpts

Overview

ExcerptReference
"In man, nitrogen narcosis is characterized by euphoria, impaired cognitive function, neuromuscular incoordination and, ultimately, loss of consciousness."( Barthelemy-Requin, M; Risso, JJ; Semelin, P, 1994)
"Inert gas narcosis is a neurological syndrome appearing when humans or animals are exposed to hyperbaric inert gases (nitrogen, argon) composed by motor and cognitive impairments."( Balon, N; Blanc, F; Risso, JJ; Rostain, JC; Weiss, M, 2003)

Context

ExcerptReference
"Nitrogen narcosis has a detrimental impact on the manual dexterity of divers and prior research has suggested that this impairment may be magnified by anxiety."( Higham, P; Hobbs, M; Kneller, W, 2012)

Actions

ExcerptReference
"We examined whether inert gas narcosis affects the response-selection stage of sensorimotor information processing."( Blatteau, JE; Hasbroucq, T; Meckler, C; Risso, JJ; Schmid, B; Vidal, F, 2014)

Research

Studies (184)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990119 (64.67)23.3326
1990's22 (11.96)12.5806
2000's23 (12.50)18.1394
2010's16 (8.70)28.8240
2020's4 (2.17)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
benzene0low10
carbon monoxide0low10
chlorine0low10
3,4-dihydroxyphenylacetic acid0low40
hydrogen0low70
nitrous oxide0medium302
homovanillic acid0low40
acetaminophen0low10
aspirin0low10
baclofen0low10
bemegride0low10
amphetamine0low20
glutethimide0low10
halothane0low10
hexobarbital0low10
methyl parathion0medium41
apnea0low40
pentobarbital0low10
phenacetin0low10
propranolol0low10
succinylcholine0low10
tetraethylammonium0low10
dextroamphetamine0low30
carbachol0low10
pentylenetetrazole0low10
carbon tetrachloride0low10
aspartic acid0low30
glutamine0low30
physostigmine0low10
zoxazolamine0low10
asparagine0low30
potassium cyanide0low10
ephedrine0low10
methamphetamine0low10
propanidid0low10
azacyclonol0low10
paraquat0low10
sulfur hexafluoride0low10
n-methylaspartate0low10
neon0low70
argon0low100
helium0low480
xenon0low20
fluorine0low10
clemastine0medium11
glutamic acid0low40
proroxan0low10
fomesafen0low10
saclofen0low10
heliox0low20
lithium0low10
quinine0low10
nervonic acid0low10
phosphorus0low10
scopolamine hydrobromide0low10
nad0low10
piperidines0low10

Protein Targets (782)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE100010
euchromatic histone-lysine N-methyltransferase 2180018
Bloom syndrome protein isoform 1130013
peripheral myelin protein 22 isoform 14004
D(1A) dopamine receptor7007
lamin isoform A-delta10150015
Glutamate receptor 10516
Glutamate receptor ionotropic, NMDA 1 19213
Glutamate receptor ionotropic, kainate 30505
Glutamate receptor ionotropic, NMDA 2A 09212
Glutamate receptor ionotropic, NMDA 2B09212
Glutamate receptor ionotropic, NMDA 2C09212
Glutamate receptor ionotropic, NMDA 2D09212
Glutamate receptor ionotropic, NMDA 3B09212
Glutamate receptor ionotropic, NMDA 3A09212
ATP-dependent phosphofructokinase9009
thioredoxin reductase150015
nonstructural protein 12002
arylsulfatase A9009
thyroid hormone receptor beta isoform a6006
histone acetyltransferase KAT2A isoform 16006
neuropeptide S receptor isoform A4004
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, Protocatechuate 3,4-dioxygenase0011
Chain M, Protocatechuate 3,4-dioxygenase0011
Olfactory receptor class A-like protein 10011
Luciferase4004
endonuclease IV1001
RGS121001
phosphopantetheinyl transferase7007
NFKB1 protein, partial5005
GLS protein110011
TDP1 protein170017
Microtubule-associated protein tau6006
Thrombopoietin2002
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
thyroid stimulating hormone receptor110011
hypothetical protein, conserved2002
regulator of G-protein signaling 47007
lysosomal alpha-glucosidase preproprotein2002
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
intestinal alkaline phosphatase precursor0101
chromobox protein homolog 18008
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
DNA polymerase beta2002
flap endonuclease 13003
DNA polymerase iota isoform a (long)4004
geminin9009
M-phase phosphoprotein 84004
alkaline phosphatase, germ cell type preproprotein0011
POsterior Segregation0011
muscarinic acetylcholine receptor M17007
Prolyl 4-hydroxylase subunit alpha-10101
Sodium-dependent noradrenaline transporter 0437
Zinc finger protein mex-50011
RAR-related orphan receptor gamma6006
ATAD5 protein, partial7007
Smad33003
aldehyde dehydrogenase 1 family, member A1120012
nuclear receptor subfamily 1, group I, member 3100010
progesterone receptor6006
EWS/FLI fusion protein3003
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha9009
estrogen nuclear receptor alpha120012
peroxisome proliferator activated receptor gamma8008
aryl hydrocarbon receptor8008
thyroid hormone receptor beta isoform 25005
peripheral myelin protein 228008
cytochrome P450 3A4 isoform 16006
Gamma-aminobutyric acid receptor subunit pi63110
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Solute carrier family 22 member 60303
Carbonic anhydrase 120202
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0303
Voltage-dependent calcium channel gamma-2 subunit2002
Bile salt export pump012012
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10509
Carbonic anhydrase 20509
Myoglobin0101
Cytochrome P450 1A10225
Cytochrome P450 1A20305
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30202
Cytochrome P450 3A40404
Cytochrome P450 2D60707
Cytochrome P450 2C9 0404
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit beta-163110
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta63110
Gamma-aminobutyric acid receptor subunit gamma-263312
UDP-glucuronosyltransferase 1-60102
Glutamate receptor 22316
Gamma-aminobutyric acid receptor subunit alpha-563110
Gamma-aminobutyric acid receptor subunit alpha-363110
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0102
Carbonic anhydrase 40303
Prostaglandin G/H synthase 10303
Carbonic anhydrase 60202
Gamma-aminobutyric acid receptor subunit gamma-163110
Gamma-aminobutyric acid receptor subunit alpha-263110
Gamma-aminobutyric acid receptor subunit alpha-463110
Gamma-aminobutyric acid receptor subunit gamma-363110
Gamma-aminobutyric acid receptor subunit alpha-663110
Carbonic anhydrase 5A, mitochondrial0202
Prostaglandin G/H synthase 20304
Carbonic anhydrase 70202
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-164313
Gamma-aminobutyric acid receptor subunit beta-363110
Gamma-aminobutyric acid receptor subunit beta-263312
Carbonic anhydrase 90202
GABA theta subunit63110
Canalicular multispecific organic anion transporter 10808
Carbonic anhydrase 150202
Carbonic anhydrase 130202
Gamma-aminobutyric acid receptor subunit epsilon63110
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0202
toxin B0001
Solute carrier family 22 member 30203
5-hydroxytryptamine receptor 2C0123
Phenylethanolamine N-methyltransferase0303
Cytochrome P450 2A60101
Substance-P receptor0101
5-hydroxytryptamine receptor 2A0123
5-hydroxytryptamine receptor 1A0438
Cytochrome P450 2A50101
Sodium-dependent dopamine transporter0213
5-hydroxytryptamine receptor 1B0325
5-hydroxytryptamine receptor 1D0123
5-hydroxytryptamine receptor 1F0123
5-hydroxytryptamine receptor 2B0123
5-hydroxytryptamine receptor 60022
5-hydroxytryptamine receptor 7 0022
5-hydroxytryptamine receptor 5A0022
5-hydroxytryptamine receptor 5B0022
5-hydroxytryptamine receptor 3A0022
Sigma non-opioid intracellular receptor 10112
5-hydroxytryptamine receptor 4 0022
Beta-2 adrenergic receptor0214
5-hydroxytryptamine receptor 3B0022
Sigma non-opioid intracellular receptor 10123
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Carbonic anhydrase-like protein, putative0004
Amino acid transporter0202
Chain A, Ferritin light chain3003
cytochrome P450 2C19 precursor5005
lethal factor (plasmid)4004
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase 40001
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
AR protein9009
cytochrome P450 family 3 subfamily A polypeptide 46006
glucocorticoid receptor [Homo sapiens]8008
cytochrome P450 2D65005
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta4004
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
DNA polymerase kappa isoform 13003
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0101
Integrin beta-34116
Myeloperoxidase0202
Seed linoleate 13S-lipoxygenase-10204
Integrin alpha-IIb4116
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10202
Adenosine receptor A2a0202
Substance-P receptor0202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10516
Chain A, Beta-lactamase2002
GLI family zinc finger 38008
bromodomain adjacent to zinc finger domain 2B2002
cytochrome P450 2D6 isoform 13003
potassium voltage-gated channel subfamily H member 2 isoform d4004
nuclear receptor ROR-gamma isoform 13003
Histamine H1 receptor0303
Potassium voltage-gated channel subfamily H member 20505
TAR DNA-binding protein 433003
67.9K protein4004
activating transcription factor 65005
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
Chain A, Integrase0101
Chain A, Integrase0101
Chain A, T4 LYSOZYME0011
Chain A, GCN4P10011
Chain B, GCN4P10011
Chain C, GCN4P10011
Chain A, T4 LYSOZYME0011
Chain A, T4 LYSOZYME0011
Chain A, Replicase polyprotein 1ab0101
Chain A, 3C-like proteinase0101
pregnane X receptor2002
cellular tumor antigen p53 isoform a4004
Endolysin0011
Cellular tumor antigen p535005
acetylcholinesterase4004
GALC protein2002
thyroid stimulating hormone receptor3003
thyrotropin-releasing hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Neuronal acetylcholine receptor subunit alpha-30101
Muscarinic acetylcholine receptor M20539
Muscarinic acetylcholine receptor M40629
Muscarinic acetylcholine receptor M10417
Muscarinic acetylcholine receptor M30315
Muscarinic acetylcholine receptor M40304
Muscarinic acetylcholine receptor M50304
Muscarinic acetylcholine receptor M50528
Neuronal acetylcholine receptor subunit alpha-40101
Muscarinic acetylcholine receptor M20517
Muscarinic acetylcholine receptor M106310
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M306310
Neuronal acetylcholine receptor subunit alpha-50101
Delta-type opioid receptor0102
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Muscarinic acetylcholine receptor0202
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100101
Cytochrome P450 2E10101
Carbonic anhydrase0101
cytochrome P450 2C9 precursor2002
Solute carrier family 22 member 1 0507
Polyunsaturated fatty acid lipoxygenase ALOX15B2103
5-hydroxytryptamine receptor 40404
Aldo-keto reductase family 1 member B10303
Alpha-2A adrenergic receptor0326
Angiotensin-converting enzyme0202
D(2) dopamine receptor0314
Alpha-2B adrenergic receptor0214
Alpha-2C adrenergic receptor0326
D(1A) dopamine receptor0314
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0214
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2C0415
Cytochrome P450 2C190202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0415
Histamine H2 receptor2002
5-hydroxytryptamine receptor 60415
5-hydroxytryptamine receptor 70304
Sodium-dependent dopamine transporter 0415
Sigma intracellular receptor 20101
Nuclear receptor subfamily 3 group C member 3 0202
Amine oxidase [flavin-containing] B0202
Amine oxidase [flavin-containing] A0202
Amine oxidase [flavin-containing] B0202
Sodium-dependent serotonin transporter0426
Sodium-dependent serotonin transporter0112
Amine oxidase [flavin-containing] B0303
Trace amine-associated receptor 10022
Trace amine-associated receptor 10022
Trace amine-associated receptor 10022
Trace amine-associated receptor 10022
hypoxia-inducible factor 1 alpha subunit2002
pregnane X nuclear receptor6006
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
Histone H2A.x3003
nuclear factor erythroid 2-related factor 2 isoform 16006
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20123
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20123
Gamma-aminobutyric acid receptor subunit beta-20123
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial1001
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0303
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0123
ATP-citrate synthase 0101
Glutamate receptor 30314
Glutamate receptor 40314
Glutamate receptor ionotropic, kainate 10314
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20314
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40303
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50303
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
15-lipoxygenase, partial3003
Asc-type amino acid transporter 10101
G2002
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
Chain A, Cruzipain2002
Albumin0123
Voltage-dependent L-type calcium channel subunit alpha-1C0303
nuclear factor erythroid 2-related factor 2 isoform 22002
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Spike glycoprotein1012
ClpP1001
Fumarate hydratase1001
polyprotein1001
Solute carrier family 22 member 80001
Synaptic vesicular amine transporter0101
USP1 protein, partial2002
estrogen receptor 2 (ER beta)2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
vitamin D3 receptor isoform VDRA4004
heat shock protein beta-12002
mitogen-activated protein kinase 12002
nuclear factor NF-kappa-B p105 subunit isoform 11001
survival motor neuron protein isoform d3003
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Photosystem I iron-sulfur center 0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Alpha-synuclein1102
Cytochrome P450 1A2 0002
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1A40101
Arylacetamide deacetylase0001
UDP-glucuronosyltransferase 2B10 0101
Solute carrier family 22 member 60101
Multidrug and toxin extrusion protein 10101
ATPase family AAA domain-containing protein 51001
Ataxin-22002
Arylacetamide deacetylase0001
Arylacetamide deacetylase0001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
Acetylcholinesterase0203
Acetylcholinesterase0101
Cholinesterase0202
Alpha-1B adrenergic receptor0314
Acetylcholinesterase0202
Acetylcholinesterase0203
Acetylcholinesterase 0101
Alpha-1D adrenergic receptor0213
Acetylcholinesterase0101
Acetylcholinesterase0101
Alpha-1A adrenergic receptor0213
Cholinesterase0203
Cholinesterase0101
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0101
Polyphenol oxidase 20203
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Beta-2 adrenergic receptor0213
ATP-dependent translocase ABCB10517
Beta-1 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0112
Adenosine receptor A30213
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80202
Beta-3 adrenergic receptor0213
Beta-1 adrenergic receptor0214
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Mu-type opioid receptor0112
Vasopressin V1a receptor0112
Delta-type opioid receptor0112
Kappa-type opioid receptor0112
Beta-2 adrenergic receptor0101
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0101
Nuclear receptor subfamily 2 group E member 10022
huntingtin isoform 21001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, APH(2')-Id0101
glucose-6-phosphate dehydrogenase0101
Nrf21001
SMAD family member 21001
SMAD family member 31001
signal transducer and activator of transcription 6, interleukin-4 induced1001
DNA polymerase III, partial1001
Neuraminidase 0202
Parkin1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
hexokinase0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
galactokinase1001
interferon gamma precursor0001
polyunsaturated fatty acid lipoxygenase ALOX121001
histone deacetylase 9 isoform 31001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
tyrosine-protein kinase Yes1001
DNA polymerase eta isoform 11001
muscleblind-like protein 1 isoform 11001
Transmembrane protease serine 20011
Maltase-glucoamylase, intestinal0101
NUAK family SNF1-like kinase 10101
Lysine-specific histone demethylase 1A0101
B2 bradykinin receptor0101
G2/mitotic-specific cyclin-B20101
Arginase 0101
Pancreatic triacylglycerol lipase0101
Prothrombin 0101
Urokinase-type plasminogen activator0101
Cationic trypsin0101
Chymotrypsinogen A0101
Chymotrypsin-like elastase family member 10101
Beta-lactamase0101
Protein E60101
Neuraminidase0101
Interstitial collagenase0112
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Amyloid-beta precursor protein0101
Beta-lactamase0101
Tyrosine-protein kinase Lck0101
Cyclin-dependent kinase 10101
Glycogen phosphorylase, liver form0101
Epoxide hydrolase 1 0101
Trypsin-10101
Trypsin-20101
Procathepsin L0011
Tyrosine-protein kinase Yes0101
Proto-oncogene tyrosine-protein kinase receptor Ret0101
Insulin-like growth factor 1 receptor0101
Neutrophil elastase0202
72 kDa type IV collagenase0101
Stromelysin-10101
Hepatocyte growth factor receptor0101
Heterogeneous nuclear ribonucleoprotein A10011
Polyunsaturated fatty acid 5-lipoxygenase0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0213
Calmodulin-10101
Replicase polyprotein 1ab0213
Alpha-amylase 1A 0101
Lysosomal alpha-glucosidase0101
Sialidase0101
Malate dehydrogenase0101
Solute carrier family 2, facilitated glucose transporter member 20101
Serine/threonine-protein kinase pim-10112
Aromatase0101
Cyclin-dependent kinase 40101
Polyunsaturated fatty acid 5-lipoxygenase0101
Proto-oncogene tyrosine-protein kinase Src0101
Cystic fibrosis transmembrane conductance regulator0011
Sucrase-isomaltase, intestinal0101
G2/mitotic-specific cyclin-B10101
Tyrosinase0101
Matrix metalloproteinase-90101
Urease subunit alpha0202
Serine/threonine-protein kinase B-raf0101
Aldo-keto reductase family 1 member B10101
G2/mitotic-specific cyclin-B0101
Cytochrome P450 11B1, mitochondrial0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Aldo-keto reductase family 1 member B10101
Chymotrypsinogen B0101
Tyrosine-protein phosphatase non-receptor type 10101
Polyunsaturated fatty acid lipoxygenase ALOX120101
Glycogen synthase kinase-3 beta0101
Solute carrier family 2, facilitated glucose transporter member 4 0101
Casein kinase II subunit alpha'0202
Amine oxidase [flavin-containing] A 0101
5'-nucleotidase0101
D(4) dopamine receptor0101
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal0101
G1/S-specific cyclin-D10101
Cyclin-dependent kinase 20101
C-X-C chemokine receptor type 10101
Dipeptidyl peptidase 40101
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Proteasome subunit beta type-50101
Cytosol aminopeptidase0101
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Vasopressin V2 receptor0101
Tyrosine-protein kinase receptor UFO0101
RAC-alpha serine/threonine-protein kinase0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Trypsin-30101
Prostaglandin G/H synthase 2 0101
Vascular endothelial growth factor receptor 20101
Receptor-type tyrosine-protein kinase FLT30101
17-beta-hydroxysteroid dehydrogenase type 20101
Macrophage metalloelastase0101
Kappa-type opioid receptor0101
Glutathione reductase0101
Tyrosine-protein kinase SYK0112
Collagenase 30101
1-deoxy-D-xylulose 5-phosphate reductoisomerase0101
Xanthine dehydrogenase/oxidase0202
Prolyl endopeptidase0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Glycogen synthase kinase-3 alpha0101
Glycogen synthase kinase-3 beta0101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
C-C chemokine receptor type 40101
Serine/threonine-protein kinase Nek20101
Oligo-1,6-glucosidase IMA10101
Serine/threonine-protein kinase PLK10101
Death-associated protein kinase 10101
Mitogen-activated protein kinase 100101
Monocarboxylate transporter 10101
Beta-secretase 10202
Anthrax toxin receptor 20101
Casein kinase II subunit beta0202
Casein kinase II subunit alpha0202
Urease subunit beta0202
Disintegrin and metalloproteinase domain-containing protein 171001
Lactoperoxidase0101
Aldo-keto reductase family 1 member B10101
Xanthine dehydrogenase/oxidase0203
Inositol monophosphatase 11001
Cyclin-dependent kinase 60101
Cyclin-dependent-like kinase 5 0101
Heat shock factor protein 10101
Sorbitol dehydrogenase0101
Cyclin homolog0101
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Dual specificity mitogen-activated protein kinase kinase 10101
Lactoylglutathione lyase0202
Focal adhesion kinase 10101
Calcium/calmodulin-dependent protein kinase type II subunit beta0101
ELAV-like protein 30101
Cyclin-dependent kinase 5 activator 10101
ELAV-like protein 10101
Serine/threonine-protein kinase N10101
Mitogen-activated protein kinase 140101
Cytochrome P450 1B10213
Probable maltase-glucoamylase 20101
Carbonic anhydrase 30101
Monocarboxylate transporter 20101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Prostaglandin G/H synthase 1 0101
Substance-K receptor0101
Integrase 0101
Casein kinase II subunit alpha 30202
Inositol polyphosphate multikinase0101
G2/mitotic-specific cyclin-B30101
Aldo-keto reductase family 1 member C210202
Enoyl-acyl-carrier protein reductase 0202
3-oxoacyl-acyl-carrier protein reductase 0101
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
Aurora kinase B0101
Chymotrypsin-C0101
Angiotensin-converting enzyme 2 0011
Cyclin-dependent kinase 10101
Phosphodiesterase 0101
G-protein coupled receptor 350112
Serine/threonine-protein kinase Nek60101
NADPH oxidase 40101
Hypoxia-inducible factor 1-alpha inhibitor0101
Dipeptidyl peptidase 30101
Inositol hexakisphosphate kinase 20101
Short transient receptor potential channel 50101
ALK tyrosine kinase receptor0101
Broad substrate specificity ATP-binding cassette transporter ABCG20112
Sialidase-20101
phosphoglycerate kinase1001
farnesoid X nuclear receptor1001
Solute carrier family 22 member 10304
Solute carrier family 22 member 20204
Solute carrier organic anion transporter family member 1A40101
Solute carrier family 22 member 20203
Potassium channel subfamily K member 20101
Histidine-rich protein PFHRP-II0101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Solute carrier organic anion transporter family member 1A10101
Solute carrier family 22 member 10305
Cytochrome P450 2D40101
Solute carrier family 22 member 20304
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Solute carrier family 22 member 50001
Solute carrier family 22 member 30202
Potassium voltage-gated channel subfamily A member 10101
Solute carrier family 22 member 40001
Solute carrier family 22 member 40101
Solute carrier family 22 member 30001
Solute carrier family 22 member 50001
Solute carrier family 22 member 40001
Mitogen-activated protein kinase 10011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]