Target type: molecularfunction
Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:20622853, PMID:26214369, PMID:32209475]
Histone H4K20 demethylase activity refers to the enzymatic removal of methyl groups from lysine 20 (K20) of histone H4. This activity is crucial for regulating gene expression and other cellular processes. Histone H4 is a core component of the nucleosome, the fundamental unit of chromatin. Methylation of histone H4K20 is a dynamic process that can be modulated by histone methyltransferases and demethylases. Histone H4K20 methylation plays a significant role in chromatin compaction and gene expression. Methylation at H4K20 can be mono-, di-, or trimethylated. Each methylation state is associated with distinct effects on chromatin structure and gene expression. Histone H4K20 demethylases, also known as KDM4 family enzymes, utilize a variety of mechanisms to remove methyl groups from H4K20. These enzymes play important roles in developmental processes, DNA repair, and the regulation of cell cycle progression. For example, KDM4A has been implicated in the activation of genes involved in cell growth and differentiation. KDM4B has been linked to the suppression of tumor suppressor genes. By modulating the methylation state of histone H4K20, histone H4K20 demethylases contribute to the dynamic regulation of chromatin structure and gene expression. This activity has significant implications for various biological processes and is a target for drug development in the treatment of cancer and other diseases.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Histone lysine demethylase PHF8 | A histone lysine demethylase PHF8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UPP1] | Homo sapiens (human) |
| Lysine-specific demethylase 7A | A lysine-specific demethylase 7A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZMT4] | Homo sapiens (human) |
| Lysine-specific demethylase PHF2 | A lysine-specific demethylase PHF2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75151] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| amiodarone | amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance. | 1-benzofurans; aromatic ketone; organoiodine compound; tertiary amino compound | cardiovascular drug |
| succinylacetone | 4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia. succinylacetone: inhibitor of heme biosynthesis | beta-diketone; dioxo monocarboxylic acid | human metabolite |
| 2,4-pyridinedicarboxylic acid | lutidinic acid : A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 4. | pyridinedicarboxylic acid | |
| daminozide | daminozide: induces tumors | straight-chain fatty acid | |
| oxalylglycine | N-oxalylglycine : An amino dicarboxylic acid that is iminodiacetic acid with an oxo substituent. It is used as an inhibitor of alpha-ketoglutarate dependent (EC 1.14.11.*) enzymes. oxalylglycine: structure given in first source | amino dicarboxylic acid; N-acylglycine | EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor |
| 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid | organonitrogen heterocyclic compound |