Coloboma

Congenital anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation.

Synonym
Uveoretinal Coloboma
Ocular Coloboma
Coloboma, Ocular
Coloboma, Uveoretinal
Coloboma
Coloboma Of Iris, Choroid, And Retina

Excerpt	Reference
"Typical isolated ocular coloboma is a congenital abnormality caused by a defective closure of the embryonic fissure of the optic cup."	( Barros-Nuñez, P; Garcia-Cruz, D; Medina, C; Mendoza, R; Sanchez-Corona, J, 1995)
"Chylothorax and colobomas are uncommon features reported in Noonan syndrome."	( Alves, VV; Carvalho, DR; Minaré-Júnior, A; Peres, LC; Pina-Neto, JM; Ramos, ES, 2003)
"The choroidal coloboma is a congenital malformation that results from an anomaly of the embryonic fissure."	( El Moussaif, H; Kermane, A; Mohcine, Z; Tachfouti, S, 2004)
"Iris coloboma is particularly important in terms of perinatal diagnosis because its detection in the newborn requires a careful and regular examination of the lens."	( Beby, F; Bozon, M; Commeaux, C; Denis, P; Edery, P; Morlé, L, 2007)
"Lens coloboma is a rare congenital disorder of crystalline lens characterized by notching of the equator of the lens."	( Hu, Z; Li, J; Ma, X, 2011)
"Ocular coloboma is sometimes accompanied by corectopia in humans and therefore ectopic pupil may indicate ocular coloboma in experimental animals."	( Matsuura, T; Narama, I; Ozaki, K; Tsuji, N, 2011)
"Ocular coloboma is a potentially blinding congenital eye malformation caused by failure of optic fissure closure during early embryogenesis."	( Inbal, A; Kaufman, R; Michaeli, N; Weiss, O, 2012)
"Congenital ocular colobomas are the result of a failure in closure of the embryonal fissure."	( Berbis, J; Denis, D; Girard, N; Levy-Mozziconacci, A; Matonti, F, 2013)
"Coloboma is a congenital disease that contributes significantly to childhood blindness."	( Chen, S; Lewis, B; Moran, A; Xie, T, 2012)
"Ocular coloboma is a congenital defect resulting from failure of normal closure of the optic fissure during embryonic eye development."	( Bacchelli, C; Beales, PL; Bitner-Glindzicz, M; Buck, A; Chanudet, E; Islam, L; Jacques, TS; Kelberman, D; Kohlhase, J; Lakowski, J; Lehmann, OJ; Lescai, F; Liasis, A; Nischal, KK; Patel, A; Sowden, JC; Stupka, E; Wolf, S, 2014)
"Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts."	( Fichera, M; Lehmann, OJ; Lo-Castro, A; Morris, AC; Musumeci, SA; Pillai-Kastoori, L; Strachan, E; Wen, W; Wilson, SG, 2014)
"Coloboma is a term used to denote a partial or complete absence of specific ocular tissues."	( Loba, P; Wilcynski, M, 2016)
"Congenital ocular colobomas are due to incomplete closure of the fetal fissure during organogenesis."	( Zerkaoui, N, 2018)
"Ocular coloboma is an uncommon, but often severe, sight-threatening condition that can be identified from birth."	( ALSomiry, AS; Gregory-Evans, CY; Gregory-Evans, K, 2019)
"Retinal coloboma is a rare condition which is difficult to diagnose in foetuses."	( Barjol, A; Bault, JP; Collin, A; Egloff, C; Mandelbrot, L; Picone, O; Sibiude, J; Simon, I; Tassin, M, 2020)
"Ocular coloboma is caused by failure of optic fissure closure during development and recognized as part of the microphthalmia, anophthalmia, and coloboma (MAC) spectrum."	( Basel, D; McCarrier, J; Reis, LM; Semina, EV; Weinberg, DV, 2020)
"Ocular coloboma is a congenital disorder of the eye where a gap exists in the inferior retina, lens, iris, or optic nerve tissue."	( Dicipulo, R; Fox, SC; Lehmann, OJ; Waskiewicz, AJ; Yoon, KH, 2020)
"Ocular coloboma is a congenital eye malformation, resulting from a failure in optic fissure closure (OFC) and causing visual impairment."	( Anderson, G; Balys, M; Galea, GL; Patel, A; Sowden, JC, 2020)
"Ocular coloboma is a developmental eye disorder that presents as a physical gap in the ventral eye, and is a major cause of childhood blindness."	( Hardy, H; Rainger, J, 2023)

Excerpt	Reference
"Clinically, coloboma has been described as a feature in a WDR37-related disorder and a PACS1-related disorder (Schuurs-Hoeijmakers syndrome), but not in a PACS2-related disorder."	( Kosaki, K; Miyama, S; Sakaguchi, Y; Takenouchi, T; Uehara, T; Yoshihashi, H, 2021)

Excerpt	Reference
"The natural history of an untreated coloboma with an orbital cleft in a 14-year-old girl is presented."	( Sergott, TJ; Vistnes, LM, 1986)
"The authors treated a case of colobomatous ocular cyst associated with a mild microphthalmos by cyst excision and pedicle ligature, via a transconjunctival orbitotomy."	( Leccisotti, A; Polito, E, 1995)
"Retinal detachment secondary to coloboma of choroid is treated best by pars plana vitrectomy along with silicone oil tamponade."	( Agrawal, R; Badrinath, SS; Bhende, PS; Deshpande, DA; Gopal, L; Parikh, SN; Shanmugam, MS; Sharma, T, 1998)
"The size of the coloboma in gup zebrafish mutants treated with diferuloylmethane was greatly reduced."	( Gregory-Evans, CY; Gregory-Evans, K; Moosajee, M; Shan, X, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	278 (44.41)	23.3326
1990's	92 (14.70)	12.5806
2000's	98 (15.65)	18.1394
2010's	114 (18.21)	28.8240
2020's	44 (7.03)	9.53

Drug	Relationship Strength	Studies
quinacrine	low	1
salicylic acid	low	5
phenytoin	low	1
carbamazepine	low	1
amphetamine	low	2
valproic acid	low	2
dsp 4	low	2
erythrosine	low	6
2-propanol	low	373
apnea	low	1
oxyphenbutazone	low	1
potassium chloride	low	1
pramoxine	low	1
saccharin	low	1
spiperone	low	1
thalidomide	low	3
lysergic acid diethylamide	low	1
thymidine	low	2
bromodeoxyuridine	low	1
aniline	low	1
ampicillin	low	1
cytarabine	low	1
perfluoroethane	low	1
perflutren	low	3
perfluorodecalin	low	1
perfluorooctane	low	2
testosterone enanthate	low	1
ethylnitrosourea	low	1
fluorescein	low	1
sulfur hexafluoride	low	1
enbucrilate	low	1
silver	low	1
trolamine salicylate	low	1
transferrin	low	1
glutamic acid	low	1
timolol	low	1
propiconazole	low	49
fomesafen	low	1
perfluorophenanthrene	low	1
fibrinogen	low	1
organophosphonates	low	1
inositol 3-phosphate	low	6
netilmicin	low	1
cyclopamine	low	2
tretinoin	low	2
retinol	low	3
mycophenolic acid	low	2
bromochloroacetic acid	low	1
arginine vasopressin	low	2
curcumin	low	1
methimazole	low	1
ethylenethiourea	low	1
succimer	low	1
freedom	low	1
alpha-chymotrypsin	low	1
rutin	low	1
travoprost	low	1
phenylephrine hydrochloride	low	41
desonide	low	1
latanoprost	low	1
iridal	low	1
cysteine	low	1
indocyanine green	low	2
cytochrome c-t	low	1
thymosin	low	1
transforming growth factor beta	low	4
cyclin d1	low	1
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	low	2
eye	low	103
concanavalin a	low	1

Protein Targets (837)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	19	0	0	19
GLI family zinc finger 3	19	0	0	19
AR protein	23	0	0	23
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
retinoid X nuclear receptor alpha	17	0	0	17
estrogen nuclear receptor alpha	29	0	0	29
peroxisome proliferator-activated receptor delta	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
activating transcription factor 6	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	9	0	0	9
thyroid hormone receptor beta isoform a	11	0	0	11
heat shock protein beta-1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
lamin isoform A-delta10	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Glutamate receptor 2	9	3	1	13
Solute carrier family 22 member 3	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	1	4
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Substance-P receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	3	6
5-hydroxytryptamine receptor 1A	0	7	2	9
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	0	1	1
5-hydroxytryptamine receptor 7	0	2	2	4
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	1	2
Beta-2 adrenergic receptor	0	1	1	2
5-hydroxytryptamine receptor 3B	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Cruzipain	4	0	0	4
Beta-lactamase	0	0	0	1
acid sphingomyelinase	1	0	0	1
GLS protein	7	0	0	7
apical membrane antigen 1, AMA1	2	0	0	2
farnesoid X nuclear receptor	13	0	0	13
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
chromobox protein homolog 1	13	0	0	13
thyroid hormone receptor beta isoform 2	16	0	0	16
DNA polymerase beta	3	0	0	3
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	7	0	0	7
geminin	16	0	0	16
DNA polymerase kappa isoform 1	7	0	0	7
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	5	0	6
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	4	0	0	4
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
ATP-dependent phosphofructokinase	7	0	0	7
thyroid stimulating hormone receptor	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
Steroid C26-monooxygenase	0	0	1	1
Cytochrome P450 130	0	0	1	1
Cytochrome P450 130	0	0	1	1
thioredoxin reductase	14	0	0	14
ATAD5 protein, partial	8	0	0	8
TDP1 protein	25	0	0	25
Microtubule-associated protein tau	10	0	0	10
estrogen-related nuclear receptor alpha	24	0	0	24
arylsulfatase A	8	0	0	8
Bloom syndrome protein isoform 1	7	0	0	7
D(1A) dopamine receptor	4	0	0	4
neuropeptide S receptor isoform A	2	0	0	2
vitamin D3 receptor isoform VDRA	7	0	0	7
peripheral myelin protein 22	9	0	0	9
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	9
Bile salt export pump	0	14	0	14
Translocator protein	0	0	1	1
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	9	0	9
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
thyroid stimulating hormone receptor	10	0	0	10
Cellular tumor antigen p53	16	0	0	16
Nuclear receptor ROR-gamma	6	1	1	8
interleukin 8	4	0	0	4
pregnane X receptor	7	0	0	7
progesterone receptor	10	0	0	10
glucocorticoid receptor [Homo sapiens]	15	0	0	15
pregnane X nuclear receptor	14	0	0	14
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
IDH1	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
Nuclear hormone receptor family member daf-12	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
survival motor neuron protein isoform d	5	0	0	5
muscarinic acetylcholine receptor M1	5	0	0	5
Thymidine kinase, cytosolic	0	4	0	6
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	10	0	0	10
acetylcholinesterase	9	0	0	9
USP1 protein, partial	9	0	0	9
mitogen-activated protein kinase 1	7	0	0	7
Vpr	2	0	0	2
Bile salt export pump	0	4	0	4
Albumin	0	0	1	1
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	2	1	3
UDP-glucuronosyltransferase 2B7	0	1	0	3
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	2	0	4
Cytochrome P450 2J2	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, Ferritin light chain	4	0	0	4
Luciferase	7	0	0	7
Nrf2	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
phosphopantetheinyl transferase	9	0	0	9
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
alkaline phosphatase, intestinal	0	1	0	1
thioredoxin glutathione reductase	5	0	0	5
Smad3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	9	0	0	9
EWS/FLI fusion protein	2	0	0	3
glucocerebrosidase	1	0	0	1
Parkin	2	0	0	2
toll-like receptor 9	0	1	0	1
peroxisome proliferator activated receptor gamma	11	0	0	11
caspase-3	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
TPA: protein transporter TIM10	0	1	0	1
aryl hydrocarbon receptor	9	0	0	9
thyrotropin-releasing hormone receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
lysosomal alpha-glucosidase preproprotein	3	0	0	3
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
transcriptional regulator ERG isoform 3	3	0	0	3
huntingtin isoform 2	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	3	0	0	3
snurportin-1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	7	0	0	7
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
cytochrome P450 3A4 isoform 1	7	0	0	7
muscleblind-like protein 1 isoform 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
hypothetical protein SA1422	0	1	0	1
lethal factor (plasmid)	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	7	1	1	9
Prostaglandin E synthase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Histone deacetylase 3	0	3	0	3
Acetylcholinesterase	0	1	0	1
Lysine-specific histone demethylase 1A	0	2	0	2
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Amyloid-beta precursor protein	0	3	0	4
Integrin beta-3	2	0	1	3
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Cholinesterase	0	2	0	2
Heme oxygenase 1	0	1	0	1
Integrin alpha-IIb	2	0	1	3
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
60 kDa chaperonin	0	2	0	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	3	1	4
Microtubule-associated protein tau	0	1	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	2	0	2
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	7	1	1	9
Alpha-1B adrenergic receptor	0	5	0	5
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	7	1	1	9
Gamma-aminobutyric acid receptor subunit gamma-2	7	1	1	9
Gamma-aminobutyric acid receptor subunit alpha-5	7	1	1	9
Gamma-aminobutyric acid receptor subunit alpha-3	7	1	1	9
Amine oxidase [flavin-containing] A	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Acetylcholinesterase	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	7	1	1	9
Gamma-aminobutyric acid receptor subunit alpha-2	7	1	1	9
Heme oxygenase 2	0	1	0	1
Alpha-1D adrenergic receptor	0	5	0	5
Amine oxidase [flavin-containing] B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	7	1	1	9
Gamma-aminobutyric acid receptor subunit gamma-3	7	1	1	9
Gamma-aminobutyric acid receptor subunit alpha-6	7	1	1	9
Prostaglandin G/H synthase 2	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-synuclein	2	3	1	6
Alpha-1A adrenergic receptor	0	6	0	6
Histamine H2 receptor	4	0	0	5
Glycogen synthase kinase-3 beta	0	1	0	1
Caspase-7	1	0	0	1
Histone deacetylase 4	0	3	0	3
Beta-secretase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	1	1	9
Gamma-aminobutyric acid receptor subunit beta-3	7	1	1	9
Guanine nucleotide-binding protein G	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	7	1	1	9
Cholinesterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Serine/threonine-protein kinase PAK 1	0	1	0	1
Histone deacetylase 1	0	4	0	4
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Histone deacetylase 7	0	3	0	3
GABA theta subunit	7	1	1	9
Histone deacetylase 2	0	4	0	4
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone deacetylase 8	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	7	1	1	9
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Histone deacetylase 5	0	3	0	3
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	2	0	2
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Smoothened homolog	0	1	0	1
Sonic hedgehog protein	0	1	0	1
Sonic hedgehog protein	0	1	1	2
Smoothened homolog	0	2	1	3
endonuclease IV	2	0	0	2
glp-1 receptor, partial	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
G	6	0	0	6
67.9K protein	4	0	0	4
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Thymidine kinase 2, mitochondrial	0	1	0	1
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	0	0	2
Cytochrome P450 3A4	0	3	1	4
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	2	0	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
NFKB1 protein, partial	2	0	0	2
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C19 precursor	2	0	0	2
Genome polyprotein	0	2	1	3
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Fumarate hydratase	5	0	0	5
hypothetical protein, conserved	2	0	0	2
cytochrome P450 2D6	7	0	0	7
polyprotein	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Hsf1 protein	0	0	1	1
Taste receptor type 2 member 38	0	0	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
regulator of G-protein signaling 4	5	0	0	5
beta-2 adrenergic receptor	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	3
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Chymotrypsinogen A	0	2	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Beta-2 adrenergic receptor	0	3	0	3
Beta-1 adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	2	1	3
D(2) dopamine receptor	0	3	1	4
D(4) dopamine receptor	0	3	0	3
D(1B) dopamine receptor	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Histamine H1 receptor	0	1	0	1
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
D	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Polyphenol oxidase 2	0	4	0	6
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Microphthalmia-associated transcription factor	0	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
Caspase-7	2	0	0	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
GALC protein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Gamma-aminobutyric acid	0	1	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 60	0	0	1	1
Carbonic anhydrase 9	0	3	0	3
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
nonstructural protein 1	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
N	0	1	0	1
dopamine D1 receptor	1	0	0	1
NPYLR7B	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
cystic fibrosis transmembrane conductance regulator	0	1	0	1
M-phase phosphoprotein 8	2	0	0	2
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	2	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	3	0	3
ATP-dependent translocase ABCB1	0	2	1	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	3	0	3
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Trypanothione reductase	0	2	0	2
Aldehyde oxidase 1	0	1	0	1
Aldehyde oxidase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	2	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	1	1	2
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D6	0	3	1	4
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Neuraminidase	0	2	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
L-lactate dehydrogenase A chain	0	1	0	1
Albumin	0	1	0	1
Neuraminidase	0	1	0	1
Beta-lactamase	0	1	0	1
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Dipeptidyl peptidase 4	0	1	0	1
Substance-P receptor	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 12	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
D(3) dopamine receptor	0	2	0	3
Carbonic anhydrase 6	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
RmtA	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
alternatively spliced Trp4	0	0	1	1
5-hydroxytryptamine receptor 1E	0	1	0	1
sphingosine 1-phosphate receptor 3	0	1	0	1
Beta-casein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Glycogen phosphorylase, brain form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
D	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Endothelin receptor type B	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Endothelin receptor type B	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	3
Vesicular acetylcholine transporter	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Cytochrome P450 1A2	0	0	1	1
Ornithine decarboxylase	0	0	0	1
Adenosine receptor A3	0	2	0	2
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2C19	0	0	1	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (626)

Protein Targets (837)

Coloboma

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (626)

Drugs Studied (91)

Protein Targets (837)