desonide and Coloboma

When encountered in children, xanthomas are most commonly associated with a group of disorders known as familial hyperlipidemias. Aside from cosmetic concerns, these xanthomas are typically asymptomatic, but when generalized pruritus is a prominent associated symptom, clinicians should consider a different set of diagnoses that includes cholestasis of the liver. In this article we present two illustrative cases of children with cholestatic disease, pruritus, and xanthomas and discuss other disorders that may include this triad.

Topics: Abnormalities, Multiple; Alagille Syndrome; Anesthetics, Local; Ataxia; Brain; Child; Child, Preschool; Cholestasis; Coloboma; Desonide; Diagnosis, Differential; Dyslipidemias; Female; Histamine Antagonists; Humans; Liver Diseases; Morpholines; Pruritus; Xanthomatosis