midazolam has been researched along with Agitated Emergence in 22 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect on pre-operative anxiety of premedication with midazolam, playing video games or watching a cartoon about anaesthesia." | 9.41 | Which is good for pre-operative anxiety? Midazolam, video games or teaching with cartoons: A randomised trial. ( Bolat, M; Donmez, A; Polat, R; Sakızcı Uyar, B, 2021) |
| "In paediatric patients undergoing strabismus surgery intranasal dexmedetomidine 2 μg kg premedication decreases the incidence of emergence delirium and PONV, and improves parents' satisfaction compared with oral midazolam." | 9.34 | Intranasal dexmedetomidine versus oral midazolam premedication to prevent emergence delirium in children undergoing strabismus surgery: A randomised controlled trial. ( Chen, W; Lin, J; Lin, Y; Sun, Y; Yao, Y; Zheng, X, 2020) |
| "The purpose of this study was to compare effects of tablet-based interactive distraction (TBID; 1 minute preseparation) with oral midazolam (15 to 45 minutes of preseparation) on preoperative anxiety, emergence delirium, and postanesthesia length of stay in children, 4 to 12 years undergoing outpatient surgery." | 9.30 | Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay. ( Cazzell, MA; Pearcy, T; Stewart, B, 2019) |
| " Compared with midazolam, dexmedetomidine was favorable in reducing both emergence delirium and pain in the postoperative care unit, and both clonidine and dexmedetomidine reduced anxiety in the postoperative care unit." | 5.69 | Postoperative recovery in preschool-aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine. ( Bromfalk, Å; Engström, Å; Hultin, M; Myrberg, T; Walldén, J, 2023) |
| "We investigated the effect on pre-operative anxiety of premedication with midazolam, playing video games or watching a cartoon about anaesthesia." | 5.41 | Which is good for pre-operative anxiety? Midazolam, video games or teaching with cartoons: A randomised trial. ( Bolat, M; Donmez, A; Polat, R; Sakızcı Uyar, B, 2021) |
| "In paediatric patients undergoing strabismus surgery intranasal dexmedetomidine 2 μg kg premedication decreases the incidence of emergence delirium and PONV, and improves parents' satisfaction compared with oral midazolam." | 5.34 | Intranasal dexmedetomidine versus oral midazolam premedication to prevent emergence delirium in children undergoing strabismus surgery: A randomised controlled trial. ( Chen, W; Lin, J; Lin, Y; Sun, Y; Yao, Y; Zheng, X, 2020) |
| "The purpose of this study was to compare effects of tablet-based interactive distraction (TBID; 1 minute preseparation) with oral midazolam (15 to 45 minutes of preseparation) on preoperative anxiety, emergence delirium, and postanesthesia length of stay in children, 4 to 12 years undergoing outpatient surgery." | 5.30 | Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay. ( Cazzell, MA; Pearcy, T; Stewart, B, 2019) |
| " This prospective observational study included 638 pediatric American Society of Anesthesiologists I-II patients who underwent ambulatory pediatric surgery, grouped into four preoperative preparation groups: NADA (not premedicated), MDZ (premedicated with midazolam), PPIA (parental presence during induction of anesthesia), and PPIA + MDZ." | 4.12 | Parental Presence during Induction of Anesthesia Improves Compliance of the Child and Reduces Emergence Delirium. ( Alonso Calderón, J; Gajate Martin, L; Gil Mayo, D; Gomez Rojo, M; Hernández Oliveros, F; Sanabria Carretero, P, 2022) |
| " A prospective, double-blind, randomized, controlled study was performed to compare the efficacy of minimal dosage of midazolam versus dexmedetomidine to prevent ED in children undergoing tonsillectomy." | 2.94 | Comparison of single minimum dose administration of dexmedetomidine and midazolam for prevention of emergence delirium in children: a randomized controlled trial. ( Ahn, JH; Cha, YB; Cho, EA; Lee, SH; Ryu, KH; Shim, JG, 2020) |
| "A blinded observer in the PACU assessed emergence delirium using the Pediatric Anesthesia Emergence Delirium (PAED) scale." | 2.94 | Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement. ( Cusick, J; Lalwani, K; Martin, CS; Piper, L; Treggiari, MM; Yanez, ND, 2020) |
| "Remifentanil has a significant effect on reducing the occurrence of delirium (P = 0." | 2.84 | The influence of analgesic-based sedation protocols on delirium and outcomes in critically ill patients: A randomized controlled trial. ( An, Y; Liu, D; Lyu, J; Zhao, H, 2017) |
| "Incidence of EA and postoperative pain scores were recorded at 10-min intervals in the postanaesthetic care unit (PACU)." | 2.82 | Comparison of effects of intravenous midazolam and ketamine on emergence agitation in children: Randomized controlled trial. ( Jung, JW; Kang, E; Kim, KM; Kim, YH; Ko, MJ; Lee, KH, 2016) |
| "Postoperative emergence delirium develops in 12% to 18% of all children undergoing general anesthesia for surgery." | 2.55 | Effectiveness of preoperative intranasal dexmedetomidine, compared with oral midazolam, for the prevention of emergence delirium in the pediatric patient undergoing general anesthesia: a systematic review. ( Badeaux, J; Bonanno, LS; FitzSimons, J; Pierce, S, 2017) |
| "Midazolam premedication was administered to 782 (40%) patients (median [IQR] dose 2 [1,2] mg)." | 2.44 | The association between midazolam premedication and postoperative delirium - a retrospective cohort study. ( Cohen, B; Davydov, T; Iacubovici, L; Karol, D; Kiselevich, Y; Matot, I; Shaylor, R; Weiss, Y; Zarour, S, 2024) |
| "Oral midazolam was reported as standard premedication by 84% of respondents, the second largest group was 'no premedication' (5%)." | 1.46 | Prevention and Therapy of Pediatric Emergence Delirium: A National Survey. ( Baehner, T; Bode, C; Ellerkmann, RK; Erdfelder, F; Hoeft, A; Hoehne, C; Huett, C, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 14 (63.64) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, HY | 1 |
| Chen, TY | 1 |
| Li, DJ | 1 |
| Lin, PY | 1 |
| Su, KP | 1 |
| Chiang, MH | 1 |
| Carvalho, AF | 1 |
| Stubbs, B | 1 |
| Tu, YK | 1 |
| Wu, YC | 1 |
| Roerecke, M | 1 |
| Smith, L | 1 |
| Tseng, PT | 1 |
| Hung, KC | 1 |
| Zarour, S | 1 |
| Weiss, Y | 1 |
| Kiselevich, Y | 1 |
| Iacubovici, L | 1 |
| Karol, D | 1 |
| Shaylor, R | 1 |
| Davydov, T | 1 |
| Matot, I | 1 |
| Cohen, B | 1 |
| Bağcaz, A | 1 |
| Ayhan, A | 1 |
| Bromfalk, Å | 1 |
| Hultin, M | 1 |
| Myrberg, T | 1 |
| Engström, Å | 1 |
| Walldén, J | 1 |
| Yoshimura, M | 1 |
| Hidaka, Y | 1 |
| Morimoto, Y | 1 |
| Zhang, D | 1 |
| Jia, X | 1 |
| Lin, D | 1 |
| Ma, J | 1 |
| Cho, EA | 1 |
| Cha, YB | 1 |
| Shim, JG | 1 |
| Ahn, JH | 1 |
| Lee, SH | 1 |
| Ryu, KH | 1 |
| Martin, CS | 1 |
| Yanez, ND | 1 |
| Treggiari, MM | 1 |
| Piper, L | 1 |
| Cusick, J | 1 |
| Lalwani, K | 1 |
| Wang, L | 1 |
| Huang, L | 1 |
| Zhang, T | 1 |
| Peng, W | 1 |
| Yao, Y | 1 |
| Sun, Y | 1 |
| Lin, J | 1 |
| Chen, W | 1 |
| Lin, Y | 1 |
| Zheng, X | 1 |
| Sakızcı Uyar, B | 1 |
| Polat, R | 1 |
| Bolat, M | 1 |
| Donmez, A | 1 |
| Singla, L | 1 |
| Mathew, PJ | 1 |
| Jain, A | 1 |
| Yaddanapudi, S | 1 |
| Peters, NJ | 1 |
| Gil Mayo, D | 1 |
| Sanabria Carretero, P | 1 |
| Gajate Martin, L | 1 |
| Alonso Calderón, J | 1 |
| Hernández Oliveros, F | 1 |
| Gomez Rojo, M | 1 |
| FitzSimons, J | 1 |
| Bonanno, LS | 2 |
| Pierce, S | 2 |
| Badeaux, J | 2 |
| Liu, D | 1 |
| Lyu, J | 1 |
| Zhao, H | 1 |
| An, Y | 1 |
| Wu, XL | 1 |
| Peng, B | 1 |
| Shan, CJ | 1 |
| Liu, JJ | 1 |
| Zhang, FC | 1 |
| Keles, S | 1 |
| Kocaturk, O | 1 |
| Stewart, B | 1 |
| Cazzell, MA | 1 |
| Pearcy, T | 1 |
| Kim, KM | 1 |
| Lee, KH | 1 |
| Kim, YH | 1 |
| Ko, MJ | 1 |
| Jung, JW | 1 |
| Kang, E | 1 |
| Guo, Y | 1 |
| Jia, P | 1 |
| Zhang, J | 1 |
| Wang, X | 1 |
| Jiang, H | 1 |
| Jiang, W | 1 |
| FitzSimons, JJ | 1 |
| Huett, C | 1 |
| Baehner, T | 1 |
| Erdfelder, F | 1 |
| Hoehne, C | 1 |
| Bode, C | 1 |
| Hoeft, A | 1 |
| Ellerkmann, RK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dexmedetomidine Versus Midazolam Premedication on Emergence Agitation After Strabismus Surgery in Children[NCT01895023] | Phase 4 | 156 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| The Effect of Three Different Interventions on Preoperative Anxiety in Children[NCT03530670] | Phase 4 | 138 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| Utility of Oral Dexmedetomidine as the Sole Sedative Agent in Pediatric Population Undergoing MRI[NCT05619627] | Phase 1 | 120 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
| The Effect of Visualized Education and Distraction in the Preoperative Process on Reducing the Anxiety of Children and Their Parents: A Randomized Controlled Study[NCT05279976] | 210 participants (Anticipated) | Interventional | 2023-06-06 | Recruiting | |||
| Comparison of the Effectiveness of Two Different Distraction Interventions in Reducing Preoperative Anxiety of Children and Parents Who Are Scheduled for Elective Surgery: A Randomized Controlled Study[NCT05538039] | 210 participants (Anticipated) | Interventional | 2022-09-16 | Recruiting | |||
| Intelligent Customer-driven Solution for Children and Their Parents Undergoing Children´s Day Surgery[NCT04277299] | 40 participants (Actual) | Interventional | 2020-08-12 | Completed | |||
| Midazolam Effect on Agitation Postnasal Surgery: A Double Blinded Randomized Controlled Trial[NCT05165914] | 100 participants (Actual) | Interventional | 2021-05-27 | Completed | |||
| Intranasal Sedation With Dexmedetomidine for Vitroretinal Procedures[NCT03251222] | Phase 4 | 40 participants (Anticipated) | Interventional | 2017-01-01 | Recruiting | ||
| Investigation of the DNA Methylation Profile in Children Who Presented Emergence Delirium[NCT03787849] | 175 participants (Actual) | Interventional | 2018-09-24 | Completed | |||
| Effectivity of 0.5 mg/kg Propofol in the End of Anesthesia to Reduce the Incidence of Postanesthetic Emergence Agitation in Pediatric Patients Under General Inhalation Anesthesia[NCT03528954] | 54 participants (Actual) | Interventional | 2018-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for midazolam and Agitated Emergence
| Article | Year |
|---|---|
Association of pharmacological prophylaxis with the risk of pediatric emergence delirium after sevoflurane anesthesia: An updated network meta-analysis.
Topics: Anesthesia, General; Child; Emergence Delirium; Humans; Midazolam; Network Meta-Analysis; Sevofluran | 2021 |
Melatonin or its analogs as premedication to prevent emergence agitation in children: a systematic review and meta-analysis.
Topics: Adolescent; Child; Dexmedetomidine; Emergence Delirium; Humans; Melatonin; Methyl Ethers; Midazolam; | 2023 |
Effectiveness of preoperative intranasal dexmedetomidine, compared with oral midazolam, for the prevention of emergence delirium in the pediatric patient undergoing general anesthesia: a systematic review.
Topics: Administration, Intranasal; Adrenergic alpha-2 Receptor Agonists; Anesthesia, General; Child; Child, | 2017 |
11 trials available for midazolam and Agitated Emergence
| Article | Year |
|---|---|
Postoperative recovery in preschool-aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, General; Child; Child, Preschool; Clonidine; Dexme | 2023 |
Comparison of single minimum dose administration of dexmedetomidine and midazolam for prevention of emergence delirium in children: a randomized controlled trial.
Topics: Child; Dexmedetomidine; Double-Blind Method; Emergence Delirium; Humans; Hypnotics and Sedatives; In | 2020 |
Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement.
Topics: Acupuncture Therapy; Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool; Emerg | 2020 |
Comparison of Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Dental Patients under General Anesthesia: A Randomised Clinical Trial.
Topics: Administration, Intranasal; Administration, Oral; Anesthesia, General; Child; Child, Preschool; Dexm | 2020 |
Intranasal dexmedetomidine versus oral midazolam premedication to prevent emergence delirium in children undergoing strabismus surgery: A randomised controlled trial.
Topics: Child; Dexmedetomidine; Double-Blind Method; Emergence Delirium; Humans; Hypnotics and Sedatives; Mi | 2020 |
Which is good for pre-operative anxiety? Midazolam, video games or teaching with cartoons: A randomised trial.
Topics: Anxiety; Child; Emergence Delirium; Humans; Midazolam; Prospective Studies; Video Games | 2021 |
Oral melatonin as part of multimodal anxiolysis decreases emergence delirium in children whereas midazolam does not: A randomised, double-blind, placebo-controlled study.
Topics: Anesthesia, General; Child; Child, Preschool; Double-Blind Method; Emergence Delirium; Humans; Melat | 2021 |
The influence of analgesic-based sedation protocols on delirium and outcomes in critically ill patients: A randomized controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Critical Illness; Deep Sedation; Emergence Delirium; Fem | 2017 |
The influence of dexmedetomidine on the emergence agitation of pediatric patients after the operations of sense organs under general anesthesia using sevoflurane.
Topics: Anesthesia Recovery Period; Anesthesia, General; Child; Dexmedetomidine; Emergence Delirium; Humans; | 2022 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Single-Blinded Randomized Controlled Study on Use of Interactive Distraction Versus Oral Midazolam to Reduce Pediatric Preoperative Anxiety, Emergence Delirium, and Postanesthesia Length of Stay.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anti-Anxiety Agents; Anxiet | 2019 |
Comparison of effects of intravenous midazolam and ketamine on emergence agitation in children: Randomized controlled trial.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Inhalation; | 2016 |
8 other studies available for midazolam and Agitated Emergence
| Article | Year |
|---|---|
The association between midazolam premedication and postoperative delirium - a retrospective cohort study.
Topics: Aged; Emergence Delirium; Female; Humans; Male; Midazolam; Postoperative Complications; Premedicatio | 2024 |
Emergence Agitation with Earthquake-Related Traumatic Stress Symptoms After Intravenous Sedation.
Topics: Anesthesia; Anesthetics, Intravenous; Earthquakes; Emergence Delirium; Humans; Ketamine; Midazolam | 2023 |
Association Between the Use of Midazolam During Cardiac Anesthesia and the Incidence of Postoperative Delirium: A Retrospective Cohort Study Using a Nationwide Database.
Topics: Anesthesia, Cardiac Procedures; Emergence Delirium; Humans; Incidence; Midazolam; Postoperative Comp | 2023 |
Parental Presence during Induction of Anesthesia Improves Compliance of the Child and Reduces Emergence Delirium.
Topics: Anesthesia; Anxiety; Child; Emergence Delirium; Humans; Infant; Midazolam; Parents; Prospective Stud | 2022 |
Comparison of oral dexmedetomidine and midazolam for premedication and emergence delirium in children after dental procedures under general anesthesia: a retrospective study.
Topics: Administration, Oral; Anesthesia, Dental; Child; Child, Preschool; Dexmedetomidine; Emergence Deliri | 2018 |
Prevalence and risk factors of postoperative delirium in elderly hip fracture patients.
Topics: Age Factors; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Intravenous; Arthroplasty, R | 2016 |
Effectiveness of preoperative intranasal dexmedetomidine compared with oral midazolam for the prevention of emergence delirium in pediatric patients undergoing general anesthesia: a systematic review protocol.
Topics: Anesthesia, General; Child; Dexmedetomidine; Emergence Delirium; Humans; Hypnotics and Sedatives; Mi | 2016 |
Prevention and Therapy of Pediatric Emergence Delirium: A National Survey.
Topics: Child; Dexmedetomidine; Emergence Delirium; Humans; Midazolam; Pediatrics; Propofol | 2017 |
Prevention and Therapy of Pediatric Emergence Delirium: A National Survey.
Topics: Child; Dexmedetomidine; Emergence Delirium; Humans; Midazolam; Pediatrics; Propofol | 2017 |
Prevention and Therapy of Pediatric Emergence Delirium: A National Survey.
Topics: Child; Dexmedetomidine; Emergence Delirium; Humans; Midazolam; Pediatrics; Propofol | 2017 |
Prevention and Therapy of Pediatric Emergence Delirium: A National Survey.
Topics: Child; Dexmedetomidine; Emergence Delirium; Humans; Midazolam; Pediatrics; Propofol | 2017 |