clonidine has been researched along with Agitated Emergence in 5 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine appears a safe and beneficial drug with moderate to high-quality evidence supporting its use in pediatric anesthesia." | 9.01 | Clonidine in pediatric anesthesia: the new panacea or a drug still looking for an indication? ( Afshari, A, 2019) |
| " Compared with midazolam, dexmedetomidine was favorable in reducing both emergence delirium and pain in the postoperative care unit, and both clonidine and dexmedetomidine reduced anxiety in the postoperative care unit." | 5.69 | Postoperative recovery in preschool-aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine. ( Bromfalk, Å; Engström, Å; Hultin, M; Myrberg, T; Walldén, J, 2023) |
| "Clonidine appears a safe and beneficial drug with moderate to high-quality evidence supporting its use in pediatric anesthesia." | 5.01 | Clonidine in pediatric anesthesia: the new panacea or a drug still looking for an indication? ( Afshari, A, 2019) |
| "Clonidine is an effective adjunctive agent for the prevention of emergence agitation in children, but evidence in the smallest age groups is sparse We aim to investigate the efficacy and safety of an intraoperative bolus of intravenous clonidine for preventing emergence agitation in children 3-12 months of age." | 3.30 | Clonidine for preventing emergence agitation in infants (PREVENT AGITATION II): Protocol and statistical analysis plan. ( Afshari, A; Falcon, L; Garioud, ALB; Mondrup, F; Nielsen, BN, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garioud, ALB | 1 |
| Nielsen, BN | 2 |
| Falcon, L | 1 |
| Mondrup, F | 1 |
| Afshari, A | 3 |
| Bromfalk, Å | 1 |
| Hultin, M | 1 |
| Myrberg, T | 1 |
| Engström, Å | 1 |
| Walldén, J | 1 |
| Ydemann, M | 1 |
| Wetterslev, J | 1 |
| Henneberg, S | 1 |
| Lauritsen, T | 1 |
| Steen, N | 1 |
| Edström, B | 1 |
| Moore, AD | 1 |
| Anghelescu, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clonidine for Tourniquet-related Pain in Children: A Pilot Study[NCT04564430] | Phase 4 | 20 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| Does Intraoperative Clonidine Reduce Post Operative Agitation in Children Anaesthetised With Sevoflurane? A RCT Including Pharmacokinetic Investigation.[NCT02361476] | Phase 4 | 379 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Effect of Different Administrations of Propofol on Emergence Agitation in Preschool Children Undergoing Ambulatory Surgery[NCT05420402] | 168 participants (Anticipated) | Interventional | 2022-08-01 | Active, not recruiting | |||
| Investigation of the DNA Methylation Profile in Children Who Presented Emergence Delirium[NCT03787849] | 175 participants (Actual) | Interventional | 2018-09-24 | Completed | |||
| Effectivity of 0.5 mg/kg Propofol in the End of Anesthesia to Reduce the Incidence of Postanesthetic Emergence Agitation in Pediatric Patients Under General Inhalation Anesthesia[NCT03528954] | 54 participants (Actual) | Interventional | 2018-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Amount used (NCT02361476)
Timeframe: Recorded during the stay in the postoperative recovery room
| Intervention | mg morphine equivalents (Mean) |
|---|---|
| Intervention | 0.46 |
| Placebo | 0.7 |
Time to administration (NCT02361476)
Timeframe: recovery room
| Intervention | MEDIAN time (min) to administration (Median) |
|---|---|
| Intervention | 105 |
| Placebo | 60 |
"Pain score used:~FLACC score = Face, Legs, Activity, Cry, Consolability Score ranges from 0 to 10 (severity increases with increasing score) Pain is FLACC score more than 3" (NCT02361476)
Timeframe: recovery room - hours
| Intervention | Pain Score (Mean) |
|---|---|
| Intervention | 1.57 |
| Placebo | 2.45 |
Measured by Watchae Scale (score 1-4), scores 1-2 = no agitation and scores 3-4 = agitated (NCT02361476)
Timeframe: 1 day
| Intervention | participants with agitation (Number) |
|---|---|
| Intervention | 46 |
| Placebo | 86 |
(NCT02361476)
Timeframe: from intervention to discharge from the recovery room
| Intervention | participants (Number) | ||
|---|---|---|---|
| adverse events | serious adverse events | Treated for low blood pressure | |
| Intervention | 0 | 2 | 0 |
| Placebo | 5 | 2 | 0 |
2 reviews available for clonidine and Agitated Emergence
| Article | Year |
|---|---|
Clonidine in pediatric anesthesia: the new panacea or a drug still looking for an indication?
Topics: Adrenergic alpha-2 Receptor Agonists; Age Factors; Anesthesia; Child; Clonidine; Emergence Delirium; | 2019 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
Emergence Delirium in Pediatric Anesthesia.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Desflurane; Dexmedetomidine; Emergence | 2017 |
3 trials available for clonidine and Agitated Emergence
| Article | Year |
|---|---|
Clonidine for preventing emergence agitation in infants (PREVENT AGITATION II): Protocol and statistical analysis plan.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Child; Clonidine; Double-B | 2023 |
Postoperative recovery in preschool-aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, General; Child; Child, Preschool; Clonidine; Dexme | 2023 |
Effect of clonidine to prevent agitation in children after sevoflurane anaesthesia: a randomised placebo controlled multicentre trial.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-2 Receptor Agonists; Anesthesia; Anesthetics, Inhalation; Ch | 2016 |
Effect of clonidine to prevent agitation in children after sevoflurane anaesthesia: a randomised placebo controlled multicentre trial.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-2 Receptor Agonists; Anesthesia; Anesthetics, Inhalation; Ch | 2016 |
Effect of clonidine to prevent agitation in children after sevoflurane anaesthesia: a randomised placebo controlled multicentre trial.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-2 Receptor Agonists; Anesthesia; Anesthetics, Inhalation; Ch | 2016 |
Effect of clonidine to prevent agitation in children after sevoflurane anaesthesia: a randomised placebo controlled multicentre trial.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-2 Receptor Agonists; Anesthesia; Anesthetics, Inhalation; Ch | 2016 |